ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes

Obesity

Volumn 21, Issue 3, 2013, Pages 516-524

  Dixen, Karen ^a   Basse, Astrid L ^a   Murholm, Maria ^a   Isidor, Marie S ^a   Hansen, Lillian H L ^a   Petersen, M Christine H ^a   Madsen, Lise ^a,b   Petrovic, Natasa ^c   Nedergaard, Jan ^c   Quistorff, Bjørn ^a   Hansen, Jacob B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b INSTITUTE OF MARINE RESEARCH   (Norway)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; ESTROGEN RELATED RECEPTOR GAMMA; FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ADIPOGENESIS; ADRENERGIC ACTIVITY; ANIMAL CELL; ARTICLE; BIOGENESIS; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CELL FUNCTION; CELL METABOLISM; CELL STIMULATION; COLD; ENERGY EXPENDITURE; FATTY ACID OXIDATION; GENE EXPRESSION; LIPID STORAGE; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; WHITE ADIPOSE TISSUE;

ADIPOCYTES, BROWN; ADIPOCYTES, WHITE; ADIPOGENESIS; ADIPOSE TISSUE, WHITE; ANIMALS; BIOGENESIS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA COPY NUMBER VARIATIONS; DNA, MITOCHONDRIAL; ENERGY METABOLISM; FEMALE; ION CHANNELS; L-LACTATE DEHYDROGENASE; LIPID METABOLISM; LIPOLYSIS; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; OXIDATION-REDUCTION; PALMITOYLCARNITINE; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 84876485080     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20067     Document Type: Article

References (39)

1. Cannon B, Nedergaard J,. Brown adipose tissue: function and physiological significance. Physiol Rev 2004; 84: 277-359.
2. Villena JA, Kralli A,. ERRalpha: a metabolic function for the oldest orphan. Trends Endocrinol Metab 2008; 19: 269-276.
3. Cristancho AG, Lazar MA,. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011; 12: 722-734.
4. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM,. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92: 829-839.
5. Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM,. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab 2006; 3: 333-341.
6. Seale P, Kajimura S, Yang W, et al. Transcriptional control of brown fat determination by PRDM16. Cell Metab 2007; 6: 38-54.
7. Christian M, Kiskinis E, Debevec D, Leonardsson G, White R, Parker MG,. RIP140-targeted repression of gene expression in adipocytes. Molecular and Cellular Biology 2005; 25: 9383-9391.
8. Hansen JB, Jorgensen C, Petersen RK, et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc Natl Acad Sci USA 2004; 101: 4112-4117.
9. Giguere V,. Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev 2008; 29: 677-696.
10. Sladek R, Bader JA, Giguere V,. The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol 1997; 17: 5400-5409.
11. Vega RB, Kelly DP,. A role for estrogen-related receptor alpha in the control of mitochondrial fatty acid beta-oxidation during brown adipocyte differentiation. J Biol Chem 1997; 272: 31693-31699.
12. Kubo M, Ijichi N, Ikeda K, Horie-Inoue K, Takeda S, Inoue S,. Modulation of adipogenesis-related gene expression by estrogen-related receptor gamma during adipocytic differentiation. Biochim Biophys Acta 2009; 1789: 71-77.
13. Huss JM, Kopp RP, Kelly DP,. Peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1 alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma-Identification of novel leucine-rich interaction motif within PGC-1 alpha. J Biol Chem 2002; 277: 40265-40274.
14. Hentschke M, Susens U, Borgmeyer U,. PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. Biochem Biophys Res Commun 2002; 299: 872-879.
15. Mootha VK, Handschin C, Arlow D, et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci USA 2004; 101: 6570-6575.
16. Schreiber SN, Emter R, Hock, MB, et al. The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci USA 2004; 101: 6472-6477.
17. Rangwala SM, Li X, Lindsley L, et al. Estrogen-related receptor alpha is essential for the expression of antioxidant protection genes and mitochondrial function. Biochem Biophys Res Commun 2007; 357: 231-236.
18. Debevec D, Christian M, Morganstein D, et al. Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha. Mol Endocrinol 2007; 21: 1581-1592.
19. Villena JA, Hock MB, Chang WY, Barcas JE, Giguere V, Kralli A,. Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proceedings of the National Academy of Sciences of the United States of America 2007; 104: 1418-1423.
20. Murholm M, Dixen K, Qvortrup K, et al. Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. Plos One 2009; 4: e8458.
21. Cannon B, Nedergaard J,. Cultures of adipose precursor cells from brown adipose tissue and of clonal brown-adipocyte-like cell lines. Methods Mol Biol 2001; 155: 213-224.
22. Green H, Kehinde O,. Sublines of mouse 3t3 cells that accumulate lipid. Cell 1974; 1: 113-116.
23. Tseng YH, Kriauciunas KM, Kokkotou E, Kahn, CR,. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol 2004; 24: 1918-1929.
24. Murholm M, Dixen K, Hansen JB,. Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis. Biochim Biophys Acta 2010; 1800: 619-627.
25. Park YY, Ahn SW, Kim HJ, et al. An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma. Nucleic Acids Res 2005; 33: 6756-6768.
26. Huppunen J, Wohlfahrt G, Aarnisalo P,. Requirements for transcriptional regulation by the orphan nuclear receptor ERRgamma. Mol Cell Endocrinol 2004; 219: 151-160.
27. Coward P, Lee D, Hull MV, Lehmann JM,. 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma. Proc Natl Acad Sci USA 2001; 98: 8880-8884.
28. Tremblay GB, Bergeron D, Giguere V,. 4-hyroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. Endocrinology 2001; 142: 4572-4575.
29. Wang L, Liu J, Saha P, et al. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab 2005; 2: 227-238.
30. Zhang Y, Ma K, Sadana P, et al. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem 2006; 281: 39897-39906.
31. Sanyal S, Kim JY, Kim HJ, et al. Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem 2002; 277: 1739-1748.
32. Liu D, Zhang Z, Teng CT,. Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element. J Mol Endocrinol 2005; 34: 473-487.
33. Goglia F, Geloen A, Lanni A, Minaire Y, Bukowiecki LJ,. Morphometric-stereologic analysis of brown adipocyte differentiation in adult mice. Am J Physiol 1992; 262: C1018-1023.
34. Narkar VA, Fan W, Downes M, et al. Exercise and PGC-1alpha-independent synchronization of type I muscle metabolism and vasculature by ERRgamma. Cell Metab 2011; 13: 283-293.
35. Luo JM, Sladek R, Carrier J, Bader JA, Richard D, Giguere V,. Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol 2003; 23: 7947-7956.
36. Alaynick WA, Kondo RP, Xie W, et al. ERR gamma directs and maintains the transition to oxidative metabolism in the postnatal heart. Cell Metab 2007; 6: 13-24.
37. Lidell ME, Enerback S,. Brown adipose tissue-a new role in humans? Nat Rev Endocrinol 2010; 6: 319-325.
38. Lin J, Wu PH, Tarr PT, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 2004; 119: 121-135.
39. Sandberg MB, Bloksgaard M, Duran-Sandoval D, Duval C, Staels B, Mandrup S,. The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes. J Biol Chem 2005; 280: 5258-5266.