메뉴 건너뛰기




Volumn 118, Issue 14, 2012, Pages 3455-3467

Mechanisms of resistance to vascular endothelial growth factor blockade

Author keywords

cancer; resistance; signaling; vascular endothelial growth factor

Indexed keywords

ALPHA INTERFERON; ANGIOPOIETIN 1; AXITINIB; BEVACIZUMAB; BRIVANIB; CARBOPLATIN; CEDIRANIB; COLONY STIMULATING FACTOR; EPHRIN; FIBROBLAST GROWTH FACTOR; FLUOROURACIL; LINIFANIB; MOTESANIB; NINTEDANIB; PACLITAXEL; PAZOPANIB; SORAFENIB; SUNITINIB; VASCULOTROPIN A; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 84863305116     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26540     Document Type: Review
Times cited : (77)

References (107)
  • 1
    • 33745189194 scopus 로고    scopus 로고
    • Aristotle: The first student of angiogenesis
    • DOI 10.1038/sj.leu.2404256, PII 2404256
    • Crivellato E, Ribatti D,. Aristotle: the first student of angiogenesis. Leukemia. 2006; 20: 1209-1210. (Pubitemid 43905822)
    • (2006) Leukemia , vol.20 , Issue.7 , pp. 1209-1210
    • Crivellato, E.1    Ribatti, D.2
  • 3
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W,. Mechanisms of angiogenesis. Nature. 1997; 386: 671-674. (Pubitemid 27193480)
    • (1997) Nature , vol.386 , Issue.6626 , pp. 671-674
    • Risau, W.1
  • 4
    • 0036948242 scopus 로고    scopus 로고
    • Intussusceptive angiogenesis - The alternative to capillary sprouting
    • PII S0098299702000961
    • Burri PH, Djonov V,. Intussusceptive angiogenesis-the alternative to capillary sprouting. Mol Aspects Med. 2002; 23: S1-S27. (Pubitemid 36092148)
    • (2002) Molecular Aspects of Medicine , vol.23 , Issue.SUPPL.
    • Burri, P.H.1    Djonov, V.2
  • 5
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • DOI 10.1038/74651
    • Carmeliet P,. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000; 6: 389-395. (Pubitemid 30208155)
    • (2000) Nature Medicine , vol.6 , Issue.4 , pp. 389-395
    • Carmeliet, P.1
  • 6
    • 0142112011 scopus 로고    scopus 로고
    • Hemostatic regulators of tumor angiogenesis: A source of antiangiogenic agents for cancer treatment?
    • Daly ME, Makris A, Reed M, Lewis CE,. Hemostatic regulators of tumor angiogenesis: a source of antiangiogenic agents for cancer treatment? J Natl Cancer Inst. 2003; 95: 1660-1673. (Pubitemid 37509075)
    • (2003) Journal of the National Cancer Institute , vol.95 , Issue.22 , pp. 1660-1673
    • Daly, M.E.1    Makris, A.2    Reed, M.3    Lewis, C.E.4
  • 7
    • 0036114404 scopus 로고    scopus 로고
    • Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
    • Zhou Y, McMaster M, Woo K, et al. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002; 160: 1405-1423. (Pubitemid 34411644)
    • (2002) American Journal of Pathology , vol.160 , Issue.4 , pp. 1405-1423
    • Zhou, Y.1    McMaster, M.2    Woo, K.3    Janatpour, M.4    Perry, J.5    Karpanen, T.6    Alitalo, K.7    Damsky, C.8    Fisher, S.J.9
  • 9
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • DOI 10.1038/nrc1093
    • Bergers G, Benjamin LE,. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003; 3: 401-410. (Pubitemid 37328844)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 10
    • 0038126870 scopus 로고    scopus 로고
    • B-cell non-Hodgkin's lymphomas express heterogeneous patterns of neovascularization
    • Crivellato E, Nico B, Vacca A, Ribatti D,. B-cell non-Hodgkin's lymphomas express heterogeneous patterns of neovascularization. Haematologica. 2003; 88: 671-678. (Pubitemid 36781594)
    • (2003) Haematologica , vol.88 , Issue.6 , pp. 671-678
    • Crivellato, E.1    Nico, B.2    Vacca, A.3    Ribatti, D.4
  • 11
    • 0032710319 scopus 로고    scopus 로고
    • Clinical applications of angiogenic growth factors and their inhibitors
    • Ferrara N, Alitalo K,. Clinical applications of angiogenic growth factors and their inhibitors. Nat Med. 1999; 5: 1359-1364.
