Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice

Asian Pacific Journal of Tropical Biomedicine

Volumn 1, Issue 3, 2011, Pages 193-199

  Sengupta, Mahuya ^a   Sharma, Gauri Dutta ^a   Chakraborty, Biswajit ^a  

^a ASSAM UNIVERSITY   (India)

Author keywords

Bilirubin; Curcuma longa; Hepatoprotectivity; Hepatotoxicity; Hepatoxicity; Immune system; Immunotherapeutic agents; Liver function; Morphological alteration; Nitric oxide; Transaminase enzyme; Turmeric rhizome

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; CURCUMA LONGA EXTRACT; MYELOPEROXIDASE; NITRIC OXIDE; WATER; IMMUNOLOGIC FACTOR; PEROXIDASE; PLANT EXTRACT; PROTECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CELL ADHESION; CELL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; ENZYME RELEASE; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR KILLING; LIVER FUNCTION; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PRIORITY JOURNAL; ANIMAL; BLOOD; CHEMISTRY; CURCUMA; CYTOTOXICITY; DRUG EFFECTS; IMMUNOLOGY; LIVER; METABOLISM; PATHOLOGY;

ANIMALS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; CARBON TETRACHLORIDE; CELL ADHESION; CURCUMA; CYTOTOXICITY, IMMUNOLOGIC; IMMUNOLOGIC FACTORS; LIVER; MACROPHAGES, PERITONEAL; MALE; MICE; NITRIC OXIDE; PEROXIDASE; PLANT EXTRACTS; PROTECTIVE AGENTS;

EID: 79953894205     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(11)60026-9     Document Type: Article

References (26)

1. Bishayi B, Roychowdhury S, Ghosh S, Sengupta M Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCl4 intoxicated mature albino rats. J Toxicol Sci 2002, 27:139-146.
2. Apisariyakul A, Vanittanakom N, Buddhasukh D Antifunga activity of turmeric oil extracted from Curcuma longa (Zingiberaceae). J Ethnopharmacol 1995, 49:163-169.
3. Singh R, Chandra R, Bose M, Luthra M Antimicrobial activity of C. longa rhizome extract on pathogenic bacteria. Curr Sci 2002, 83(6):737.
4. Suhit G, Meghana K, Ramesh B, Anant P Activity of water-soluble turmeric extract using hydrophilic excipients. Food Sci Technol 2010, 43(1):59-66.
5. Li X, Liu X Effect of curcumin on immune function of mice. J Huazhong Univ Sci Technol Med Sci 2005, 25(2):137-140.
6. Giri RK, Rajagopal V, Kalra VK Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor. J Neurochem 2004, 91(5):1199-1210.
7. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 2005, 280(7):5892-5901.
8. Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, et al. Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis 2006, 10:1-7.
9. Gamal Allam Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni. Immunobiology 2009, 214(8):712-727.
10. Shao ZM, Shen ZZ, Liu CH, Sartippour MR, Go VL, Heber D, et al. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int J Cancer 2002, 98:234-240.
11. Singh S, Aggarwal BB Activation of transcription factor NF-kB is suppressed by curcumin (diferuloylmethane). J Biol Chem 1995, 270:24995-25000.
12. Ranjan D, Chen C, Johnston TD, Jeon H, Nagabhushan M Curcumin inhibits mitogen stimulated lymphocyte proliferation, NF- _B activation, and IL-2 signaling. J Surg Res 2004, 121(2):171-177.
13. Joe B, Lokesh BR Dietary n-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages. Mol Cell Biochem 2000, 203(1-2):153-161.
14. Yadav VS, Mishra KP, Singh DP, Singh ML Immunomodulatory effects of curcumin. Immunopharmacol Immunotoxicol 2005, 27:485-497.
15. Cipriani B, Borsellino G, Knowles H, Tramont D, Cavaliere F, Bernardi G, et al. CF Curcumin inhibits activation of V_ 9V_2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. J Immunol 2001, 167(6):3454-3462.
16. Ramchandran SV, Bhide SD, Lambe CS, Vaidya BD Antiinflammatory activity of turmeric oil in arthritis model in rat 2000, 199-200. Proceeding of International Congress on Ayurveda, Chennai.
17. Mishra N, Gupta SS Anti-inflammatory and anti-hyaluronidase activity of volatile oil of Curcuma longa. J Res Ayur Siddha 1997, 1-2(18):56-62.
18. Bergmeyer J, Marianne G Total bilirubin. Methods of enzymatic analysis 1985, 591-598. Academic Press Inc, New York. H. Bergmeyer (Ed.).
19. Reitman S, Frankel S A colorometric method for the determination of serum glutamate oxaloacetate and serum glutamate pyruvate transaminase. Am J Clin Pathol 1957, 28(1):28-56.
20. Matsumoto H, Naraba M, Murakami I, Kudo K, Yamaki A, Ueno A Concordant induction of prostaglandin E2 synthase with cycloxygenase-2 leads to preferred production of prostaglandin E2 over thrombaxane and prostaglandin D2 in LPS stimulated rat peritoneal macrophages. Biochem Biophys Res Commun 1997, 230:110-116.
21. Qu J, Condliffe MA, Lawson M, Pelvin RJ, Chlivers E Lack of effect of recombinant platelet derived growth factor on human neuttrophil function. J Immunol 1997, 159:2952-2959.
22. Lin TH, Roselles C, Mondol KL, Bolen JB, Haskell, Juliano RL Integrin mediated tyrosine phosphorylation and message induction in monocytic cells. J Biol Chem 1995, 270:16189-16202.
23. Czuprynski CJ, Henson PM, Campbell PA Killing of Listeria monocytogenes by inflammatory neutrophils and mononuclear phagocytes from immune and non immune mice. J Leuk Biol 1984, 35:193-208.
24. Bos AR, Weaver R, Roos D Characterization and qualification of the peroxidase in human neutrophils. Biochem Biophys Acta 1990, 525:4133-4141.
25. Sasaki M, Gonzales ZM, Huang H, Herring WJ, Ahn S, Ginty DD, et al. Dynamic regulation of neuronal nitric oxide synthase transcription by calcium influx through a CREB family transcription factor-dependant mechanism. Proc Nalt Acad Sci 2000, 18:8617-8622.
26. Leigh PCJ, Van FR, Zwet TL In vitro determination of phagocytosis and intracellular killing by polymorphonuclear neutrophils and mononuclear phagocytes. Handbook of experimental immunology 1986, 1-19. Blackwell Scientific Publications, Oxford. 4th ed. D.M. Weir (Ed.).