-
1
-
-
0037588986
-
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
-
Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101: 3765-3777, 2003.
-
(2003)
Blood
, vol.101
, pp. 3765-3777
-
-
Aird, W.C.1
-
2
-
-
0036841093
-
Fas and Fas ligand are upregulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome
-
Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB. Fas and Fas ligand are upregulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol 161: 1783-1796, 2002.
-
(2002)
Am J Pathol
, vol.161
, pp. 1783-1796
-
-
Albertine, K.H.1
Soulier, M.F.2
Wang, Z.3
Ishizaka, A.4
Hashimoto, S.5
Zimmerman, G.A.6
Matthay, M.A.7
Ware, L.B.8
-
3
-
-
0029880871
-
Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and nature of the mediators
-
Ayala A, Herdon CD, Lehman DL, Chaudry IH. Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and nature of the mediators. Blood 87: 4261-4275, 1996.
-
(1996)
Blood
, vol.87
, pp. 4261-4275
-
-
Ayala, A.1
Herdon, C.D.2
Lehman, D.L.3
Chaudry, I.H.4
-
4
-
-
0028034172
-
The role of programmed cell death (apoptosis) in thymic involution following sepsis
-
Barke RA, Roy S, Chapin RB, Charboneau R. The role of programmed cell death (apoptosis) in thymic involution following sepsis. Arch Surg 129: 1256-1261, 1994.
-
(1994)
Arch Surg
, vol.129
, pp. 1256-1261
-
-
Barke, R.A.1
Roy, S.2
Chapin, R.B.3
Charboneau, R.4
-
5
-
-
33847401104
-
Multiple triggers of cell death in sepsis: Death receptor and mitochondrial-mediated apoptosis
-
Chang KC, Unsinger J, Davis CG, Schwulst SJ, Muenzer JT, Strasser A, Hotchkiss RS. Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J 21: 708-719, 2007.
-
(2007)
FASEB J
, vol.21
, pp. 708-719
-
-
Chang, K.C.1
Unsinger, J.2
Davis, C.G.3
Schwulst, S.J.4
Muenzer, J.T.5
Strasser, A.6
Hotchkiss, R.S.7
-
6
-
-
0032525207
-
Endothelial cells in physiology and in the pathophysiology of vascular disorders
-
Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM, Stern DM. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 91: 3527-3561, 1998.
-
(1998)
Blood
, vol.91
, pp. 3527-3561
-
-
Cines, D.B.1
Pollak, E.S.2
Buck, C.A.3
Loscalzo, J.4
Zimmerman, G.A.5
McEver, R.P.6
Pober, J.S.7
Wick, T.M.8
Konkle, B.A.9
Schwartz, B.S.10
Barnathan, E.S.11
McCrae, K.R.12
Hug, B.A.13
Schmidt, A.M.14
Stern, D.M.15
-
7
-
-
0842281645
-
Cell death: Critical control points
-
Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 116: 205-219, 2004.
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
8
-
-
0034900902
-
The kiss of death: Promises and failures of death receptors and ligands in cancer therapy
-
Daniel PT, Wieder T, Sturm I, Schulze-Osthoff K. The kiss of death: promises and failures of death receptors and ligands in cancer therapy. Leukemia 15: 1022-1032, 2001.
-
(2001)
Leukemia
, vol.15
, pp. 1022-1032
-
-
Daniel, P.T.1
Wieder, T.2
Sturm, I.3
Schulze-Osthoff, K.4
-
9
-
-
0031606321
-
Animal models of sepsis and shock: A review and lessons learned
-
Deitch EA. Animal models of sepsis and shock: a review and lessons learned. Shock 9: 1-11, 1998.
-
(1998)
Shock
, vol.9
, pp. 1-11
-
-
Deitch, E.A.1
-
10
-
-
0036791637
-
The roles of Bid
-
Esposti MD. The roles of Bid. Apoptosis 7: 433-440, 2002.
-
(2002)
Apoptosis
, vol.7
, pp. 433-440
-
-
Esposti, M.D.1
-
11
-
-
0345487501
-
Lipopolysaccharide induces apoptosis in a bovine endothelial cell line via a soluble CD14 dependent pathway
-
Frey EA, Finlay BB. Lipopolysaccharide induces apoptosis in a bovine endothelial cell line via a soluble CD14 dependent pathway. Microb Pathog 24: 101-109, 1998.
-
(1998)
Microb Pathog
, vol.24
, pp. 101-109
-
-
Frey, E.A.1
Finlay, B.B.2
-
12
-
-
0035839556
-
Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells
-
Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, Sessa WC. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem 276: 30359-30365, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 30359-30365
-
-
Gratton, J.P.1
Morales-Ruiz, M.2
Kureishi, Y.3
Fulton, D.4
Walsh, K.5
Sessa, W.C.6
-
13
-
-
0034918411
-
The endothelium in sepsis: Source of and a target for inflammation
-
Hack CE, Zeerleder S. The endothelium in sepsis: source of and a target for inflammation. Crit Care Med 29: S21-S27, 2001.
