Effect of curcumin and its analogue on lipids in carbon tetrachloride - Induced hepatotoxicity: A comparative study

Pharmaceutical Biology

Volumn 43, Issue 5, 2005, Pages 460-466

  Kamalakkannan, N ^a   Rukkumani, R ^a   Viswanathan, P ^a   Rajasekharan, K N ^b   Menon, Venugopal P ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b UNIVERSITY OF KERALA   (India)

Author keywords

bisdemethoxy curcumin analogue; Carbon tetrachloride; Curcumin; Lipids

Indexed keywords

ALKALINE PHOSPHATASE; ANTILIPEMIC AGENT; ASPARTATE AMINOTRANSFERASE; CHLOROFORM; CHOLESTEROL; CURCUMIN; DIDEMETHOXYCURCUMIN; FATTY ACID; GAMMA GLUTAMYLTRANSFERASE; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; FATTY ACID BLOOD LEVEL; HEART; HISTOPATHOLOGY; KIDNEY; LIVER; LIVER TOXICITY; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; RAT; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL;

RATTUS NORVEGICUS;

EID: 24744458145     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1080/13880200590963880     Document Type: Article

References (36)

1. Akila GV, Rajakrishnan V, Viswanathan P, Rajasekharan KN, Menon VP (1998): Effects of curcumin on lipid profile and lipid peroxidation status in experimental hepatic fibrosis. Hepatol Res 11: 147-157.
2. Anto RJ, George J, Babu DKV, Rajasekharan KN, Kuttan R (1996): Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. Mutat Res 17: 127-131.
3. Anusuya S, Viswanathan P, Rajashekaran KN, Menon VP (2003): Protection of pancreatic β-cell by the potential antioxidant bis-O-hydroxycinnamoyl methane, analogue of natural curcuminoid in experimental diabetes. J Pharm Pharmaceut Sci 6: 327-333.
4. Asai A, Miyazawa T (2001): Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr 131: 2932-2935.
5. Babu KV, Rajasekaran KN (1994): Simplified conditions for the synthesis of curcumin 1 and other curcuminoids. Org Prep Procedure Int 26: 674-677.
6. Babu PS, Srinivasan K (1997): Hypolipidemic action of curcumin, the active principle of turmeric (Curcuma longa) in streptozotocin induced diabetic rats. Mol Cell Biochem 166: 169-175.
7. 4 by cytochrome P450 and effects on lipid homeostasis. Z Naturforsch 56c: 111-121.
8. Cheeseman KH, Albano EF, Tomasi A, Slater TF (1985): Biochemical studies on the metabolic activation of halogenated alkanes. Environ Health Perspect 64: 85-101.
9. 4-induced hepatic injury. J Biosci 10: 227-234.
10. Falholt K, Falholt W, Lund B (1973): An easy colorimetric method for routine determination of free fatty acids in plasma. Clin Chim Acta 46: 105-111.
11. Fiala S, Fiala AE, Dixon B (1972): Gamma glutamyl transpeptidase in transplantable chemically induced rat hepatomas and spontaneous mouse hepatomas. J Natl Cancer Inst 481: 1393-1409.
12. Folch J, Lees M, Solane SGH (1957): A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem 26: 497-509.
13. Foster CS, Dunn O (1973): Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin Chim Acta 19: 338-340.
14. Honma T, Suda M (1997): Changes in plasma lipo-proteins as toxicity markers for carbon tetrachloride, chloroform and dichloromethane. Ind Health 35: 519-531.
15. King EJ, Armstrong AR (1988): Calcium, phosphorus and phosphatases. In: Practical Clinical Biochemistry. New Delhi, CBS Publishers, pp. 431-467.
16. Lamb RG, Snyder JW, Coleman JB (1988): New trends in the prevention of hepatocellular death. Modifiers of calcium movement and of membrane phospholipid metabolism. In: Testa B, Perrissaud D, eds., Liver Drugs: From Experimental Pharmacology to Therapeutic Application. Boca Raton, CRC Press, pp. 53-66.
17. Lieber CS (2000): Alcoholic liver disease: New insights on pathogenesis lead to new treatment. J Hepatol 32: 113-128.
18. McGregor D, Lang M (1996): Carbon tetrachloride: Genetic effects and other modes of action. Mutat Res 366: 181-195.
19. Morrow JD, Awad JA, Boss HJ, Blair IA, Roberts II LJ (1992): Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc Natl Acad Sci USA 89: 10721-10725.
20. Muriel P (1997): Peroxidation of lipids and liver damage. In: Baskin SI, Salem H, eds., Antioxidants, Oxidants and Free Radicals. Washington, DC, Taylor & Francis, p. 237.
21. Murray RK, Granner DK, Mayes PA, Rodwell VW (1993): Harper's Biochemistry, 23rd ed. Appleton and Lange, Stamford, Connecticut, pp. 258-265.
22. Pan GX, Spencer L, Leary GJ (1999): Reactivity of ferulic acid and its derivative towards hydrogen peroxide and peracetic acid. J Agric Food Chem 47: 3325-3331.
23. Quiles JL, Mesa DM, Ramirez-Tortosa CL, Aguilere CM, Battino M, Gil A, Ramirez-Tortosa MC (2002): Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Thromb Vasc Biol 22: 1225-1231.
24. Rao DS, Chandrasekharan N, Sathyanarayanan MN, Srinivasan M (1970): Effect of curcumin in serum and liver cholesterol levels in rats. J Nutr 100: 1307-1315.
25. Reitman S, Frankel A (1957): A colorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic transaminases. Am J Clin Pathol 28: 56-63.
26. Rukkumani R, Balasubashini MS, Viswanathan P, Menon VP (2002): Comparative effects of curcumin and photo-irradiated curcumin on alcohol and polyunsaturated fatty acid-induced hyperlipidemia. Pharmacol Res 46: 257-264.
27. Rukkumani R, Balasubashini MS, Menon VP (2003): Protective effects of curcumin and photo-irradiated curcumin on circulatory lipids and lipid peroxidation products in alcohol and polyunsaturated fatty acid-induced toxicity. Phytother Res 17: 925-929.
28. Rukkumani R, Aruna K, Varma PS, Rajasekharan KN, Menon VP (2004a): Protective role of a novel curcuminoid in alcohol and PUFA induced hyperlipidemia. Toxicol Mech Meth (in press).
29. Rukkumani R, Aruna K, Varma PS, Rajasekharan KN, Menon VP (2004b): Comparative effects of curcumin and an analog of curcumin on alcohol and PUFA induced oxidative stress. J Med Food (in press).
30. Schroeter H, Williams RJ, Martin R, Iversen L, Evans R (2000): Phenolic antioxidants attenuate neuronal cell death following uptake of oxidised low density lipoprotein. Free Radic Biol Med 29: 1222-1233.
31. Soni KB, Kuttan R (1992): Effect of oral administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol 36: 273-275.
32. Soudamini KK, Unnikrishnan MC, Soni KB, Kuttan R (1992): Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin. Indian J Physiol Pharmacol 36: 239-243.
33. Tribble DL, Aw TY, Jones DP (1987): The pathophysiological significance of lipid peroxidation in oxidative cell injury. Hepatology 7: 377-387.
34. Wiggins D, Gibbons GF (1996): Origin of hepatic very-low-density lipoprotein triacylglycerol: The contribution of cellular phospholipid. Biochem J 320: 673-679.
35. Zilversmit DB, Davis AK (1950): Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med 35: 155-159.
36. Zlatkis A, Zak B, Boyl AJ (1953): A new method for the direct determination of serum cholesterol. J Lab Clin Med 45: 486-492.