Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats

Asian Pacific Journal of Tropical Medicine

Volumn 6, Issue 4, 2013, Pages 285-295

  Soliman, Amel M ^a   Abu El Zahab, Helal S ^a   Alswiai, Gamiaa A ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Omar Al Mukhtar Un   (Libyan Arab Jamahiriya)

Author keywords

132 KD isolated protein; Carbon tetrachloride; Oxidative stress; Peganum harmala

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BOVINE SERUM ALBUMIN; CARBON TETRACHLORIDE; CATALASE; GLUTATHIONE; LIPID; MALONALDEHYDE; OLIVE OIL; SUPEROXIDE DISMUTASE; VEGETABLE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INDUCTION; IN VITRO STUDY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PEGANUM HARMALA; PLANT SEED; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN ISOLATION; PROTEIN PURIFICATION; RAT; TREATMENT DURATION;

EID: 84876696007     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(13)60058-9     Document Type: Article

References (88)

1. Abraham P, Wilfred G, Cathrine SP Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication. Clin Chim Acta 1999, 289:177-179.
2. Goeptar AR, Scheerens H, Vermeulen NP Oxygen and xenobiotic reductase activites of cytochrom P450. Crit Rev Toxicol 1995, 25:25-65.
3. Sarkar K, Ghosh A, Kinter M, Mazumder B, Sil PC Purification and characterization of a 43 kDa hepatoprotective protein from the herb Cajanus indicus L. Protein J 2006, 25:411-421.
4. Weber LWD, Boll M, Stampfl A Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003, 33:105-136.
5. Vitaglione P, Morisco F, Caporaso V Dietary antioxidant compound and liver health. Crit Rev Food Sci Nutr 2004, 44:575-586.
6. Ko JH, Lim KT Glycoprotein isolated from Ulmus davidian NAKAI protects against carbon tetrachloride induced liver injury in the mouse. J Pharm Sci 2006, 101:205-213.
7. Poli G Liver damage due to free radicals. Br Med Bull 1993, 49:604-620.
8. Murugesan GS, Sathishkumar M, Jayabalan R, Binupriya AR, Swaminathan1 K, Yun SE Hepatoprotective and curative properties of kombucha tea against carbon tetrachloride-induced toxicity. J Microbiol Biotechnol 2009, 19(4):397-402.
9. Maitraie D, Hung CF, Tu HY, Liou YT, Wei BL, Yang SC, et al. Synthesis, anti-inflammatory, and antioxidant activities of 18beta-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors. Bioorg Med Chem 2009, 17(7):2785-2792.
10. Mansour HH, Hafez HF, Fahmy NM Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats. J Biochem Mol Biol 2006, 39:656-661.
11. Sobhani AM, Ebrahimi SA, Mahmoudian M An in vitro evaluation of human DNA topoismerase I inhibition by Peganum harmala L. Seeds extract and its a-carboline alkaloids. J Pharm Pharmac Sci 2000, 5:19-23.
12. Kuhn MA, Winston D Herbal therapy and supplements, a scientific and traditional approach 2000, 347-350. Lippincott, New York.
13. Tse SYH, Mak II, Dickens BF Antioxidative properties of harmane and b-carboline alkaloids. Biochem Pharmacol 1991, 42:459-464.
14. Abdel-Fattah AFM, Matsumoto K, Murakami Y Central serotonin level-dependent changes in body temperature following administration of tryptophan to pargyline and harmaline pretreated rats. Gen Pharmacol 1997, 28:405-409.
15. Lamchouri F, Settaf A, Cherrah Y Antitumour principles from Peganum harmala seeds. Ther 1999, 54:753-758.
16. Gamiaa AA " The possible protective or curative role of protein isolated from seeds of Peganum harmala plant against carbon tetrachloride induced toxicity in male albino rats" 2010, Cairo University, M.Sc. thesis.
17. Liyana-Pathiranan CM, Shahidi F Antioxidant activity of commercial soft and hard wheat (Triticum aestivum L.) as affected by gastric pH conditions. J Agric Food Chem 2005, 53:2433-2440.
