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Volumn 11, Issue 2, 2013, Pages 65-74

Corneal crosslinking with riboflavin and ultraviolet A. I. principles

Author keywords

Cornea; Crosslinking; Keratectasia; Keratoconus; Riboflavin; Ultraviolet radiation

Indexed keywords

RIBOFLAVIN;

EID: 84876536307     PISSN: 15420124     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jtos.2013.01.002     Document Type: Review
Times cited : (228)

References (111)
  • 1
    • 0026522950 scopus 로고
    • Ageing of the human corneal stroma: Structural and biochemical changes
    • Malik NS, Moss SJ, Ahmed N, et al. Ageing of the human corneal stroma: structural and biochemical changes. Biochim Biophys Acta 1992;1138:222-8
    • (1992) Biochim Biophys Acta , vol.1138 , pp. 222-228
    • Malik, N.S.1    Moss, S.J.2    Ahmed, N.3
  • 2
    • 0028807851 scopus 로고
    • Advanced Maillard reaction and crosslinking of corneal collagen in diabetes
    • Sady C, Khosrof S, Nagaraj R. Advanced Maillard reaction and crosslinking of corneal collagen in diabetes. Biochem Biophys Res Commun 1995;214:793-7
    • (1995) Biochem Biophys Res Commun , vol.214 , pp. 793-797
    • Sady, C.1    Khosrof, S.2    Nagaraj, R.3
  • 3
    • 0032401898 scopus 로고    scopus 로고
    • Mechanisms of maturation and ageing of collagen
    • Bailey AJ, Paul RG, Knott L. Mechanisms of maturation and ageing of collagen. Mech Ageing Dev 1998;106:1-56
    • (1998) Mech Ageing Dev , vol.106 , pp. 1-56
    • Bailey, A.J.1    Paul, R.G.2    Knott, L.3
  • 4
    • 1542667179 scopus 로고    scopus 로고
    • Increased resistance of crosslinked cornea against enzymatic digestion
    • Spoerl E, Wollensak G, Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 2004;29:35-40
    • (2004) Curr Eye Res , vol.29 , pp. 35-40
    • Spoerl, E.1    Wollensak, G.2    Seiler, T.3
  • 5
    • 77958041974 scopus 로고    scopus 로고
    • Collagen cross-linking: Strengthening the unstable cornea
    • Tomkins O, Garzozi HJ. Collagen cross-linking: Strengthening the unstable cornea. Clin Ophthalmol 2008;2:863-7
    • (2008) Clin Ophthalmol , vol.2 , pp. 863-867
    • Tomkins, O.1    Garzozi, H.J.2
  • 6
    • 0019128538 scopus 로고
    • Biomechanical properties of keratoconus and normal corneas
    • Andreassen TT, Simonsen AH, Oxlund H. Biomechanical properties of keratoconus and normal corneas. Exp Eye Res 1980;31:435-41
    • (1980) Exp Eye Res , vol.31 , pp. 435-441
    • Andreassen, T.T.1    Simonsen, A.H.2    Oxlund, H.3
  • 8
    • 33747069382 scopus 로고    scopus 로고
    • Post-laser insitu keratomileusis ectasia: Current understanding and future directions
    • Randleman JB. Post-laser insitu keratomileusis ectasia: current understanding and future directions. Curr Opin Ophthalmol 2006;17:406-12
    • (2006) Curr Opin Ophthalmol , vol.17 , pp. 406-412
    • Randleman, J.B.1
  • 9
    • 33847014493 scopus 로고    scopus 로고
    • Assessment of corneal biomechanical properties and their variation with age
    • Elsheikh A, Wang D, Brown M, et al. Assessment of corneal biomechanical properties and their variation with age. Curr Eye Res 2007;32:11-9
    • (2007) Curr Eye Res , vol.32 , pp. 11-19
    • Elsheikh, A.1    Wang, D.2    Brown, M.3
  • 11
    • 0031412417 scopus 로고    scopus 로고
    • Influence of cigarette smoke on cross-linking of dermal collagen
    • Madhukumar E, Vijayammal PL. Influence of cigarette smoke on cross-linking of dermal collagen. Indian J Exp Biol 1997;35:483-6
    • (1997) Indian J Exp Biol , vol.35 , pp. 483-486
    • Madhukumar, E.1    Vijayammal, P.L.2
  • 13
  • 14
    • 33644833756 scopus 로고    scopus 로고
    • Photochemical crosslinking improves the physicochemical properties of collagen scaffolds
    • Chan BP, So KF. Photochemical crosslinking improves the physicochemical properties of collagen scaffolds. J Biomed Mater Res A 2005;75:689-701
    • (2005) J Biomed Mater Res A , vol.75 , pp. 689-701
    • Chan, B.P.1    So, K.F.2
  • 15
    • 0037405409 scopus 로고    scopus 로고
    • Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus
    • Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 2003;135:620-7
    • (2003) Am J Ophthalmol , vol.135 , pp. 620-627
    • Wollensak, G.1    Spoerl, E.2    Seiler, T.3
  • 16
    • 35348851125 scopus 로고    scopus 로고
    • Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis
