The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I

Biochemical and Biophysical Research Communications

Volumn 433, Issue 4, 2013, Pages 508-512

  Craig, Theodore A ^a   Ramachandran, Pradeep L ^a   Bergen, H Robert ^b   Podratz, Jewel L ^a   Windebank, Anthony J ^a   Kumar, Rajiv ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Apoptosis; Calcium; Calsenilin; DREAM; EF hand proteins; Hexokinase I; KChIP3; Neuronal calcium sensor proteins

Indexed keywords

CALCIUM ION; CALSENILIN; CASPASE 3; CISPLATIN; HEXOKINASE 1;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM BINDING; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CASPASE 3; CELL LINE, TUMOR; CISPLATIN; EDETIC ACID; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HEXOKINASE; KV CHANNEL-INTERACTING PROTEINS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEUROBLASTOMA; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; TRANSFECTION;

EID: 84876473175     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.016     Document Type: Article

References (44)

1. Bredesen D.E., Rao R.V., Mehlen P. Cell death in the nervous system. Nature 2006, 443:796-802.
2. Crawford E.D., Wells J.A. Caspase substrates and cellular remodeling. Annual Review of Biochemistry 2011, 80:1055-1087.
3. Evan G.I., Vousden K.H. Proliferation, cell cycle and apoptosis in cancer. Nature 2001, 411:342-348.
4. Hammerman P.S., Fox C.J., Thompson C.B. Beginnings of a signal-transduction pathway for bioenergetic control of cell survival. Trends in Biochemical Sciences 2004, 29:586-592.
5. Jiang X., Wang X. Cytochrome C-mediated apoptosis. Annual Review of Biochemistry 2004, 73:87-106.
6. Baehrecke E.H. How death shapes life during development. Nature Reviews Molecular Cell Biology 2002, 3:779-787.
7. Mathew R., Karantza-Wadsworth V., White E. Role of autophagy in cancer. Nature Reviews Cancer 2007, 7:961-967.
8. 2+-regulated transcriptional repressor. Nature 1999, 398:80-84.
9. Buxbaum J.D., Choi E.K., Luo Y., Lilliehook C., Crowley A.C., Merriam D.E., Wasco W. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nature Medicine 1998, 4:1177-1181.
10. Choi E.K., Zaidi N.F., Miller J.S., Crowley A.C., Merriam D.E., Lilliehook C., Buxbaum J.D., Wasco W. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. The Journal of Biological Chemistry 2001, 276:19197-19204.
11. Hammond P.I., Craig T.A., Kumar R., Brimijoin S. Regional and cellular distribution of DREAM in adult rat brain consistent with multiple sensory processing roles. Brain Research Molecular Brain Research 2003, 111:104-110.
12. Shibata R., Misonou H., Campomanes C.R., Anderson A.E., Schrader L.A., Doliveira L.C., Carroll K.I., Sweatt J.D., Rhodes K.J., Trimmer J.S. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. The Journal of Biological Chemistry 2003, 278:36445-36454.
13. Alexander J.C., McDermott C.M., Tunur T., Rands V., Stelly C., Karhson D., Bowlby M.R., An W.F., Sweatt J.D., Schrader L.A. The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning. Learning & Memory 2009, 16:167-177.
14. Cheng H.Y., Pitcher G.M., Laviolette S.R., Whishaw I.Q., Tong K.I., Kockeritz L.K., Wada T., Joza N.A., Crackower M., Goncalves J., Sarosi I., Woodgett J.R., Oliveira-dos-Santos A.J., Ikura M., van der Kooy D., Salter M.W., Penninger J.M. DREAM is a critical transcriptional repressor for pain modulation. Cell 2002, 108:31-43.
15. Jo D.G., Lee J.Y., Hong Y.M., Song S., Mook-Jung I., Koh J.Y., Jung Y.K. Induction of pro-apoptotic calsenilin/DREAM/KChIP3 in Alzheimer's disease and cultured neurons after amyloid-beta exposure. Journal of Neurochemistry 2004, 88:604-611.
16. Lilliehook C., Chan S., Choi E.K., Zaidi N.F., Wasco W., Mattson M.P., Buxbaum J.D. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Molecular and Cellular Neurosciences 2002, 19:552-559.
17. Jo D.G., Chang J.W., Hong H.S., Mook-Jung I., Jung Y.K. Contribution of presenilin/gamma-secretase to calsenilin-mediated apoptosis. Biochemical and Biophysical Research Communications 2003, 305:62-66.
18. 2+-dependent repressor DREAM. Antioxidants & Redox Signaling 2011, 14:1237-1243.
19. Leissring M.A., Yamasaki T.R., Wasco W., Buxbaum J.D., Parker I., LaFerla F.M. Calsenilin reverses presenilin-mediated enhancement of calcium signaling. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:8590-8593.
