-
1
-
-
17644361955
-
The NOD mouse: a model of immune dysregulation
-
Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005; 23:447-485.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 447-485
-
-
Anderson, M.S.1
Bluestone, J.A.2
-
2
-
-
77954611378
-
Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor
-
Tian L, Gao J, Hao J etal. Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by a dipeptidyl peptidase IV inhibitor. Endocrinology 2010; 151:3049-3060.
-
(2010)
Endocrinology
, vol.151
, pp. 3049-3060
-
-
Tian, L.1
Gao, J.2
Hao, J.3
-
3
-
-
0032796221
-
Anti-GAD monoclonal antibody delays the onset of diabetes mellitus in NOD mice
-
Menard V, Jacobs H, Jun HS, Yoon JW, Kim SW. Anti-GAD monoclonal antibody delays the onset of diabetes mellitus in NOD mice. Pharm Res 1999; 16:1059-1066.
-
(1999)
Pharm Res
, vol.16
, pp. 1059-1066
-
-
Menard, V.1
Jacobs, H.2
Jun, H.S.3
Yoon, J.W.4
Kim, S.W.5
-
4
-
-
0031569177
-
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice
-
Chatenoud L, Primo J, Bach JF. CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice. J Immunol 1997; 158:2947-2954.
-
(1997)
J Immunol
, vol.158
, pp. 2947-2954
-
-
Chatenoud, L.1
Primo, J.2
Bach, J.F.3
-
5
-
-
0019945886
-
Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice
-
Yamada K, Nonaka K, Hanafusa T, Miyazaki A, Toyoshima H, Tarui S. Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice. Diabetes 1982; 31:749-753.
-
(1982)
Diabetes
, vol.31
, pp. 749-753
-
-
Yamada, K.1
Nonaka, K.2
Hanafusa, T.3
Miyazaki, A.4
Toyoshima, H.5
Tarui, S.6
-
6
-
-
0026636411
-
Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice
-
Baeder WL, Sredy J, Sehgal SN, Chang JY, Adams LM. Rapamycin prevents the onset of insulin-dependent diabetes mellitus (IDDM) in NOD mice. Clin Exp Immunol 1992; 89:174-178.
-
(1992)
Clin Exp Immunol
, vol.89
, pp. 174-178
-
-
Baeder, W.L.1
Sredy, J.2
Sehgal, S.N.3
Chang, J.Y.4
Adams, L.M.5
-
7
-
-
0025472820
-
Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy
-
Atkinson MA, Maclaren NK, Luchetta R. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 1990; 39:933-937.
-
(1990)
Diabetes
, vol.39
, pp. 933-937
-
-
Atkinson, M.A.1
Maclaren, N.K.2
Luchetta, R.3
-
8
-
-
0025837184
-
Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
-
Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci USA 1991; 88:10252-10256.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10252-10256
-
-
Zhang, Z.J.1
Davidson, L.2
Eisenbarth, G.3
Weiner, H.L.4
-
9
-
-
1642277657
-
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes
-
European Nicotinamide Diabetes Intervention Trial (ENDIT) Group.
-
Gale EAM, Bingley PJ, Emmett CL, Collier T, European Nicotinamide Diabetes Intervention Trial (ENDIT) Group. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004; 363:925-931.
-
(2004)
Lancet
, vol.363
, pp. 925-931
-
-
Gale, E.A.M.1
Bingley, P.J.2
Emmett, C.L.3
Collier, T.4
-
10
-
-
0037198427
-
Effects of insulin in relatives of patients with type 1 diabetes mellitus
-
Diabetes Prevention Trial-Type 1 Diabetes Study Group.
-
Diabetes Prevention Trial-Type 1 Diabetes Study Group. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 2002; 346:1685-1691.
-
(2002)
N Engl J Med
, vol.346
, pp. 1685-1691
-
-
-
11
-
-
80051471700
-
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
-
Sherry N, Hagopian W, Ludvigsson J etal. Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial. Lancet 2011; 378:487-497.