    • Hafezi F, Kanellopoulos J, Wiltfang R, Seiler T. Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis. J Cataract Refract Surg 2007;33: 2035-40
    • (2007) J Cataract Refract Surg , vol.33 , pp. 2035-2040
    • Hafezi, F.1    Kanellopoulos, J.2    Wiltfang, R.3    Seiler, T.4
  • 17
    • 20444468883 scopus 로고    scopus 로고
    • A new treatment of keratectasia after LASIK by using collagen with riboflavin/UVA light cross-linking
    • German
    • Kohlhaas M, Spoerl E, Speck A, et al. [A new treatment of keratectasia after LASIK by using collagen with riboflavin/UVA light cross-linking]. Klin Monbl Augenheilkd 2005;222:430-6. German
    • (2005) Klin Monbl Augenheilkd , vol.222 , pp. 430-436
    • Kohlhaas, M.1    Spoerl, E.2    Speck, A.3
  • 19
    • 33749149463 scopus 로고    scopus 로고
    • Two-stage genome-wide linkage scan in keratoconus sib pair families
    • Li X, Rabinowitz YS, Tang YG, et al. Two-stage genome-wide linkage scan in keratoconus sib pair families. Invest Ophthalmol Vis Sci 2006;47:3791-5
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 3791-3795
    • Li, X.1    Rabinowitz, Y.S.2    Tang, Y.G.3
  • 20
    • 84866285805 scopus 로고    scopus 로고
    • Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and casecontrol studies
    • Bykhovskaya Y, Li X, Epifantseva I, et al. Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and casecontrol studies. Invest Ophthalmol Vis Sci 2012;53:4152-7
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 4152-4157
    • Bykhovskaya, Y.1    Li, X.2    Epifantseva, I.3
  • 21
    • 79961193704 scopus 로고    scopus 로고
    • The role of tear acidity and Cu-cofactor of lysyl oxidase activity in the pathogenesis of keratoconus
    • Russian
    • Avetisov S, Mamikonian V, Novikov I. [The role of tear acidity and Cu-cofactor of lysyl oxidase activity in the pathogenesis of keratoconus]. Vestn Oftalmol 2011;127:3-8. Russian
    • (2011) Vestn Oftalmol , vol.127 , pp. 3-8
    • Avetisov, S.1    Mamikonian, V.2    Novikov, I.3
  • 22
    • 0032575579 scopus 로고    scopus 로고
    • Altered posttranslational modifications of collagen in keloid
    • Uzawa K, Marshall MK, Katz EP, et al. Altered posttranslational modifications of collagen in keloid. Biochem Biophys Res Commun 1998;249:652-5
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 652-655
    • Uzawa, K.1    Marshall, M.K.2    Katz, E.P.3
  • 23
    • 0032755904 scopus 로고    scopus 로고
    • Techniques for stiffening the cornea
    • Spoerl E, Seiler T. Techniques for stiffening the cornea. J Refract Surg 1999;15:711-3
    • (1999) J Refract Surg , vol.15 , pp. 711-713
    • Spoerl, E.1    Seiler, T.2
  • 24
    • 50849122668 scopus 로고    scopus 로고
    • Aliphatic beta-nitro alcohols for non-enzymatic collagen cross-linking of scleral tissue
    • Paik DC, Wen Q, Airiani S, et al. Aliphatic beta-nitro alcohols for non-enzymatic collagen cross-linking of scleral tissue. Exp Eye Res 2008;87:279-85
    • (2008) Exp Eye Res , vol.87 , pp. 279-285
    • Paik, D.C.1    Wen, Q.2    Airiani, S.3
  • 25
    • 62649083211 scopus 로고    scopus 로고
    • Initial studies using aliphatic beta-nitro alcohols for therapeutic corneal cross-linking
    • Paik DC, Wen Q, Braunstein RE, et al. Initial studies using aliphatic beta-nitro alcohols for therapeutic corneal cross-linking. Invest Ophthalmol Vis Sci 2009;50:1098-105
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1098-1105
    • Paik, D.C.1    Wen, Q.2    Braunstein, R.E.3
  • 26
    • 84860873615 scopus 로고    scopus 로고
    • Corneal crosslinking with genipin, comparison with UV-Riboflavin in exvivo model
    • Avila MY, Gerena VA, Navia JL. Corneal crosslinking with genipin, comparison with UV-Riboflavin in exvivo model. Mol Vis 2012;18: 1068-73
    • (2012) Mol Vis , vol.18 , pp. 1068-1073
    • Avila, M.Y.1    Gerena, V.A.2    Navia, J.L.3
  • 27
    • 77950132645 scopus 로고    scopus 로고
    • Effect of genipin collagen crosslinking on porcine corneas
    • Avila MY, Navia JL. Effect of genipin collagen crosslinking on porcine corneas. J Cataract Refract Surg 2010;36:659-64
    • (2010) J Cataract Refract Surg , vol.36 , pp. 659-664
    • Avila, M.Y.1    Navia, J.L.2
  • 28
    • 31644447812 scopus 로고    scopus 로고
    • Is there an association between diabetes and keratoconus?