18. Gornal AG, Bardawill CJ, David MM Determination of serum protein by means of biuret reagent. J Biol Chem 1949, 177:751-756.
19. Reitman S, Frankel S A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transminase. Am J Clin Pathol 1957, 2:56-60.
20. Young DS, Pestner LC, Gibberman V Effects of drugs on clinical laboratory tests. Clin Chem 1975, 21:246D.
21. Knight TA, Anderson S, James MR Chemical basis of the sulphophospho - vanilline reaction for estimating total serum lipids. Clin Chem 1972, 18(3):199-202.
22. Fossati P, Prencipe L Serum triglycerides determined colorimetrically with an enzyme that produced hydrogen peroxide. Clin Chem 1982, 28(10):2077-2080.
23. Allain CC, Poon LS, Chan CS, Richmond W, Fu PC Enzymatic determination of total serum cholesterol. Clin Chem 1974, 20:470-475.
24. Lopez-Virella MF, Stone P, Ellis S, Colwell JA Cholesterol determination in high density lipoproteins separated by three different methods. Clin Chem 1977, 23(5):882-884.
25. Wieland H, Seidel D A simple specific method for precipitation of low density lipoproteins. J Lipid Res 1983, 24:904-909.
26. Nishikimi M, Rao NA, Yagi K The occurrence of superoxid anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Comm 1972, 46:849-854.
27. Aebi H Catalase in vitro. Methods Enzymol 1984, 105:121-126.
28. Aykac M, Uysal M, Yalcin AS, Kocak-Toker N, Sivas NA, Oz H The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione peroxidase, and glutathione transferase in rats. Toxicology 1985, 36:71-76.
29. Ohkawa H, Ohishi N, Yagi K Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
30. Bancroft JD, Stevens A Theory and practice of histological techniques 1996, 99-102. Churchill livingestone, New York, Edinburgh, London, Madrid, Melbourne, San Francisco, Tokyo. Fourth ed.
31. Steel RGD, Torrie JH Principles and procedures of statistics 1980, 185-186. McGraw-Hill Book Inc, New York. 5th ed.
32. Villano D, Fernandez-Pachona MS, Moyab ML, Troncosoa AM, Garcia-Parrilla MC Radical scavenging ability of polyphenolic compounds towards DPPH free radical. Talanta 2007, 71:230-235.
33. Porto CD, Calligaris S, Celloti E, Nicoli MC Antiradical properties of commercial cognacs assessed by the DPPH test. J Agri Food Chem 2000, 48:4241-4245.
34. Conforti F, Loizzo MR, Statti GA, Menichini F Comparative radical scavenging and antidiabetic activities of methanolic extract and fractions from Achille aligustica All. Bio Pharm Bull 2005, 28:1791-1794.
35. Rekka E, Kourounakis PN Effect of hydroxyl ethyl rutenosides and related compounds on lipid peroxidation and free radical scavenging activity-some structural aspects. J Pharm Pharmacol 1991, 43:486-491.
36. Day CP Alcohol and the liver. Med 2007, 35:22-25.
37. Lee KJ, Woo ER, Choi CY, Shin DW, Lee DG, You HJ, et al. Protective effect of acteoside on carbon tetrachloride-induced hepatotoxicity. Life Sci 2004, 74:1051-1064.
38. Dudley RE, Svoboda DJ, Klaassen CD Time course of cadmium induced ultra structural changes in rat liver. Toxicol Appl Pharmacol 1984, 76:150-160.
39. Gitnick G Current Hepatology 1993, Vol. 13:179-196. Medical publisher Inc, Mosby. 2nd E.
40. Sengupta M, Sharma GD, Chakraborty B Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pac J Trop Biomed 2011, 193-199.
41. Gonzalez R, Corcho R, Raminez D, Rodriguez E Hepatoprotective effects of propilis extract on carbon tetrachloride-induced liver injury in rats. Phytother Res 1995, 9:114-117.
42. Mankani KL, Krishna V, Manjunatha BK, Vidya S, Singh JSD Evalution of hepatoprotective activity of stem bark of Pterocarpus marsupium Roxb. Indian J Pharmacol 2005, 37:165-168.
