메뉴 건너뛰기




Volumn 50, Issue 7, 2009, Pages 3337-3345

NC-1059: A channel-forming peptide that modulates drug delivery across in vitro corneal epithelium

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN; FLUORESCEIN SODIUM; LYSYLLYSYLLYSYLLYSYLALANYLALANYLARGINYLVALYLGLYCYLLEUCYLGLYCYLISOLEUCYLTHREONYLTHREONYLVALYLLEUCYLVALYLTHREONYLTHREONYLISOLEUCYLGLYCYLLEUCYLGLYCYLVALYLARGINYLALANYLALANINE; METHOTREXATE; NC 1059; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; DEXTRAN; DRUG DERIVATIVE; FLUORESCEIN; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; ION CHANNEL; NC-1059; PEPTIDE; TISSUE SCAFFOLD;

EID: 67649986425     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-3053     Document Type: Article
Times cited : (12)

References (58)
  • 1
    • 0017872741 scopus 로고
    • Penetration routes of topically applied eye medications
    • Doane MG, Jensen AD, Dohlman CH. Penetration routes of topically applied eye medications. Am J Ophthalmol. 1978;85:383-386.
    • (1978) Am J Ophthalmol , vol.85 , pp. 383-386
    • Doane, M.G.1    Jensen, A.D.2    Dohlman, C.H.3
  • 3
    • 0034733993 scopus 로고    scopus 로고
    • Modulation of epithelial and endothelial paracellular permeability by leukocytes
    • Edens HA, Parkos CA. Modulation of epithelial and endothelial paracellular permeability by leukocytes. Adv Drug Deliv Rev. 2000;41:315-328.
    • (2000) Adv Drug Deliv Rev , vol.41 , pp. 315-328
    • Edens, H.A.1    Parkos, C.A.2
  • 4
    • 0033672942 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: Nutrients, cytokines, and immune cells
    • Nusrat A, Turner JR, Madara JL. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol. 2000;279:G851-G857.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279
    • Nusrat, A.1    Turner, J.R.2    Madara, J.L.3
  • 5
    • 0030067318 scopus 로고    scopus 로고
    • Antagonistic regulation of tight junction dynamics by glucocorticoids and transforming growth factor-beta in mouse mammary epithelial cells
    • Woo PL, Cha HH, Singer KL, Firestone GL. Antagonistic regulation of tight junction dynamics by glucocorticoids and transforming growth factor-beta in mouse mammary epithelial cells. J Biol Chem. 1996;271:404-412.
    • (1996) J Biol Chem , vol.271 , pp. 404-412
    • Woo, P.L.1    Cha, H.H.2    Singer, K.L.3    Firestone, G.L.4
  • 6
    • 0034889218 scopus 로고    scopus 로고
    • Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation
    • Nguyen DA, Parlow AF, Neville MC. Hormonal regulation of tight junction closure in the mouse mammary epithelium during the transition from pregnancy to lactation. J Endocrinol. 2001;170: 347-356.
    • (2001) J Endocrinol , vol.170 , pp. 347-356
    • Nguyen, D.A.1    Parlow, A.F.2    Neville, M.C.3
  • 9
    • 0027255102 scopus 로고
    • Synthetic peptides and four-helix bundle proteins as model systems for the poreforming structure of channel proteins. II. Transmembrane segment M2 of the brain glycine receptor is a plausible candidate for the pore-lining structure
    • Reddy GL, Iwamoto T, Tomich JM, Montal M. Synthetic peptides and four-helix bundle proteins as model systems for the poreforming structure of channel proteins. II. Transmembrane segment M2 of the brain glycine receptor is a plausible candidate for the pore-lining structure. J Biol Chem. 1993;268:14608-14615.
