Tumor-promoting role of signal transducer and activator of transcription (Stat)1 in late-stage melanoma growth

Clinical and Experimental Metastasis

Volumn 27, Issue 3, 2010, Pages 133-140

  Schultz, Julia ^a   Koczan, Dirk ^a   Schmitz, Ulf ^a   Ibrahim, Saleh M ^b   Pilch, Dominik ^b   Landsberg, Jenny ^c   Kunz, Manfred ^b  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Carcinogenesis; Cell migration; Genomics; Mouse models

Indexed keywords

MATRIGEL; STAT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CANCER GROWTH; CANCER MODEL; CANCER STAGING; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DATA ANALYSIS; GENE EXPRESSION; GENE IDENTIFICATION; GENE SILENCING; MELANOMA; MELANOMA CELL; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR PROMOTION;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MELANOMA; MICE; MICE, NUDE; MICROARRAY ANALYSIS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TUMOR MARKERS, BIOLOGICAL;

EID: 77950861762     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-010-9310-7     Document Type: Article

References (26)

1. AJ Miller Mihm MCJr 2006 Melanoma N Engl J Med 355 1 51 65 10.1056/NEJMra052166 1:CAS:528:DC%2BD28Xms1ChsLo%3D 16822996
2. NK Haass KSM Smalley L Li M Herlyn 2005 Adhesion, migration and communication in melanocytes and melanoma Pigment Cell Res 18 3 150 159 10.1111/j.1600-0749.2005.00235.x 1:CAS:528:DC%2BD2MXlsFeiurY%3D 15892711 (Pubitemid 40733333)
3. VR Greene MM Johnson EA Grimm, et al. 2009 Frequencies of NRAS and BRAF mutations increase from the radial to the vertical growth phase in cutaneous melanoma J Invest Dermatol 129 6 1483 1488 10.1038/jid.2008.374 1:CAS:528:DC%2BD1MXlslGit7w%3D 19037234
4. L Norton J Massagué 2006 Is cancer a disease of self-seeding? Nat Med 12 8 875 878 10.1038/nm0806-875 1:CAS:528:DC%2BD28Xnsl2itLk%3D 16892025 (Pubitemid 44175132)
5. MM Brierley EN Fish 2005 Stats: multifaceted regulators of transcription J Interferon Cytokine Res 25 12 733 744 10.1089/jir.2005.25.733 1:CAS:528:DC%2BD2MXhtlCnsrnL 16375601 (Pubitemid 43071210)
6. DE Levy JE Darnell Jr 2002 Stats: transcriptional control and biological impact Nat Rev Mol Cell Biol 3 9 651 662 10.1038/nrm909 1:CAS:528: DC%2BD38Xmslansrw%3D 12209125 (Pubitemid 34987786)
7. K Shuai C Schindler VR Prezioso, et al. 1992 Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein Science 258 5098 1808 1812 10.1126/science.1281555 1:CAS:528:DyaK3sXlslyktw%3D%3D 1281555 (Pubitemid 23087351)
8. C Schindler DE Levy T Decker 2007 JAK-STAT signaling: from interferons to cytokines J Biol Chem 282 28 20059 20063 10.1074/jbc.R700016200 1:CAS:528:DC%2BD2sXnsFWntr8%3D 17502367 (Pubitemid 47099977)
9. A Chapgier S Boisson-Dupuis E Jouanguy, et al. 2006 Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease PLoS Genet 2 8 e131 10.1371/journal.pgen.0020131 16934001 (Pubitemid 44298494)
10. J Jaeger D Koczan HJ Thiesen, et al. 2007 Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues Clin Cancer Res 13 3 806 815 10.1158/1078-0432.CCR-06-1820 1:CAS:528:DC%2BD2sXhsVyrsrY%3D 17289871 (Pubitemid 46340353)
