-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-1310. (Pubitemid 32641789)
-
(2001)
Critical Care Medicine
, vol.29
, Issue.7
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
2
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
DOI 10.1056/NEJMra021333
-
Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348: 138-150. (Pubitemid 36056721)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.2
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
3
-
-
39449112833
-
Role of toll-like receptors in the development of sepsis
-
DOI 10.1097/SHK.0b013e318157ee55, PII 0002438220080300000002
-
Tsujimoto H, Ono S, Efron PA, Scumpia PO, Moldawer LL, Mochizuki H. Role of Toll-like receptors in the development of sepsis. Shock 2008; 29: 315-321. (Pubitemid 351271701)
-
(2008)
Shock
, vol.29
, Issue.3
, pp. 315-321
-
-
Tsujimoto, H.1
Ono, S.2
Efron, P.A.3
Scumpia, P.O.4
Moldawer, L.L.5
Mochizuki, H.6
-
4
-
-
33750288937
-
Apoptosis and caspases regulate death and inflammation in sepsis
-
DOI 10.1038/nri1943, PII NRI1943
-
Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 2006; 6: 813-822. (Pubitemid 44631650)
-
(2006)
Nature Reviews Immunology
, vol.6
, Issue.11
, pp. 813-822
-
-
Hotchkiss, R.S.1
Nicholson, D.W.2
-
5
-
-
0032770246
-
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
-
DOI 10.1097/00003246-199907000-00002
-
Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27: 1230-1251. (Pubitemid 29379358)
-
(1999)
Critical Care Medicine
, vol.27
, Issue.7
, pp. 1230-1251
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Freeman, B.D.3
Tinsley, K.W.4
Cobb, J.P.5
Matuschak, G.M.6
Buchman, T.G.7
Karl, I.E.8
-
6
-
-
55349102040
-
Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis
-
Weber SU, Schewe JC, Lehmann LE, Müller S, Book M, Klaschik S et al. Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis. Crit Care 2008; 12:R128.
-
(2008)
Crit Care
, vol.12
-
-
Weber, S.U.1
Schewe, J.C.2
Lehmann, L.E.3
Müller, S.4
Book, M.5
Klaschik, S.6
-
7
-
-
23044477087
-
Leukocyte apoptosis and its significance in sepsis and shock
-
DOI 10.1189/jlb.0105017
-
Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol 2005; 78: 325-337. (Pubitemid 41061305)
-
(2005)
Journal of Leukocyte Biology
, vol.78
, Issue.2
, pp. 325-337
-
-
Wesche, D.E.1
Lomas-Neira, J.L.2
Perl, M.3
Chung, C.-S.4
Ayala, A.5
-
8
-
-
48249107889
-
Apoptosis in sepsis: Mechanisms, clinical impact and potential therapeutic targets
-
Ayala A, Perl M, Venet F, Lomas-Neira J, Swan R, Chung CS. Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets. Curr Pharm Des 2008; 14: 1853-1859.
-
(2008)
Curr Pharm des
, vol.14
, pp. 1853-1859
-
-
Ayala, A.1
Perl, M.2
Venet, F.3
Lomas-Neira, J.4
Swan, R.5
Chung, C.S.6
-
9
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
-
(1972)
Br J Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
10
-
-
0032511880
-
Cell suicide for beginners
-
DOI 10.1038/24055
-
Raff M. Cell suicide for beginners. Nature 1998; 396: 119-122. (Pubitemid 28523602)
-
(1998)
Nature
, vol.396
, Issue.6707
, pp. 119-122
-
-
Raff, M.1
-
11
-
-
0035938922
-
Why is apoptosis important to clinicians?
-
Haslett C, Savill J. Why is apoptosis important to clinicians? BMJ 2001; 322: 1499-1500. (Pubitemid 32588341)
-
(2001)
British Medical Journal
, vol.322
, Issue.7301
, pp. 1499-1500
-
-
Haslett, C.1
Savill, J.2
-
12
-
-
17044413706
-
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
-
Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol 2005; 174: 5110-5118.
-
(2005)
J Immunol
, vol.174
, pp. 5110-5118
-
-
Hotchkiss, R.S.1
Osmon, S.B.2
Chang, K.C.3
Wagner, T.H.4
Coopersmith, C.M.5
Karl, I.E.6
-
13
-
-
0029282018
-
The induction of accelerated thymic programmed cell death during polymicrobial sepsis: Control by cortico-steroids but not tumor necrosis factor
-
Ayala A, Herdon CD, Lehman DL, DeMaso CM, Ayala CA, Chaudry IH. The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by cortico-steroids but not tumor necrosis factor. Shock 1995; 3: 259-267.
