메뉴 건너뛰기




Volumn 14, Issue 4, 2013, Pages 7829-7852

Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways

Author keywords

Alzheimer disease; Cancer; Cell signaling; Down syndrome; Endocytosis; Glioblastoma; Intersectin; Neuroblastoma; PI3KC2 ; Ras

Indexed keywords

INTERSECTIN; LATENT MEMBRANE PROTEIN 2; PROTEIN K15; PROTEIN TYROSINE KINASE; RAS PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; GUANOSINE TRIPHOSPHATASE; INTERSECTIN 1; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 3 KINASE; PIK3C2B PROTEIN, HUMAN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

EID: 84876342905     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14047829     Document Type: Review
Times cited : (42)

References (118)
  • 1
    • 0029890281 scopus 로고    scopus 로고
    • Cloning of ligand targets: Systematic isolation of sh3 domain-containing proteins
    • Sparks, A.B.; Hoffman, N.G.; McConnell, S.J.; Fowlkes, D.M.; Kay, B.K. Cloning of ligand targets: Systematic isolation of sh3 domain-containing proteins. Nat. Biotechnol. 1996, 14, 741-744.
    • (1996) Nat. Biotechnol , vol.14 , pp. 741-744
    • Sparks, A.B.1    Hoffman, N.G.2    McConnell, S.J.3    Fowlkes, D.M.4    Kay, B.K.5
  • 4
    • 0037441559 scopus 로고    scopus 로고
    • Neuronal distribution of ehsh1/intersectin: Molecular linker between clathrin-mediated endocytosis and signaling pathways
    • Ma, Y.J.; Okamoto, M.; Gu, F.; Obata, K.; Matsuyama, T.; Desaki, J.; Tanaka, J.; Sakanaka, M. Neuronal distribution of ehsh1/intersectin: Molecular linker between clathrin-mediated endocytosis and signaling pathways. J. Neurosci. Res. 2003, 71, 468-477.
    • (2003) J. Neurosci. Res , vol.71 , pp. 468-477
    • Ma, Y.J.1    Okamoto, M.2    Gu, F.3    Obata, K.4    Matsuyama, T.5    Desaki, J.6    Tanaka, J.7    Sakanaka, M.8
  • 5
    • 0032211687 scopus 로고    scopus 로고
    • Two isoforms of a human intersectin (itsn) protein are produced by brain-specific alternative splicing in a stop codon
    • Guipponi, M.; Scott, H.S.; Chen, H.; Schebesta, A.; Rossier, C.; Antonarakis, S.E. Two isoforms of a human intersectin (itsn) protein are produced by brain-specific alternative splicing in a stop codon. Genomics 1998, 53, 369-376.
    • (1998) