Inhibitory effect of IL-17 on neural stem cell proliferation and neural cell differentiation

BMC Immunology

Volumn 14, Issue 1, 2013, Pages

  Li, Zichen ^a,b   Li, Ke ^a   Zhu, Lin ^b   Kan, Quancheng ^b   Yan, Yaping ^a   Kumar, Priyanka ^a   Xu, Hui ^a   Rostami, Abdolmohamad ^a   Zhang, Guang Xian ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

IL 17; NSCs

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOTOXICITY; EMBRYO; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ANNEXIN A5; APOPTOSIS; CELL COUNT; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOTOXICITY, IMMUNOLOGIC; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROPIDIUM; RECEPTORS, INTERLEUKIN-17; SPHEROIDS, CELLULAR;

EID: 84876723332     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-14-20     Document Type: Article

References (46)

1. Yang J, Rostami A, Zhang GX. Cellular remyelinating therapy in multiple sclerosis. J Neurol Sci 2009, 276:1-5. 10.1016/j.jns.2008.08.020, 18814888.
2. Carpentier PA, Palmer TD. Immune influence on adult neural stem cell regulation and function. Neuron 2009, 64:79-92. 10.1016/j.neuron.2009.08.038, 2789107, 19840551.
3. Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999, 97:703-716. 10.1016/S0092-8674(00)80783-7, 10380923.
4. Johansson CB, Momma S, Clarke DL, Risling M, Lendahl U, Frisen J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 1999, 96:25-34. 10.1016/S0092-8674(00)80956-3, 9989494.
5. Daniela F, Vescovi AL, Bottai D. The stem cells as a potential treatment for neurodegeneration. Methods Mol Biol 2007, 399:199-213. 10.1007/978-1-59745-504-6_14, 18309934.
6. Franklin RJ, Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat Rev Neurosci 2008, 9:839-855. 10.1038/nrn2480, 18931697.
7. Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol 2007, 8:345-350.
8. Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007, 25:821-852. 10.1146/annurev.immunol.25.022106.141557, 17201677.
9. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005, 6:1123-1132. 10.1038/ni1254, 16200070.
10. Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 2004, 21:467-476. 10.1016/j.immuni.2004.08.018, 15485625.
11. Lovett-Racke AE, Yang Y, Racke MK. Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?. Biochim Biophys Acta 2011, 1812:246-251. 10.1016/j.bbadis.2010.05.012, 3004998, 20600875.
12. Zhang GX, Gran B, Yu S, Li J, Siglienti I, Chen X, Kamoun M, Rostami A. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol 2003, 170:2153-2160.
13. Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 2005, 6:1133-1141. 10.1038/ni1261, 1618871, 16200068.
14. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748. 10.1038/nature01355, 12610626.
15. El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, Zhang GX, Dittel BN, Rostami A. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 2011, 12:568-575. 10.1038/ni.2031, 3116521, 21516111.
16. Chang SH, Dong C. Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal 2011, 23:1069-1075. 10.1016/j.cellsig.2010.11.022, 3078175, 21130872.
17. Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J Immunol 2006, 177:566-573.
18. McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 2007, 8:913-919. 10.1038/ni1507, 17712344.
19. Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, Fugger L. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 2008, 172:146-155. 10.2353/ajpath.2008.070690, 2189615, 18156204.
20. Paintlia MK, Paintlia AS, Singh AK, Singh I. Synergistic activity of interleukin-17 and tumor necrosis factor-alpha enhances oxidative stress-mediated oligodendrocyte apoptosis. J Neurochem 2011, 116:508-521. 10.1111/j.1471-4159.2010.07136.x, 3033460, 21143599.
21. Yang J, Jiang Z, Fitzgerald DC, Ma C, Yu S, Li H, Zhao Z, Li Y, Ciric B, Curtis M. Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis. J Clin Invest 2009, 119:3678-3691. 10.1172/JCI37914, 2786785, 19884657.
22. Magnus T, Rao MS. Neural stem cells in inflammatory CNS diseases: mechanisms and therapy. J Cell Mol Med 2005, 9:303-319. 10.1111/j.1582-4934.2005.tb00357.x, 15963251.
23. Clarke D, Frisen J. Differentiation potential of adult stem cells. Curr Opin Genet Dev 2001, 11:575-580. 10.1016/S0959-437X(00)00235-5, 11532401.
24. Horner PJ, Gage FH. Regenerating the damaged central nervous system. Nature 2000, 407:963-970. 10.1038/35039559, 11069169.