-
(1995)
Shock
, vol.3
, pp. 259-267
-
-
Ayala, A.1
Herdon, C.D.2
Lehman, D.L.3
Demaso, C.M.4
Ayala, C.A.5
Chaudry, I.H.6
-
14
-
-
0034676089
-
Cross-talk in cell death signaling
-
Roy S, Nicholson DW. Cross-talk in cell death signaling. J Exp Med 2000; 192:F21-25.
-
(2000)
J Exp Med
, vol.192
-
-
Roy, S.1
Nicholson, D.W.2
-
15
-
-
0142027948
-
Ways of dying: Multiple pathways to apoptosis
-
DOI 10.1101/gad.1126903
-
Adams JM. Ways of dying: multiple pathways to apoptosis. Genes Dev 2003; 17: 2481-2495. (Pubitemid 37271417)
-
(2003)
Genes and Development
, vol.17
, Issue.20
, pp. 2481-2495
-
-
Adams, J.M.1
-
16
-
-
0036791637
-
The roles of Bid
-
Esposti MD. The roles of Bid. Apoptosis 2002; 7: 433-440.
-
(2002)
Apoptosis
, vol.7
, pp. 433-440
-
-
Esposti, M.D.1
-
17
-
-
0038021272
-
Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more
-
DOI 10.1146/annurev.immunol.21.120601.141029
-
Marsden VS, Strasser A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol 2003; 21: 71-105. (Pubitemid 37174527)
-
(2003)
Annual Review of Immunology
, vol.21
, pp. 71-105
-
-
Marsden, V.S.1
Strasser, A.2
-
18
-
-
0142093069
-
Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacity
-
DOI 10.1189/jlb.0102006
-
Chung CS, Song GY , Lomas J, Simms HH, Chaudry IH, Ayala A. Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J Leukoc Biol 2003; 74: 344-351. (Pubitemid 38040394)
-
(2003)
Journal of Leukocyte Biology
, vol.74
, Issue.3
, pp. 344-351
-
-
Chung, C.-S.1
Song, G.Y.2
Lomas, J.3
Simms, H.H.4
Chaudry, I.H.5
Ayala, A.6
-
20
-
-
0032770246
-
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
-
DOI 10.1097/00003246-199907000-00002
-
Hotchkiss RS, Swanson PE, Freeman BD, Tinsley KW, Cobb JP, Matuschak GM et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27: 1230-1251. (Pubitemid 29379358)
-
(1999)
Critical Care Medicine
, vol.27
, Issue.7
, pp. 1230-1251
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Freeman, B.D.3
Tinsley, K.W.4
Cobb, J.P.5
Matuschak, G.M.6
Buchman, T.G.7
Karl, I.E.8
-
21
-
-
0033120115
-
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis
-
Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF et al. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 1999; 162: 4148-4156. (Pubitemid 29314800)
-
(1999)
Journal of Immunology
, vol.162
, Issue.7
, pp. 4148-4156
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Knudson, C.M.3
Chang, K.C.4
Cobb, J.P.5
Osborne, D.F.6
Zollner, K.M.7
Buchman, T.G.8
Korsmeyer, S.J.9
Karl, I.E.10
-
22
-
-
0035338993
-
+ T lymphocytes in humans
-
Hotchkiss RS, Tinsley KW, Swanson PE, Schmieg RE Jr, Hui JJ , Chang KC et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 2001; 166: 6952-6963. (Pubitemid 32467243)
-
(2001)
Journal of Immunology
, vol.166
, Issue.11
, pp. 6952-6963
-
-
Hotchkiss, R.S.1
Tinsley, K.W.2
Swanson, P.E.3
Schmieg Jr., R.E.4
Hui, J.J.5
Chang, K.C.6
Osborne, D.F.7
Freeman, B.D.8
Cobb, J.P.9
Buchman, T.G.10
Karl, I.E.11
-
23
-
-
6444244641
-
Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome
-
Le Tulzo Y, Pangault C, Gacouin A, Guilloux V, Tribut O, Amiot L et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock 2002; 18: 487-494.