    • (1999) Nat Med. , vol.5 , pp. 1359-1364
    • Ferrara, N.1    Alitalo, K.2
  • 12
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J,. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971; 285: 1182-1186.
    • (1971) N Engl J Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 13
    • 0031001536 scopus 로고    scopus 로고
    • The preclinical evaluation of angiogenesis inhibitors
    • DOI 10.1023/A:1005762410476
    • O'Reilly MS,. The preclinical evaluation of angiogenesis inhibitors. Invest New Drugs. 1997; 15: 5-13. (Pubitemid 27217747)
    • (1997) Investigational New Drugs , vol.15 , Issue.1 , pp. 5-13
    • O'Reilly, M.S.1
  • 15
    • 0015311426 scopus 로고
    • Anti-angiogenesis: New concept for therapy of solid tumors
    • Folkman J,. Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg. 1972; 175: 409-416.
    • (1972) Ann Surg. , vol.175 , pp. 409-416
    • Folkman, J.1
  • 16
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J, Klagsbrun M,. Angiogenic factors. Science. 1987; 235: 442-447. (Pubitemid 17009577)
    • (1987) Science , vol.235 , Issue.4787 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 17
    • 0030242225 scopus 로고    scopus 로고
    • Fighting cancer by attacking its blood supply
    • Folkman J,. Fighting cancer by attacking its blood supply. Sci Am. 1996; 275: 150-154.
    • (1996) Sci Am. , vol.275 , pp. 150-154
    • Folkman, J.1
  • 18
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • DOI 10.1016/S0092-8674(00)80108-7
    • Hanahan D, Folkman J,. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86: 353-364. (Pubitemid 26272076)
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 21
    • 84863317751 scopus 로고    scopus 로고
    • Bayer Healthcare Pharmaceuticals Inc. Wayne, NJ: Bayer Healthcare Pharmaceuticals Inc.
    • Bayer Healthcare Pharmaceuticals Inc. NEXAVAR (sorafenib) tablets, oral [package insert]. Wayne, NJ: Bayer Healthcare Pharmaceuticals Inc.; 2010.
    • (2010) NEXAVAR (Sorafenib) Tablets, Oral [Package Insert]
  • 22
    • 84855815781 scopus 로고    scopus 로고
    • GlaxoSmithKline. Research Triangle Park, NC: GlaxoSmithKline.
    • GlaxoSmithKline. Votrient (pazopanib) [package insert]. Research Triangle Park, NC: GlaxoSmithKline; 2010.
    • (2010) Votrient (Pazopanib) [Package Insert]
  • 23
    • 4344583344 scopus 로고    scopus 로고
    • What makes vessels grow with exercise training?
    • DOI 10.1152/japplphysiol.00035.2004
    • Prior BM, Yang HT, Terjung RL,. What makes vessels grow with exercise training? J Appl Physiol. 2004; 97: 1119-1128. (Pubitemid 39121441)
    • (2004) Journal of Applied Physiology , vol.97 , Issue.3 , pp. 1119-1128
    • Prior, B.M.1    Yang, H.T.2    Terjung, R.L.3
  • 24
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE,. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer. 2008; 8: 618-631.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 25
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF,. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983; 219: 983-985.