    • Kuo IC, Broman A, Pirouzmanesh A, Melia M. Is there an association between diabetes and keratoconus? Ophthalmology 2006;113: 184-90
    • (2006) Ophthalmology , vol.113 , pp. 184-190
    • Kuo, I.C.1    Broman, A.2    Pirouzmanesh, A.3    Melia, M.4
  • 30
    • 10944254240 scopus 로고    scopus 로고
    • Kinetics for singlet oxygen formation by riboflavin photosensitization and the reaction between riboflavin and singlet oxygen
    • Huang R, Choe E, Min DB. Kinetics for singlet oxygen formation by riboflavin photosensitization and the reaction between riboflavin and singlet oxygen. J Food Sci 2004;69:C726-32
    • (2004) J Food Sci , vol.69
    • Huang, R.1    Choe, E.2    Min, D.B.3
  • 33
    • 4243238315 scopus 로고    scopus 로고
    • Molecular pathology of dityrosine cross-links in proteins: Structural and functional analysis of four proteins
    • Balasubramanian D, Kanwar R. Molecular pathology of dityrosine cross-links in proteins: structural and functional analysis of four proteins. Mol Cell Biochem 2002;234-235:27-38
    • (2002) Mol Cell Biochem , vol.234-235 , pp. 27-38
    • Balasubramanian, D.1    Kanwar, R.2
  • 34
    • 0028386526 scopus 로고
    • Aggregation of collagen exposed to UVA in the presence of riboflavin: A plausible role of tyrosine modification
    • Kato Y, Uchida K, Kawakishi S. Aggregation of collagen exposed to UVA in the presence of riboflavin: a plausible role of tyrosine modification. Photochem Photobiol 1994;59:343-9
    • (1994) Photochem Photobiol , vol.59 , pp. 343-349
    • Kato, Y.1    Uchida, K.2    Kawakishi, S.3
  • 35
    • 84871690842 scopus 로고    scopus 로고
    • Stiffening of rabbit corneas by the bacteriochlorphyll derivate WST11 using near infrared light
    • Marcovich AL, Brandis A, Daphna O, et al. Stiffening of rabbit corneas by the bacteriochlorphyll derivate WST11 using near infrared light. Invest Ophthalmol Vis Sci 2012;53:6378-88
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 6378-6388
    • Marcovich, A.L.1    Brandis, A.2    Daphna, O.3
  • 36
    • 75749104200 scopus 로고    scopus 로고
    • Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA)
    • McCall AS, Kraft S, Edelhauser HF, et al. Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA). Invest Ophthalmol Vis Sci 2010;51:129-38
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 129-138
    • McCall, A.S.1    Kraft, S.2    Edelhauser, H.F.3
  • 37
    • 80053543136 scopus 로고    scopus 로고
    • The role of non-enzymatic glycation and carbonyls in collagen crosslinking for the treatment of keratoconus
    • Brummer G, Littlechild S, McCall S, et al. The role of non-enzymatic glycation and carbonyls in collagen crosslinking for the treatment of keratoconus. Invest Ophthalmol Vis Sci 2011;52:6363-9
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 6363-6369
    • Brummer, G.1    Littlechild, S.2    McCall, S.3
  • 38
    • 79953869354 scopus 로고    scopus 로고
    • Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking
    • Zhang Y, Conrad AH, Conrad GW. Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking. J Biol Chem 2011;286:13011-22
    • (2011) J Biol Chem , vol.286 , pp. 13011-13022
    • Zhang, Y.1    Conrad, A.H.2    Conrad, G.W.3
  • 39
    • 79956363647 scopus 로고    scopus 로고
    • Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light
    • Wollensak G, Sporl E, Mazzotta C, et al. Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light. Br J Ophthalmol 2011;95:876-80
    • (2011) Br J Ophthalmol , vol.95 , pp. 876-880
    • Wollensak, G.1    Sporl, E.2    Mazzotta, C.3
  • 40
    • 0342748630 scopus 로고    scopus 로고
    • Studies on the stabilization of the cornea in rabbits
    • German
    • Sporl E, Schreiber J, Hellmund K, et al. [Studies on the stabilization of the cornea in rabbits]. Ophthalmologe 2000;97:203-6. German
    • (2000) Ophthalmologe , vol.97 , pp. 203-206
    • Sporl, E.1    Schreiber, J.2    Hellmund, K.3
  • 41
    • 41249090511 scopus 로고    scopus 로고
    • Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy
    • Hayes S, O'Brart DP, Lamdin LS, et al. Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy. J Cataract Refract Surg 2008;34:657-61
    • (2008) J Cataract Refract Surg , vol.34 , pp. 657-661
    • Hayes, S.1    O'Brart, D.P.2    Lamdin, L.S.3
  • 42
    • 34247562727 scopus 로고    scopus 로고
    • Safety of UVA-riboflavin crosslinking of the cornea
    • Spoerl E, Mrochen M, Sliney D, et al. Safety of UVA-riboflavin crosslinking of the cornea. Cornea 2007;26:385-9
    • (2007) Cornea , vol.26 , pp. 385-389
    • Spoerl, E.1    Mrochen, M.2    Sliney, D.3
  • 43
    • 84858979333 scopus 로고    scopus 로고
    • Optimization model for UV-riboflavin corneal cross-linking
    • Schumacher S, Mrochen M, Wernli J, et al. Optimization model for UV-riboflavin corneal cross-linking. Invest Ophthalmol Vis Sci 2012;53:762-9
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 762-769
    • Schumacher, S.1    Mrochen, M.2    Wernli, J.3
  • 44
    • 79956060409 scopus 로고    scopus 로고
    • High-resolution, noninvasive, twophoton fluorescence measurement of molecular concentrations in corneal tissue