-
(2002)
Shock
, vol.18
, pp. 487-494
-
-
Le Tulzo, Y.1
Pangault, C.2
Gacouin, A.3
Guilloux, V.4
Tribut, O.5
Amiot, L.6
-
24
-
-
16644390415
-
Increased lymphoid tissue apoptosis in baboons with bacteremic shock
-
Efron PA, Tinsley K, Minnich DJ, Monterroso V, Wagner J, Lainee P et al. Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock 2004; 21: 566-571.
-
(2004)
Shock
, vol.21
, pp. 566-571
-
-
Efron, P.A.1
Tinsley, K.2
Minnich, D.J.3
Monterroso, V.4
Wagner, J.5
Lainee, P.6
-
25
-
-
70249094666
-
Lymphocyte apoptosis in murine Pneumocystis pneumonia
-
Shi X, LeCapitaine NJ, Rudner XL, Ruan S, Shellito JE. Lymphocyte apoptosis in murine Pneumocystis pneumonia. Respir Res 2009; 10:57.
-
(2009)
Respir Res
, vol.10
, pp. 57
-
-
Shi, X.1
Lecapitaine, N.J.2
Rudner, X.L.3
Ruan, S.4
Shellito, J.E.5
-
26
-
-
3142704153
-
Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity
-
DOI 10.1097/01.CCM.0000129975.26905.77
-
Taneja R, Parodo J, Jia SH, Kapus A, Rotstein OD, Marshall JC. Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med 2004; 32: 1460-1469. (Pubitemid 38925173)
-
(2004)
Critical Care Medicine
, vol.32
, Issue.7
, pp. 1460-1469
-
-
Taneja, R.1
Parodo, J.2
Song, H.J.3
Kapus, A.4
Rotstein, O.D.5
Marshall, J.C.6
-
27
-
-
0036154973
-
A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo
-
DOI 10.1097/00000658-200202000-00018
-
Sookhai S, Wang JJ , McCourt M, Kirwan W, Bouchier-Hayes D, Redmond P. A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo. Ann Surg 2002; 235: 285-291. (Pubitemid 34111959)
-
(2002)
Annals of Surgery
, vol.235
, Issue.2
, pp. 285-291
-
-
Sookhai, S.1
Wang, J.J.2
McCourt, M.3
Kirwan, W.4
Bouchier-Hayes, D.5
Redmond, P.6
-
28
-
-
0042333417
-
Over-expression of Bcl-2 provides protection in septic mice by a trans effect
-
Iwata A, Stevenson VM, Minard A, Tasch M, Tupper J, Lagasse E et al. Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol 2003; 171: 3136-3141. (Pubitemid 37093537)
-
(2003)
Journal of Immunology
, vol.171
, Issue.6
, pp. 3136-3141
-
-
Iwata, A.1
Stevenson, V.M.2
Minard, A.3
Tasch, M.4
Tupper, J.5
Lagasse, E.6
Weissman, I.7
Harlan, J.M.8
Winn, R.K.9
-
29
-
-
0036499162
-
Depletion of dendritic cells, but not macrophages, in patients with sepsis
-
Hotchkiss RS, Tinsley KW, Swanson PE, Grayson MH, Osborne DF, Wagner TH et al. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 2002; 168: 2493-2500. (Pubitemid 34171855)
-
(2002)
Journal of Immunology
, vol.168
, Issue.5
, pp. 2493-2500
-
-
Hotchkiss, R.S.1
Tinsley, K.W.2
Swanson, P.E.3
Grayson, M.H.4
Osborne, D.F.5
Wagner, T.H.6
Cobb, J.P.7
Coopersmith, C.8
Karl, I.E.9
-
30
-
-
0037384023
-
Role of intestinal epithelial apoptosis in survival
-
DOI 10.1097/00075198-200304000-00013
-
Husain KD, Coopersmith CM. Role of intestinal epithelial apoptosis in survival. Curr Opin Crit Care 2003; 9: 159-163. (Pubitemid 36408136)
-
(2003)
Current Opinion in Critical Care
, vol.9
, Issue.2
, pp. 159-163
-
-
Husain, K.D.1
Coopersmith, C.M.2
-
32
-
-
0035015031
-
Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand
-
Serrao KL, Fortenberry JD, Owens ML, Harris FL, Brown LA. Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand. Am J Physiol Lung Cell Mol Physiol 2001; 280:L298-305.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.280
-
-
Serrao, K.L.1
Fortenberry, J.D.2
Owens, M.L.3
Harris, F.L.4
Brown, L.A.5
-
33
-
-
34548432210
-
Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock
-
DOI 10.1016/j.cardiores.2007.05.024, PII S0008636307002568
-
Matsuda N, Takano Y, Kageyama SI, Hatakeyama N, Shakunaga K, Kitajima I et al. Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res 2007; 76: 132-140. (Pubitemid 47362040)
-
(2007)
Cardiovascular Research
, vol.76
, Issue.1
, pp. 132-140
-
-
Matsuda, N.1
Takano, Y.2
Kageyama, S.-i.3
Hatakeyama, N.4
Shakunaga, K.5
Kitajima, I.6
Yamazaki, M.7
Hattori, Y.8
-
34
-
-
34447644423
-
Death of the septic monocyte: Is more better?
