Automation of an in vitro cytotoxicity assay used to estimate starting doses in acute oral systemic toxicity tests

Food and Chemical Toxicology

Volumn 50, Issue 6, 2012, Pages 2084-2096

  Bouhifd, Mounir ^a   Bories, Gilles ^a   Casado, Juan ^a   Coecke, Sandra ^a   Norlén, Hedvig ^a   Parissis, Nicholaos ^a   Rodrigues, Robim M ^a   Whelan, Maurice P ^a  

^a JOINT RESEARCH CENTRE   (Italy)

Author keywords

Acute oral toxicity; Alternative methods; Cytotoxicity; High throughput screening; Safety assessment; Validation

Indexed keywords

1,2,4 TRICHLOROBENZENE; ACETOPHENONE; ATROPINE; BARIUM CHLORIDE; BENZYL BENZOATE; CADMIUM; CAFFEINE; CARBAMAZEPINE; CHEMICAL COMPOUND; CHLORIDE; CHLOROACETIC ACID ETHYL ESTER; COPPER SULFATE; CYCLOHEXIMIDE; DIISOPROPANOLAMINE; DODECYL SULFATE SODIUM; EDETIC ACID; MERCURY CHLORIDE; METHENAMINE; OCTANOIC ACID; PARACETAMOL; POTASSIUM SULFATE; PROPANOL; RESORCINOL; SALICYLIC ACID; SODIUM CYANATE; SORBITAN LAURATE; UNCLASSIFIED DRUG; VALPROIC ACID; VERAPAMIL; ZINC OXIDE;

ACUTE TOXICITY; ARTICLE; ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; HIGH THROUGHPUT SCREENING; IC 50; INSTRUMENTATION; LABORATORY AUTOMATION; TOXICITY TESTING; VALIDATION STUDY;

3T3 CELLS; ANIMAL TESTING ALTERNATIVES; ANIMALS; AUTOMATION; CELL CULTURE TECHNIQUES; CELL SURVIVAL; DATA INTERPRETATION, STATISTICAL; ENDPOINT DETERMINATION; HIGH-THROUGHPUT SCREENING ASSAYS; LETHAL DOSE 50; MICE; SOFTWARE; TOXICITY TESTS, ACUTE;

ANIMALIA; RODENTIA;

EID: 84860203780     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.03.046     Document Type: Article

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