메뉴 건너뛰기




Volumn 29, Issue 6, 2010, Pages 920-929

Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer

Author keywords

Autoinductive loop; Breast cancer; IFNg; Inflammation; MUC1; STAT1

Indexed keywords

GAMMA INTERFERON; INTERFERON; MUCIN 1; STAT1 PROTEIN;

EID: 76849109309     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.391     Document Type: Article
Times cited : (85)

References (46)
  • 1
    • 70149111064 scopus 로고    scopus 로고
    • MUC1-C oncoprotein functions as a direct activator of the NF-kappaB p65 transcription factor
    • Ahmad R, Raina D, Joshi MD, Kawano T, Kharbanda S, Kufe D. (2009). MUC1-C oncoprotein functions as a direct activator of the NF-kappaB p65 transcription factor. Cancer Res 69: 7013-7021.
    • (2009) Cancer Res , vol.69 , pp. 7013-7021
    • Ahmad, R.1    Raina, D.2    Joshi, M.D.3    Kawano, T.4    Kharbanda, S.5    Kufe, D.6
  • 2
    • 36749092728 scopus 로고    scopus 로고
    • MUC1 oncoprotein activates the IkB kinase b complex and constitutive NF-kB signaling
    • Ahmad R, Raina D, Trivedi V, Ren J, Rajabi H, Kharbanda S et al. (2007). MUC1 oncoprotein activates the IkB kinase b complex and constitutive NF-kB signaling. Nat Cell Biol 9: 1419-1427.
    • (2007) Nat Cell Biol , vol.9 , pp. 1419-1427
    • Ahmad, R.1    Raina, D.2    Trivedi, V.3    Ren, J.4    Rajabi, H.5    Kharbanda, S.6
  • 3
    • 41549114264 scopus 로고    scopus 로고
    • A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer
    • Chanrion M, Negre V, Fontaine H, Salvetat N, Bibeau F, Mac Grogan G et al. (2008). A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer. Clin Cancer Res 14: 1744-1752.
    • (2008) Clin Cancer Res , vol.14 , pp. 1744-1752
    • Chanrion, M.1    Negre, V.2    Fontaine, H.3    Salvetat, N.4    Bibeau, F.5    Mac Grogan, G.6
  • 4
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell Jr JE, Kerr IM, Stark GR. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 5
    • 0028874354 scopus 로고
    • Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth
    • Deblandre GA, Marinx OP, Evans SS, Majjaj S, Leo O, Caput D et al. (1995). Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J Biol Chem 270: 23860-23866.
    • (1995) J Biol Chem , vol.270 , pp. 23860-23866
    • Deblandre, G.A.1    Marinx, O.P.2    Evans, S.S.3    Majjaj, S.4    Leo, O.5    Caput, D.6
  • 6
    • 0032417696 scopus 로고    scopus 로고
    • Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays
    • Der SD, Zhou A, Williams BR, Silverman RH. (1998). Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci USA 95: 15623-15628.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15623-15628
    • Der, S.D.1    Zhou, A.2    Williams, B.R.3    Silverman, R.H.4
  • 7
    • 0035794196 scopus 로고    scopus 로고
    • A STAT-responsive element in the promoter of the episialin/ MUC1 gene is involved in its overexpression in carcinoma cells
    • Gaemers IC, Vos HL, Volders HH, van der Valk SW, Hilkens J. (2001). A STAT-responsive element in the promoter of the episialin/ MUC1 gene is involved in its overexpression in carcinoma cells. J Biol Chem 276: 6191-6199.
    • (2001) J Biol Chem , vol.276 , pp. 6191-6199
    • Gaemers, I.C.1    Vos, H.L.2    Volders, H.H.3    Van Der Valk, S.W.4    Hilkens, J.5
  • 8
    • 28544448610 scopus 로고    scopus 로고
    • MUC1 oncoprotein blocks GSK3beta-mediated phosphorylation and degradation of beta-catenin
    • Huang L, Chen D, Liu D, Yin L, Kharbanda S, Kufe D. (2005). MUC1 oncoprotein blocks GSK3beta-mediated phosphorylation and degradation of beta-catenin. Cancer Res 65: 10413-10422.
    • (2005) Cancer Res , vol.65 , pp. 10413-10422
    • Huang, L.1    Chen, D.2    Liu, D.3    Yin, L.4    Kharbanda, S.5    Kufe, D.6
  • 9
    • 79960815298 scopus 로고    scopus 로고
    • MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation
    • Huang L, Ren J, Chen D, Li Y, Kharbanda S, Kufe D. (2003). MUC1 cytoplasmic domain coactivates Wnt target gene transcription and confers transformation. Cancer Biol Ther 2: 702-706.
    • (2003) Cancer Biol Ther , vol.2 , pp. 702-706
    • Huang, L.1    Ren, J.2    Chen, D.3    Li, Y.4    Kharbanda, S.5    Kufe, D.6
  • 10
    • 66149151809 scopus 로고    scopus 로고
    • MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer
    • Khodarev N, Pitroda S, Beckett M, MacDermed D, Huang L, Kufe D et al. (2009). MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res 69: 2833-2837.
    • (2009) Cancer Res , vol.69 , pp. 2833-2837
    • Khodarev, N.1    Pitroda, S.2    Beckett, M.3    MacDermed, D.4    Huang, L.5    Kufe, D.6
  • 11
    • 1242319531 scopus 로고    scopus 로고
    • STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells
    • Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR. (2004). STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci USA 101: 1714-1719.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1714-1719
    • Khodarev, N.N.1    Beckett, M.2    Labay, E.3    Darga, T.4    Roizman, B.5    Weichselbaum, R.R.6
  • 12
    • 35148879113 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells
    • Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M et al. (2007). Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res 67: 9214-9220.
    • (2007) Cancer Res , vol.67 , pp. 9214-9220
    • Khodarev, N.N.1    Minn, A.J.2    Efimova, E.V.3    Darga, T.E.4    Labay, E.5    Beckett, M.6
  • 13
    • 0037294213 scopus 로고    scopus 로고
    • Receiver operating characteristic analysis: A general tool for DNA array data filtration and performance estimation
    • Khodarev NN, Park J, Kataoka Y, Nodzenski E, Hellman S, Roizman B et al. (2003). Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation. Genomics 81: 202-209.
    • (2003) Genomics , vol.81 , pp. 202-209
    • Khodarev, N.N.1    Park, J.2    Kataoka, Y.3    Nodzenski, E.4    Hellman, S.5    Roizman, B.6
  • 14
    • 20244365649 scopus 로고    scopus 로고
    • Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcrip-tional programs of epidermal differentiation
    • Kimchi ET, Posner MC, Park JO, Darga TE, Kocherginsky M, Karrison T et al. (2005). Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcrip-tional programs of epidermal differentiation. Cancer Res 65: 3146-3154.
    • (2005) Cancer Res , vol.65 , pp. 3146-3154
    • Kimchi, E.T.1    Posner, M.C.2    Park, J.O.3    Darga, T.E.4    Kocherginsky, M.5    Karrison, T.6
  • 17
    • 0021740104 scopus 로고
    • Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors
    • Kufe D, Inghirami G, Abe M, Hayes D, Justi-Wheeler H, Schlom J. (1984). Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 3: 223-232.
    • (1984) Hybridoma , vol.3 , pp. 223-232
    • Kufe, D.1    Inghirami, G.2    Abe, M.3    Hayes, D.4    Justi-Wheeler, H.5    Schlom, J.6
  • 18
    • 0036022141 scopus 로고    scopus 로고
    • Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha
    • Lagow EL, Carson DD. (2002). Synergistic stimulation of MUC1 expression in normal breast epithelia and breast cancer cells by interferon-gamma and tumor necrosis factor-alpha. J Cell Biochem 86: 759-772.
    • (2002) J Cell Biochem , vol.86 , pp. 759-772
    • Lagow, E.L.1    Carson, D.D.2
  • 19
    • 34547092962 scopus 로고    scopus 로고
    • Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62
    • Leng Y, Cao C, Ren J, Huang L, Chen D, Ito M et al. (2007). Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62. J Biol Chem 282: 19321-19330.
    • (2007) J Biol Chem , vol.282 , pp. 19321-19330
    • Leng, Y.1    Cao, C.2    Ren, J.3    Huang, L.4    Chen, D.5    Ito, M.6
  • 20
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy DE, Darnell Jr JE. (2002). Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3: 651-662.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell Jr., J.E.2
  • 21
    • 0031723707 scopus 로고    scopus 로고
    • Interaction of glycogen synthase kinase 3b with the DF3/MUC1 carcinoma-associated antigen and b-catenin
    • Li Y, Bharti A, Chen D, Gong J, Kufe D. (1998). Interaction of glycogen synthase kinase 3b with the DF3/MUC1 carcinoma-associated antigen and b-catenin. Mol Cell Biol 18: 7216-7224.
    • (1998) Mol Cell Biol , vol.18 , pp. 7216-7224
    • Li, Y.1    Bharti, A.2    Chen, D.3    Gong, J.4    Kufe, D.5
  • 22
    • 0035794215 scopus 로고    scopus 로고
    • The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3b and b-catenin
    • Li Y, Kuwahara H, Ren J, Wen G, Kufe D. (2001a). The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3b and b-catenin. J Biol Chem 276: 6061-6064.
    • (2001) J Biol Chem , vol.276 , pp. 6061-6064
    • Li, Y.1    Kuwahara, H.2    Ren, J.3    Wen, G.4    Kufe, D.5
  • 23
    • 0041850346 scopus 로고    scopus 로고
