Inhibition of in vitro cytokine production by human peripheral blood mononuclear cells treated with xenobiotics: Implications for the prediction of general toxicity and immunotoxicity

Toxicology in Vitro

Volumn 24, Issue 6, 2010, Pages 1782-1789

  Kooijman, Ron ^a   Devos, Sabrina ^a   Hooghe Peters, Elisabeth ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Acute systemic toxicity; Alternative tests; Cytokines; Immunotoxicology; In vitro assays; Leukocytes

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; CYCLOSPORIN A; CYTOKINE; DIAZEPAM; DIGOXIN; GAMMA INTERFERON; INTERLEUKIN 5; MALATHION; PENTACHLOROPHENOL; TUMOR NECROSIS FACTOR ALPHA; VERAPAMIL; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; IC 50; IMMUNOTOXICITY; IN VITRO STUDY; KERATINOCYTE; LC 50; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTION; PROTEIN SYNTHESIS INHIBITION; TOXICITY;

3T3 CELLS; ANIMAL TESTING ALTERNATIVES; ANIMALS; CELLS, CULTURED; CYTOKINES; FIBROBLASTS; HUMANS; IMMUNE SYSTEM; INHIBITORY CONCENTRATION 50; INTERFERON-GAMMA; INTERLEUKIN-5; KERATINOCYTES; LEUKOCYTES, MONONUCLEAR; MICE; PREDICTIVE VALUE OF TESTS; TUMOR NECROSIS FACTOR-ALPHA; XENOBIOTICS;

MURINAE;

EID: 77956177747     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.07.007     Document Type: Article

References (27)