    • (1993) J Biol Chem , vol.268 , pp. 14608-14615
    • Reddy, G.L.1    Iwamoto, T.2    Tomich, J.M.3    Montal, M.4
  • 10
    • 0037062632 scopus 로고    scopus 로고
    • Distinct structural elements that direct solution aggregation and membrane assembly in the channel-forming peptide M2GlyR
    • Broughman JR, Shank LP, Takeguchi W, et al. Distinct structural elements that direct solution aggregation and membrane assembly in the channel-forming peptide M2GlyR. Biochemistry. 2002;41: 7350-7358.
    • (2002) Biochemistry , vol.41 , pp. 7350-7358
    • Broughman, J.R.1    Shank, L.P.2    Takeguchi, W.3
  • 12
    • 41149165232 scopus 로고    scopus 로고
    • A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability
    • Becker U, Ehrhardt C, Schneider M, et al. A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability. Altern Lab Anim. 2008;36:33-44.
    • (2008) Altern Lab Anim , vol.36 , pp. 33-44
    • Becker, U.1    Ehrhardt, C.2    Schneider, M.3
  • 13
    • 0028953829 scopus 로고
    • An SV40-immortalized human corneal epithelial cell line and its characterization
    • Araki-Sasaki K, Ohashi Y, Sasabe T, et al. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci. 1995;36:614-621.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 614-621
    • Araki-Sasaki, K.1    Ohashi, Y.2    Sasabe, T.3
  • 14
    • 0034030506 scopus 로고    scopus 로고
    • Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology
    • Ryeom SW, Paul D, Goodenough DA. Truncation mutants of the tight junction protein ZO-1 disrupt corneal epithelial cell morphology. Mol Biol Cell. 2000;11:1687-1696.
    • (2000) Mol Biol Cell , vol.11 , pp. 1687-1696
    • Ryeom, S.W.1    Paul, D.2    Goodenough, D.A.3
  • 15
    • 0033653266 scopus 로고    scopus 로고
    • Corneal epithelial tight junctions and their response to lipopolysaccharide challenge
    • Yi X, Wang Y, Yu FS. Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Invest Ophthalmol Vis Sci. 2000;41:4093-4100.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 4093-4100
    • Yi, X.1    Wang, Y.2    Yu, F.S.3
  • 16
    • 0042343886 scopus 로고    scopus 로고
    • Production of fibronectin and tenascin isoforms and their role in the adhesion of human immortalized corneal epithelial cells
    • Filenius S, Tervo T, Virtanen I. Production of fibronectin and tenascin isoforms and their role in the adhesion of human immortalized corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003;44:3317-3325.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3317-3325
    • Filenius, S.1    Tervo, T.2    Virtanen, I.3
  • 17
    • 33746675805 scopus 로고    scopus 로고
    • SRC-family tyrosine kinases in wound-and ligand-induced epidermal growth factor receptor activation in human corneal epithelial cells
    • Xu KP, Yin J, Yu FS. SRC-family tyrosine kinases in wound-and ligand-induced epidermal growth factor receptor activation in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006;47: 2832-2839.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 2832-2839
    • Xu, K.P.1    Yin, J.2    Yu, F.S.3
  • 18
    • 33847700488 scopus 로고    scopus 로고
    • Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor
    • Xu KP, Yin J, Yu FS. Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor. Invest Ophthalmol Vis Sci. 2007;48:636-643.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 636-643
    • Xu, K.P.1    Yin, J.2    Yu, F.S.3
  • 19
    • 0037330631 scopus 로고    scopus 로고
    • A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test
    • Huhtala A, Alajuuma P, Burgalassi S, et al. A collaborative evaluation of the cytotoxicity of two surfactants by using the human corneal epithelial cell line and the WST-1 test. J Ocul Pharmacol Ther. 2003;19:11-21.
    • (2003) J Ocul Pharmacol Ther , vol.19 , pp. 11-21
    • Huhtala, A.1    Alajuuma, P.2    Burgalassi, S.3
  • 20
    • 0031961814 scopus 로고    scopus 로고
    • Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function
    • Tomich JM, Wallace D, Henderson K, et al. Aqueous solubilization of transmembrane peptide sequences with retention of membrane insertion and function. Biophys J. 1998;74:256-267.