    • Cui L, Huxlin KR, Xu L, et al. High-resolution, noninvasive, twophoton fluorescence measurement of molecular concentrations in corneal tissue. Invest Ophthalmol Vis Sci 2011;52:2556-64
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 2556-2564
    • Cui, L.1    Huxlin, K.R.2    Xu, L.3
  • 45
    • 77955866438 scopus 로고    scopus 로고
    • Influence of corneal collagen crosslinking with riboflavin and ultraviolet-A irradiation on excimer laser surgery
    • Kampik D, Ralla B, Keller S, et al. Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery. Invest Ophthalmol Vis Sci 2010;51:3929-34
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 3929-3934
    • Kampik, D.1    Ralla, B.2    Keller, S.3
  • 46
    • 77958489783 scopus 로고    scopus 로고
    • Correlation between UV absorption and riboflavin concentration in different depths of the cornea in CXL
    • author reply 1042-3
    • Spoerl E, Raiskup F, Kampik D, Geerling G. Correlation between UV absorption and riboflavin concentration in different depths of the cornea in CXL. Curr Eye Res 2010;35:1040-1. author reply 1042-3
    • (2010) Curr Eye Res , vol.35 , pp. 1040-1041
    • Spoerl, E.1    Raiskup, F.2    Kampik, D.3    Geerling, G.4
  • 47
    • 84887022468 scopus 로고    scopus 로고
    • Advanced corneal crosslinking system with fluorescence dosimetry
    • Friedman MD, Pertaub R, Usher D, et al. Advanced corneal crosslinking system with fluorescence dosimetry. J Ophthalmol 2012;2012: 303459
    • (2012) J Ophthalmol , vol.2012 , pp. 303459
    • Friedman, M.D.1    Pertaub, R.2    Usher, D.3
  • 48
    • 77955155937 scopus 로고    scopus 로고
    • Corneal collagen cross-linking with riboflavin
    • Boxer Wachler BS. Corneal collagen cross-linking with riboflavin. Cataract Refract Surg Today 2005;1:73-4
    • (2005) Cataract Refract Surg Today , vol.1 , pp. 73-74
    • Boxer Wachler, B.S.1
  • 49
    • 77955156697 scopus 로고    scopus 로고
    • Corneal crosslinking with riboflavin: Entering a new era in ophthalmology
    • Pinelli R. Corneal crosslinking with riboflavin: Entering a new era in ophthalmology. Ophthalmology Times Europe 2006;2:36-8
    • (2006) Ophthalmology Times Europe , vol.2 , pp. 36-38
    • Pinelli, R.1
  • 50
    • 61549117787 scopus 로고    scopus 로고
    • Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement
    • Wollensak G, Iomdina E. Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 2009;35:540-6
    • (2009) J Cataract Refract Surg , vol.35 , pp. 540-546
    • Wollensak, G.1    Iomdina, E.2
  • 51
    • 77955149133 scopus 로고    scopus 로고
    • Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/Riboflavin corneal collagen cross-linking
    • Kissner A, Spoerl E, Jung R, et al. Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/Riboflavin corneal collagen cross-linking. Curr Eye Res 2010;35:715-21
    • (2010) Curr Eye Res , vol.35 , pp. 715-721
    • Kissner, A.1    Spoerl, E.2    Jung, R.3
  • 52
    • 84857391941 scopus 로고    scopus 로고
    • Riboflavin osmolar modification for transepithelial corneal cross-linking
    • Raiskup F, Pinelli R, Spoerl E. Riboflavin osmolar modification for transepithelial corneal cross-linking. Curr Eye Res 2012;37:234-8
    • (2012) Curr Eye Res , vol.37 , pp. 234-238
    • Raiskup, F.1    Pinelli, R.2    Spoerl, E.3
  • 53
    • 67649986425 scopus 로고    scopus 로고
    • NC-1059: A channel-forming peptide that modulates drug delivery across in vitro corneal epithelium
    • Martin J, Malreddy P, Iwamoto T, et al. NC-1059: a channel-forming peptide that modulates drug delivery across in vitro corneal epithelium. Invest Ophthalmol Vis Sci 2009;50:3337-45
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 3337-3345
    • Martin, J.1    Malreddy, P.2    Iwamoto, T.3
  • 54
    • 43049091861 scopus 로고    scopus 로고
    • Epithelial barrier modulation by a channel forming peptide
    • Somasekharan S, Brandt R, Iwamoto T, et al. Epithelial barrier modulation by a channel forming peptide. J Membr Biol 2008;222:17-30
    • (2008) J Membr Biol , vol.222 , pp. 17-30
    • Somasekharan, S.1    Brandt, R.2    Iwamoto, T.3
  • 55
    • 84860602158 scopus 로고    scopus 로고
    • Effect of the synthetic NC-1059 peptide on diffusion of riboflavin across an intact corneal epithelium
    • Zhang Y, Sukthankar P, Tomich JM, Conrad GW. Effect of the synthetic NC-1059 peptide on diffusion of riboflavin across an intact corneal epithelium. Invest Ophthalmol Vis Sci 2012;53:2620-9
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 2620-2629
    • Zhang, Y.1    Sukthankar, P.2    Tomich, J.M.3    Conrad, G.W.4
  • 56
    • 84876569392 scopus 로고    scopus 로고
    • The future of corneal collagen crosslinking
    • Jan
    • Cummings A, Daya SM, Kanellopoulos AJ, et al. The future of corneal collagen crosslinking. Cataract Refract Surg Today Europe 2011:36-58. Jan. http://bmctoday.net/crstodayeurope/2011/01/article. asp?f=the-future-of-corneal- collagen-crosslinking
    • (2011) Cataract Refract Surg Today Europe , pp. 36-58
    • Cummings, A.1    Daya, S.M.2    Kanellopoulos, A.J.3
  • 57
    • 77958151123 scopus 로고    scopus 로고