-
(2011)
Lancet
, vol.378
, pp. 487-497
-
-
Sherry, N.1
Hagopian, W.2
Ludvigsson, J.3
-
12
-
-
79960743608
-
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial
-
Wherrett DK, Bundy B, Becker DJ etal. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet 2011; 378:319-327.
-
(2011)
Lancet
, vol.378
, pp. 319-327
-
-
Wherrett, D.K.1
Bundy, B.2
Becker, D.J.3
-
13
-
-
18144391496
-
Effects of oral insulin in relatives of patients with type 1 diabetes: the diabetes prevention trial-type 1
-
Skyler JS, Krischer JP, Wolfsdorf J etal. Effects of oral insulin in relatives of patients with type 1 diabetes: the diabetes prevention trial-type 1. Diabetes Care 2005; 28:1068-1076.
-
(2005)
Diabetes Care
, vol.28
, pp. 1068-1076
-
-
Skyler, J.S.1
Krischer, J.P.2
Wolfsdorf, J.3
-
14
-
-
33745151060
-
(2 S,3 S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)- N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5- a]- pyridin-6-ylphenyl)butanamide: a aelective α-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
-
Edmondson SD, Mastracchio A, Mathvink RJ etal. (2 S, 3 S)-3-Amino-4-(3, 3-difluoropyrrolidin-1-yl)- N, N-dimethyl-4-oxo-2-(4-[1, 2, 4]triazolo[1, 5- a]- pyridin-6-ylphenyl)butanamide: a aelective α-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem 2006; 49:3614-3627.
-
(2006)
J Med Chem
, vol.49
, pp. 3614-3627
-
-
Edmondson, S.D.1
Mastracchio, A.2
Mathvink, R.J.3
-
15
-
-
33846006173
-
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368:1696-1705.
-
(2006)
Lancet
, vol.368
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
16
-
-
84866303239
-
The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice
-
Jelsing J, Vrang N, van Witteloostuijn SB, Mark M, Klein T. The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves β-cell mass in non-obese diabetic mice. J Endocrinol 2012; 214:381-387.
-
(2012)
J Endocrinol
, vol.214
, pp. 381-387
-
-
Jelsing, J.1
Vrang, N.2
van Witteloostuijn, S.B.3
Mark, M.4
Klein, T.5
-
17
-
-
0031908130
-
The structure and function of CD26 in the T-cell immune response
-
Morimoto C, Schlossman SF. The structure and function of CD26 in the T-cell immune response. Immunol Rev 1998; 161:55-70.
-
(1998)
Immunol Rev
, vol.161
, pp. 55-70
-
-
Morimoto, C.1
Schlossman, S.F.2
-
18
-
-
0030952018
-
Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes
-
Reinhold D, Bank U, Bühling F etal. Inhibitors of dipeptidyl peptidase IV (DP IV, CD26) induces secretion of transforming growth factor-beta 1 (TGF-beta 1) in stimulated mouse splenocytes and thymocytes. Immunol Lett 1997; 58:29-35.
-
(1997)
Immunol Lett
, vol.58
, pp. 29-35
-
-
Reinhold, D.1
Bank, U.2
Bühling, F.3
-
19
-
-
0030744259
-
Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells
-
Reinhold D, Bank U, Bühling F etal. Inhibitors of dipeptidyl peptidase IV induce secretion of transforming growth factor-beta 1 in PWM-stimulated PBMC and T cells. Immunology 1997; 91:354-360.
-
(1997)
Immunology
, vol.91
, pp. 354-360
-
-
Reinhold, D.1
Bank, U.2
Bühling, F.3
-
20
-
-
33947686803
-
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
-
Preller V, Gerber A, Wrenger S etal. TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26. J Immunol 2007; 178:4632-4640.
-
(2007)
J Immunol
, vol.178
, pp. 4632-4640
-
-
Preller, V.1
Gerber, A.2
Wrenger, S.3
-
21
-
-
33646495294
-
The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo
-
Leoni F, Fossati G, Lewis EC etal. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med 2005; 11:1-15.