    • (1998) Biophys J , vol.74 , pp. 256-267
    • Tomich, J.M.1    Wallace, D.2    Henderson, K.3
  • 21
    • 0344688189 scopus 로고    scopus 로고
    • Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells
    • Wang Y, Zhang J, Yi XJ, Yu FS. Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells. Exp Eye Res. 2004;78:125-136.
    • (2004) Exp Eye Res , vol.78 , pp. 125-136
    • Wang, Y.1    Zhang, J.2    Yi, X.J.3    Yu, F.S.4
  • 22
    • 2442585595 scopus 로고    scopus 로고
    • Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro
    • Cha SH, Lee JS, Oum BS, Kim CD. Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro. Clin Exp Ophthalmol. 2004;32:180-184.
    • (2004) Clin Exp Ophthalmol , vol.32 , pp. 180-184
    • Cha, S.H.1    Lee, J.S.2    Oum, B.S.3    Kim, C.D.4
  • 23
    • 0023936023 scopus 로고
    • Toxic endothelial degeneration in ocular surface disease treated with topical medications containing benzalkonium chloride
    • Lemp MA, Zimmerman LE. Toxic endothelial degeneration in ocular surface disease treated with topical medications containing benzalkonium chloride. Am J Ophthalmol. 1988;105:670-673.
    • (1988) Am J Ophthalmol , vol.105 , pp. 670-673
    • Lemp, M.A.1    Zimmerman, L.E.2
  • 24
    • 0027368535 scopus 로고
    • Human corneal epithelial primary cultures and cell lines with extended life span: In vitro model for ocular studies
    • Kahn CR, Young E, Lee IH, Rhim JS. Human corneal epithelial primary cultures and cell lines with extended life span: in vitro model for ocular studies. Invest Ophthalmol Vis Sci. 1993;34: 3429-3441.
    • (1993) Invest Ophthalmol Vis Sci , vol.34 , pp. 3429-3441
    • Kahn, C.R.1    Young, E.2    Lee, I.H.3    Rhim, J.S.4
  • 25
    • 0041382674 scopus 로고    scopus 로고
    • Development of genetically engineered tet HPV16-E6/E7 transduced human corneal epithelial clones having tight regulation of proliferation and normal differentiation
    • Mohan RR, Possin DE, Sinha S, Wilson SE. Development of genetically engineered tet HPV16-E6/E7 transduced human corneal epithelial clones having tight regulation of proliferation and normal differentiation. Exp Eye Res. 2003;77:395-407.
    • (2003) Exp Eye Res , vol.77 , pp. 395-407
    • Mohan, R.R.1    Possin, D.E.2    Sinha, S.3    Wilson, S.E.4
  • 26
    • 0032903944 scopus 로고    scopus 로고
    • Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies
    • Offord EA, Sharif NA, Mace K, et al. Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies. Invest Ophthalmol Vis Sci. 1999;40:1091-1101.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 1091-1101
    • Offord, E.A.1    Sharif, N.A.2    Mace, K.3
  • 27
    • 0032797273 scopus 로고    scopus 로고
    • Functional human corneal equivalents constructed from cell lines
    • Griffith M, Osborne R, Munger R, et al. Functional human corneal equivalents constructed from cell lines. Science. 1999;286:2169-2172.
    • (1999) Science , vol.286 , pp. 2169-2172
    • Griffith, M.1    Osborne, R.2    Munger, R.3
  • 28
    • 1842557335 scopus 로고    scopus 로고
    • Human corneal equivalent as cell culture model for in vitro drug permeation studies
    • Reichl S, Bednarz J, Muller-Goymann CC. Human corneal equivalent as cell culture model for in vitro drug permeation studies. Br J Ophthalmol. 2004;88:560-565.