43. Atta AH, Nasr SM, Mouneir SM Potential protective effect of some plant extracts against carbon tetrachloride-induced hepatotoxicity. Afr J Trad Complem Altern Med 2006, 3:1-9.
44. Wei YH Oxidative stress and mitochondrial DNA mutations in human aging. Proc Soc Exp Biol Med 1998, 217:53-63.
45. Smitha S, Dhananjaya BL, Dinesha R, Srinivas L Purification and characterization of a 34 kDa antioxidant protein (B-turmerin) turmeric (Curcuma longa) waste grits. Biochem 2009, 91:1156-1162.
46. Muriel P, Escobar Y Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride. J Appl Toxicol 2003, 23:103-108.
47. Sallie E, Tredger JM, Willam R Drugs and the liver. Biopharmaceutical Drug Dispos 1991, 12:251-259.
48. Adesanoye OA, Farombi EO Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Exp Toxicol Pathol 2010, 62:197-206.
49. Roy SP, Shirode D, Patel T, Shastry CS, Gheewala N, Sonara G, et al. Antioxidant and hepatoprotective activity of Madhuca longifolia (Koenig) bark against carbon tetrachloride induced hepatic injury in rats: In vitro and in vivo studies. Res J Pharmaceutical Biol Chem Sci 2010, 1:1-10.
50. 4 induced hepatic damage in rats. J Ethnopharmacol 2010, 127:777-780.
51. Ghosh A, Sil PC A protein from Cajanus indicus Spereng protects liver and kidney against mercuric chloride-induced oxidative stress. Biol Pharm Bull 2008, 31:1651-1658.
52. Dubey GP, Agrawal A, Dixit SP Effect of Liv 52 on different biochemical parameters on alcoholic cirrhosis. Antiseptic 1994, 91:205-208.
53. Bhandarkar MR, Khan A Antihepatotoxic effect of Nymphaea stellata wild. Against carbon. J Ethnopharmacol 2004, 91:61-64.
54. Koneri R, Balaraman R, Firdous, Kumar VM Hepatoprotective effect of Momordica cymbalaria Fenzl. Against carbon tetrachloride induced hepatic injury in rats. Pharmacology online 2008, 1:365-374.
55. Uday B, Das D, Banerjee KR Reactive oxygen species: Oxidative damage and pathogensis. Curr Sci 1999, 77:658-666.
56. Faroon O, De Rosa CT, Smith L Carbon tetrachloride: Health effects toxicokinetics, human exposure and environmental fate. Toxic. Indust Health 1994, 10:4-20.
57. Tiwari BK, Khosa RL Evaluation of the hepatoprotective and antioxidant effect of Berberis asiatica against experimentally induced liver injury in rats. Inter. J Pharmacy Pharmaceutical Sci 2010, 2:92-97.
58. Sureshkumar SV, Mishra SH Hepatoprotective effect of extracts from Pergularia daemia Forsk. J Ethnopharmacol 2006, 107:164-168.
59. Awang D Milk Thistle. Can Pharmacy J 1993, 23:749-754.
60. 4-treated male rats. Indian. J Pharmacol 2002, 34:269-275.
61. Kamalakkannan N, Viswanathan P, Menon VP, Rukkumani E, Rajasekharan KN Effect of currcumin and its analogue on lipids in carbon tetrachloride-induced hepatotoxicity: a comparative study. Pharmaceutic Biol 2005, 43:460-466.
62. 4 administration in albino rats. World J Zool 2007, 2:19-28.
63. Plaa GL, Charbonneau M Detection and evaluation of chemically induced liver injury. Principles and methods of toxicology 1994, 839-870. Raven Press, New York. 3rd ed. A.W. Hayes (Ed.).
64. Younes M, Strubelt O Alcohol induced hepatotoxicity: A role for oxygen free radicals. Free Rad Res Comm 1987, 3:19-26.
65. Sanogo R, Germano PM, Angelo VD, Guglielmo M, De Pasquale R Antihepatotoxic properties of Entada africana (Mimosaceae). Phytother Res 1998, 12:157-159.
66. Gould AL, Rossouw JE, Santanello NC, Heyse JF, Furberg CD Cholesterol reduction yields clinical benefit. Circulation 1998, 97:946-952.
67. 4 intoxicated rats. Advan Biol Res 2009, 3:9-15.
68. Sies H Oxidative stress: oxidants and antioxidants. Exp Physiol 1997, 82:291-295.