25. Teng YD, Lavik EB, Qu X, Park KI, Ourednik J, Zurakowski D, Langer R, Snyder EY. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 2002, 99:3024-3029. 10.1073/pnas.052678899, 122466, 11867737.
26. Ben-Hur T, Einstein O, Mizrachi-Kol R, Ben-Menachem O, Reinhartz E, Karussis D, Abramsky O. Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 2003, 41:73-80. 10.1002/glia.10159, 12465047.
27. Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 2003, 422:688-694. 10.1038/nature01552, 12700753.
28. Rasmussen S, Imitola J, Ayuso-Sacido A, Wang Y, Starossom SC, Kivisakk P, Zhu B, Meyer M, Bronson RT, Garcia-Verdugo JM. Reversible neural stem cell niche dysfunction in a model of multiple sclerosis. Ann Neurol 2011, 69:878-891. 10.1002/ana.22299, 3082630, 21391234.
29. Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C. Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E. Immunity 2011, 35:611-621. 10.1016/j.immuni.2011.09.010, 21982598.
30. Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity 2011, 34:149-162. 10.1016/j.immuni.2011.02.012, 21349428.
31. Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H, Suzumura A. Production and functions of IL-17 in microglia. J Neuroimmunol 2008, 194:54-61. 10.1016/j.jneuroim.2007.11.006, 18164424.
32. Chang SH, Dong C. IL-17F: regulation, signaling and function in inflammation. Cytokine 2009, 46:7-11. 10.1016/j.cyto.2008.12.024, 2663007, 19233684.
33. Ivanov VN, Hei TK. Induction of apoptotic death and retardation of neuronal differentiation of human neural stem cells by sodium arsenite treatment. Exp Cell Res 2013, 319:875-887. 10.1016/j.yexcr.2012.11.019, 23219847.
34. De Smaele E, Zazzeroni F, Papa S, Nguyen DU, Jin R, Jones J, Cong R, Franzoso G. Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling. Nature 2001, 414:308-313. 10.1038/35104560, 11713530.
35. Iyoda M, Shibata T, Kawaguchi M, Hizawa N, Yamaoka T, Kokubu F, Akizawa T. IL-17A and IL-17F stimulate chemokines via MAPK pathways (ERK1/2 and p38 but not JNK) in mouse cultured mesangial cells: synergy with TNF-alpha and IL-1beta. Am J Physiol Renal Physiol 2010, 298:F779-F787. 10.1152/ajprenal.00198.2009, 20042461.
36. Labbe K, Saleh M. Cell death in the host response to infection. Cell Death Differ 2008, 15:1339-1349. 10.1038/cdd.2008.91, 18566602.
37. Tardito S, Isella C, Medico E, Marchio L, Bevilacqua E, Hatzoglou M, Bussolati O, Franchi-Gazzola R. The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem 2009, 284:24306-24319. 10.1074/jbc.M109.026583, 2782024, 19561079.
38. Decker T, Lohmann-Matthes ML. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods 1988, 115:61-69. 10.1016/0022-1759(88)90310-9, 3192948.
39. Iyoda K, Sasaki Y, Horimoto M, Toyama T, Yakushijin T, Sakakibara M, Takehara T, Fujimoto J, Hori M, Wands JR. Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma. Cancer 2003, 97:3017-3026. 10.1002/cncr.11425, 12784337.
40. Chen Y, Kijlstra A, Yang P. IL-17A stimulates the production of inflammatory mediators via Erk1/2, p38 MAPK, PI3K/Akt, and NF-kappaB pathways in ARPE-19 cells. Mol Vis 2011, 17:3072-3077. 3233389, 22162626.
41. Noubade R, Krementsov DN, Del Rio R, Thornton T, Nagaleekar V, Saligrama N, Spitzack A, Spach K, Sabio G, Davis RJ. Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood 2011, 118:3290-3300. 10.1182/blood-2011-02-336552, 3179398, 21791428.
42. Ko YA, Ko YJ, Kim HW, Lim SH, Yang BW, Jung SH, Im S. Nerve conduction study of the superficial peroneal sensory distal branches in koreans. Ann Rehabil Med 2011, 35:548-556. 10.5535/arm.2011.35.4.548, 3309246, 22506172.
43. Crampton SJ, Collins LM, Toulouse A, Nolan YM, O'Keeffe GW. Exposure of foetal neural progenitor cells to IL-1beta impairs their proliferation and alters their differentiation - a role for maternal inflammation?. J Neurochem 2012, 120:964-973.
44. Pluchino S, Martino G. The therapeutic plasticity of neural stem/precursor cells in multiple sclerosis. J Neurol Sci 2008, 265:105-110. 10.1016/j.jns.2007.07.020, 17706971.
45. Franklin RJ, Ffrench Constant C, Edgar JM, Smith KJ. Neuroprotection and repair in multiple sclerosis. Nat Rev Neurol 2012, 8:624-634. 10.1038/nrneurol.2012.200, 23026979.
46. Yan Y, Ding X, Li K, Ciric B, Wu S, Xu H, Gran B, Rostami A, Zhang GX. CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes. Mol Ther 2012, 20:1338-1348. 10.1038/mt.2012.12, 22434134.