Liver failure after extended hepatectomy in mice is mediated by a p21-dependent barrier to liver regeneration

Gastroenterology

Volumn 143, Issue 6, 2012, Pages

  Lehmann, Kuno ^a   Tschuor, Christoph ^a   Rickenbacher, Andreas ^a   Jang, Jae Hwi ^a   Oberkofler, Christian E ^a   Tschopp, Oliver ^a   Schultze, Simon M ^a   Raptis, Dimitri A ^a   Weber, Achim ^a   Graf, Rolf ^a   Humar, Bostjan ^a   Clavien, Pierre Alain ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Extended Hepatectomy; Liver Regeneration; Liver Regeneration Failure; Small For Size Syndrome

Indexed keywords

CELL NUCLEUS ANTIGEN; HISTONE H3; KI 67 ANTIGEN; PROTEIN P21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CHOLESTASIS; CONTROLLED STUDY; EXPERIMENTAL MODEL; EXTENDED HEPATECTOMY; LIVER CELL; LIVER DYSFUNCTION; LIVER FAILURE; LIVER REGENERATION; LIVER RESECTION; LIVER SINUSOID; LIVER WEIGHT; MITOSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PLOIDY; PRIORITY JOURNAL; SURVIVAL; WEIGHT GAIN;

EID: 84869848119     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2012.08.043     Document Type: Article

References (27)

1. P.A. Clavien, C.E. Oberkofler, D.A. Raptis What is critical for liver surgery and partial liver transplantation: size or quality? Hepatology 52 2010 715 729
2. P.A. Clavien, H. Petrowsky, M.L. DeOliveira Strategies for safer liver surgery and partial liver transplantation N Engl J Med 356 2007 1545 1559
3. G.K. Michalopoulos Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas Am J Pathol 176 2010 2 13
4. G. Cataldegirmen, S. Zeng, N. Feirt RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaB J Exp Med 201 2005 473 484
5. S. He, C. Atkinson, F. Qiao A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice J Clin Invest 119 2009 2304 2316
6. X. Jin, Z. Zhang, D. Beer-Stolz Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection Hepatology 46 2007 802 812
7. H. Rehman, J. Sun, Y. Shi NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy Transplantation 91 2011 406 412
8. J.H. Jang, W. Moritz, R. Graf Preconditioning with death ligands FasL and TNF-alpha protects the cirrhotic mouse liver against ischaemic injury Gut 57 2008 492 499
9. C. Heinlein, D. Speidel High-resolution cell cycle and DNA ploidy analysis in tissue samples Curr Protoc Cytom 2011 39 Chapter 7, Unit 7
10. M. Ilmakunnas, E.M. Tukiainen, A. Rouhiainen High mobility group box 1 protein as a marker of hepatocellular injury in human liver transplantation Liver Transpl 14 2008 1517 1525
11. N. Yoshida, H. Iwata, T. Yamada Improvement of the survival rate after rat massive hepatectomy due to the reduction of apoptosis by caspase inhibitor J Gastroenterol Hepatol 22 2007 2015 2021
12. M. Malumbres, M. Barbacid Cell cycle, CDKs and cancer: a changing paradigm Nat Rev Cancer 9 2009 153 166
13. R. Boutros, C. Dozier, B. Ducommun The when and wheres of CDC25 phosphatases Curr Opin Cell Biol 18 2006 185 191
14. X. Wang, H. Kiyokawa, M.B. Dennewitz The forkhead box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration Proc Natl Acad Sci U S A 99 2002 16881 16886
15. T. Abbas, A. Dutta p21 in cancer: intricate networks and multiple activities Nat Rev Cancer 9 2009 400 414
16. I.C. Wang, Y.J. Chen, D. Hughes Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase Mol Cell Biol 25 2005 10875 10894
17. N. Fausto, J.S. Campbell, K.J. Riehle Liver regeneration Hepatology 43 2006 S45 S53
18. Y. Tian, W. Jochum, P. Georgiev Kupffer cell-dependent TNF-alpha signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse Proc Natl Acad Sci U S A 103 2006 4598 4603
19. H. Wu, M. Wade, L. Krall Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration Genes Dev 10 1996 245 260
20. J.H. Albrecht, R.Y. Poon, C.L. Ahonen Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver Oncogene 16 1998 2141 2150
21. T.T. Hui, T. Mizuguchi, N. Sugiyama Immediate early genes and p21 regulation in liver of rats with acute hepatic failure Am J Surg 183 2002 457 463
22. Y. Hong, P.J. Stambrook Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation Proc Natl Acad Sci U S A 101 2004 14443 14448
23. K. Bedelbaeva, A. Snyder, D. Gourevitch Lack of p21 expression links cell cycle control and appendage regeneration in mice Proc Natl Acad Sci U S A 107 2010 5845 5850
24. H. Willenbring, A.D. Sharma, A. Vogel Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis Cancer Cell 14 2008 59 67
25. K.L. Auer, J.S. Park, P. Seth Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice Biochem J 336 1998 551 560
26. M. Penzo, P.E. Massa, E. Olivotto Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1 J Cell Physiol 218 2009 215 227
27. M. Ninomiya, K. Shirabe, T. Terashi Deceleration of regenerative response improves the outcome of rat with massive hepatectomy Am J Transplant 10 2010 1580 1587