-
(2005)
Mol Med
, vol.11
, pp. 1-15
-
-
Leoni, F.1
Fossati, G.2
Lewis, E.C.3
-
22
-
-
79957949655
-
The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro
-
Lewis EC, Blaabjerg L, Storling J etal. The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro. Mol Med 2011; 17:369-377.
-
(2011)
Mol Med
, vol.17
, pp. 369-377
-
-
Lewis, E.C.1
Blaabjerg, L.2
Storling, J.3
-
23
-
-
33847676166
-
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells
-
Larsen L, Tonnesen M, Ronn SG etal. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells. Diabetologia 2007; 50:779-789.
-
(2007)
Diabetologia
, vol.50
, pp. 779-789
-
-
Larsen, L.1
Tonnesen, M.2
Ronn, S.G.3
-
24
-
-
84866080005
-
Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children
-
Lundh M, Christensen DP, Damgaard Nielsen M etal. Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia 2012; 55:2421-2431.
-
(2012)
Diabetologia
, vol.55
, pp. 2421-2431
-
-
Lundh, M.1
Christensen, D.P.2
Damgaard Nielsen, M.3
-
25
-
-
84862726998
-
Inhibition of histone deacetylase 3 protects Beta cells from cytokine-induced apoptosis
-
Chou DH-C, Holson EB, Wagner FF etal. Inhibition of histone deacetylase 3 protects Beta cells from cytokine-induced apoptosis. Chem Biol 2012; 19:669-673.
-
(2012)
Chem Biol
, vol.19
, pp. 669-673
-
-
Chou, D.-C.1
Holson, E.B.2
Wagner, F.F.3
-
26
-
-
35948980739
-
Deacetylase inhibition promotes the generation and function of regulatory T cells
-
Tao R, de Zoeten EF, Ozkaynak E etal. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007; 13:1299-1307.
-
(2007)
Nat Med
, vol.13
, pp. 1299-1307
-
-
Tao, R.1
de Zoeten, E.F.2
Ozkaynak, E.3
-
27
-
-
50849102708
-
The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice
-
Reilly CM, Thomas M, Gogal R etal. The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. J Autoimmun 2008; 31:123-130.
-
(2008)
J Autoimmun
, vol.31
, pp. 123-130
-
-
Reilly, C.M.1
Thomas, M.2
Gogal, R.3
-
28
-
-
0037022598
-
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
-
Leoni F, Zaliani A, Bertolini G etal. The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc Natl Acad Sci USA 2002; 99:2995-3000.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2995-3000
-
-
Leoni, F.1
Zaliani, A.2
Bertolini, G.3
-
29
-
-
84859553400
-
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model
-
Tersey SA, Nishiki Y, Templin AT etal. Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 2012; 61:818-827.
-
(2012)
Diabetes
, vol.61
, pp. 818-827
-
-
Tersey, S.A.1
Nishiki, Y.2
Templin, A.T.3
-
30
-
-
64649092274
-
PPAR-{gamma} activation restores islet function in diabetic mice through reduction of ER stress and maintenance of euchromatin structure
-
Evans-Molina C, Robbins RD, Kono T etal. PPAR-{gamma} activation restores islet function in diabetic mice through reduction of ER stress and maintenance of euchromatin structure. Mol Cell Biol 2009; 29:2053-2067.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2053-2067
-
-
Evans-Molina, C.1
Robbins, R.D.2
Kono, T.3
-
31
-
-
84870225003
-
Targeting regulatory T cells in the treatment of type 1 diabetes mellitus
-
Cabrera SM, Rigby MR, Mirmira RG. Targeting regulatory T cells in the treatment of type 1 diabetes mellitus. Curr Mol Med 2012; 12:1261-1272.
