Astaxanthin suppresses MPP+-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway

Marine Drugs

Volumn 11, Issue 4, 2013, Pages 1019-1034

  Ye, Qinyong ^a   Zhang, Xiaodong ^a   Huang, Bixia ^a   Zhu, Yuangui ^a   Chen, Xiaochun ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Astaxanthin; NR1; Parkinson's disease; PC12 cells; Sp1

Indexed keywords

ASTAXANTHIN; MESSENGER RNA; MITHRAMYCIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR SP1;

ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG RECEPTOR BINDING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; NEUROPROTECTION; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84876961942     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11041019     Document Type: Article

References (39)

1. Hou, R.R.; Chen, J.Z.; Chen, H.; Kang, X.G.; Li, M.G.; Wang, B.R. Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) on paraquat-induced apoptosis in PC12 cells. Cell Biol. Int. 2008, 32, 22-30.
2. +-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. Neurosci. Lett. 2010, 483, 1-5.
3. Jenner, P.; Olanow, C.W. Understanding cell death in Parkinson's disease. Ann. Neurol. 1998, 44, 72-84.
4. Ikeda, Y.; Tsuji, S.; Satoh, A.; Ishikura, M.; Shirasawa, T.; Shimizu, T. Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J. Neurochem. 2008, 107, 1730-1740.
5. Shen, H.; Kuo, C.C.; Chou, J.; Delvolve, A.; Jackson, S.N.; Post, J.; Woods, A.S.; Hoffer, B.J.; Wang, Y.; Harvey, B.K. Astaxanthin reduces ischemic brain injury in adult rats. FASEB J. 2009, 23, 1958-1968.
6. Liu, X.; Osawa, T. Astaxanthin Protects Neuronal Cells against Oxidative Damage and Is a Potent Candidate for Brain Food. In Food Factors for Health Promotion; Yoshikawa, T., Ed.; Karger: Basel, Switzerland, 2009; Volume 61, pp. 129-135.
7. Hota, S.K.; Prasad, D.; Ilavazhagan, G.; Singh, S.B. Oxidative-Stress- induced alterations in Sp factors mediate transcriptional regulation of the NR1 subunit in hippocampus during hypoxia. Free Radic. Biol. Med. 2010, 49, 178-191.
8. Awobuluyi, M.; Vazhappilly, R.; Sucher, N.J. Translational activity of N-methyl-D-aspartate receptor subunit NR1 mRNA in PC12 cells. Neurosignals 2003, 12, 283-291.
9. Chatterton, J.E.; Awobuluyi, M.; Premkumar, L.S.; Takahashi, H.; Talantova, M.; Shin, Y.; Cui, J.; Tu, S.; Sevarino, K.A.; Nakanishi, N.; et al. Excitatory glycine receptors con-taining the NR3 family of NMDA receptor subunits. Nature 2002, 415, 793-798.
10. Lee, J.; Kosaras, B.; Aleyasin, H.; Han, J.A.; Park, D.S.; Ratan, R.R.; Kowall, N.W.; Ferrante, R.J.; Lee, S.W.; Ryu, H. Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response. FASEB J. 2006, 20, 2375-2377.
11. Wang, C.; Zhang, X.; Liu, F.; Paule, M.G.; Slikker, W., Jr. Anesthetic-induced oxidative stress and potential protection. Sci. World J. 2010, 10, 1473-1482.
12. Lu, C.; Chan, S.L.; Haughey, N.; Lee, W.T.; Mattson, M.P. Selective and biphasic effect of the membrane lipid peroxidation product 4-hydroxy-2,3-nonenal on N-methyl-D-aspartate channels. J. Neurochem. 2001, 78, 577-589.
13. Vazhappilly, R.; Wee, K.S.; Sucher, N.J.; Low, C.M. A non-muscle myosin II motor links NR1 to retrograde trafficking and proteasomal degradation in PC12 cells. Neurochem. Int. 2010, 56, 569-576.
14. +): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci. Lett. 1984, 48, 87-92.
15. Haleagraharan, N.; Ponnusamy, K. Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats. J. Toxicol. Sci. 2010, 35, 41-47.
16. +. Free Radic. Biol. Med. 1992, 13, 581-583.
17. Wang, W.; Shi, L.; Xie, Y.; Ma, C.; Li, W.; Su, X.; Huang, S.; Chen, R.; Zhu, Z.; Mao, Z.; Han, Y.; Li, M. SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neurosci. Res . 2004, 48, 195-202.