-
Moraes TJ, Downey GP. Death of the septic monocyte: is more better? Crit Care 2006; 10:146.
-
(2006)
Crit Care
, vol.10
, pp. 146
-
-
Moraes, T.J.1
Downey, G.P.2
-
35
-
-
75549084325
-
Cell death in sepsis: A matter of how, when, and where
-
Bantel H, Schulze-Osthoff K. Cell death in sepsis: a matter of how, when, and where. Crit Care 2009; 13:173.
-
(2009)
Crit Care
, vol.13
, pp. 173
-
-
Bantel, H.1
Schulze-Osthoff, K.2
-
36
-
-
0037611384
-
Cellular apoptosis and organ injury in sepsis: A review
-
Power C, Fanning N, Redmond HP. Cellular apoptosis and organ injury in sepsis: a review. Shock 2002; 18: 197-211.
-
(2002)
Shock
, vol.18
, pp. 197-211
-
-
Power, C.1
Fanning, N.2
Redmond, H.P.3
-
37
-
-
0038312126
-
Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis
-
DOI 10.1073/pnas.1031788100
-
Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG et al. Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis. Proc Natl Acad Sci U S A 2003; 100: 6724-6729. (Pubitemid 36666647)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.11
, pp. 6724-6729
-
-
Hotchkiss, R.S.1
Chang, K.C.2
Grayson, M.H.3
Tinsley, K.W.4
Dunne, B.S.5
Davis, C.G.6
Osborne, D.F.7
Karl, I.E.8
-
38
-
-
1642368260
-
Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care
-
DOI 10.1007/s00134-003-2118-z
-
Bilbault P, Lavaux T, Lahlou A, Uring-Lambert B, Gaub MP, Ratomponirina C et al. Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care. Intensive Care Med 2004; 30: 408-415. (Pubitemid 38375614)
-
(2004)
Intensive Care Medicine
, vol.30
, Issue.3
, pp. 408-415
-
-
Bilbault, P.1
Lavaux, T.2
Lahlou, A.3
Uring-Lambert, B.4
Gaub, M.-P.5
Ratomponirina, C.6
Meyer, N.7
Oudet, P.8
Schneider, F.9
-
39
-
-
77954390494
-
Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients
-
Turrel-Davin F, Guignant C, Lepape A, Mougin B, Monneret G, Venet F. Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients. Crit Care 2010; 14:R133.
-
(2010)
Crit Care
, vol.14
-
-
Turrel-Davin, F.1
Guignant, C.2
Lepape, A.3
Mougin, B.4
Monneret, G.5
Venet, F.6
-
40
-
-
0033120115
-
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis
-
Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF et al. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 1999; 162: 4148-4156. (Pubitemid 29314800)
-
(1999)
Journal of Immunology
, vol.162
, Issue.7
, pp. 4148-4156
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Knudson, C.M.3
Chang, K.C.4
Cobb, J.P.5
Osborne, D.F.6
Zollner, K.M.7
Buchman, T.G.8
Korsmeyer, S.J.9
Karl, I.E.10
-
41
-
-
27144512743
-
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice
-
DOI 10.1182/blood-2004-10-4086
-
Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood 2005; 106: 2295-2301. (Pubitemid 41510799)
-
(2005)
Blood
, vol.106
, Issue.7
, pp. 2295-2301
-
-
Wesche-Soldato, D.E.1
Chung, C.-S.2
Lomas-Neira, J.3
Doughty, L.A.4
Gregory, S.H.5
Ayala, A.6
-
42
-
-
0033628936
-
Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis
-
Tinsley KW, Cheng SL, Buchman TG, Chang KC, Hui JJ , Swanson PE et al. Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis. Shock 2000; 13: 1-7.