1. Andersson J., Nagy S., Groth C.G., Andersson U. Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level. Immunology 1992, 75:136-142.
2. Blakley B.R. Effect of roundup and tordon 202C herbicides on antibody production in mice. Vet. Hum. Toxicol. 1997, 39:204-206.
3. Blakley B.R., Yole M.J., Brousseau P., Boermans H., Fournier M. Effect of pentachlorophenol on immune function. Toxicology 1998, 125:141-148.
4. Cato A.C., Wade E. Molecular mechanisms of anti-inflammatory action of glucocorticoids. Bioessays 1996, 18:371-378.
5. Cerrato L., Valeri A., Bueren J.A., Albella B. In vitro sensitivity of granulo-monocytic progenitors as a new toxicological cell system and endpoint in the ACuteTox Project. Toxicol. Appl. Pharmacol. 2009, 238:111-119.
6. Clemedson C. The European ACuteTox project: a modern integrative in vitro approach to better prediction of acute toxicity. Clin. Pharmacol. Ther. 2008, 84:200-202.
7. Clothier R., Dierickx P., Lakhanisky T., Fabre M., Betanzos M., Curren R., Sjöström M., Raabe H., Bourne N., Hernandez V., Mainez J., Owen M., Watts S., Anthonissen R. A database of IC50 values and principal component analysis of results from six basal cytotoxicity assays, for use in the modelling of the in vivo and in vitro data of the EU ACuteTox project. Altern. Lab. Anim. 2008, 36:503-519.
8. Daniel V., Huber W., Bauer K., Opelz G. Impaired in-vitro lymphocyte responses in patients with elevated pentachlorophenol (PCP) blood levels. Arch. Environ. Health 1995, 50:287-292.
9. Daniel V., Huber W., Bauer K., Suesal C., Mytilineos J., Melk A., Conradt C., Opelz G. Association of elevated blood levels of pentachlorophenol (PCP) with cellular and humoral immunodeficiencies. Arch. Environ. Health 2001, 56:77-83.
10. Ekwall B., Clemedson C., Crafoord B., Ekwall B., Hallander S., Walum E., Bondesson I. MEIC evaluation of acute systemic toxicity: part V. Rodent and human toxicity data for the 50 reference chemicals. Altern. Lab. Anim. 1998, 26:571-616.
11. Ekwall B., Ekwall B., Sjöström M. MEIC evaluation of acute systemic toxicity: Part VIII. Multivariate partial least squares evaluation, including the selection of a battery of cell line tests with a good prediction of human acute lethal peak blood concentrations for 50 chemicals. Altern. Lab. Anim. 2000, 28:201-234.
12. Exon J.H., Koller L.D. Effects of chlorinated phenols on immunity in rats. Int. J. Immunopharmacol. 1983, 5:131-136.
13. Fukuyama T., Tajima Y., Ueda H., Hayashi K., Shutoh Y., Harada T., Kosaka T. Allergic reaction induced by dermal and/or respiratory exposure to low-dose phenoxyacetic acid, organophosphorus, and carbamate pesticides. Toxicology 2009, 261:152-161.
14. Igarashi A., Ohtsu S., Muroi M., Tanamoto K. Effects of possible endocrine disrupting chemicals on bacterial component-induced activation of NF-kappaB. Biol. Pharm. Bull. 2006, 29:2120-2122.
15. Kinsner-Ovaskainen A., Rzepka R., Rudowski R., Coecke S., Cole T., Prieto P. Acutoxbase, an innovative database for in vitro acute toxicity studies. Toxicol. In Vitro 2009, 23:476-485.
16. Koller M., Kotzmann H., Clodi M., Riedl M., Luger A. Effect of elevated serum prolactin concentrations on the immunophenotype of human lymphocytes, mitogen-induced proliferation and phagocytic activity of polymorphonuclear cells. Eur. J. Clin. Invest. 1997, 27:662-666.
17. Kooijman R., Coppens A. Insulin-like growth factor-I stimulates IL-10 production in human T cells. J. Leukoc. Biol. 2004, 76:862-867.
18. McConnachie P.R., Zahalsky A.C. Immunological consequences of exposure to pentachlorophenol. Arch. Environ. Health 1991, 46:249-253.
19. Nnodu U., Whalen M.M. Pentachlorophenol decreases ATP levels in human natural killer cells. J. Appl. Toxicol. 2008, 28:1016-1020.
20. Ohnishi T., Yoshida T., Igarashi A., Muroi M., Tanamoto K. Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling. FEMS Immunol. Med. Microbiol. 2008, 52:293-295.
21. Resch K., Szamel M. Molecular mechanisms of the immunosuppressive action of cyclosporin A. Int. J. Immunopharmacol. 2009, 19:579-585.
22. Romagnani S., Maggi E., Liotta F., Cosmi L., Annunziato F. Properties and origin of human Th17 cells. Mol. Immunol. 2009, 47:3-7.
23. Salazar K.D., de la R.P., Barnett J.B., Schafer R. The polysaccharide antibody response after Streptococcus pneumoniae vaccination is differentially enhanced or suppressed by 3,4-dichloropropionanilide and 2,4-dichlorophenoxyacetic acid. Toxicol. Sci. 2005, 87:123-133.
24. Sjöström M., Kolman A., Clemedson C., Clothier R. Estimation of human blood LC50 values for use in modeling of in vitro-in vivo data of the ACuteTox project. Toxicol. In Vitro 2008, 22:1405-1411.
25. Tominaga A., Takaki S., Koyama N., Katoh S., Matsumoto R., Migita M., Hitoshi Y., Hosoya Y., Yamauchi S., Kanai Y. Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. J. Exp. Med. 1991, 173:429-437.
26. Yoon B.I., Hirabayashi Y., Kawasaki Y., Kodama Y., Kaneko T., Kim D.Y., Inoue T. Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM). Exp. Hematol. 2001, 29:278-285.
27. Yoshida T., Ikuta K., Sugaya H., Maki K., Takagi M., Kanazawa H., Sunaga S., Kinashi T., Yoshimura K., Miyazaki J., Takaki S., Takatsu K. Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity 1996, 4:483-494.