Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice

Molecules

Volumn 18, Issue 4, 2013, Pages 3841-3858

  McCall, Kelly D ^a,b,c   Schmerr, Martin J ^d   Thuma, Jean R ^a   James, Calvin B L ^a,b   Courreges, Maria C ^a   Benencia, Fabian ^a,b,c   Malgor, Ramiro ^a,b,c   Schwartz, Frank L ^a,c  

^a OHIO UNIVERSITY   (United States)

^b OHIO UNIVERSITY   (United States)

^c Ohio University   (United States)

^d Central Ohio Technical College   (United States)

Author keywords

Beta cell death; DsRNA; Phenylmethimazole (C10); Type 1diabetes

Indexed keywords

CXCL10 PROTEIN, MOUSE; CYTOKINE; DOUBLE STRANDED RNA; DRUG DERIVATIVE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; PHENYL METHIMAZOLE; THIAMAZOLE; THIOKETONE; TLR3 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 3;

ANIMAL; APOPTOSIS; ARTICLE; BLOOD; CELL LINE; CELL SURVIVAL; DRUG EFFECT; ENTEROVIRUS; FEMALE; GENETICS; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PATHOGENICITY; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; VIROLOGY;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; CHEMOKINE CXCL10; CYTOKINES; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS; FEMALE; INFLAMMATION; INSULIN-SECRETING CELLS; METHIMAZOLE; MICE; MICE, INBRED NOD; REAL-TIME POLYMERASE CHAIN REACTION; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; THIONES; TOLL-LIKE RECEPTOR 3; UP-REGULATION;

EID: 84876754017     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18043841     Document Type: Article

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