-
(2012)
Curr Mol Med
, vol.12
, pp. 1261-1272
-
-
Cabrera, S.M.1
Rigby, M.R.2
Mirmira, R.G.3
-
32
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N etal. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198:1875-1886.
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
-
33
-
-
33845523340
-
Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes
-
Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes A-MB, Herold KC. Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 2006; 55:3238-3245.
-
(2006)
Diabetes
, vol.55
, pp. 3238-3245
-
-
Sherry, N.A.1
Kushner, J.A.2
Glandt, M.3
Kitamura, T.4
Brillantes, A.-M.5
Herold, K.C.6
-
34
-
-
78650053328
-
Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes
-
Robbins RD, Tersey SA, Ogihara T etal. Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes. J Biol Chem 2010; 285:39943-39952.
-
(2010)
J Biol Chem
, vol.285
, pp. 39943-39952
-
-
Robbins, R.D.1
Tersey, S.A.2
Ogihara, T.3
-
35
-
-
70449480577
-
Rituximab, B-lymphocyte depletion, and preservation of beta-cell function
-
Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H etal. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 2009; 361:2143-2152.
-
(2009)
N Engl J Med
, vol.361
, pp. 2143-2152
-
-
Pescovitz, M.D.1
Greenbaum, C.J.2
Krause-Steinrauf, H.3
-
36
-
-
79959386535
-
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited
-
Atkinson MA, Bluestone JA, Eisenbarth GS etal. How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes 2011; 60:1370-1379.
-
(2011)
Diabetes
, vol.60
, pp. 1370-1379
-
-
Atkinson, M.A.1
Bluestone, J.A.2
Eisenbarth, G.S.3
-
37
-
-
0032539890
-
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
-
Richon VM, Emiliani S, Verdin E etal. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci USA 1998; 95:3003-3007.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3003-3007
-
-
Richon, V.M.1
Emiliani, S.2
Verdin, E.3
-
38
-
-
79959994999
-
Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice
-
Patel T, Patel V, Singh R, Jayaraman S. Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice. Immunol Cell Biol 2011; 89:640-649.
-
(2011)
Immunol Cell Biol
, vol.89
, pp. 640-649
-
-
Patel, T.1
Patel, V.2
Singh, R.3
Jayaraman, S.4
-
39
-
-
17844362518
-
Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes
-
Mest HJ, Mentlein R. Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes. Diabetologia 2005; 48:616-620.
-
(2005)
Diabetologia
, vol.48
, pp. 616-620
-
-
Mest, H.J.1
Mentlein, R.2
-
40
-
-
80053003537
-
Effect of sitagliptin on glucose control in adult patients with Type 1 diabetes: a pilot, double-blind, randomized, crossover trial
-
Ellis SL, Moser EG, Snell-Bergeon JK, Rodionova AS, Hazenfield RM, Garg SK. Effect of sitagliptin on glucose control in adult patients with Type 1 diabetes: a pilot, double-blind, randomized, crossover trial. Diabet Med 2011; 28:1176-1181.
-
(2011)
Diabet Med
, vol.28
, pp. 1176-1181
-
-
Ellis, S.L.1
Moser, E.G.2
Snell-Bergeon, J.K.3
Rodionova, A.S.4
Hazenfield, R.M.5
Garg, S.K.6
-
41
-
-
21344462346
-
Five-year follow-up after clinical islet transplantation
-
Ryan EA, Paty BW, Senior PA etal. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54:2060-2069.
-
(2005)
Diabetes
, vol.54
, pp. 2060-2069
-
-
Ryan, E.A.1
Paty, B.W.2
Senior, P.A.3
-
42
-
-
0041666293
-
Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial
-
Steffes MW, Sibley S, Jackson M, Thomas W. Beta-cell function and the development of diabetes-related complications in the diabetes control and complications trial. Diabetes Care 2003; 26:832-836.
-
(2003)
Diabetes Care
, vol.26
, pp. 832-836
-
-
Steffes, M.W.1
Sibley, S.2
Jackson, M.3
Thomas, W.4
|