11. F Carlotti M Bazuine T Kekarainen, et al. 2004 Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes Mol Ther 9 2 209 217 10.1016/j.ymthe.2003.11.021 1:CAS:528:DC%2BD2cXptVWruw%3D%3D 14759805 (Pubitemid 38256547)
12. R Buettner LB Mora R Jove 2002 Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention Clin Cancer Res 8 4 945 954 1:CAS:528:DC%2BD38XjsF2lsb4%3D 11948098 (Pubitemid 35177340)
13. SX Hou Z Zheng X Chen N Perrimon 2002 The JAK/STAT Pathway in model organisms: emerging roles in cell movement Dev Cell 3 6 765 778 10.1016/S1534-5807(02)00376-3 1:CAS:528:DC%2BD38XpslCls78%3D 12479803 (Pubitemid 35460778)
14. DL Silver DJ Montell 2001 Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila Cell 107 7 831 841 10.1016/S0092-8674(01)00607-9 1:CAS:528: DC%2BD38XjtlKmtA%3D%3D 11779460 (Pubitemid 34084975)
15. DL Silver H Naora J Liu, et al. 2004 Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility Cancer Res 64 10 3550 3558 10.1158/0008-5472.CAN-03-3959 1:CAS:528:DC%2BD2cXktVWhsbs%3D 15150111 (Pubitemid 38657931)
16. B Xie J Zhao M Kitagawa, et al. 2001 Focal adhesion kinase activates STAT1 in integrin-mediated cell migration and adhesion J Biol Chem 276 22 19512 19523 10.1074/jbc.M009063200 1:CAS:528:DC%2BD3MXkt12rt7g%3D 11278462 (Pubitemid 37411289)
17. M Bienz H Clevers 2003 Armadillo/β-catenin signals in the nucleus-proof beyond a reasonable doubt? Nat Cell Biol 5 3 179 182 10.1038/ncb0303-179 1:CAS:528:DC%2BD3sXitFKmsL8%3D 12646868 (Pubitemid 36322238)
18. A Gütgemann M Golob S Müller, et al. 2001 Isolation of invasion-associated cDNAs in melanoma Arch Dermatol Res 293 6 283 290 10.1007/s004030100232 11480587 (Pubitemid 32661495)
19. NN Khodarev P Roach SP Pitroda, et al. 2009 STAT1 pathway mediates amplification of metastatic potential and resistance to therapy PloS ONE 4 6 e5821 10.1371/journal.pone.0005821 19503789
20. NN Khodarev AJ Minn EV Efimova, et al. 2007 Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells Cancer Res 67 19 9214 9220 10.1158/0008-5472.CAN-07-1019 1:CAS:528:DC%2BD2sXhtFSnurzI 17909027 (Pubitemid 47535908)
21. RR Weichselbaum H Ishwaran T Yoon, et al. 2008 An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer Proc Natl Acad Sci USA 105 47 18490 18495 10.1073/pnas.0809242105 1:CAS:528:DC%2BD1cXhsVOmsbfJ 19001271
22. GP Gupta J Massagué 2006 Cancer metastasis: building a framework Cell 127 4 679 695 10.1016/j.cell.2006.11.001 1:CAS:528:DC%2BD28Xht1yqs7rL 17110329 (Pubitemid 44781029)
23. TE Battle DA Frank 2002 The role of STATs in apoptosis Curr Mol Med 2 4 381 392 10.2174/1566524023362456 1:CAS:528:DC%2BD38XltVWqurs%3D 12108949 (Pubitemid 35452886)
24. SE Hartman P Bertone AK Nath, et al. 2005 Global changes in STAT target selection and transcription regulation upon interferon treatments Genes Dev 19 24 2953 2968 10.1101/gad.1371305 1:CAS:528:DC%2BD28XmtF0%3D 16319195 (Pubitemid 41798112)
25. S Wormald DJ Hilton GK Smyth, et al. 2006 Proximal genomic localization of STAT1 binding and regulated transcriptional activity BMC Genomics 7 254 10.1186/1471-2164-7-254 17032459 (Pubitemid 44680219)
26. RA Gatenby RJ Gillies 2008 A microenvironmental model of carcinogenesis Nat Rev Cancer 8 1 56 61 10.1038/nrc2255 1:CAS:528:DC%2BD2sXhsVKku73J 18059462