69. Bhatia S, Shukla R, Madhu SV, Gambhir JK, Prabhu KM Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type-2 diabetes mellitus with nephropathy. Chin Biochem 2003, 36:557-562.
70. Selvakumar E, Prahalathan C, Mythili Y, Varalakshmi P Protective effect of dl-alpha-lipoic acid in cyclophosphamide induced injury in rat testis. Rep Toxicol 2004, 19:163-167.
71. Escobar JA, Rubio MA, Lissi EA SOD and catalase inactivation by singlet oxygen and peroxyl radicals. Free Rad Biol Med 1996, 20:285-290.
72. Manna P, Sinha M, Sil PC Aqueous extract of Terminalia arjuna prevents carbon tetrachloride-induced hepatic and renal disorders. BMC Complement Altern Med 2006, 6:33-42.
73. Srivastava A, Shivanandappa T Hepatoprotective effect of the root extract of Decalepis hamiltonii against carbon tetrachloride induced oxidative stress in rats. Food Chem 2010, 118:411-417.
74. Mark D, Ip S, Li P, Poon M, Ko K Alteration in tissue glutathione antioxidant system in streptozotocin-induced diabetic rat. Mol Biochem 1996, 20:153-158.
75. Murugesh KS, Yelgar VC, Maiti BC, Maity TK Hepatoprotective and antioxidant role of Berberis tinctoria lesch leaves on paracetamol induced hepatic damage. Iranian. J Pharmacol Ther 2005, 4:64-69.
76. Hewawasam RP, Jayatilaka KAPW, Pathirana C, Mudduwa LKB Protective effect of Asteracantha longifolia extracts mouse liver injury induced by carbon tetrachloride and paracetamol. J Pharmacy Pharmacol 2003, 55:1413-1418.
77. Seven A, Güzel S, Seymen O, Civelek S, Bolayirh M, Uncu M, et al. Effects of vitamin E supplementaion on oxidative stress in streptozotocin induced diabetic rats: Investigation of liver and plasma. J Yonsei Med 2004, 45:703-710.
78. Recknagel RO, Glende EA, Dolak JA, Waller RL Mechanism of carbon tetrachloride. Toxicity Pharmacol Ther 1989, 43:139-154.
79. Hoek JB, Pastorino JG Ethanol, oxidative stress, and cytokine induced liver damage. Alcohol 2002, 27:63-68.
80. Kurata M, Suzuki M, Agar NS Antioxidant systems and erythrocyte life span in mammals. Biochem Physiol 1993, 106:477-487.
81. Ramalakshmi S, Edaydulla N, Ramesh P, Muthuchelian K Investigation on cytotoxic, antioxidant, antimicrobial and volatile profile of Wrightia tinctoria (Roxb.) R. Br. flower used in Indian medicine. Asian Pac J Trop Dis 2012, 2(Suppl 1):S68-S75.
82. Guruvaiah Ponmari, Arunachalam Annamalai, Velan Lakshmi Palanisamy Thanga Evaluation of phytochemical constituents and antioxidant activities of successive solvent extracts of leaves of Indigofera caerulea Roxb using various in vitro antioxidant assay systems. Asian Pac J Trop Dis 2012, 2(Suppl 1):S118-S123.
83. Thambiraj J, Paulsamy S, Sevukaperumal R Evaluation of in vitro antioxidant activity in the traditional medicinal shrub of western districts of Tamilnadu, India, Acalypha fruticosa Forssk. (Euphorbiaceae). Asian Pac J Trop Biomed 2012, 2(Suppl 1):S127-S1230.
84. Sundaram R, Murugesan G Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa. Asian Pac J Trop Biomed 2011, 1(5):348-352.
85. Szymonik-Lesiuk S, Czechowska G, Stryjecka Zimmer M, Slomka M, Madro A, Gelinski K, et al. Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. J Hepatobiliary Pancreat Surg 2003, 10:309-315.
86. Liu J, Tan H, Sun Y, Zhou S, Cao J, Wang F The preventive effects of heparin superoxide dismutase on carbon tetrachloride-induced acute liver failure and hepatic fibrosis in mice. Mol Cell Biochem 2009, 327:219-228.
87. Hong RT, Xu JM, Mei Q Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol 2009, 15:1452-1458.
88. Yun-hui C, Zhang W, Shi-Ying XU Antioxidant properties of wheat germ protein hydrolysates evaluated in vitro. J Cent South Univ Technol 2006, 13:160-166.