Metabolic Fate of Green Tea Catechins in Humans

Tea in Health and Disease Prevention

Volumn , Issue , 2013, Pages 953-969

  Feng, Wan Yong ^a  

^a WUXI APPTEC   (China)

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EID: 84876720923     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-384937-3.00081-1     Document Type: Chapter

References (52)

1. A.M. Aura (2008) Microbial metabolism of dietary phenolic compounds in the colon. Phytochem. Rev. 7 407-429.
2. A.M. Aura, I. Mattila, T. Seppänen-Laakso, et al. (2008) Microbial metabolism of catechin stereoisomers by human faecal microbiota: comparison of targeted analysis and a non-targeted metabolomics method. Phytochem Lett. 1 18-22.
3. H.H. Chow, Y. Cai, D.S. Alberts, et al. (2001) Phase 1 pharmacokinetic study of tea polyphenols following single dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol. Biomarkers Prev 10 53-58.
4. K. Chow and I. Kramer (1990) All the tea in China. San Francisco: China Books and Periodicals
5. N.P. Das (1971) Studies on flavonoid metabolism, absorption and metabolism of (+)-catechin in man. Biochem. Pharmacol. 20 3435-3445.
6. D. Del Rio, L. Calani, F. Scazzina, et al. (2010) Bioavailability of catechins from ready-to-drink tea flavan-3-ols in humans. Nutr. 26 1110-1116.
7. D. Del Rio, A. Stalmach, L. Calani and A. Crozier (2010) Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols. Nutrients 2 820-833.
8. W.Y. Feng (2006) Metabolism of green tea catechins: an overview. Curr. Drug Metab. 7 755-809.
9. A.R. Giles and A. Gumma (1973) Biopharmaceutical evaluation of cyanidanol tablets using pharmacokinetic techniques. Arzneim Forsch 23 98-100.
10. A.M. Hackett, L.A. Griffiths, A. Broillet and M. Wermeille (1983) The metabolism and excretion of (+)-[14C]cyanidanol-3 in man following oral administration. Xenobiotica 13 279-286.
11. P.A. Kroon, M.N. Clifford, A. Crozier, et al. (2004) How should we assess the effects of exposure to dietary polyphenons in vitro? Am. J. Clin. Nutr. 80 15-21.
12. C. Lakenbrink, S. Lapczynski, B. Maiwald and U.H. Engelhardt (2000) Flavanoids and other polyphenols in consumer brews of tea and other caffeinated beverages in vitro. J. Agric. Food Chem. 48 2848-2852.
13. J.D. Lambert, S.M. Sang, A.Y.H. Lu and C.S. Yang (2007) Metabolism of dietary polyphenols and possible interactions with drugs. Curr. Drug Metab. 8 499-507.
14. J.D. Lambert, S.M. Sang and C.S. Yang (2007) Biotransformation of green tea polyphenols and the biological activities of those metabolites. Mol. Pharm. 4 819-825.
15. J.M. Laparra and Y. Sanz (2010) Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol. Res. 61 210-225.
16. H.C. Lee, A.M. Jenner, C.S. Low and Y.K. Lee (2006) Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res. Biol. 157 876-884.
17. M.J. Lee, P. Maliakal, L. Chen, et al. (2002) Pharmacokinetics of tea catechins after ingestion of green tea and (−)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol. Biomarkers Prev. 11 1025-1032.
18. C. Li, M.J. Lee, S.Q. Sheng, X.F. Meng, et al. (2000) Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem. Res. Toxicol. 13 177-184.
19. C. Li, X.F. Meng, B. Winnik, et al. (2001) Analysis of urinary metabolites of tea catechins by liquid chromatography/electrospray ionization mass spectrometry. Chem. Res. Toxicol. 14 702-707.
20. H. Lu, X. Meng, C. Li, et al. (2003) Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (−)-epigallocatechin gallate. Drug Metab. Dispos. 31 572-579.
21. H. Lu, X. Meng, C. Li, et al. (2003) Glucuronides of tea catechins: enzymology of biosynthesis and biological activities. Drug Metab. Dispos. 31 452-461.
22. D.L. Mckay and J.B. Blumberg (2002) The role of tea in human health: an update. J. Am. Coll. Nutr. 21 1-13.
23. C. Manach and J.L. Donovan (2004) Pharmacokinetics and metabolism of dietary flavanoids in humans. Free Radic. Res. 38 771-785.
24. C. Manach, A. Scalbert, C. Morand, et al. (2004) Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr. 79 727-747.
25. X. Meng, M.J. Lee, C. Li, et al. (2001) Formation and identification of 4′-O-methyl-(−)-epigallocatechin in humans. Drug Metab. Dispos. 29 789-793.
