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Volumn 118, Issue 12, 2011, Pages 3290-3300

Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 4E; INTERLEUKIN 17; MITOGEN ACTIVATED PROTEIN KINASE P38;

EID: 80053184152     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-02-336552     Document Type: Article
Times cited : (134)

References (50)
  • 1
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: Fates, functions, and faults
    • Zhu J, Paul WE. CD4 T cells: fates, functions, and faults. Blood. 2008;112(5):1557-1569.
    • (2008) Blood , vol.112 , Issue.5 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 2
    • 42649115767 scopus 로고    scopus 로고
    • H17 cells in development: An updated view of their molecular identity and genetic programming
    • DOI 10.1038/nri2295, PII NRI2295
    • Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol. 2008;8(5):337-348. (Pubitemid 351595217)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.5 , pp. 337-348
    • Dong, C.1
  • 3
    • 65549152333 scopus 로고    scopus 로고
    • Th17 cells: From precursors to players in inflammation and infection
    • Awasthi A, Kuchroo VK. Th17 cells: from precursors to players in inflammation and infection. Int Immunol. 2009;21(5):489-498.
    • (2009) Int Immunol , vol.21 , Issue.5 , pp. 489-498
    • Awasthi, A.1    Kuchroo, V.K.2
  • 4
    • 46949104323 scopus 로고    scopus 로고
    • IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
    • DOI 10.1084/jem.20080159
    • Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med. 2008;205(7):1535-1541. (Pubitemid 351962016)
    • (2008) Journal of Experimental Medicine , vol.205 , Issue.7 , pp. 1535-1541
    • Kroenke, M.A.1    Carlson, T.J.2    Andjelkovic, A.V.3    Segal, B.M.4
  • 6
    • 77952304784 scopus 로고    scopus 로고
    • Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
    • Betz BC, Jordan-Williams KL, Wang C, et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010;207(5):933-942.
    • (2010) J Exp Med , vol.207 , Issue.5 , pp. 933-942
    • Betz, B.C.1    Jordan-Williams, K.L.2    Wang, C.3
  • 7
    • 67651001561 scopus 로고    scopus 로고
    • The AP-1 transcription factor Batf controls T(H)17 differentiation
    • Schraml BU, Hildner K, Ise W, et al. The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009;460(7253):405-409.
    • (2009) Nature , vol.460 , Issue.7253 , pp. 405-409
    • Schraml, B.U.1    Hildner, K.2    Ise, W.3
  • 8
    • 34548800403 scopus 로고    scopus 로고
    • p38 pathway kinases as anti-inflammatory drug targets
    • Schindler JF, Monahan JB, Smith WG. p38 pathway kinases as anti-inflammatory drug targets. J Dent Res. 2007;86(9):800-811.
    • (2007) J Dent Res , vol.86 , Issue.9 , pp. 800-811
    • Schindler, J.F.1    Monahan, J.B.2    Smith, W.G.3
  • 9
    • 61849123548 scopus 로고    scopus 로고
    • Regulation of the immune response by stress-activated protein kinases
    • Rincon M, Davis RJ. Regulation of the immune response by stress-activated protein kinases. Immunol Rev. 2009;228(1):212-224.
    • (2009) Immunol Rev , vol.228 , Issue.1 , pp. 212-224
    • Rincon, M.1    Davis, R.J.2
  • 10
    • 33745530860 scopus 로고    scopus 로고
    • The many paths to p38 mitogen-activated protein kinase activation in the immune system
    • DOI 10.1038/nri1865, PII N1865
    • Ashwell JD. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol. 2006;6(7):532-540. (Pubitemid 43980525)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.7 , pp. 532-540
    • Ashwell, J.D.1
  • 11
    • 77952777819 scopus 로고    scopus 로고
    • Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells
    • Lu L, Wang J, Zhang F, et al. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010;184(8):4295-4306.
