Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition: Mutation of methionine 593 abolishes malonyl-CoA inhibition

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9058-9063

  Morillas, Montserrat ^a   Gómez Puertas, Paulino ^b   Bentebibel, Assia ^a   Sellés, Eva ^a   Casals, Nuria ^c   Valencia, Alfonso ^b   Hegardt, Fausto G ^a,d   Asins, Guillermina ^a   Serra, Dolors ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c UNIVERSITAT INTERNACIONAL DE CATALUNYA   (Spain)

^d School of Pharmacy   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHMS; AMINO ACIDS; CELL MEMBRANES; ENZYME INHIBITION; SENSITIVITY ANALYSIS;

MUTANTS;

BIOCHEMISTRY;

ALANINE; AMINO ACID; ASPARAGINE; CARNITINE PALMITOYLTRANSFERASE; CYSTEINE; MALONYL COENZYME A; METHIONINE; THREONINE; CARNITINE ACYLTRANSFERASE; ISOPROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CATALYST; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RAT; SEQUENCE ANALYSIS; ALGORITHM; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; HUMAN; IC 50; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; POINT MUTATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ANIMALIA; FELIS CATUS; VALENCIA;

ALANINE; ALGORITHMS; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CARNITINE ACYLTRANSFERASES; CARNITINE O-PALMITOYLTRANSFERASE; CATALYSIS; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MALONYL COENZYME A; METHIONINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; POINT MUTATION; PROTEIN BINDING; PROTEIN ISOFORMS; RATS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; THREONINE;

EID: 0037646548     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209999200     Document Type: Article

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