    • (2004) Br J Ophthalmol , vol.88 , pp. 560-565
    • Reichl, S.1    Bednarz, J.2    Muller-Goymann, C.C.3
  • 30
    • 0015577521 scopus 로고
    • The activation of chloride transport by epinephrine and Db cyclic-AMP in the cornea of the rabbit
    • Klyce SD, Neufeld AH, Zadunaisky JA. The activation of chloride transport by epinephrine and Db cyclic-AMP in the cornea of the rabbit. Invest Ophthalmol. 1973;12:127-139.
    • (1973) Invest Ophthalmol , vol.12 , pp. 127-139
    • Klyce, S.D.1    Neufeld, A.H.2    Zadunaisky, J.A.3
  • 31
    • 36849010158 scopus 로고    scopus 로고
    • Electrophysiological characterization of tight junctional pathway of rabbit cornea treated with ophthalmic ingredients
    • Nakamura T, Yamada M, Teshima M, et al. Electrophysiological characterization of tight junctional pathway of rabbit cornea treated with ophthalmic ingredients. Biol Pharm Bull. 2007;30: 2360-2364.
    • (2007) Biol Pharm Bull , vol.30 , pp. 2360-2364
    • Nakamura, T.1    Yamada, M.2    Teshima, M.3
  • 32
    • 0141678821 scopus 로고    scopus 로고
    • Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells
    • Ranta VP, Laavola M, Toropainen E, Vellonen KS, Talvitie A, Urtti A. Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells. Pharm Res. 2003;20:1409-1416.
    • (2003) Pharm Res , vol.20 , pp. 1409-1416
    • Ranta, V.P.1    Laavola, M.2    Toropainen, E.3    Vellonen, K.S.4    Talvitie, A.5    Urtti, A.6
  • 34
    • 10744229446 scopus 로고    scopus 로고
    • Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model
    • Toropainen E, Ranta VP, Vellonen KS, et al. Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. Eur J Pharm Sci. 2003;20:99-106.
    • (2003) Eur J Pharm Sci , vol.20 , pp. 99-106
    • Toropainen, E.1    Ranta, V.P.2    Vellonen, K.S.3
  • 35
    • 0022362287 scopus 로고
    • Transport processes across the rabbit corneal epithelium: A review
    • Klyce SD, Crosson CE. Transport processes across the rabbit corneal epithelium: a review. Curr Eye Res. 1985;4:323-331.
    • (1985) Curr Eye Res , vol.4 , pp. 323-331
    • Klyce, S.D.1    Crosson, C.E.2
  • 36
    • 0346787779 scopus 로고    scopus 로고
    • Vesicular systems in ocular drug delivery: An overview
    • Kaur IP, Garg A, Singla AK, Aggarwal D. Vesicular systems in ocular drug delivery: an overview. Int J Pharm. 2004;269:1-14.
    • (2004) Int J Pharm , vol.269 , pp. 1-14
    • Kaur, I.P.1    Garg, A.2    Singla, A.K.3    Aggarwal, D.4
  • 37
    • 0014973692 scopus 로고
    • The influence of non-ionic detergents and other surfactants on human corneal permeability
    • Marsh RJ, Maurice DM. The influence of non-ionic detergents and other surfactants on human corneal permeability. Exp Eye Res. 1971;11:43-48.
    • (1971) Exp Eye Res , vol.11 , pp. 43-48
    • Marsh, R.J.1    Maurice, D.M.2
  • 38
    • 0015155067 scopus 로고
    • Influence of various agents on corneal permeability
    • Green K, Tonjum A. Influence of various agents on corneal permeability. Am J Ophthalmol. 1971;72:897-905.
    • (1971) Am J Ophthalmol , vol.72 , pp. 897-905
    • Green, K.1    Tonjum, A.2
  • 39
    • 0023133188 scopus 로고
    • Evaluation of permeability enhancement of hydrophilic compounds and macromolecular compounds by bile salts through rabbit corneas in-vitro
    • Morimoto K, Nakai T, Morisaka K. Evaluation of permeability enhancement of hydrophilic compounds and macromolecular compounds by bile salts through rabbit corneas in-vitro. J Pharm Pharmacol. 1987;39:124-126.
