Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells

Cardiovascular Research

Volumn 69, Issue 2, 2006, Pages 512-519

  Wu, GuiFu ^a,b   Luo, Jincai ^c   Rana, Jamal S ^a   Laham, Roger ^a   Sellke, Frank W ^a   Li, Jian ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Angiogenesis; COX 2; HUVEC; JNK; MAPK; p38; VEGF

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOOXYGENASE 2; MATRIGEL; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; THYMIDINE; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPOXIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTHRACENES; BUTADIENES; CELLS, CULTURED; CYCLOOXYGENASE 2; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE DELETION; HUMANS; IMIDAZOLES; MAP KINASE KINASE 4; MEMBRANE PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; NITRILES; NITROBENZENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SULFONAMIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 30744476528     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2005.09.019     Document Type: Article

References (20)

1. M. Goppelt-Struebe Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression Prostaglandins Leukot Essent Fatty Acids 52 1995 213 222
2. H.U. Kasper, H. Wolf, U. Drebber, H.K. Wolf, and M.A. Kern Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: correlation with microvessel density World J Gastroenterol 10 2004 1918 1922
3. S. Gately, and W.W. Li Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy Semin Oncol 31 2004 2 11
4. R. Bolli, K. Shinmura, X.L. Tang, E. Kodani, Y.T. Xuan, and Y. Guo Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning Cardiovasc Res 55 2002 506 519
5. L.A. Garcia Rodriguez The effect of NSAIDs on the risk of coronary heart disease: fusion of clinical pharmacology and pharmacoepidemiologic data Clin Exp Rheumatol 19 2001 S41 S44
6. S. Gottlieb COX 2 inhibitors may increase risk of heart attack BMJ 323 2001 471
7. Y. Wang, E. Kodani, J. Wang, S.X. Zhang, H. Takano, and X.L. Tang Cardioprotection during the final stage of the late phase of ischemic preconditioning is mediated by neuronal NO synthase in concert with cyclooxygenase-2 Circ Res 95 2004 84 91
8. K. Shinmura, X.L. Tang, Y. Wang, Y.T. Xuan, S.Q. Liu, and H. Takano Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits Proc Natl Acad Sci U S A 97 2000 10197 10202
9. H.H. Marti Angiogenesis-a self-adapting principle in hypoxia EXS 2005 163 180
10. G. Wu, A.P. Mannam, J. Wu, S. Kirbis, J.L. Shie, and C. Chen Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF Am J Physiol Heart Circ Physiol 285 2003 H2420 H2429
11. M.J. Cross, J. Dixelius, T. Matsumoto, and L. Claesson-Welsh VEGF-receptor signal transduction Trends Biochem Sci 28 2003 488 494
12. L. Claesson-Welsh Signal transduction by vascular endothelial growth factor receptors Biochem Soc Trans 31 2003 20 24
13. I. Zachary VEGF signalling: integration and multi-tasking in endothelial cell biology Biochem Soc Trans 31 2003 1171 1177
14. M.N. Nakatsu, R.C. Sainson, S. Perez-del-Pulgar, J.N. Aoto, M. Aitkenhead, and K.L. Taylor VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model Lab Invest 83 2003 1873 1885
15. L. Lamalice, F. Houle, G. Jourdan, and J. Huot Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38 Oncogene 23 2004 434 445
16. P.R. Kvietys, and D.N. Granger Endothelial cell monolayers as a tool for studying microvascular pathophysiology Am J Physiol 273 1997 G1189 G1199
17. S. Rousseau, F. Houle, J. Landry, and J. Huot p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells Oncogene 15 1997 2169 2177
18. M.A. Bachelor, and G.T. Bowden UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression Semin Cancer Biol 14 2004 131 138
19. T. Takahashi, H. Ueno, and M. Shibuya VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells Oncogene 18 1999 2221 2230
20. A.S. Cheng, H.L. Chan, K.F. To, W.K. Leung, K.K. Chan, and C.T. Liew Cyclooxygenase-2 pathway correlates with vascular endothelial growth factor expression and tumor angiogenesis in hepatitis B virus-associated hepatocellular carcinoma Int J Oncol 24 2004 853 860