    • (1983) Science. , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 26
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N,. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989; 246: 1306-1309. (Pubitemid 20066716)
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 28
    • 0038363443 scopus 로고    scopus 로고
    • Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
    • DOI 10.1038/nm848
    • Cao R, Brakenhielm E, Pawliuk R, et al. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med. 2003; 9: 604-613. (Pubitemid 36597108)
    • (2003) Nature Medicine , vol.9 , Issue.5 , pp. 604-613
    • Cao, R.1    Brakenhielm, E.2    Pawliuk, R.3    Wariaro, D.4    Post, M.J.5    Wahlberg, E.6    Leboulch, P.7    Cao, Y.8
  • 29
    • 43249125514 scopus 로고    scopus 로고
    • Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8
    • Abdel-Malak NA, Srikant CB, Kristof AS, Magder SA, Di Battista JA, Hussain SN,. Angiopoietin-1 promotes endothelial cell proliferation and migration through AP-1-dependent autocrine production of interleukin-8. Blood. 2008; 111: 4145-4154.
    • (2008) Blood. , vol.111 , pp. 4145-4154
    • Abdel-Malak, N.A.1    Srikant, C.B.2    Kristof, A.S.3    Magder, S.A.4    Di Battista, J.A.5    Hussain, S.N.6
  • 31
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • DOI 10.1038/nm0603-677
    • Pugh CW, Ratcliffe PJ,. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003; 9: 677-684. (Pubitemid 36749216)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 32
    • 0030660196 scopus 로고    scopus 로고
    • Syndecans: Multifunctional cell-surface co-receptors
    • Carey DJ,. Syndecans: multifunctional cell-surface co-receptors. Biochem J. 1997; 327 (pt 1): 1-16. (Pubitemid 27455453)
    • (1997) Biochemical Journal , vol.327 , Issue.1 , pp. 1-16
    • Carey, D.J.1
  • 34
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • Folkman J,. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov. 2007; 6: 273-286. (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 35
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM,. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005; 23: 1011-1027. (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 36
    • 65649109754 scopus 로고    scopus 로고
    • Snake venom vascular endothelial growth factors (VEGF-Fs) exclusively vary their structures and functions among species
    • Yamazaki Y, Matsunaga Y, Tokunaga Y, Obayashi S, Saito M, Morita T,. Snake venom vascular endothelial growth factors (VEGF-Fs) exclusively vary their structures and functions among species. J Biol Chem. 2009; 284: 9885-9891.
    • (2009) J Biol Chem. , vol.284 , pp. 9885-9891
    • Yamazaki, Y.1    Matsunaga, Y.2    Tokunaga, Y.3    Obayashi, S.4    Saito, M.5    Morita, T.6
  • 37
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • DOI 10.1042/CS20040370
    • Takahashi H, Shibuya M,. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin Sci (London). 2005; 109: 227-241. (Pubitemid 41337127)
    • (2005) Clinical Science , vol.109 , Issue.3 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 38
    • 63749125392 scopus 로고    scopus 로고
    • VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
    • Lohela M, Bry M, Tammela T, Alitalo K,. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol. 2009; 21: 154-165.
    • (2009) Curr Opin Cell Biol. , vol.21 , pp. 154-165
    • Lohela, M.1    Bry, M.2    Tammela, T.3    Alitalo, K.4
  • 39
    • 0032954241 scopus 로고    scopus 로고
    • Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature
    • DOI 10.1002/(SICI)1097-0177(199905)215:1<12::AID-DVDY3>3.0.CO;2-N
    • Aase K, Lymboussaki A, Kaipainen A, Olofsson B, Alitalo K, Eriksson U,. Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature. Dev Dyn. 1999; 215: 12-25. (Pubitemid 29215700)
    • (1999) Developmental Dynamics , vol.215 , Issue.1 , pp. 12-25
    • Aase, K.1    Lymboussaki, A.2    Kaipainen, A.3    Olofsson, B.4    Alitalo, K.5    Eriksson, U.6
  • 41
    • 69949107753 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor genetic variability in cancer
    • Schneider BP, Radovich M, Miller KD,. The role of vascular endothelial growth factor genetic variability in cancer. Clin Cancer Res. 2009; 15: 5297-5302.