    • Corneal crosslinking and visual rehabilitation in keratoconus in one session without epithelial debridement: New technique
    • Daxer A, Mahmoud HA, Venkateswaran RS. Corneal crosslinking and visual rehabilitation in keratoconus in one session without epithelial debridement: new technique. Cornea 2010;29:1176-9
    • (2010) Cornea , vol.29 , pp. 1176-1179
    • Daxer, A.1    Mahmoud, H.A.2    Venkateswaran, R.S.3
  • 58
    • 71549169919 scopus 로고    scopus 로고
    • Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen crosslinking for keratoconus
    • Coskunseven E, Jankov 2nd MR, Hafezi F, et al. Effect of treatment sequence in combined intrastromal corneal rings and corneal collagen crosslinking for keratoconus. J Cataract Refract Surg 2009;35:2084-91
    • (2009) J Cataract Refract Surg , vol.35 , pp. 2084-2091
    • Coskunseven, E.1    Jankov II, M.R.2    Hafezi, F.3
  • 59
    • 70349306376 scopus 로고    scopus 로고
    • Refractive and topographic results of transepithelial cross-linking treatment in eyes with intacs
    • Ertan A, Karacal H, Kamburoglu G. Refractive and topographic results of transepithelial cross-linking treatment in eyes with intacs. Cornea 2009;28:719-23
    • (2009) Cornea , vol.28 , pp. 719-723
    • Ertan, A.1    Karacal, H.2    Kamburoglu, G.3
  • 60
    • 51149091672 scopus 로고    scopus 로고
    • Intacs implantation with sequential collagen cross-linking treatment in postoperative LASIK ectasia
    • Kamburoglu G, Ertan A. Intacs implantation with sequential collagen cross-linking treatment in postoperative LASIK ectasia. J Refract Surg 2008;24:S726-9
    • (2008) J Refract Surg , vol.24
    • Kamburoglu, G.1    Ertan, A.2
  • 61
    • 77955303947 scopus 로고    scopus 로고
    • Hollow microneedle arrays for intradermal drug delivery and DNA electroporation
    • Daugimont L, Baron N, Vandermeulen G, et al. Hollow microneedle arrays for intradermal drug delivery and DNA electroporation. J Membr Biol 2010;236:117-25
    • (2010) J Membr Biol , vol.236 , pp. 117-125
    • Daugimont, L.1    Baron, N.2    Vandermeulen, G.3
  • 62
    • 85019394194 scopus 로고    scopus 로고
    • Comparative stress strain measurements of human corneas after transepithelial UV-induced cross-linking: Impregnation with iontophoresis, different riboflavin solutions and irradiance power
    • E-abstract #1518
    • Vinciguerra R, Spoerl E, Romano MR, et al. Comparative stress strain measurements of human corneas after transepithelial UV-induced cross-linking: impregnation with iontophoresis, different riboflavin solutions and irradiance power. Invest Ophthalmol Vis Sci 2012;53. E-abstract #1518
    • (2012) Invest Ophthalmol Vis Sci , pp. 53
    • Vinciguerra, R.1    Spoerl, E.2    Romano, M.R.3
  • 63
    • 0036896206 scopus 로고    scopus 로고
    • Corneal thickness indices discriminate between keratoconus and contact lens-induced corneal thinning
    • Pflugfelder SC, Liu Z, Feuer W, Verm A. Corneal thickness indices discriminate between keratoconus and contact lens-induced corneal thinning. Ophthalmology 2002;109:2336-41
    • (2002) Ophthalmology , vol.109 , pp. 2336-2341
    • Pflugfelder, S.C.1    Liu, Z.2    Feuer, W.3    Verm, A.4
  • 65
  • 66
    • 79953020387 scopus 로고    scopus 로고
    • Laboratory measurement of the absorption coefficient of riboflavin for ultraviolet light (365 nm)
    • Iseli HP, Popp M, Seiler T, et al. Laboratory measurement of the absorption coefficient of riboflavin for ultraviolet light (365 nm). J Refract Surg 2011;27:195-201
    • (2011) J Refract Surg , vol.27 , pp. 195-201
    • Iseli, H.P.1    Popp, M.2    Seiler, T.3
  • 67
    • 0031941909 scopus 로고    scopus 로고
    • Induction of cross-links in corneal tissue
    • Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res 1998;66:97-103
    • (1998) Exp Eye Res , vol.66 , pp. 97-103
    • Spoerl, E.1    Huhle, M.2    Seiler, T.3
  • 68
    • 38949201710 scopus 로고    scopus 로고
    • Non-destructive mechanical characterisation of UVA/riboflavin crosslinked collagen hydrogels
    • Ahearne M, Yang Y, Then KY, Liu KK. Non-destructive mechanical characterisation of UVA/riboflavin crosslinked collagen hydrogels. Br J Ophthalmol 2008;92:268-71
    • (2008) Br J Ophthalmol , vol.92 , pp. 268-271
    • Ahearne, M.1    Yang, Y.2    Then, K.Y.3    Liu, K.K.4
  • 69
    • 80052704832 scopus 로고    scopus 로고
    • Biomechanical property analysis after corneal collagen cross-linking in relation to ultraviolet A irradiation time
    • Lanchares E, Del Buey MA, Cristobal JA, et al. Biomechanical property analysis after corneal collagen cross-linking in relation to ultraviolet A irradiation time. Graefes Arch Clin Exp Ophthalmol 2011;249:1223-7
    • (2011) Graefes Arch Clin Exp Ophthalmol , vol.249 , pp. 1223-1227
    • Lanchares, E.1    Del Buey, M.A.2    Cristobal, J.A.3
  • 70
    • 22144450962 scopus 로고    scopus 로고
    • Thermal stability of UV-irradiated collagen in bovine lens capsules and in bovine cornea
    • Sionkowska A. Thermal stability of UV-irradiated collagen in bovine lens capsules and in bovine cornea. J Photochem Photobiol B 2005;80:87-92
    • (2005) J Photochem Photobiol B , vol.80 , pp. 87-92
    • Sionkowska, A.1
  • 72