    • (1987) J Pharm Pharmacol , vol.39 , pp. 124-126
    • Morimoto, K.1    Nakai, T.2    Morisaka, K.3
  • 41
    • 0029963022 scopus 로고    scopus 로고
    • Effect of benzalkonium chloride/EDTA on the ocular bioavailability of ketorolac tromethamine following ocular instillation to normal and de-epithelialized corneas of rabbits
    • Madhu C, Rix PJ, Shackleton MJ, Nguyen TG, Tang-Liu DD. Effect of benzalkonium chloride/EDTA on the ocular bioavailability of ketorolac tromethamine following ocular instillation to normal and de-epithelialized corneas of rabbits. J Pharm Sci. 1996;85:415-418.
    • (1996) J Pharm Sci , vol.85 , pp. 415-418
    • Madhu, C.1    Rix, P.J.2    Shackleton, M.J.3    Nguyen, T.G.4    Tang-Liu, D.D.5
  • 42
    • 0025336531 scopus 로고
    • The effect of chlorhexidine acetate on the corneal penetration of sorbitol from an arnolol formulation in the albino rabbit
    • Ashton P, Diepold R, Platzer A, Lee VH. The effect of chlorhexidine acetate on the corneal penetration of sorbitol from an arnolol formulation in the albino rabbit. J Ocul Pharmacol. 1990;6:37-42.
    • (1990) J Ocul Pharmacol , vol.6 , pp. 37-42
    • Ashton, P.1    Diepold, R.2    Platzer, A.3    Lee, V.H.4
  • 43
    • 0016517336 scopus 로고
    • The effect of benzalkonium chloride on the electropotential of the rabbit cornea
    • Green K, Tonjum AM. The effect of benzalkonium chloride on the electropotential of the rabbit cornea. Acta Ophthalmol (Copenh). 1975;53:348-357.
    • (1975) Acta Ophthalmol (Copenh) , vol.53 , pp. 348-357
    • Green, K.1    Tonjum, A.M.2
  • 44
    • 0037203690 scopus 로고    scopus 로고
    • Increased corneal hydration induced by potential ocular penetration enhancers: Assessment by differential scanning calorimetry (DSC) and by desiccation
    • Monti D, Chetoni P, Burgalassi S, Najarro M, Saettone MF. Increased corneal hydration induced by potential ocular penetration enhancers: assessment by differential scanning calorimetry (DSC) and by desiccation. Int J Pharm. 2002;232:139-147.
    • (2002) Int J Pharm , vol.232 , pp. 139-147
    • Monti, D.1    Chetoni, P.2    Burgalassi, S.3    Najarro, M.4    Saettone, M.F.5
  • 45
    • 0033981207 scopus 로고    scopus 로고
    • Toxicity of preserved and unpreserved antiglaucoma topical drugs in an in vitro model of conjunctival cells
    • De Saint Jean M, Debbasch C, Brignole F, Rat P, Warnet JM, Baudouin C. Toxicity of preserved and unpreserved antiglaucoma topical drugs in an in vitro model of conjunctival cells. Curr Eye Res. 2000;20:85-94.
    • (2000) Curr Eye Res , vol.20 , pp. 85-94
    • de Saint Jean, M.1    Debbasch, C.2    Brignole, F.3    Rat, P.4    Warnet, J.M.5    Baudouin, C.6
  • 46
    • 0025602325 scopus 로고
    • Mechanisms of action of some penetration enhancers in the cornea: Laser scanning confocal microscopic and electrophysiological studies
    • Rojanasakul Y, Liaw J, Robinson J. Mechanisms of action of some penetration enhancers in the cornea: Laser scanning confocal microscopic and electrophysiological studies. Int J Pharm. 1990; 66:131-142.