    • Human DF3/ MUC1 carcinoma-associated protein functions as an oncogene
    • Li Y, Liu D, Chen D, Kharbanda S, Kufe D. (2003). Human DF3/ MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 22: 6107-6110.
    • (2003) Oncogene , vol.22 , pp. 6107-6110
    • Li, Y.1    Liu, D.2    Chen, D.3    Kharbanda, S.4    Kufe, D.5
  • 24
    • 0035929643 scopus 로고    scopus 로고
    • The EGF receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and b-catenin
    • Li Y, Ren J, Yu W-H, Li G, Kuwahara H, Yin L et al. (2001b). The EGF receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and b-catenin. J Biol Chem 276: 35239-35242.
    • (2001) J Biol Chem , vol.276 , pp. 35239-35242
    • Li, Y.1    Ren, J.2    Yu, W.-H.3    Li, G.4    Kuwahara, H.5    Yin, L.6
  • 26
    • 34247145491 scopus 로고    scopus 로고
    • Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade
    • Loi S, Haibe-Kains B, Desmedt C, Lallemand F, Tutt AM, Gillet C et al. (2007). Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J Clin Oncol 25: 1239-1246.
    • (2007) J Clin Oncol , vol.25 , pp. 1239-1246
    • Loi, S.1    Haibe-Kains, B.2    Desmedt, C.3    Lallemand, F.4    Tutt, A.M.5    Gillet, C.6
  • 27
    • 30044448792 scopus 로고    scopus 로고
    • Autopro-teolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin
    • Macao B, Johansson DG, Hansson GC, Hard T. (2006). Autopro-teolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat Struct Mol Biol 13: 71-76.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 71-76
    • MacAo, B.1    Johansson, D.G.2    Hansson, G.C.3    Hard, T.4
  • 28
    • 0034669111 scopus 로고    scopus 로고
    • Nuclear export signal located within the DNA-binding domain of the STAT1 transcription factor
    • McBride KM, McDonald C, Reich NC. (2000). Nuclear export signal located within the DNA-binding domain of the STAT1 transcription factor. EMBO J 19: 6196-6206.
    • (2000) EMBO J , vol.19 , pp. 6196-6206
    • McBride, K.M.1    McDonald, C.2    Reich, N.C.3
  • 29
    • 0041660942 scopus 로고    scopus 로고
    • DNA binding controls inactivation and nuclear accumulation of the transcription factor STAT1
    • Meyer T, Marg A, Lemke P, Wiesner B, Vinkemeier U. (2003). DNA binding controls inactivation and nuclear accumulation of the transcription factor STAT1. Genes Dev 17: 1992-2005.
    • (2003) Genes Dev , vol.17 , pp. 1992-2005
    • Meyer, T.1    Marg, A.2    Lemke, P.3    Wiesner, B.4    Vinkemeier, U.5
  • 30
    • 65249127544 scopus 로고    scopus 로고
    • MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment
    • Pitroda S, Khodarev N, Beckett M, Kufe D, Weichselbaum R. (2009). MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci USA 106: 5837-5841.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 5837-5841
    • Pitroda, S.1    Khodarev, N.2    Beckett, M.3    Kufe, D.4    Weichselbaum, R.5
  • 31
    • 67449127094 scopus 로고    scopus 로고
    • Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells
    • Raina D, Ahmad R, Joshi M, Yin L, Wu Z, Kawano T et al. (2009). Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res 69: 5133-5141.
    • (2009) Cancer Res , vol.69 , pp. 5133-5141
    • Raina, D.1    Ahmad, R.2    Joshi, M.3    Yin, L.4    Wu, Z.5    Kawano, T.6
  • 32
    • 33748055445 scopus 로고    scopus 로고
    • MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
    • Raina D, Ahmad R, Kumar S, Ren J, Yoshida K, Kharbanda S et al. (2006). MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J 25: 3774-3783.
    • (2006) EMBO J , vol.25 , pp. 3774-3783
    • Raina, D.1    Ahmad, R.2    Kumar, S.3    Ren, J.4    Yoshida, K.5    Kharbanda, S.6
  • 33
    • 34748902247 scopus 로고    scopus 로고
    • The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop
    • Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S, Kufe D. (2007). The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell 27: 992-1004.
    • (2007) Mol Cell , vol.27 , pp. 992-1004
    • Ramasamy, S.1    Duraisamy, S.2    Barbashov, S.3    Kawano, T.4    Kharbanda, S.5    Kufe, D.6
  • 34
    • 10744220453 scopus 로고    scopus 로고
    • Human MUC1 carcinoma-associated protein confers resistance to genotoxic anti-cancer agents
    • Ren J, Agata N, Chen D, Li Y, Yu W-H, Huang L et al. (2004). Human MUC1 carcinoma-associated protein confers resistance to genotoxic anti-cancer agents. Cancer Cell 5: 163-175.