    • 84874983825 scopus 로고    scopus 로고
    • The efficacy of corneal cross-linking shows a sudden decrease with very high intensity UV-light and short treatment time
    • Jan 8. Epub ahead of print
    • Wernli J, Schumacher S, Spoerl E, Mrochen M. The efficacy of corneal cross-linking shows a sudden decrease with very high intensity UV-light and short treatment time. Invest Ophthalmol Vis Sci 2013 Jan 8. Epub ahead of print
    • (2013) Invest Ophthalmol Vis Sci
    • Wernli, J.1    Schumacher, S.2    Spoerl, E.3    Mrochen, M.4
  • 73
    • 0141707873 scopus 로고    scopus 로고
    • Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking
    • Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg 2003;29:1780-5
    • (2003) J Cataract Refract Surg , vol.29 , pp. 1780-1785
    • Wollensak, G.1    Spoerl, E.2    Seiler, T.3
  • 74
    • 33645311253 scopus 로고    scopus 로고
    • Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light
    • Kohlhaas M, Spoerl E, Schilde T, et al. Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg 2006;32:279-83
    • (2006) J Cataract Refract Surg , vol.32 , pp. 279-283
    • Kohlhaas, M.1    Spoerl, E.2    Schilde, T.3
  • 75
    • 33847152526 scopus 로고    scopus 로고
    • Hydration behavior of porcine cornea crosslinked with riboflavin and ultraviolet A
    • Wollensak G, Aurich H, Pham DT, Wirbelauer C. Hydration behavior of porcine cornea crosslinked with riboflavin and ultraviolet A. J Cataract Refract Surg 2007;33:516-21
    • (2007) J Cataract Refract Surg , vol.33 , pp. 516-521
    • Wollensak, G.1    Aurich, H.2    Pham, D.T.3    Wirbelauer, C.4
  • 76
    • 48549095568 scopus 로고    scopus 로고
    • Riboflavin-ultraviolet light induced cross-linking in endothelial decompensation
    • Ehlers N, Hjortdal J. Riboflavin-ultraviolet light induced cross-linking in endothelial decompensation. Acta Ophthalmol 2008;86:549-51
    • (2008) Acta Ophthalmol , vol.86 , pp. 549-551
    • Ehlers, N.1    Hjortdal, J.2
  • 77
    • 1542667180 scopus 로고    scopus 로고
    • Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA
    • Wollensak G, Wilsch M, Spoerl E, Seiler T. Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA. Cornea 2004;23:503-7
    • (2004) Cornea , vol.23 , pp. 503-507
    • Wollensak, G.1    Wilsch, M.2    Spoerl, E.3    Seiler, T.4
  • 78
    • 33746702777 scopus 로고    scopus 로고
    • Collagenolytic proteinases in keratoconus
    • Mackiewicz Z, Maatta M, Stenman M, et al. Collagenolytic proteinases in keratoconus. Cornea 2006;25:603-10
    • (2006) Cornea , vol.25 , pp. 603-610
    • MacKiewicz, Z.1    Maatta, M.2    Stenman, M.3
  • 79
    • 33645987912 scopus 로고    scopus 로고
    • EMMPRIN and MMP-1 in keratoconus
    • Seppala HP, Maatta M, Rautia M, et al. EMMPRIN and MMP-1 in keratoconus. Cornea 2006;25:325-30
    • (2006) Cornea , vol.25 , pp. 325-330
    • Seppala, H.P.1    Maatta, M.2    Rautia, M.3
  • 80
    • 41149107466 scopus 로고    scopus 로고
    • Gel electrophoretic analysis of corneal collagen after photodynamic cross-linking treatment
    • Wollensak G, Redl B. Gel electrophoretic analysis of corneal collagen after photodynamic cross-linking treatment. Cornea 2008;27:353-6
    • (2008) Cornea , vol.27 , pp. 353-356
    • Wollensak, G.1    Redl, B.2
  • 81
    • 58249089422 scopus 로고    scopus 로고
    • Exogenous collagen crosslinking reduces scleral permeability: Modeling the effects of age-related cross-link accumulation
    • Stewart JM, Schultz DS, Lee OT, Trinidad ML. Exogenous collagen crosslinking reduces scleral permeability: modeling the effects of age-related cross-link accumulation. Invest Ophthalmol Vis Sci 2009;50:352-7
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 352-357
    • Stewart, J.M.1    Schultz, D.S.2    Lee, O.T.3    Trinidad, M.L.4
  • 83
    • 34249063730 scopus 로고    scopus 로고
    • Riboflavin and ultraviolet A collagen crosslinking: In vivo thermographic analysis of the corneal surface
    • Mencucci R, Mazzotta C, Rossi F, et al. Riboflavin and ultraviolet A collagen crosslinking: in vivo thermographic analysis of the corneal surface. J Cataract Refract Surg 2007;33:1005-8
    • (2007) J Cataract Refract Surg , vol.33 , pp. 1005-1008
    • Mencucci, R.1    Mazzotta, C.2    Rossi, F.3
  • 84
    • 40249106142 scopus 로고    scopus 로고
    • Enzymatic evidence of the depth dependence of stiffening on riboflavin/UVA treated corneas
    • German
    • Schilde T, Kohlhaas M, Spoerl E, Pillunat LE. [Enzymatic evidence of the depth dependence of stiffening on riboflavin/UVA treated corneas]. Ophthalmologe 2008;105:165-9. German
    • (2008) Ophthalmologe , vol.105 , pp. 165-169
    • Schilde, T.1    Kohlhaas, M.2    Spoerl, E.3    Pillunat, L.E.4
  • 85
    • 1542513294 scopus 로고    scopus 로고
    • Thermomechanical behavior of collagen-cross-linked porcine cornea
    • Spoerl E, Wollensak G, Dittert DD, Seiler T. Thermomechanical behavior of collagen-cross-linked porcine cornea. Ophthalmologica 2004;218:136-40
    • (2004) Ophthalmologica , vol.218 , pp. 136-140
    • Spoerl, E.1    Wollensak, G.2    Dittert, D.D.3    Seiler, T.4
  • 86
    • 38549099639 scopus 로고    scopus 로고
    • Effect of riboflavin-UVA-induced collagen cross-linking on intraocular pressure measurement
    • Romppainen T, Bachmann LM, Kaufmann C, et al. Effect of riboflavin-UVA-induced collagen cross-linking on intraocular pressure measurement. Invest Ophthalmol Vis Sci 2007;48:5494-8
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 5494-5498
    • Romppainen, T.1    Bachmann, L.M.2    Kaufmann, C.3
  • 87
    • 13844313434 scopus 로고    scopus 로고
    • Influence of corneal biomechanical properties on intraocular pressure measurement. Quantitative analysis
    • Liu J, Roberts CJ. Influence of corneal biomechanical properties on intraocular pressure measurement. Quantitative analysis. J Cataract Refract Surg 2005;31:146-55
    • (2005) J Cataract Refract Surg , vol.31 , pp. 146-155
    • Liu, J.1    Roberts, C.J.2
  • 88
    • 77957761776 scopus 로고    scopus 로고
    • Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus
    • Kymionis GD, Grentzelos MA, Kounis GA, et al. Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus. J Cataract Refract Surg 2010;36:1724-7
    • (2010) J Cataract Refract Surg , vol.36 , pp. 1724-1727
    • Kymionis, G.D.1    Grentzelos, M.A.2    Kounis, G.A.3
  • 89
    • 81355160554 scopus 로고    scopus 로고
    • Limbal and conjunctival epithelium after corneal cross-linking using riboflavin and UVA
    • Wollensak G, Mazzotta C, Kalinski T, Sel S. Limbal and conjunctival epithelium after corneal cross-linking using riboflavin and UVA. Cornea 2011;30:1448-54
    • (2011) Cornea , vol.30 , pp. 1448-1454
    • Wollensak, G.1    Mazzotta, C.2    Kalinski, T.3    Sel, S.4
  • 90
    • 84860471654 scopus 로고    scopus 로고
    • Morphological and functional correlations in riboflavin UV A corneal collagen cross-linking for keratoconus
    • Mazzotta C, Caporossi T, Denaro R, et al. Morphological and functional correlations in riboflavin UV A corneal collagen cross-linking for keratoconus. Acta Ophthalmol 2012;90:259-65
    • (2012) Acta Ophthalmol , vol.90 , pp. 259-265
    • Mazzotta, C.1    Caporossi, T.2    Denaro, R.3
  • 91
    • 4344690758 scopus 로고    scopus 로고
    • Keratocyte cytotoxicity of riboflavin/UVA-treatment in vitro
    • Wollensak G, Spoerl E, Reber F, Seiler T. Keratocyte cytotoxicity of riboflavin/UVA-treatment in vitro. Eye (Lond) 2004;18:718-22
    • (2004) Eye (Lond) , vol.18 , pp. 718-722
    • Wollensak, G.1    Spoerl, E.2    Reber, F.3    Seiler, T.4
  • 92
    • 0346788527 scopus 로고    scopus 로고
    • Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment
    • Wollensak G, Spoerl E, Wilsch M, Seiler T. Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment. Cornea 2004;23:43-9
    • (2004) Cornea , vol.23 , pp. 43-49
    • Wollensak, G.1    Spoerl, E.2    Wilsch, M.3    Seiler, T.4
  • 93
    • 77649204853 scopus 로고    scopus 로고
    • Histological changes in human cornea after crosslinking with riboflavin and ultraviolet A
    • Wollensak G. Histological changes in human cornea after crosslinking with riboflavin and ultraviolet A. Acta Ophthalmol 2010;88: e17-8
    • (2010) Acta Ophthalmol , vol.88
    • Wollensak, G.1
  • 94
    • 34547401572 scopus 로고    scopus 로고
    • Wound healing in the rabbit cornea after corneal collagen cross-linking with riboflavin and UVA
    • Wollensak G, Iomdina E, Dittert DD, Herbst H. Wound healing in the rabbit cornea after corneal collagen cross-linking with riboflavin and UVA. Cornea 2007;26:600-5
    • (2007) Cornea , vol.26 , pp. 600-605
    • Wollensak, G.1    Iomdina, E.2    Dittert, D.D.3    Herbst, H.4
  • 95
    • 78651376182 scopus 로고    scopus 로고
    • Short-term corneal response to cross-linking in rabbit eyes assessed by in vivo confocal laser scanning microscopy and histology
    • Hovakimyan M, Guthoff R, Knappe S, et al. Short-term corneal response to cross-linking in rabbit eyes assessed by in vivo confocal laser scanning microscopy and histology. Cornea 2011;30:196-203
    • (2011) Cornea , vol.30 , pp. 196-203
    • Hovakimyan, M.1    Guthoff, R.2    Knappe, S.3
  • 96
    • 77955175870 scopus 로고    scopus 로고
    • Significance of the lacunar hydration pattern after corneal cross linking
    • Wollensak G, Herbst H. Significance of the lacunar hydration pattern after corneal cross linking. Cornea 2010;29:899-903
    • (2010) Cornea , vol.29 , pp. 899-903
    • Wollensak, G.1    Herbst, H.2
  • 97
    • 64449087930 scopus 로고    scopus 로고
    • One-year follow-up of corneal confocal microscopy after corneal cross-linking in patients with post laser in situ keratosmileusis ectasia and keratoconus
    • 778 e1
    • Kymionis GD, Diakonis VF, Kalyvianaki M, et al. One-year follow-up of corneal confocal microscopy after corneal cross-linking in patients with post laser in situ keratosmileusis ectasia and keratoconus. Am J Ophthalmol 2009;147:774-8. 778 e1
    • (2009) Am J Ophthalmol , vol.147 , pp. 774-778
    • Kymionis, G.D.1    Diakonis, V.F.2    Kalyvianaki, M.3
  • 98
    • 51649086023 scopus 로고    scopus 로고
    • Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: Early and late modifications
    • Mazzotta C, Traversi C, Baiocchi S, et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 2008;146:527-33