26. X. Meng, S. Shang, N. Zhu, et al. (2002) Identification and characterization of methylated and ring-fission metabolites of tea catechins formed in humans, mice, and rats. Chem. Res. Toxicol. 15 1042-1050.
27. M.R. Meselhy, N. Nakamura and M. Hattori (1997) Biotransformation of (−)-epicatechin 3-O-gallate by human intestinal bacteria. Chem. Pharm. Bull. (Tokyo) 45 888-893.
28. M. Natsume, N. Osakabe, M. Oyama, et al. (2003) Structures of (−)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (−)-epicatechin: differences between human and rat. J. Free Radic. Biol. Res. 34 840-849.
29. Y.Y. Ow and I. Stupans (2003) Gallic acid and gallic acid derivatives: effects on drug metabolizing enzymes. Curr. Drug Metab. 4 241-248.
30. P.G. Pietta, P. Simonetti, C. Gardana, et al. (1998) Catechin metabolites after intake of green tea infusions. Biofactors 8 111-118.
31. S. Roowi, A. Stalmach, W. Mullen, et al. (2010) Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans. J. Agric. Food Chem. 58 1296-1304.
32. J.A. Ross and C.M. Kasum (2002) Dietary flavanoids: bioavailability, metabolic effects and safety. Annu. Rev. Nutr. 22 19-34.
33. S. Sang, J.D. Lambert, C.T. Ho and C.S. Yang (2011) The chemistry and biotransformation of tea constituents. Pharmacol. Res. 64 87-99.
34. A. Scalbert, C. Morand, C. Manach and C. Remesy (2002) Absorption and metabolism of polyphenols in the gut and impact on health. Biomed. Pharmacother. 56 276-282.
35. A. Scalbert and G. Williamson (2000) Dietary intake and bioavailability of polyphenols. J. Nutr. 130(8S Suppl), 2073S-2085S.
36. M. Schantz, T. Erk and E. Ricjling (2010) Metabolism of green tea catechins by the human small intestine. Biotechnol. J. 5 1050-1059.
37. R.R. Scheline (1991) Catechins. CRC Handbook of Mammalian Metabolism of Plant Compounds Boca Raton, FL: CRC Press Inc. 243-295.
38. S.M. Shang, M.J. Lee, I. Yang, et al. (2008) Human urinary metabolite profile of tea polyphenols analyzed by liquid chromatography/electrospray ionization tandem mass spectrometry with data-dependent acquisition. Rapid. Commun. Mass Spectrom. 22 1567-1578.
39. J.P. Spencer (2003) Metabolism of tea flavonoids in the gastrointestinal tract. J. Nutr. 133 3255S-3261S.
40. J.P. Spencer, M.M. Abd-el-Mohsen and C. Rice-Evans (2004) Cellular uptake and metabolism of flavanoids and their metabolites: implications for their bioactivity. Arch. Biochem. Biophys. 423 148-161.
41. J.P. Spencer, H. Schoeter, A. Recthner and C. Rice-Evans (2001) Bioavailability of flavan-3-ols and procyanidins: gastrointestinal tract influences and their relevance to bioactive forms in vitro. Antioxid. Redox Signal. 3 1023-1040.
42. J.B. Vaidyanathan and T. Walle (2002) Glucuronidation and sulfation of the tea flavanoid (−)-epicatechin by the human and rat enzymes. Drug Metab. Dispos. 30 897-903.
43. J.M. van Amelsvoort, K.H. van Hof, J.N. Mathot, et al. (2001) Plasma concentrations of individual tea catechins after a single oral dose to humans. Xenobiotica 31 891-901.
44. T. Walle (2004) Absorption and metabolism of flavonoids. Free Radic. Biol. Med. 36 829-837.
45. L.Q. Wang, M.R. Meselhy, Y. Li, et al. (2001) The heterocyclic ring fission and dehydroxylation of catechins and related compounds by eubacterium sp. Strain SDG-2, a human intestinal bacterium. Chem. Pharm. Bull. (Tokyo) 49 1640-1643.
46. G. Williamson (2002) The use of flavanoid aglycones in in vitro systems to test biological activities: based on bioavailability data, is this a valid approach? Phytochem. Rev. 1 215-222.
47. S. Wiseman, T. Mulder and A. Rietveld (2001) Tea flavonoids: bioavailability in vivo and effects on cell signaling pathways in vitro. Antio. Redox Signal 3 1009-1021.
48. C.S. Yang and J.M. Landau (2000) Effects of tea consumption on nutrition and health. J. Nutr. 130 2409-2412.
49. C.S. Yang, M.J. Lee and L. Chen (1999) Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies. Cancer Epidemiol. Biomarkers Prev. 8 83-89.
50. S. Zhou, Y.H. Gao, W.Q. Jiang, et al. (2003) Interactions of herbs with cytochrome P450. Drug Metab. Rev. 35 35-98.
51. S. Zhou, L.Y. Lim and B. Chowbay (2004) Herbal modulation of p-glycoprotein. Drug Metab. Rev. 36 57-104.
52. B.T. Zhu, U.K. Patel, M.X. Cai and A.H. Conney (2000) O-methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase. Drug Metab. Dispos. 28 1024-1030.