    • (2009) Clin Cancer Res. , vol.15 , pp. 5297-5302
    • Schneider, B.P.1    Radovich, M.2    Miller, K.D.3
  • 42
    • 0033047875 scopus 로고    scopus 로고
    • VEGFs, receptors and angiogenesis
    • DOI 10.1006/scbi.1998.0091
    • Veikkola T, Alitalo K,. VEGFs, receptors and angiogenesis. Semin Cancer Biol. 1999; 9: 211-220. (Pubitemid 29273837)
    • (1999) Seminars in Cancer Biology , vol.9 , Issue.3 , pp. 211-220
    • Veikkola, T.1    Alitalo, K.2
  • 43
    • 47949102937 scopus 로고    scopus 로고
    • The semaphorins: Versatile regulators of tumour progression and tumour angiogenesis
    • Neufeld G, Kessler O,. The semaphorins: versatile regulators of tumour progression and tumour angiogenesis. Nat Rev Cancer. 2008; 8: 632-645.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 632-645
    • Neufeld, G.1    Kessler, O.2
  • 46
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • DOI 10.1126/science.1125950
    • Kerbel RS,. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science. 2006; 312: 1171-1175. (Pubitemid 43801134)
    • (2006) Science , vol.312 , Issue.5777 , pp. 1171-1175
    • Kerbel, R.S.1
  • 47
    • 31144458716 scopus 로고    scopus 로고
    • How Avastin potentiates chemotherapeutic drugs: Action and reaction in antiangiogenic therapy
    • Blagosklonny MV,. How Avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy. Cancer Biol Ther. 2005; 4: 1307-1310. (Pubitemid 43131171)
    • (2005) Cancer Biology and Therapy , vol.4 , Issue.12 , pp. 1307-1310
    • Blagosklonny, M.V.1
  • 48
    • 54849409466 scopus 로고    scopus 로고
    • Targeting the VEGF pathway: Antiangiogenic strategies in the treatment of non-small cell lung cancer
    • Aita M, Fasola G, Defferrari C, et al. Targeting the VEGF pathway: antiangiogenic strategies in the treatment of non-small cell lung cancer. Crit Rev Oncol Hematol. 2008; 68: 183-196.
    • (2008) Crit Rev Oncol Hematol. , vol.68 , pp. 183-196
    • Aita, M.1    Fasola, G.2    Defferrari, C.3
  • 50
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008; 68: 4774-4782.
    • (2008) Cancer Res. , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 51
    • 58149175849 scopus 로고    scopus 로고
    • Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
    • Huynh H, Ngo VC, Fargnoli J, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res. 2008; 14: 6146-6153.
    • (2008) Clin Cancer Res. , vol.14 , pp. 6146-6153
    • Huynh, H.1    Ngo, V.C.2    Fargnoli, J.3
  • 52
    • 77956225558 scopus 로고    scopus 로고
    • Phase 1 study of the investigational, oral angiogenesis inhibitor motesanib in Japanese patients with advanced solid tumors
    • Fujisaka Y, Yamada Y, Yamamoto N, et al. Phase 1 study of the investigational, oral angiogenesis inhibitor motesanib in Japanese patients with advanced solid tumors. Cancer Chemother Pharmacol. 2010; 66: 935-943.
    • (2010) Cancer Chemother Pharmacol. , vol.66 , pp. 935-943
    • Fujisaka, Y.1    Yamada, Y.2    Yamamoto, N.3
  • 56
    • 24944453855 scopus 로고    scopus 로고
    • Phase i trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol. 2005; 23: 5474-5483.
    • (2005) J Clin Oncol. , vol.23 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 57
    • 58149337448 scopus 로고    scopus 로고
    • Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3
    • Hu-Lowe DD, Zou HY, Grazzini ML, et al. Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 2008; 14: 7272-7283.
