Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: Effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice

Journal of Pharmacological and Toxicological Methods

Volumn 63, Issue 1, 2011, Pages 102-114

  Redfern, William S ^a   Storey, Sharon ^a   Tse, Karen ^a,b   Hussain, Qasim ^a,b   Maung, Khine Phu ^a,c   Valentin, Jean Pierre ^a   Ahmed, Gulshanara ^a   Bigley, Alison ^a   Heathcote, Dan ^a   McKay, Jennifer S ^a  

^a ASTRAZENECA   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c Takeda Cambridge Ltd   (United Kingdom)

Author keywords

Immunohistochemistry; Methods; Optomotor response; Retina; Retinal toxicity; Visual acuity

Indexed keywords

SODIUM IODATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; EYE TRACKING; GRATING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; RAT; RETINA; RETINA NECROSIS; TOXICITY TESTING; VISUAL ACUITY; VISUAL IMPAIRMENT;

ALBINISM; ANIMALS; IODATES; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, LONG-EVANS; RATS, WISTAR; RETINA; TIME FACTORS; TOXICITY TESTS; VISUAL ACUITY;

ANIMALIA; MUS; RATTUS; RODENTIA;

EID: 78650761734     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2010.06.008     Document Type: Article

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