-
(2000)
Shock
, vol.13
, pp. 1-7
-
-
Tinsley, K.W.1
Cheng, S.L.2
Buchman, T.G.3
Chang, K.C.4
Hui, J.J.5
Swanson, P.E.6
-
43
-
-
0033431682
-
Prevention of lymphocyte cell death in sepsis improves survival in mice
-
DOI 10.1073/pnas.96.25.14541
-
Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG et al. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A 1999; 96: 14541-14546. (Pubitemid 30000686)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.25
, pp. 14541-14546
-
-
Hotchkiss, R.S.1
Tinsley, K.W.2
Swanson, P.E.3
Chang, K.C.4
Cobb, J.P.5
Buchman, T.G.6
Korsmeyer, S.J.7
Karl, I.E.8
-
44
-
-
63849152461
-
Caspase-7 deficiency protects from endotoxininduced lymphocyte apoptosis and improves survival
-
Lamkanfi M, Moreira LO, Makena P, Spierings DCJ, Boyd K, Murray PJ et al. Caspase-7 deficiency protects from endotoxininduced lymphocyte apoptosis and improves survival. Blood 2009; 113: 2742-2745.
-
(2009)
Blood
, vol.113
, pp. 2742-2745
-
-
Lamkanfi, M.1
Moreira, L.O.2
Makena, P.3
Spierings, D.C.J.4
Boyd, K.5
Murray, P.J.6
-
45
-
-
77949892535
-
VX-166: A novel potent small molecule caspase inhibitor as a potential therapy for sepsis
-
Weber P, Wang P, Maddens S, Wang PS, Wu R, Miksa M et al. VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit Care 2009; 13:R146.
-
(2009)
Crit Care
, vol.13
-
-
Weber, P.1
Wang, P.2
Maddens, S.3
Wang, P.S.4
Wu, R.5
Miksa, M.6
-
46
-
-
34147170934
-
Surviving sepsis: Bcl-2 overexpression modulates splenocyte transcriptional responses in vivo
-
DOI 10.1152/ajpregu.00656.2006
-
Wagner TH, Drewry AM, Macmillan S, Dunne WM, Chang KC, Karl IE et al. Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. Am J Physiol Regul Integr Comp Physiol 2007; 292:R1751-R1759. (Pubitemid 46557808)
-
(2007)
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
, vol.292
, Issue.4
-
-
Wagner, T.H.1
Drewry, A.M.2
MacMillan, S.3
Dunne, W.M.4
Chang, K.C.5
Karl, I.E.6
Hotchkiss, R.S.7
Cobb, J.P.8
-
47
-
-
64849114020
-
Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages
-
Peck-Palmer OM, Unsinger J, Chang KC, McDonough JS, Perlman H, McDunn JE et al. Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages. Shock 2009; 31: 359-366.
-
(2009)
Shock
, vol.31
, pp. 359-366
-
-
Peck-Palmer, O.M.1
Unsinger, J.2
Chang, K.C.3
McDonough, J.S.4
Perlman, H.5
McDunn, J.E.6
-
48
-
-
67649306715
-
CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis
-
Stromberg PE, Woolsey CA, Clark AT, Clark JA, Turnbull IR, McConnell KW et al. CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis. FASEB J 2009; 23: 1817-1825.
-
(2009)
FASEB J
, vol.23
, pp. 1817-1825
-
-
Stromberg, P.E.1
Woolsey, C.A.2
Clark, A.T.3
Clark, J.A.4
Turnbull, I.R.5
McConnell, K.W.6
-
49
-
-
5944251623
-
Caspase inhibitors improve survival in sepsis: A critical role of the lymphocyte
-
Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ , Klender P et al. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol 2000; 1: 496-501.
-
(2000)
Nat Immunol
, vol.1
, pp. 496-501
-
-
Hotchkiss, R.S.1
Chang, K.C.2
Swanson, P.E.3
Tinsley, K.W.4
Hui, J.J.5
Klender, P.6
-
50
-
-
77955009943
-
Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival
-
Chung CS, Venet F, Chen Y, Jones LN, Wilson DC, Ayala CA et al. Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival. Shock 2010; 34: 150-161.