    • (2008) Clin Cancer Res. , vol.14 , pp. 7272-7283
    • Hu-Lowe, D.D.1    Zou, H.Y.2    Grazzini, M.L.3
  • 58
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • DOI 10.1038/nrc905
    • Kerbel R, Folkman J,. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer. 2002; 2: 727-739. (Pubitemid 37328908)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.10 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 59
    • 57049093954 scopus 로고    scopus 로고
    • Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells [serial online]
    • Wu E, Palmer N, Tian Z, et al. Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells [serial online]. PLoS One. 2008; 3: e3794.
    • (2008) PLoS One. , vol.3
    • Wu, E.1    Palmer, N.2    Tian, Z.3
  • 60
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • DOI 10.1172/JCI200318549
    • Abramsson A, Lindblom P, Betsholtz C,. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest. 2003; 112: 1142-1151. (Pubitemid 38056291)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.8 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 61
    • 34447253095 scopus 로고    scopus 로고
    • Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies
    • DOI 10.2174/138161207781039689
    • Rusnati M, Presta M,. Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies. Curr Pharm Des. 2007; 13: 2025-2044. (Pubitemid 47040487)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.20 , pp. 2025-2044
    • Rusnati, M.1    Presta, M.2
  • 62
    • 18144364350 scopus 로고    scopus 로고
    • Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
    • DOI 10.1016/j.cytogfr.2005.01.004
    • Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, Rusnati M,. Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev. 2005; 16: 159-178. (Pubitemid 40616114)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.SPEC. ISS. , pp. 159-178
    • Presta, M.1    Dell'Era, P.2    Mitola, S.3    Moroni, E.4    Ronca, R.5    Rusnati, M.6
  • 63
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D,. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 2005; 8: 299-309. (Pubitemid 41443415)
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 64
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D,. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008; 8: 592-603.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 65
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R, Thurnher A, Katsen AD, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 2004; 18: 338-340.
    • (2004) FASEB J. , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 68
    • 57849117384 scopus 로고    scopus 로고
    • New Response Evaluation Criteria in Solid Tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer EA, Therasse P, Bogaerts J, et al. New Response Evaluation Criteria in Solid Tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009; 45: 228-247.
    • (2009) Eur J Cancer. , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 69
    • 65949122058 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma
    • Rini BI,. Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma. Cancer. 2009; 115: 2306-2312.
    • (2009) Cancer. , vol.115 , pp. 2306-2312
    • Rini, B.I.1
  • 70
    • 70549102293 scopus 로고    scopus 로고
    • Drug resistance associated with antiangiogenesis therapy
    • Eikesdal HP, Kalluri R,. Drug resistance associated with antiangiogenesis therapy. Semin Cancer Biol. 2009; 19: 310-317.
    • (2009) Semin Cancer Biol. , vol.19 , pp. 310-317
    • Eikesdal, H.P.1    Kalluri, R.2
  • 71
    • 77951692165 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to tumour anti-angiogenic strategies [serial online]
    • 2010.
    • Grépin R, Pagès G,. Molecular mechanisms of resistance to tumour anti-angiogenic strategies [serial online]. J Oncol 2010: 835680, 2010.
    • (2010) J Oncol , pp. 835680
    • Grépin, R.1    Pagès, G.2
  • 73
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • DOI 10.1038/nature04480, PII NATURE04480
    • Alitalo K, Tammela T, Petrova TV,. Lymphangiogenesis in development and human disease. Nature. 2005; 438: 946-953. (Pubitemid 43093960)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 74
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell. 2009; 15: 21-34.
    • (2009) Cancer Cell. , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3
  • 75
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009; 15: 220-231.
    • (2009) Cancer Cell. , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 77
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • DOI 10.1126/science.1068327
    • Yu JL, Rak JW, Coomber BL, Hicklin DJ, Kerbel RS,. Effect of p53 status on tumor response to antiangiogenic therapy. Science. 2002; 295: 1526-1528. (Pubitemid 34174008)
    • (2002) Science , vol.295 , Issue.5559 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 78
    • 77951498489 scopus 로고    scopus 로고
    • Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis
    • Ferrara N,. Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis. Curr Opin Hematol. 2010; 17: 219-224.