    • (2010) J Immunol , vol.184 , Issue.8 , pp. 4295-4306
    • Lu, L.1    Wang, J.2    Zhang, F.3
  • 12
    • 77958128995 scopus 로고    scopus 로고
    • IL-1beta-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells
    • Li L, Kim J, Boussiotis VA. IL-1beta-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol. 2010;185(7):4148-4153.
    • (2010) J Immunol , vol.185 , Issue.7 , pp. 4148-4153
    • Li, L.1    Kim, J.2    Boussiotis, V.A.3
  • 13
    • 74649086985 scopus 로고    scopus 로고
    • The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
    • Gulen MF, Kang Z, Bulek K, et al. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity. 2010;32(1):54-66.
    • (2010) Immunity , vol.32 , Issue.1 , pp. 54-66
    • Gulen, M.F.1    Kang, Z.2    Bulek, K.3
  • 14
    • 77955908580 scopus 로고    scopus 로고
    • p38{alpha} MAP kinase controls IL-17 synthesis in vogt-koyanagi-harada syndrome and experimental autoimmune uveitis
    • Commodaro AG, Bombardieri CR, Peron JP, et al. p38{alpha} MAP kinase controls IL-17 synthesis in vogt-koyanagi-harada syndrome and experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2010;51(7):3567-3574.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , Issue.7 , pp. 3567-3574
    • Commodaro, A.G.1    Bombardieri, C.R.2    Peron, J.P.3
  • 15
    • 0032525233 scopus 로고    scopus 로고
    • Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
    • Rincon M, Enslen H, Raingeaud J, et al. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 1998;17(10):2817-2829.
    • (1998) EMBO J , vol.17 , Issue.10 , pp. 2817-2829
    • Rincon, M.1    Enslen, H.2    Raingeaud, J.3
  • 20
    • 0028988138 scopus 로고
    • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • Cuenda A, Rouse J, Doza YN, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 1995;364(2):229-233.
    • (1995) FEBS Lett , vol.364 , Issue.2 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3
  • 23
    • 0031916832 scopus 로고    scopus 로고
    • Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    • DOI 10.1074/jbc.273.3.1741
    • Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem. 1998;273(3):1741-1748. (Pubitemid 28133705)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.3 , pp. 1741-1748
    • Enslen, H.1    Raingeaud, J.2    Davis, R.J.3
  • 24
    • 79953164591 scopus 로고    scopus 로고
    • External influences on the immune system via activation of the aryl hydrocarbon receptor
    • Stockinger B, Hirota K, Duarte J, Veldhoen M. External influences on the immune system via activation of the aryl hydrocarbon receptor. Semin Immunol. 2011;23(2):99-105.
    • (2011) Semin Immunol , vol.23 , Issue.2 , pp. 99-105
    • Stockinger, B.1    Hirota, K.2    Duarte, J.3    Veldhoen, M.4
  • 25
    • 80053196380 scopus 로고    scopus 로고
    • Lack of the T cell - Specific alternative p38 activation pathway reduces autoimmunity and inflammation
    • Jirmanova L, Giardino Torchia ML, Sarma ND, Mittelstadt PR, Ashwell JD. Lack of the T cell - specific alternative p38 activation pathway reduces autoimmunity and inflammation. Blood. 2011;118(12):3280-3289.
    • (2011) Blood , vol.118 , Issue.12 , pp. 3280-3289
    • Jirmanova, L.1    Giardino Torchia, M.L.2    Sarma, N.D.3    Mittelstadt, P.R.4    Ashwell, J.D.5
  • 26
    • 0142026209 scopus 로고    scopus 로고
    • P38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar S, Boehm J, Lee JC. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov. 2003;2(9):717-726. (Pubitemid 37361787)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.9 , pp. 717-726
    • Kumar, S.1    Boehm, J.2    Lee, J.C.3
  • 28
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;264(5164):1415-1421. (Pubitemid 24217131)
    • (1994) Science , vol.264 , Issue.5164 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 29
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell. 1995;82(2):241-250.