-
(2010)
Shock
, vol.34
, pp. 150-161
-
-
Chung, C.S.1
Venet, F.2
Chen, Y.3
Jones, L.N.4
Wilson, D.C.5
Ayala, C.A.6
-
51
-
-
34548621592
-
The intrinsic apoptotic pathway is required for lipopolysaccharide- induced lung endothelial cell death
-
Wang HL, Akinci IO, Baker CM, Urich D, Bellmeyer A, Jain M et al. The intrinsic apoptotic pathway is required for lipopolysaccharide- induced lung endothelial cell death. J Immunol 2007; 179: 1834-1841.
-
(2007)
J Immunol
, vol.179
, pp. 1834-1841
-
-
Wang, H.L.1
Akinci, I.O.2
Baker, C.M.3
Urich, D.4
Bellmeyer, A.5
Jain, M.6
-
52
-
-
2942527148
-
Akt decreases lymphocyte apoptosis and improves survival in sepsis
-
Bommhardt U, Chang KC, Swanson PE, Wagner TH, Tinsley KW, Karl IE et al. Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol 2004; 172: 7583-7591. (Pubitemid 38747622)
-
(2004)
Journal of Immunology
, vol.172
, Issue.12
, pp. 7583-7591
-
-
Bommhardt, U.1
Chang, K.C.2
Swanson, P.E.3
Wagner, T.H.4
Tinsley, K.W.5
Karl, I.E.6
Hotchkiss, R.S.7
-
53
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
DOI 10.1038/35053110
-
Bernstein E, Caudy AA, Hammond SM, Hannon GJ . Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001; 409: 363-366. (Pubitemid 32151243)
-
(2001)
Nature
, vol.409
, Issue.6818
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
54
-
-
33645148088
-
The silent treatment: SiRNAs as small molecule drugs
-
Dykxhoorn DM, Palliser D, Lieberman J. The silent treatment: siRNAs as small molecule drugs. Gene Ther 2006; 13: 541-552.
-
(2006)
Gene Ther
, vol.13
, pp. 541-552
-
-
Dykxhoorn, D.M.1
Palliser, D.2
Lieberman, J.3
-
55
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitis
-
DOI 10.1038/nm828
-
Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003; 9: 347-351. (Pubitemid 36362792)
-
(2003)
Nature Medicine
, vol.9
, Issue.3
, pp. 347-351
-
-
Song, E.1
Lee, S.-K.2
Wang, J.3
Ince, N.4
Ouyang, N.5
Min, J.6
Chen, J.7
Shankar, P.8
Lieberman, J.9
-
56
-
-
33645720317
-
Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference
-
DOI 10.1086/504267
-
G eisbert TW, Hensley LE, Kagan E, Yu EZ, Geisbert JB, Daddario-DiCaprio K et al. Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference. J Infect Dis 2006; 193: 1650-1657. (Pubitemid 43839469)
-
(2006)
Journal of Infectious Diseases
, vol.193
, Issue.12
, pp. 1650-1657
-
-
Geisbert, T.W.1
Hensley, L.E.2
Kagan, E.3
Yu, E.Z.4
Geisbert, J.B.5
Daddario-DiCaprio, K.6
Fritz, E.A.7
Jahrling, P.B.8
McClintock, K.9
Phelps, J.R.10
Lee, A.C.H.11
Judge, A.12
Jeffs, L.B.13
MacLachlan, I.14
-
57
-
-
77950199822
-
Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury
-
Perl M, Chung CS, Perl U, Thakkar R, Lomas-Neira J, Ayala A. Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury. Crit Care Med 2010; 38: 1179-1186.