-
(2001)
Crit Care Med
, vol.29
-
-
Hack, C.E.1
Zeerleder, S.2
-
14
-
-
0030784482
-
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
-
Haimovitz-Friedman A, Cordon-Cardo C, Bayoumy S, Garzotto BM, McLoughlin M, Gallily R, Edwards CK III, Schuchman EH, Fuks Z, Kolesnick R. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J Exp Med 186: 1831-1841, 1997.
-
(1997)
J Exp Med
, vol.186
, pp. 1831-1841
-
-
Haimovitz-Friedman, A.1
Cordon-Cardo, C.2
Bayoumy, S.3
Garzotto, B.M.4
McLoughlin, M.5
Gallily, R.6
Edwards III, C.K.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
15
-
-
0026008802
-
Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta
-
Hattori Y, Kawasaki H, Abe K, Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol Heart Circ Physiol 261: H1086-H1094, 1991.
-
(1991)
Am J Physiol Heart Circ Physiol
, vol.261
-
-
Hattori, Y.1
Kawasaki, H.2
Abe, K.3
Kanno, M.4
-
16
-
-
0030739250
-
Apoptosis in lymphoid and parenchyma cells during sepsis: Findings in normal and T- and B-cell-deficient mice
-
Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE. Apoptosis in lymphoid and parenchyma cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med 25: 1298-1307, 1997.
-
(1997)
Crit Care Med
, vol.25
, pp. 1298-1307
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Cobb, J.P.3
Jacobson, A.4
Buchman, T.G.5
Karl, I.E.6
-
17
-
-
0033120115
-
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis
-
Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, Zollner KM, Buchman TG, Korsmeyer SJ, Karl IE. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 162: 4148-4156, 1999.
-
(1999)
J Immunol
, vol.162
, pp. 4148-4156
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Knudson, C.M.3
Chang, K.C.4
Cobb, J.P.5
Osborne, D.F.6
Zollner, K.M.7
Buchman, T.G.8
Korsmeyer, S.J.9
Karl, I.E.10
-
18
-
-
0042333417
-
Over-expression of Bcl-2 provides protection in septic mice by a trans effect
-
Iwata A, Stevenson VM, Minard A, Tasch M, Tupper J, Lagasse E, Weissmann I, Harlan JM, Winn RK. Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol 171: 3136-3141, 2003.
-
(2003)
J Immunol
, vol.171
, pp. 3136-3141
-
-
Iwata, A.1
Stevenson, V.M.2
Minard, A.3
Tasch, M.4
Tupper, J.5
Lagasse, E.6
Weissmann, I.7
Harlan, J.M.8
Winn, R.K.9
-
19
-
-
57149099973
-
Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone
-
Kamiyama K, Matsuda N, Yamamoto S, Takano K, Takano Y, Yamazaki H, Kageyama S, Yokoo H, Nagata T, Hatakeyama N, Tsukada K, Hattori Y. Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea pig lungs using methylprednisolone. Am J Physiol Lung Cell Mol Physiol 295: L998-L1006, 2008.
-
(2008)
Am J Physiol Lung Cell Mol Physiol
, vol.295
-
-
Kamiyama, K.1
Matsuda, N.2
Yamamoto, S.3
Takano, K.4
Takano, Y.5
Yamazaki, H.6
Kageyama, S.7
Yokoo, H.8
Nagata, T.9
Hatakeyama, N.10
Tsukada, K.11
Hattori, Y.12
-
20
-
-
0035076715
-
Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice
-
Kitamura Y, Hashimoto S, Mizuta N, Kobayashi A, Kooguchi K, Fijiwara I, Nakajima H. Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice. Am J Respir Crit Care Med 163: 762-769, 2001.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 762-769
-
-
Kitamura, Y.1
Hashimoto, S.2
Mizuta, N.3
Kobayashi, A.4
Kooguchi, K.5
Fijiwara, I.6
Nakajima, H.7
-
22
-
-
0033678605
-
A single endotoxin injection in the rabbit causes prolonged blood vessel dysfunction and a procoagulant state
-
Leclerc J, Pu Q, Corseaux D, Haddada E, Decoene C, Bordet R, Six I, Jude B, Vallet B. A single endotoxin injection in the rabbit causes prolonged blood vessel dysfunction and a procoagulant state. Crit Care Med 28: 3672-3678, 2000.