20. Lilliehook C., Bozdagi O., Yao J., Gomez-Ramirez M., Zaidi N.F., Wasco W., Gandy S., Santucci A.C., Haroutunian V., Huntley G.W., Buxbaum J.D. Altered abeta formation and long-term potentiation in a calsenilin knock-out. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2003, 23:9097-9106.
21. Craig T.A., Benson L.M., Venyaminov S.Y., Klimtchuk E.S., Bajzer Z., Prendergast F.G., Naylor S., Kumar R. The metal-binding properties of DREAM: evidence for calcium-mediated changes in DREAM structure. The Journal of Biological Chemistry 2002, 277:10955-10966.
22. Ramachandran P.L., Craig T.A., Atanasova E.A., Cui G., Owen B.A., Bergen H.R., Mer G., Kumar R. The potassium channel interacting Protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function. The Journal of Biological Chemistry 2012, 287:39439-39448.
23. Craig T.A., Benson L.M., Venyaminov S.Y., Klimtchuk E.S., Bajzer Z., Prendergast F.G., Naylor S., Kumar R. The metal-binding properties of DREAM: evidence for calcium-mediated changes in DREAM structure. Journal of Biological Chemistry 2002, 277:10955-10966.
24. Scheer W.D., Lehmann H.P., Beeler M.F. An improved assay for hexokinase activity in human tissue homogenates. Analytical Biochemistry 1978, 91:451-463.
25. Fischer S.J., McDonald E.S., Gross L., Windebank A.J. Alterations in cell cycle regulation underlie cisplatin induced apoptosis of dorsal root ganglion neurons in vivo. Neurobiology of Disease 2001, 8:1027-1035.
26. Leist M., Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nature Reviews Molecular Cell Biology 2001, 2:589-598.
27. Adrain C., Creagh E.M., Martin S.J. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. The EMBO Journal 2001, 20:6627-6636.
28. Azoulay-Zohar H., Israelson A., Abu-Hamad S., Shoshan-Barmatz V. In self-defence. hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochemical Journal 2004, 377:347-355.
29. Gottlob K., Majewski N., Kennedy S., Kandel E., Robey R.B., Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes & Development 2001, 15:1406-1418.
30. Green D.R., Galluzzi L., Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011, 333:1109-1112.
31. Lin M.T., Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006, 443:787-795.
32. Ow Y.P., Green D.R., Hao Z., Mak T.W. Cytochrome c: functions beyond respiration. Nature Reviews Molecular Cell Biology 2008, 9:532-542.
33. Shoshan-Barmatz V., Keinan N., Abu-Hamad S., Tyomkin D., Aram L. Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo. Biochimica et Biophysica Acta 2010, 1797:1281-1291.
34. Zamzami N., Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nature Reviews Molecular Cell Biology 2001, 2:67-71.
35. Colombini M. VDAC: the channel at the interface between mitochondria and the cytosol. Molecular and Cellular Biochemistry 2004, 256-257:107-115.
36. 2+ signals to mitochondria. Cell Death and Differentiation 2012, 19:267-273.
37. Granville D.J., Gottlieb R.A. The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death. Current Medicinal Chemistry 2003, 10:1527-1533.
38. Shoshan-Barmatz V., Mizrachi D. VDAC1: from structure to cancer therapy. Frontiers in Oncology 2012, 2:164.
39. Thomsen M.B., Wang C., Ozgen N., Wang H.G., Rosen M.R., Pitt G.S. Accessory subunit KChIP2 modulates the cardiac L-type calcium current. Circulation Research 2009, 104:1382-1389.
40. Abu-Hamad S., Zaid H., Israelson A., Nahon E., Shoshan-Barmatz V. Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding. Journal of Biological Chemistry 2008, 283:13482-13490.
41. Pastorino J.G., Hoek J.B. Hexokinase II: the integration of energy metabolism and control of apoptosis. Current Medicinal Chemistry 2003, 10:1535-1551.
42. Cuadrado-Tejedor M., Vilarino M., Cabodevilla F., Del Rio J., Frechilla D., Perez-Mediavilla A. Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer's disease transgenic mice. an insight into the pathogenic effects of amyloid-beta. Journal of Alzheimer's Disease 2011, 23:195-206.
43. Ferrer I. Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease. Journal of Bioenergetics and Biomembranes 2009, 41:425-431.
44. 2+-loaded calbindin-D(28K). Nature Structural & Molecular Biology 2006, 13:641-647.