    • (2004) Cancer Cell , vol.5 , pp. 163-175
    • Ren, J.1    Agata, N.2    Chen, D.3    Li, Y.4    Yu, W.-H.5    Huang, L.6
  • 35
    • 30044445260 scopus 로고    scopus 로고
    • MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90
    • Ren J, Bharti A, Raina D, Chen W, Ahmad R, Kufe D. (2006). MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90. Oncogene 25: 20-31.
    • (2006) Oncogene , vol.25 , pp. 20-31
    • Ren, J.1    Bharti, A.2    Raina, D.3    Chen, W.4    Ahmad, R.5    Kufe, D.6
  • 36
    • 0037124099 scopus 로고    scopus 로고
    • Protein kinase C d regulates function of the DF3/MUC1 carcinoma antigen in b-catenin signaling
    • Ren J, Li Y, Kufe D. (2002). Protein kinase C d regulates function of the DF3/MUC1 carcinoma antigen in b-catenin signaling. J Biol Chem 277: 17616-17622.
    • (2002) J Biol Chem , vol.277 , pp. 17616-17622
    • Ren, J.1    Li, Y.2    Kufe, D.3
  • 37
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: From interferons to cytokines
    • Schindler C, Levy DE, Decker T. (2007). JAK-STAT signaling: from interferons to cytokines. J Biol Chem 282: 20059-20063.
    • (2007) J Biol Chem , vol.282 , pp. 20059-20063
    • Schindler, C.1    Levy, D.E.2    Decker, T.3
  • 38
    • 0034657917 scopus 로고    scopus 로고
    • Modulation of STAT signaling by STAT-interacting proteins
    • Shuai K. (2000). Modulation of STAT signaling by STAT-interacting proteins. Oncogene 19: 2638-2644.
    • (2000) Oncogene , vol.19 , pp. 2638-2644
    • Shuai, K.1
  • 39
    • 0035964214 scopus 로고    scopus 로고
    • Significance analysis of microarrays applied to the ionizing radiation response
    • Tusher VG, Tibshirani R, Chu G. (2001). Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98: 10515.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10515
    • Tusher, V.G.1    Tibshirani, R.2    Chu, G.3
  • 40
    • 13844262819 scopus 로고    scopus 로고
    • Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    • Wei X, Xu H, Kufe D. (2005). Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 7: 167-178.
    • (2005) Cancer Cell , vol.7 , pp. 167-178
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 41
    • 30744474431 scopus 로고    scopus 로고
    • MUC1 oncoprotein stabilizes and activates estrogen receptor a
    • Wei X, Xu H, Kufe D. (2006). MUC1 oncoprotein stabilizes and activates estrogen receptor a. Mol Cell 21: 295-305.
    • (2006) Mol Cell , vol.21 , pp. 295-305
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 42
    • 33847752147 scopus 로고    scopus 로고
    • Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene
    • Wei X, Xu H, Kufe D. (2007). Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene. Cancer Res 67: 1853-1858.
    • (2007) Cancer Res , vol.67 , pp. 1853-1858
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 43
    • 57449088412 scopus 로고    scopus 로고
    • An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer
    • Weichselbaum RR, Ishwaran H, Yoon T, Nuyten DS, Baker SW, Khodarev N et al. (2008). An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer. Proc Natl Acad Sci USA 105: 18490-18495.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18490-18495
    • Weichselbaum, R.R.1    Ishwaran, H.2    Yoon, T.3    Nuyten, D.S.4    Baker, S.W.5    Khodarev, N.6
  • 44
    • 33846994065 scopus 로고    scopus 로고
    • Mucin 1 oncoprotein blocks hypoxia-inducible factor 1 alpha activation in a survival response to hypoxia
    • Yin L, Kharbanda S, Kufe D. (2007). Mucin 1 oncoprotein blocks hypoxia-inducible factor 1 alpha activation in a survival response to hypoxia. J Biol Chem 282: 257-266.
    • (2007) J Biol Chem , vol.282 , pp. 257-266
    • Yin, L.1    Kharbanda, S.2    Kufe, D.3
  • 45
    • 0042818006 scopus 로고    scopus 로고
    • Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress
    • Yin L, Kufe D. (2003). Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress. J Biol Chem 278: 35458-35464.
    • (2003) J Biol Chem , vol.278 , pp. 35458-35464
    • Yin, L.1    Kufe, D.2
  • 46
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer\-new molecular targets come of age
    • Yu H, Jove R. (2004). The STATs of cancer\-new molecular targets come of age. Nat Rev Cancer 4: 97-105.
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.