    • (2010) Curr Opin Hematol. , vol.17 , pp. 219-224
    • Ferrara, N.1
  • 79
    • 75849124916 scopus 로고    scopus 로고
    • Origin and function of tumor stroma fibroblasts
    • Xouri G, Christian S,. Origin and function of tumor stroma fibroblasts. Semin Cell Dev Biol. 2010; 21: 40-46.
    • (2010) Semin Cell Dev Biol. , vol.21 , pp. 40-46
    • Xouri, G.1    Christian, S.2
  • 80
    • 77955496673 scopus 로고    scopus 로고
    • Pericytes and vessel maturation during tumor angiogenesis and metastasis
    • Raza A, Franklin MJ, Dudek AZ,. Pericytes and vessel maturation during tumor angiogenesis and metastasis. Am J Hematol. 2010; 85: 593-598.
    • (2010) Am J Hematol. , vol.85 , pp. 593-598
    • Raza, A.1    Franklin, M.J.2    Dudek, A.Z.3
  • 81
    • 70350220627 scopus 로고    scopus 로고
    • Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents
    • Shaked Y, Tang T, Woloszynek J, et al. Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents. Cancer Res. 2009; 69: 7524-7528.
    • (2009) Cancer Res. , vol.69 , pp. 7524-7528
    • Shaked, Y.1    Tang, T.2    Woloszynek, J.3
  • 83
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • Kopetz S, Hoff PM, Morris JS, et al. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol. 2010; 28: 453-459.
    • (2010) J Clin Oncol. , vol.28 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3
  • 88
    • 1542319129 scopus 로고    scopus 로고
    • Cancer without disease
    • DOI 10.1038/427787a
    • Folkman J, Kalluri R,. Cancer without disease. Nature. 2004; 427: 787. (Pubitemid 38297724)
    • (2004) Nature , vol.427 , Issue.6977 , pp. 787
    • Folkman, J.1    Kalluri, R.2
  • 91
    • 16844381577 scopus 로고    scopus 로고
    • A new perspective on tumor endothelial cells: Unexpected chromosome and centrosome abnormalities
    • DOI 10.1158/0008-5472.CAN-05-0002
    • Hida K, Klagsbrun M,. A new perspective on tumor endothelial cells: unexpected chromosome and centrosome abnormalities. Cancer Res. 2005; 65: 2507-2510. (Pubitemid 40490041)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2507-2510
    • Hida, K.1    Klagsbrun, M.2
  • 92
    • 77949494504 scopus 로고    scopus 로고
    • Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma
    • Helfrich I, Scheffrahn I, Bartling S, et al. Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma. J Exp Med. 2010; 207: 491-503.
    • (2010) J Exp Med. , vol.207 , pp. 491-503
    • Helfrich, I.1    Scheffrahn, I.2    Bartling, S.3
  • 94
    • 7944229106 scopus 로고    scopus 로고
    • Vascular remodeling and clinical resistance to antiangiogenic cancer therapy
    • DOI 10.1016/j.drup.2004.09.001, PII S1368764604000688
    • Glade Bender J, Cooney EM, Kandel JJ, Yamashiro DJ,. Vascular remodeling and clinical resistance to antiangiogenic cancer therapy. Drug Resist Update. 2004; 7: 289-300. (Pubitemid 39469101)
    • (2004) Drug Resistance Updates , vol.7 , Issue.4-5 , pp. 289-300
    • Glade Bender, J.1    Cooney, E.M.2    Kandel, J.J.3    Yamashiro, D.J.4
  • 97
    • 0035871403 scopus 로고    scopus 로고
    • Patterns of angiogenesis in nonsmall-cell lung carcinoma
    • DOI 10.1002/1097-0142(20010415)91:8<1500::AID-CNCR1158>3.0.CO;2-M
    • Offersen BV, Pfeiffer P, Hamilton-Dutoit S, Overgaard J,. Patterns of angiogenesis in nonsmall-cell lung carcinoma. Cancer. 2001; 91: 1500-1509. (Pubitemid 32319261)
    • (2001) Cancer , vol.91 , Issue.8 , pp. 1500-1509
    • Offersen, B.V.1    Pfeiffer, P.2    Hamilton-Dutoit, S.3    Overgaard, J.4
  • 98
    • 0033822622 scopus 로고    scopus 로고
    • Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption
    • Rubenstein JL, Kim J, Ozawa T, et al. Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption. Neoplasia. 2000; 2: 306-314.