    • (1995) Cell , vol.82 , Issue.2 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 30
    • 0035834648 scopus 로고    scopus 로고
    • MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells
    • Zhang Y, Liu G, Dong Z. MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells. J Biol Chem. 2001;276(45):42534- 42542.
    • (2001) J Biol Chem , vol.276 , Issue.45 , pp. 42534-42542
    • Zhang, Y.1    Liu, G.2    Dong, Z.3
  • 31
    • 0032540244 scopus 로고    scopus 로고
    • The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways
    • DOI 10.1074/jbc.273.16.9373
    • Wang X, Flynn A, Waskiewicz AJ, et al. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J Biol Chem. 1998;273(16):9373-9377. (Pubitemid 28183016)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.16 , pp. 9373-9377
    • Wang, X.1    Flynn, A.2    Waskiewicz, A.J.3    Webb, B.L.J.4    Vries, R.G.5    Baines, I.A.6    Cooper, J.A.7    Proud, C.G.8
  • 32
    • 0030977269 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
    • DOI 10.1093/emboj/16.8.1909
    • Waskiewicz AJ, Flynn A, Proud CG, Cooper JA. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997;16(8):1909-1920. (Pubitemid 27170952)
    • (1997) EMBO Journal , vol.16 , Issue.8 , pp. 1909-1920
    • Waskiewicz, A.J.1    Flynn, A.2    Proud, C.G.3    Cooper, J.A.4
  • 33
    • 0033521535 scopus 로고    scopus 로고
    • Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E
    • DOI 10.1093/emboj/18.1.270
    • Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. EMBO J. 1999;18(1):270-279. (Pubitemid 29005042)
    • (1999) EMBO Journal , vol.18 , Issue.1 , pp. 270-279
    • Pyronnet, S.1    Imataka, H.2    Gingras, A.-C.3    Fukunaga, R.4    Hunter, T.5    Sonenberg, N.6
  • 34
    • 32344445358 scopus 로고    scopus 로고
    • Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages
    • DOI 10.1016/j.cyto.2005.11.017, PII S1043466605003467
    • Andersson K, Sundler R. Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages. Cytokine. 2006;33(1):52-57. (Pubitemid 43220353)
    • (2006) Cytokine , vol.33 , Issue.1 , pp. 52-57
    • Andersson, K.1    Sundler, R.2
  • 35
    • 0032834055 scopus 로고    scopus 로고
    • eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
    • DOI 10.1146/annurev.biochem.68.1.913
    • Gingras AC, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem. 1999;68:913-963. (Pubitemid 29449212)
    • (1999) Annual Review of Biochemistry , vol.68 , pp. 913-963
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 36
    • 0033615051 scopus 로고    scopus 로고
    • Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E: Evidence for internal ribosome repositioning in the human c-myc 5'UTR
    • DOI 10.1038/sj.onc.1202890
    • Carter PS, Jarquin-Pardo M, De Benedetti A. Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E: evidence for internal ribosome repositioning in the human c-myc 5′UTR. Oncogene. 1999;18(30):4326-4335. (Pubitemid 29392373)
    • (1999) Oncogene , vol.18 , Issue.30 , pp. 4326-4335
    • Carter, P.S.1    Jarquin-Pardo, M.2    De Benedetti, A.3
  • 37
    • 77950342281 scopus 로고    scopus 로고
    • Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions
    • Chen YJ, Tan BC, Cheng YY, Chen JS, Lee SC. Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions. Nucleic Acids Res. 2010;38(3):764-777.