    • (1990) Int J Pharm , vol.66 , pp. 131-142
    • Rojanasakul, Y.1    Liaw, J.2    Robinson, J.3
  • 48
    • 0025955609 scopus 로고
    • Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions
    • Fasano A, Baudry B, Pumplin DW, et al. Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proc Natl Acad Sci USA. 1991;88:5242-5246.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 5242-5246
    • Fasano, A.1    Baudry, B.2    Pumplin, D.W.3
  • 49
    • 0035374570 scopus 로고    scopus 로고
    • Zonula occludens toxin structurefunction analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain
    • Di Pierro M, Lu R, Uzzau S, et al. Zonula occludens toxin structurefunction analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J Biol Chem. 2001;276:19160-19165.
    • (2001) J Biol Chem , vol.276 , pp. 19160-19165
    • di Pierro, M.1    Lu, R.2    Uzzau, S.3
  • 50
    • 0036846813 scopus 로고    scopus 로고
    • Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin
    • Cox DS, Raje S, Gao H, Salama NN, Eddington ND. Enhanced permeability of molecular weight markers and poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer, zonula occludens toxin. Pharm Res. 2002;19:1680-1688.
    • (2002) Pharm Res , vol.19 , pp. 1680-1688
    • Cox, D.S.1    Raje, S.2    Gao, H.3    Salama, N.N.4    Eddington, N.D.5
  • 51
    • 12244281485 scopus 로고    scopus 로고
    • Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells
    • Karyekar CS, Fasano A, Raje S, Lu R, Dowling TC, Eddington ND. Zonula occludens toxin increases the permeability of molecular weight markers and chemotherapeutic agents across the bovine brain microvessel endothelial cells. J Pharm Sci. 2003;92:414-423.
    • (2003) J Pharm Sci , vol.92 , pp. 414-423
    • Karyekar, C.S.1    Fasano, A.2    Raje, S.3    Lu, R.4    Dowling, T.C.5    Eddington, N.D.6
  • 52
    • 11844272009 scopus 로고    scopus 로고
    • The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents
    • Salama NN, Fasano A, Thakar M, Eddington ND. The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents. J Pharmacol Exp Ther. 2005;312:199-205.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 199-205
    • Salama, N.N.1    Fasano, A.2    Thakar, M.3    Eddington, N.D.4
  • 54
    • 0036713850 scopus 로고    scopus 로고
    • Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement
    • Smith JR, Rosenbaum JT, Wilson DJ, et al. Role of intravitreal methotrexate in the management of primary central nervous system lymphoma with ocular involvement. Ophthalmology. 2002; 109:1709-1716.
    • (2002) Ophthalmology , vol.109 , pp. 1709-1716
    • Smith, J.R.1    Rosenbaum, J.T.2    Wilson, D.J.3
  • 55
    • 1642476315 scopus 로고    scopus 로고
    • Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma
    • Tourville E, Tardif Y. Intravitreal methotrexate injections for intraocular involvement in primary central nervous system lymphoma. Can J Ophthalmol. 2003;38:598-601.
    • (2003) Can J Ophthalmol , vol.38 , pp. 598-601
    • Tourville, E.1    Tardif, Y.2
  • 56
    • 0042376079 scopus 로고    scopus 로고
    • Methotrexate as a first-line corticosteroid-sparing therapy in a cohort of uveitis and scleritis
    • Kaplan-Messas A, Barkana Y, Avni I, Neumann R. Methotrexate as a first-line corticosteroid-sparing therapy in a cohort of uveitis and scleritis. Ocul Immunol Inflamm. 2003;11:131-139.
    • (2003) Ocul Immunol Inflamm , vol.11 , pp. 131-139
    • Kaplan-Messas, A.1    Barkana, Y.2    Avni, I.3    Neumann, R.4
  • 58
    • 0026516506 scopus 로고
    • Preservative-free artificial tear preparations. Assessment of corneal epithelial toxic effects
    • Berdy GJ, Abelson MB, Smith LM, George MA. Preservative-free artificial tear preparations. Assessment of corneal epithelial toxic effects. Arch Ophthalmol. 1992;110:528-532.
    • (1992) Arch Ophthalmol , vol.110 , pp. 528-532
    • Berdy, G.J.1    Abelson, M.B.2    Smith, L.M.3    George, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.