Antitumour principles from Peganum harmala seeds

Therapie

Volumn 54, Issue 6, 1999, Pages 753-758

  Lamchouri, F ^b   Settaf, A ^b   Cherrah, Y ^b   Zemzami, M ^a   Lyoussi, B ^b   Zaid, A ^b   Atif, N ^a   Hassar, M ^b  

^a Domaines Agricoles Dar Es Salam   (Morocco)

^b NONE

Author keywords

Antitumour activity; Cytotoxicity; Med mek carcinoma; Peganum harmala alkaloids; Sp2 O Ag14 cells; UCP Med carcinoma; UCP Med sarcoma

Indexed keywords

ALKALOID; ANTINEOPLASTIC AGENT; PEGANUM HARMALA EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CYCLOPHOSPHAMIDE; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROSARCOMA; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MOROCCO; MULTIPLE MYELOMA; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PHYTOTHERAPY; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SEEDS; TUMOR CELLS, CULTURED;

EID: 0033376028     PISSN: 00405957     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Farnsworth N. Returning to nature for medicinal marvels. Current Contents 1988; 31: 9-10.
2. Munir C, Zaidi MI, Nasira ATTA. An easy rapid metal mediated method of isolation of harmine and harmaline from Peganum harmala. Fitoterapia 1995; 66: 73-76.
3. Bruinvels J, Sourkes TL. Influence of drugs on the temperature lowering effect of harmaline. Eur J Pharmacol 1968; 4: 31-39.
4. Abdelfattah AFM, Matsumoto K, Hatim AG, Watanabe H. Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism. Pharmacol Biochem Behav 1995; 52: 421-426.
5. Fuentes JA, Longo VG. An investigation on the central effects of harmine, harmaline and related β-carbolines. Neuropharmacol 1971; 10: 15-23.
6. O'Hearn E, Molliver ME. Degeneration of perking cells in parasagittal zones of the cerebellar vennis after treatment with ibogaine of harmaline. Neuroscience 1993; 55: 303-310.
7. Al-sharma A, Mitscher A. Comprehensive survey of indigenous Iraqi plants for potential economic value, I: Screening results of 327 species for alkaloids and antimicrobial agents. J N Prod 1979; 42: 633-642.
8. Al-Sharma AS, Drake DL, Flynn L et al. Antimicrobial agents from higher plants. Antimicrobial agents from Peganum harmala seeds. J N Prod 1981; 44: 745-747.
9. Aqeel A, Khursheed AK, Sabiha S et al. Study of the in vitro antimicrobial activity of harmine, harmaline and their derivatives. J Ethnopharmacol 1992; 35: 289-294.
10. Zaid A, Mharzi I. Activité inhibitrice de la croissance cellulaire de quelques plantes médicinales récoltées dans le Maroc Oriental. Albiruniya Rev Mar Pharm 1993; 9: 13-18.
11. Mharzi I, Zaid A. Activité inhibitrice de la croissance cellulaire des extraits de Perganum harmala, Haloxylon scoparium et Matricaria pubescens. Premier Colloque National sur la Chimie des Substances Naturelles, Casablanca, 15-16 Novembre 1994.
12. Lamchouri F, Settaf A, Cherrah Y et al. Propriétés antitumorales de Peganum harmala sur un modèle experimental de cancer in vivo. Espérance Médicale 1999; 6: 62-64.
13. Lamchouri F, Settaf A, Zemzami M et al. Modèles expérimentaux de cancers (in vitro et in vivo) d'étude de l'activité de nouveaux agents anticancéreux. Actes du Vème Congrès National d'Endocrinologie Comparée, Oujda, 18-20 Décembre 1997.
14. Shulman M, Wilde CD, Kohler G. A better cell line for making hybridomas secreting specific antibodies. Nature 1978; 276: 269-270.
15. Moldeus P, Hogberg J, Orrhenius S. In: Fleischer S, Packer L, eds. Methods in Enzymology. New York: Academic Press, 1978: 52-60.
16. Desombre ER, Arbogast LY. Effect of anti-oestrogen C1628 on the growth of rat mammalian tumors. Cancer Res 1974; 34: 1974-1976.
17. Sneader W. Drug Discovery: The Evolution of Modern Medicines. Chichester: Wiley, 1968.
18. Bellakhdar J. La pharmacopée marocaine traditionnelle, Médecine arabe ancienne el savoirs populaires. Ibis Press, 1997: 10-535.
19. Lamchouri F, Zahidy M, Settaf A et al. Etude comparée de l'activité antimitotique du décocté d'Anabasis aretoides, Haloxylon scoparium et Peganum harmala. Espérance Médicale 1999; 6: 59-61.
20. Jacquillat CI, Khayat D, Miband PR. Les cancers: guide clinique pronostique et thérapeutique. Maloine, 1986: 13-167, 201-206, 500-503.
21. Collins C, Mortimer J, Livingston RB. High-dose cyclophosphamide in the treatment of refractory lymphomas and solid tumour malignancies. Cancer 1989; 63: 228-232.
22. Ayoub MT, Al-allaf TAK, Rachan LJ. 1994 Antiproliferative activity of harmalol. Fitoterapia 1994; 65: 14-18.
23. Mharzi I. Etude éthnopharmacologique de quelques plantes médicinales de l'oasis de Figuig (sud oriental du Maroc). Thèse de Doctorat Es-Sciences; Meknès, 1998.