    • (2000) Neoplasia. , vol.2 , pp. 306-314
    • Rubenstein, J.L.1    Kim, J.2    Ozawa, T.3
  • 99
    • 0035884609 scopus 로고    scopus 로고
    • Inhibition of glioma angiogenesis and growth in Vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    • Kunkel P, Ulbricht U, Bohlen P, et al. Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res. 2001; 61: 6624-6628. (Pubitemid 32896475)
    • (2001) Cancer Research , vol.61 , Issue.18 , pp. 6624-6628
    • Kunkel, P.1    Ulbricht, U.2    Bohlen, P.3    Brockmann, M.A.4    Fillbrandt, R.5    Stavrou, D.6    Westphal, M.7    Lamszus, K.8
  • 100
    • 36148937125 scopus 로고    scopus 로고
    • Tumour vascularization: Sprouting angiogenesis and beyond
    • DOI 10.1007/s10555-007-9094-7, Forty Years of Metastasis Research: A Tribute to Dr. Isaiah J. Fidler
    • Hillen F, Griffioen AW,. Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev. 2007; 26: 489-502. (Pubitemid 350115123)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.3-4 , pp. 489-502
    • Hillen, F.1    Griffioen, A.W.2
  • 101
    • 74849127957 scopus 로고    scopus 로고
    • Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads
    • Rapisarda A, Shoemaker RH, Melillo G,. Antiangiogenic agents and HIF-1 inhibitors meet at the crossroads. Cell Cycle. 2009; 8: 4040-4043.
    • (2009) Cell Cycle. , vol.8 , pp. 4040-4043
    • Rapisarda, A.1    Shoemaker, R.H.2    Melillo, G.3
  • 103
    • 77949394260 scopus 로고    scopus 로고
    • A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or - Dacarbazine in patients with stage IV metastatic melanoma
    • Hersey P, Sosman J, O'Day S, et al. A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or-dacarbazine in patients with stage IV metastatic melanoma. Cancer. 2010; 116: 1526-1534.
    • (2010) Cancer. , vol.116 , pp. 1526-1534
    • Hersey, P.1    Sosman, J.2    O'Day, S.3
  • 104
    • 67650087998 scopus 로고    scopus 로고
    • Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness
    • Saidi A, Hagedorn M, Allain N, et al. Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness. Int J Cancer. 2009; 125: 1054-1064.
    • (2009) Int J Cancer. , vol.125 , pp. 1054-1064
    • Saidi, A.1    Hagedorn, M.2    Allain, N.3
  • 105
    • 66149092730 scopus 로고    scopus 로고
    • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    • Shojaei F, Wu X, Qu X, et al. G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc Natl Acad Sci U S A. 2009; 106: 6742-6747.
    • (2009) Proc Natl Acad Sci U S A. , vol.106 , pp. 6742-6747
    • Shojaei, F.1    Wu, X.2    Qu, X.3
  • 106
    • 77949900433 scopus 로고    scopus 로고
    • Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: Combating tumor evasion of antiangiogenic therapy
    • Priceman SJ, Sung JL, Shaposhnik Z, et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010; 115: 1461-1471.
    • (2010) Blood. , vol.115 , pp. 1461-1471
    • Priceman, S.J.1    Sung, J.L.2    Shaposhnik, Z.3
  • 107
    • 37549030522 scopus 로고    scopus 로고
    • Delta-like 4/Notch signaling and its therapeutic implications
    • Yan M, Plowman GD,. Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res. 2007; 13: 7243-7246.
    • (2007) Clin Cancer Res. , vol.13 , pp. 7243-7246
    • Yan, M.1    Plowman, G.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.