Transition from heterotypic to homotypic PDK1 homodimerization is essential for TCR-mediated NF-κB activation

Journal of Immunology

Volumn 190, Issue 9, 2013, Pages 4508-4515

  Kang, Jung Ah ^a   Jeong, Sang Phil ^a   Park, Daeho ^a   Hayden, Matthew S ^b   Ghosh, Sankar ^b   Park, Sung Gyoo ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN CARMA1; PROTEIN KINASE C; T LYMPHOCYTE RECEPTOR; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIMERIZATION; DOWN REGULATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSIENT TRANSFECTION;

ANIMALS; ANTIGENS, CD28; BLOOD PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CELL LINE; CELL LINE, TUMOR; DIMERIZATION; GUANYLATE CYCLASE; HEK293 CELLS; HUMANS; INTERLEUKIN-2; ISOENZYMES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THREONINE;

EID: 84876785084     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202923     Document Type: Article

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