Insulitis in the human endocrine pancreas: Does a viral infection lead to inflammation and beta cell replication?

Diabetologia

Volumn 54, Issue 9, 2011, Pages 2220-2222

  In't Veld, P ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Beta cells; Enterovirus; Human; Insulitis; Replication; Type 1 diabetes; Viral infection

Indexed keywords

KI 67 ANTIGEN; PROTEIN VP1;

AUTOIMMUNITY; CELL DIVISION; CELLULAR IMMUNITY; COXSACKIE VIRUS B4; CYTOMEGALOVIRUS; DIABETOGENESIS; ENTEROVIRUS; HUMAN; IMMUNOMODULATION; INCIDENCE; INFLAMMATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MUMPS VIRUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RUBELLA VIRUS; VIRUS INFECTION; VIRUS PATHOGENESIS;

CAPSID PROTEINS; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS; FEMALE; HUMANS; ISLETS OF LANGERHANS; MALE;

EID: 80054711767     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2224-3     Document Type: Review

References (14)

1. Gamble DR, Taylor KW (1969) Seasonal incidence of diabetes mellitus. Br Med J 3:631-633
2. Yoon JW, Austin M, Onodera T, Notkins AL (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173-1179 (Pubitemid 9191515)
3. Lehuen A, Diana J, Zaccone P, Cooke A (2010) Immune cell crosstalk in type diabetes. Nat Rev Immunol 10:501-513
4. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011) Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia. doi:10.1007/s00125-011-2192-7
5. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010) Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia 53:2020-2028
6. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619-633
7. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS (1986) The histopathology of the pancreas in type 1 (insulindependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29:267-274 (Pubitemid 16080921)
8. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52:1143-1151
9. Roivainen M, Klingel K (2009) Role of enteroviruses in the pathogenesis of type 1 diabetes. Diabetologia 52:995-996
10. Foulis AK, McGill M, Farquharson MA, Hilton DA (1997) A search for evidence of viral infection in pancreases of newly diagnosed patients with IDDM. Diabetologia 40:53-61 (Pubitemid 27035710)
11. In't Veld P, Lievens D, De Grijse J, Ling Z, Van der Auwera B, Pipeleers-Marichal M, Gorus F, Pipeleers D (2007) Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 56:2400-2404 (Pubitemid 47358248)
12. Sreenan S, Pick AJ, LevisettiM, Baldwin AC, PughW, Polonsky KS (1999) Increased beta cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48:989-996 (Pubitemid 29226344)
13. In't Veld PA, De Munck N, van Belle K et al (2010) Beta cell replication is increased in donor organs from young patients after prolonged life support. Diabetes 59:1702-1708
14. LeCompte PM (1958) "Insulitis" in early juvenile diabetes. Arch Pathol Lab Med 66:450-457