-
(2000)
Crit Care Med
, vol.28
, pp. 3672-3678
-
-
Leclerc, J.1
Pu, Q.2
Corseaux, D.3
Haddada, E.4
Decoene, C.5
Bordet, R.6
Six, I.7
Jude, B.8
Vallet, B.9
-
23
-
-
35649015324
-
Vascular biology in sepsis: Pathophysiological and therapeutic significance of vascular dysfunction
-
Matsuda N, Hattori Y. Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction. J Smooth Muscle Res 43: 117-137, 2007.
-
(2007)
J Smooth Muscle Res
, vol.43
, pp. 117-137
-
-
Matsuda, N.1
Hattori, Y.2
-
26
-
-
15744394565
-
Nuclear factor-κB decoy oligonucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis
-
Matsuda N, Hattori Y, Jesmin S, Gando S. Nuclear factor-κB decoy oligonucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol Pharmacol 67: 1018-1025, 2005.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1018-1025
-
-
Matsuda, N.1
Hattori, Y.2
Jesmin, S.3
Gando, S.4
-
27
-
-
33751166411
-
Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: Reversal effect of fluvastatin therapy
-
Matsuda N, Hayashi Y, Takahashi Y, Hattori Y. Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319: 1348-1354, 2006.
-
(2006)
J Pharmacol Exp Ther
, vol.319
, pp. 1348-1354
-
-
Matsuda, N.1
Hayashi, Y.2
Takahashi, Y.3
Hattori, Y.4
-
28
-
-
34548432210
-
Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock
-
Matsuda N, Takano Y, Kageyama S, Hatakeyama N, Shakunaga K, Kitajima I, Yamazaki M, Hattori Y. Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res 76: 132-140, 2007.
-
(2007)
Cardiovasc Res
, vol.76
, pp. 132-140
-
-
Matsuda, N.1
Takano, Y.2
Kageyama, S.3
Hatakeyama, N.4
Shakunaga, K.5
Kitajima, I.6
Yamazaki, M.7
Hattori, Y.8
-
29
-
-
0022993056
-
Pathology of the adult respiratory distress syndrome
-
Meyrick B. Pathology of the adult respiratory distress syndrome. Crit Care Clin 2: 405-428, 1986.
-
(1986)
Crit Care Clin
, vol.2
, pp. 405-428
-
-
Meyrick, B.1
-
30
-
-
0035148874
-
Circulating endothelial cells in patients with septic shock
-
Mutunga M, Fulton B, Bullock R, Batchelor A, Gascoigne A, Gillespie JI, Baudouin SV. Circulating endothelial cells in patients with septic shock. Am J Respir Crit Care Med 163: 195-200, 2001.
-
(2001)
Am J Respir Crit Care Med
, vol.163
, pp. 195-200
-
-
Mutunga, M.1
Fulton, B.2
Bullock, R.3
Batchelor, A.4
Gascoigne, A.5
Gillespie, J.I.6
Baudouin, S.V.7
-
31
-
-
0035860805
-
Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids
-
Nofer JR, Levkau B, Wolinska I, Junker R, Fobker M, von Eckardstein A, Seedorf U, Assmann G. Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids. J Biol Chem 276: 34480-34485, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 34480-34485
-
-
Nofer, J.R.1
Levkau, B.2
Wolinska, I.3
Junker, R.4
Fobker, M.5
von Eckardstein, A.6
Seedorf, U.7
Assmann, G.8
-
32
-
-
0035949476
-
Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves in murine sepsis
-
Oberholzer C, Oberholzer A, Bahjat FR, Minter RM, Tannahill CL, Abouhamze A, LaFace D, Hutchins B, Clare-Salzler MJ, Moldawer LL. Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves in murine sepsis. Proc Natl Acad Sci USA 98: 11503-11508, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11503-11508
-
-
Oberholzer, C.1
Oberholzer, A.2
Bahjat, F.R.3
Minter, R.M.4
Tannahill, C.L.5
Abouhamze, A.6
LaFace, D.7
Hutchins, B.8
Clare-Salzler, M.J.9
Moldawer, L.L.10
-
33
-
-
28244480458
-
Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis
-
Perl M, Chung CS, Lomas-Neira J, Rachel TM, Biffl WL, Cioffi WG, Ayala A. Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol 167: 1545-1559, 2005.
-
(2005)
Am J Pathol
, vol.167
, pp. 1545-1559
-
-
Perl, M.1
Chung, C.S.2
Lomas-Neira, J.3
Rachel, T.M.4
Biffl, W.L.5
Cioffi, W.G.6
Ayala, A.7
-
34
-
-
0017353821
-
Scanning electron microscopy: Morphology of aortic endothelium following injury by endotoxin and during subsequent repair
-
Reidy MA, Bowyer DE. Scanning electron microscopy: morphology of aortic endothelium following injury by endotoxin and during subsequent repair. Atherosclerosis 26: 319-328, 1977.