    • (2010) Nucleic Acids Res , vol.38 , Issue.3 , pp. 764-777
    • Chen, Y.J.1    Tan, B.C.2    Cheng, Y.Y.3    Chen, J.S.4    Lee, S.C.5
  • 38
    • 0034928792 scopus 로고    scopus 로고
    • Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2
    • DOI 10.1128/MCB.21.16.5500-5511.2001
    • Knauf U, Tschopp C, Gram H. Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol Cell Biol. 2001;21(16):5500-5511. (Pubitemid 32702454)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.16 , pp. 5500-5511
    • Knauf, U.1    Tschopp, C.2    Gram, H.3
  • 39
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol. 2005;23:683-747. (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 40
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: A complicated picture of autoimmunity
    • DOI 10.1038/ni1507, PII NI1507
    • McFarland HF, Martin R. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol. 2007;8(9):913-919. (Pubitemid 47300005)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 41
    • 78650978169 scopus 로고    scopus 로고
    • T cells that trigger acute experimental autoimmune encephalomyelitis also mediate subsequent disease relapses and predominantly produce IL-17
    • Li J, Zhao X, Hao HW, Shaw MK, Tse HY. T cells that trigger acute experimental autoimmune encephalomyelitis also mediate subsequent disease relapses and predominantly produce IL-17. J Neuroimmunol. 2011;230(1-2):26-32
    • (2011) J Neuroimmunol , vol.230 , Issue.1-2 , pp. 26-32
    • Li, J.1    Zhao, X.2    Hao, H.W.3    Shaw, M.K.4    Tse, H.Y.5
  • 43
    • 0025098538 scopus 로고
    • Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level
    • Han J, Brown T, Beutler B. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med. 1990;171(2):465-475. (Pubitemid 20059041)
    • (1990) Journal of Experimental Medicine , vol.171 , Issue.2 , pp. 465-475
    • Han, J.1    Brown, T.2    Beutler, B.3
  • 44
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Chung Y, Chang SH, Martinez GJ, et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009;30(4):576-587.
    • (2009) Immunity , vol.30 , Issue.4 , pp. 576-587
    • Chung, Y.1    Chang, S.H.2    Martinez, G.J.3
  • 45
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • DOI 10.1084/jem.20060285
    • Sutton C, Brereton C, Keogh B, Mills KH, Lavelle EC. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med. 2006;203(7):1685-1691. (Pubitemid 44036274)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.G.4    Lavelle, E.C.5
  • 46
    • 65249142200 scopus 로고    scopus 로고
    • The challenge of multiple sclerosis: How do we cure a chronic heterogeneous disease?
    • Weiner HL. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann Neurol. 2009;65(3):239-248.
    • (2009) Ann Neurol , vol.65 , Issue.3 , pp. 239-248
    • Weiner, H.L.1
  • 47
    • 33745268911 scopus 로고    scopus 로고
    • Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes
    • Medicherla S, Protter AA, Ma JY, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006;318(1):99-107.
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.1 , pp. 99-107
    • Medicherla, S.1    Protter, A.A.2    Ma, J.Y.3
  • 48
    • 1642564596 scopus 로고    scopus 로고
    • The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice
    • DOI 10.1016/j.lfs.2003.09.045
    • Ando H, Kurita S, Takamura T. The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice. Life Sci. 2004;74(14):1817-1827. (Pubitemid 38117107)
    • (2004) Life Sciences , vol.74 , Issue.14 , pp. 1817-1827
    • Ando, H.1    Kurita, S.2    Takamura, T.3
  • 49
    • 77949656747 scopus 로고    scopus 로고
    • Th17 cells in autoimmune demyelinating disease
    • Segal BM. Th17 cells in autoimmune demyelinating disease. Semin Immunopathol. 2010;32(1):71-77.
    • (2010) Semin Immunopathol , vol.32 , Issue.1 , pp. 71-77
    • Segal, B.M.1
  • 50
    • 78650178184 scopus 로고    scopus 로고
    • Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?
    • Lovett-Racke AE, Yang Y, Racke MK. Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis? Biochim Biophys Acta. 2011;1812(2):246-251.
    • (2011) Biochim Biophys Acta , vol.1812 , Issue.2 , pp. 246-251
    • Lovett-Racke, A.E.1    Yang, Y.2    Racke, M.K.3


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