-
(2010)
Crit Care Med
, vol.38
, pp. 1179-1186
-
-
Perl, M.1
Chung, C.S.2
Perl, U.3
Thakkar, R.4
Lomas-Neira, J.5
Ayala, A.6
-
58
-
-
0037386245
-
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
-
DOI 10.1038/ni914
-
Cauwels A, Janssen B, Waeytens A, Cuvelier C, Brouckaert P. Caspase inhibition causes hyperacute tumor necrosis factorinduced shock via oxidative stress and phospholipase A2. Nat Immunol 2003; 4: 387-393. (Pubitemid 36432323)
-
(2003)
Nature Immunology
, vol.4
, Issue.4
, pp. 387-393
-
-
Cauwels, A.1
Janssen, B.2
Waeytens, A.3
Cuvelier, C.4
Brouckaert, P.5
-
59
-
-
0041666539
-
Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties
-
DOI 10.1023/A:1024116916932
-
Caserta TM, Smith AN, Gultice AD, Reedy MA, Brown TL. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 2003; 8: 345-352. (Pubitemid 36935206)
-
(2003)
Apoptosis
, vol.8
, Issue.4
, pp. 345-352
-
-
Caserta, T.M.1
Smith, A.N.2
Gultice, A.D.3
Reedy, M.A.4
Brown, T.L.5
-
60
-
-
33847401104
-
Multiple triggers of cell death in sepsis: Death receptor and mitochondrial-mediated apoptosis
-
DOI 10.1096/fj.06-6805com
-
Chang KC, Unsinger J, Davis CG, Schwulst SJ, Muenzer JT, Strasser A et al. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J 2007; 21: 708-719. (Pubitemid 46348247)
-
(2007)
FASEB Journal
, vol.21
, Issue.3
, pp. 708-719
-
-
Chang, K.C.1
Unsinger, J.2
Davis, C.G.3
Schwulst, S.J.4
Muenzer, J.T.5
Strasser, A.6
Hotchkiss, R.S.7
-
61
-
-
0035050888
-
Expression of Fas (CD95) and Fas ligand on peripheral blood mononuclear cells in critical illness and association with multiorgan dysfunction severity and survival
-
Papathanassoglou ED, Moynihan JA, McDermott MP, Ackerman MH. Expression of Fas (CD95) and Fas ligand on peripheral blood mononuclear cells in critical illness and association with multiorgan dysfunction severity and survival. Crit Care Med 2001; 29: 709-718. (Pubitemid 32299706)
-
(2001)
Critical Care Medicine
, vol.29
, Issue.4
, pp. 709-718
-
-
Papathanassoglou, E.D.E.1
Moynihan, J.A.2
McDermott, M.P.3
Ackerman, M.H.4
-
62
-
-
3643052918
-
Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?
-
Chung CS, Xu YX, Wang W, Chaudry IH, Ayala A. Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? Arch Surg 1998; 133: 1213-1220. (Pubitemid 28516273)
-
(1998)
Archives of Surgery
, vol.133
, Issue.11
, pp. 1213-1220
-
-
Chung, C.-S.1
Xu, Y.X.2
Wang, W.3
Chaudry, I.H.4
Ayala, A.5
-
63
-
-
33846964621
-
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
-
Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315: 856-859.
-
(2007)
Science
, vol.315
, pp. 856-859
-
-
Willis, S.N.1
Fletcher, J.I.2
Kaufmann, T.3
Van Delft, M.F.4
Chen, L.5
Czabotar, P.E.6
-
64
-
-
52149119860
-
Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis
-
Schwulst SJ, Muenzer JT, Peck-Palmer OM, Chang KC, Davis CG, McDonough JS et al. Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis. Shock 2008; 30: 127-134.
-
(2008)
Shock
, vol.30
, pp. 127-134
-
-
Schwulst, S.J.1
Muenzer, J.T.2
Peck-Palmer, O.M.3
Chang, K.C.4
Davis, C.G.5
McDonough, J.S.6
-
65
-
-
32944454941
-
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
-
DOI 10.1016/j.ymthe.2005.11.002, PII S1525001605016746
-
J udge AD, Bola G, Lee ACH, MacLachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol Ther 2006; 13: 494-505. (Pubitemid 43257617)
-
(2006)
Molecular Therapy
, vol.13
, Issue.3
, pp. 494-505
-
-
Judge, A.D.1
Bola, G.2
Lee, A.C.H.3
MacLachlan, I.4
-
66
-
-
65549100987
-
Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis
-
Matsuda N, Yamamoto S, Takano KI, Kageyama SI, Kurobe Y, Yoshihara Y et al. Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis. Am J Respir Crit Care Med 2009; 179: 806-815.
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 806-815
-
-
Matsuda, N.1
Yamamoto, S.2
Takano, K.I.3
Kageyama, S.I.4
Kurobe, Y.5
Yoshihara, Y.6
-
67
-
-
73549085373
-
Increased death receptor pathway of apoptotic signaling in septic mouse aorta: Effect of systemic delivery of FADD siRNA
-
Matsuda N, Teramae H, Yamamoto S, Takano KI, Takano Y, Hattori Y. Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA. Am J Physiol Heart Circ Physiol 2010; 298: H92-101.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
-
-
Matsuda, N.1
Teramae, H.2
Yamamoto, S.3
Takano, K.I.4
Takano, Y.5
Hattori, Y.6
-
68
-
-
67249106203
-
Targeted delivery of siRNA to cell death proteins in sepsis
-
Brahmamdam P, Watanabe E, Unsinger J, Chang KC, Schierding W, Hoekzema AS et al. Targeted delivery of siRNA to cell death proteins in sepsis. Shock 2009; 32: 131-139.
-
(2009)
Shock
, vol.32
, pp. 131-139
-
-
Brahmamdam, P.1
Watanabe, E.2
Unsinger, J.3
Chang, K.C.4
Schierding, W.5
Hoekzema, A.S.6
-
69
-
-
41849149676
-
RNAi therapeutics: An update on delivery
-
Nguyen T, Menocal EM, Harborth J, Fruehauf JH. RNAi therapeutics: an update on delivery. Curr Opin Mol Ther 2008; 10: 158-167. (Pubitemid 351498878)
-
(2008)
Current Opinion in Molecular Therapeutics
, vol.10
, Issue.2
, pp. 158-167
-
-
Nguyen, T.1
Menocal, E.M.2
Harborth, J.3
Fruehauf, J.H.4
-
70
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010; 464: 1067-1070.
-
(2010)
Nature
, vol.464
, pp. 1067-1070
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.3
Seligson, D.4
Tolcher, A.5
Alabi, C.A.6
-
71
-
-
22144498421
-
Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor
-
DOI 10.1172/JCI22954
-
Weaver JG , Tarze A, Moffat TC, Lebras M, Deniaud A, Brenner C et al. Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. J Clin Invest 2005; 115: 1828-1838. (Pubitemid 40979721)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.7
, pp. 1828-1838
-
-
Weaver, J.G.R.1
Tarze, A.2
Moffat, T.C.3
Lebras, M.4
Deniaud, A.5
Brenner, C.6
Bren, G.D.7
Morin, M.Y.8
Phenix, B.N.9
Dong, L.10
Jiang, S.X.11
Sim, V.L.12
Zurakowski, B.13
Lallier, J.14
Hardin, H.15
Wettstein, P.16
Van Heeswijk, R.P.G.17
Douen, A.18
Kroemer, R.T.19
Hou, S.T.20
Bennett, S.A.L.21
Lynch, D.H.22
Kroemer, G.23
Badley, A.D.24
more..
-
72
-
-
79952094321
-
Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis
-
Iwata A, de Claro RA, Morgan-Stevenson VL, Tupper JC, Schwartz BR, Liu L et al. Extracellular administration of BCL2 protein reduces apoptosis and improves survival in a murine model of sepsis. PLoS One 2011; 6:e14729.
-
(2011)
PLoS One
, vol.6
-
-
Iwata, A.1
De Claro, R.A.2
Morgan-Stevenson, V.L.3
Tupper, J.C.4
Schwartz, B.R.5
Liu, L.6
-
73
-
-
34548166333
-
Cytochrome c oxidase dysfunction in sepsis
-
DOI 10.1097/01.CCM.0000278604.93569.27, PII 0000324620070900100007
-
Levy RJ, Deutschman CS. Cytochrome c oxidase dysfunction in sepsis. Crit Care Med 2007; 35:S468-475. (Pubitemid 47312181)
-
(2007)
Critical Care Medicine
, vol.35
, Issue.9 SUPPL.
-
-
Levy, R.J.1
Deutschman, C.S.2
-
74
-
-
42149156087
-
Exogenous cytochrome c restores myocardial cytochrome oxidase activity into the late phase of sepsis
-
DOI 10.1097/SHK.0b013e318157e962, PII 0002438220080500000012
-
Piel DA, Deutschman CS, Levy RJ. Exogenous cytochrome C restores myocardial cytochrome oxidase activity into the late phase of sepsis. Shock 2008; 29: 612-616. (Pubitemid 351544082)
-
(2008)
Shock
, vol.29
, Issue.5
, pp. 612-616
-
-
Piel, D.A.1
Deutschman, C.S.2
Levy, R.J.3
|