18. Esposito, E.; Rotilio, D.; di Matteo, V.; di Giulio, C.; Cacchio, M.; Algeri, S. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol. Aging 2002, 23, 719-735.
19. Harish, G.; Venkateshappa, C.; Mythri, R.B.; Dubey, S.K.; Mishra, K.; Singh, N.; Vali, S.; Bharath, M.M. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease. Bioorg. Med. Chem. 2010, 18, 2631-2638.
20. Chan, K.C.; Mong, M.C.; Yin, M.C. Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells. J. Food Sci. 2009, 74, H225-H231.
21. Wolf, A.M.; Asoh, S.; Hiranuma, H.; Ohsawa, I.; Iio, K.; Satou, A.; Ishikura, M.; Ohta, S. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress. J. Nutr. Biochen. 2010, 21, 381-389.
22. Herraiz, T.; Guillén, H. Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors. Food Chem. Toxicol. 2011, 49, 1773-1781.
23. 2-induced apoptosis in PC12 cells. Biochem. Biophys. Res. Commun. 2010, 393, 773-778.
24. +-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food Chem. Toxicol. 2011, 49, 271-280.
25. 2)-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo. Brain Res. 2010, 1360, 40-48.
26. Jang, H.Y.; Ji, S.J.; Kim, Y.H.; Lee, H.Y.; Shin, J.S.; Cheong, H.T.; Kim, J.T.; Park, I.C.; Kong, H.S.; Park, C.K.; et al. Antioxidative effects of astaxanthin against nitric oxide-induced oxidative stress on cell viability and gene expression in bovine oviduct epithelial cell and the developmental competence of bovine IVM/IVF embryos. Reprod. Domest. Anim. 2010, 45, 967-974.
27. Wang, H.Q.; Sun, X.B.; Xu, Y.X.; Zhao, H.; Zhu, Q.Y.; Zhu, C.Q. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res. 2010, 1360, 159-167.
28. Dasari, A.; Bartholomew, J.N.; Volonte, D.; Galbiati, F. Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res. 2006, 66, 10805-10814.
29. Betzen, C.; White, R.; Zehendner, C.M.; Pietrowski, E.; Bender, B.; Luhmann, H.J.; Kuhlmann, C.R. Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium. Free Radic. Biol. Med. 2009, 47, 1212-1220.
30. Mueller-Burke, D.; Koehler, R.C.; Martin, L.J. Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia. Int. J. Dev. Neurosci. 2008, 26, 67-76.
31. Hota, S.K.; Barhwal, K.; Sinqh, S.B.; Sairam, M.; Ilavazhagan, G. NR1 and GluR2 expression mediates excitotoxicity in chronic hypobaric hypoxia. J. Neurosci. Res. 2008, 86, 1142-1152.
32. Lee, D.H.; Lee, Y.J.; Kwon, K.H. Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in SH-SY5Y cells and global cerebral ischemia in rat. J. Clin. Biochem. Nutr. 2010, 47, 121-129.
33. Park, J.S.; Chyun, J.H.; Kim, Y.K.; Line, L.L.; Chew, B.P. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr. Metab. (Lond.) 2010, 7, 18.
34. Ho, J.W.; Ho, P.W.; Zhang, W.Y.; Liu, H.F.; Kwok, K.H.; Yiu, D.C.; Chan, K.H.; Kung, M.H.; Ramsden, D.B.; Ho, S.L. Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity. Free Radic. Biol. Med. 2010, 49, 192-204.
35. Fountain, S.J.; Cheonq, A.; Li, J.; Dondas, N.Y.; Zeng, F.; Wood, I.C.; Beech, D.J. K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress. Am. J. Physiol. Heart Circ. Physiol. 2007, 293, H2719-H2725.
36. Sleiman, S.F.; Lanqley, B.C.; Basso, M.; Berlin, J.; Xia, L.; Payappilly, J.B.; Kharel, M.K.; Guo, H.; Marsh, J.L.; Thompson, L.M.; et al. Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. J. Neurosci. 2011, 31, 6858-6870.
37. Holland, P.M.; Abramson, R.D.; Watson, R.; Gelfand, D.H. Detection of specific polymerase chain reaction product by utilizing the 5′ - 3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc. Natl. Acad. Sci. USA 1991, 88, 7276-7280.
38. Livak, K.J.; Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(2-Delta Delta C(T)). Methods 2001, 25, 402-408.
39. +-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis . BMC Neurosci. 2012, 13, 156.