    • (2008) Am J Ophthalmol , vol.146 , pp. 527-533
    • Mazzotta, C.1    Traversi, C.2    Baiocchi, S.3
  • 99
    • 77950948624 scopus 로고    scopus 로고
    • Effects of riboflavin/UVA corneal cross-linking on keratocytes and collagen fibres in human cornea
    • Mencucci R, Marini M, Paladini I, et al. Effects of riboflavin/UVA corneal cross-linking on keratocytes and collagen fibres in human cornea. Clin Experiment Ophthalmol 2010;38:49-56
    • (2010) Clin Experiment Ophthalmol , vol.38 , pp. 49-56
    • Mencucci, R.1    Marini, M.2    Paladini, I.3
  • 100
    • 77957659007 scopus 로고    scopus 로고
    • Sequential in vivo confocal microscopy study of corneal wound healing after cross-linking in patients with keratoconus
    • Croxatto JO, Tytiun AE, Argento CJ. Sequential in vivo confocal microscopy study of corneal wound healing after cross-linking in patients with keratoconus. J Refract Surg 2010;26:638-45
    • (2010) J Refract Surg , vol.26 , pp. 638-645
    • Croxatto, J.O.1    Tytiun, A.E.2    Argento, C.J.3
  • 101
    • 0348048841 scopus 로고    scopus 로고
    • Corneal endothelial cytotoxicity of riboflavin/UVA treatment in vitro
    • Wollensak G, Sporl E, Reber F, et al. Corneal endothelial cytotoxicity of riboflavin/UVA treatment in vitro. Ophthalmic Res 2003;35:324-8
    • (2003) Ophthalmic Res , vol.35 , pp. 324-328
    • Wollensak, G.1    Sporl, E.2    Reber, F.3
  • 102
    • 0141819135 scopus 로고    scopus 로고
    • Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit
    • Wollensak G, Spoerl E, Wilsch M, Seiler T. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg 2003;29:1786-90
    • (2003) J Cataract Refract Surg , vol.29 , pp. 1786-1790
    • Wollensak, G.1    Spoerl, E.2    Wilsch, M.3    Seiler, T.4
  • 103
    • 80055052392 scopus 로고    scopus 로고
    • Corneal nerve morphology and sensitivity changes after ultraviolet A/riboflavin treatment
    • Xia Y, Chai X, Zhou C, Ren Q. Corneal nerve morphology and sensitivity changes after ultraviolet A/riboflavin treatment. Exp Eye Res 2011;93:541-7
    • (2011) Exp Eye Res , vol.93 , pp. 541-547
    • Xia, Y.1    Chai, X.2    Zhou, C.3    Ren, Q.4
  • 104
    • 62449175732 scopus 로고    scopus 로고
    • Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas
    • Hafezi F, Mrochen M, Iseli HP, Seiler T. Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg 2009;35:621-4
    • (2009) J Cataract Refract Surg , vol.35 , pp. 621-624
    • Hafezi, F.1    Mrochen, M.2    Iseli, H.P.3    Seiler, T.4
  • 105
    • 0035062925 scopus 로고    scopus 로고
    • The specific architecture of the anterior stroma accounts for maintenance of corneal curvature
    • Muller LJ, Pels E, Vrensen GF. The specific architecture of the anterior stroma accounts for maintenance of corneal curvature. Br J Ophthalmol 2001;85:437-43
    • (2001) Br J Ophthalmol , vol.85 , pp. 437-443
    • Muller, L.J.1    Pels, E.2    Vrensen, G.F.3
  • 106
    • 79960699306 scopus 로고    scopus 로고
    • Limitation of collagen cross-linking with hypoosmolar riboflavin solution: Failure in an extremely thin cornea
    • Hafezi F. Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea. Cornea 2011;30:917-9
    • (2011) Cornea , vol.30 , pp. 917-919
    • Hafezi, F.1
  • 107
    • 79959613428 scopus 로고    scopus 로고
    • Corneal cross-linking with hypo-osmolar riboflavin solution in thin keratoconic corneas
    • Raiskup F, Spoerl E. Corneal cross-linking with hypo-osmolar riboflavin solution in thin keratoconic corneas. Am J Ophthalmol 2011;152:28-32
    • (2011) Am J Ophthalmol , vol.152 , pp. 28-32
    • Raiskup, F.1    Spoerl, E.2
  • 108
    • 79960158403 scopus 로고    scopus 로고
    • Efficacy of corneal collagen crosslinking using a custom epithelial debridement technique in thin corneas: A confocal microscopy study
    • Kaya V, Utine CA, Yilmaz OF. Efficacy of corneal collagen crosslinking using a custom epithelial debridement technique in thin corneas: a confocal microscopy study. J Refract Surg 2011;27:444-50
    • (2011) J Refract Surg , vol.27 , pp. 444-450
    • Kaya, V.1    Utine, C.A.2    Yilmaz, O.F.3
  • 109
    • 20244388815 scopus 로고    scopus 로고
    • Adjustment of guidelines for exposure of the eye to optical radiation from ocular instruments: Statement from a task group of the International Commission on Non-Ionizing Radiation Protection (ICNIRP)
    • Sliney D, Aron-Rosa D, DeLori F, et al. Adjustment of guidelines for exposure of the eye to optical radiation from ocular instruments: statement from a task group of the International Commission on Non-Ionizing Radiation Protection (ICNIRP). Appl Opt 2005;44:2162-76
    • (2005) Appl Opt , vol.44 , pp. 2162-2176
    • Sliney, D.1    Aron-Rosa, D.2    Delori, F.3
  • 110
    • 61549136331 scopus 로고    scopus 로고
    • Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: One-year analysis using Scheimpflug imaging
    • Grewal DS, Brar GS, Jain R, et al. Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg 2009;35:425-32
    • (2009) J Cataract Refract Surg , vol.35 , pp. 425-432
    • Grewal, D.S.1    Brar, G.S.2    Jain, R.3


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