-
(1977)
Atherosclerosis
, vol.26
, pp. 319-328
-
-
Reidy, M.A.1
Bowyer, D.E.2
-
35
-
-
0020577374
-
-
Reidy MA, Schwartz SM. Endothelial injury and regeneration. IV. Endotoxin: a nondenuding injury to aortic endothelium. Lab Invest 48: 25-34, 1983.
-
Reidy MA, Schwartz SM. Endothelial injury and regeneration. IV. Endotoxin: a nondenuding injury to aortic endothelium. Lab Invest 48: 25-34, 1983.
-
-
-
-
36
-
-
0026093190
-
Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro
-
Robaye B, Mosselmans R, Fiers W, Dumont JE, Galand P. Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro. Am J Pathol 138: 447-453, 1991.
-
(1991)
Am J Pathol
, vol.138
, pp. 447-453
-
-
Robaye, B.1
Mosselmans, R.2
Fiers, W.3
Dumont, J.E.4
Galand, P.5
-
37
-
-
0034676089
-
Cross-talk cell death signaling
-
Roy S, Nicholson DW. Cross-talk cell death signaling. J Exp Med 192: F21-F25, 2000.
-
(2000)
J Exp Med
, vol.192
-
-
Roy, S.1
Nicholson, D.W.2
-
38
-
-
0034142374
-
Phosphorylation of FADD/MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase
-
Scaffidi C, Volkland J, Blomberg I, Hoffmann I, Krammer PH, Peter ME. Phosphorylation of FADD/MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase. J Immunol 164: 1236-1242, 2000.
-
(2000)
J Immunol
, vol.164
, pp. 1236-1242
-
-
Scaffidi, C.1
Volkland, J.2
Blomberg, I.3
Hoffmann, I.4
Krammer, P.H.5
Peter, M.E.6
-
39
-
-
0033861952
-
Death and decoy receptors and p53-mediated apoptosis
-
Sheikh MS, Fornace AJ Jr. Death and decoy receptors and p53-mediated apoptosis. Leukemia 14: 1509-1513, 2000.
-
(2000)
Leukemia
, vol.14
, pp. 1509-1513
-
-
Sheikh, M.S.1
Fornace Jr, A.J.2
-
40
-
-
0035816727
-
Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
-
Suhara T, Mano T, Oliveira BE, Walsh K. Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP). Circ Res 89: 13-19, 2001.
-
(2001)
Circ Res
, vol.89
, pp. 13-19
-
-
Suhara, T.1
Mano, T.2
Oliveira, B.E.3
Walsh, K.4
-
41
-
-
0242656497
-
Death receptor-induced cell killing
-
Thorburn A. Death receptor-induced cell killing. Cell Signal 16: 139-144, 2004.
-
(2004)
Cell Signal
, vol.16
, pp. 139-144
-
-
Thorburn, A.1
-
42
-
-
0028357297
-
Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model
-
Villar J, Ribeiro SP, Mullen JB, Kuliszwski M, Post M, Slutsky AS. Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model. Crit Care Med 22: 914-921, 1994.
-
(1994)
Crit Care Med
, vol.22
, pp. 914-921
-
-
Villar, J.1
Ribeiro, S.P.2
Mullen, J.B.3
Kuliszwski, M.4
Post, M.5
Slutsky, A.S.6
-
43
-
-
0028223194
-
Sepsis-induced apoptosis of the thymocytes in mice
-
Wang SD, Huang KJ, Lin YS, Lei HY. Sepsis-induced apoptosis of the thymocytes in mice. J Immunol 152: 5014-5021, 1994.
-
(1994)
J Immunol
, vol.152
, pp. 5014-5021
-
-
Wang, S.D.1
Huang, K.J.2
Lin, Y.S.3
Lei, H.Y.4
-
44
-
-
27144512743
-
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice
-
Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood 106: 2295-2301, 2005.
-
(2005)
Blood
, vol.106
, pp. 2295-2301
-
-
Wesche-Soldato, D.E.1
Chung, C.S.2
Lomas-Neira, J.3
Doughty, L.A.4
Gregory, S.H.5
Ayala, A.6
-
45
-
-
0034899450
-
Suppression of apoptosis: Role in cell growth and neoplasia
-
White MK, McCubrey JA. Suppression of apoptosis: role in cell growth and neoplasia. Leukemia 15: 1011-1021, 2001.
-
(2001)
Leukemia
, vol.15
, pp. 1011-1021
-
-
White, M.K.1
McCubrey, J.A.2
-
46
-
-
3242664327
-
Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis
-
Zhou M, Simms HH, Wang P. Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis. Ann Surg 240: 321-2330, 2004.
-
(2004)
Ann Surg
, vol.240
, pp. 321-2330
-
-
Zhou, M.1
Simms, H.H.2
Wang, P.3
|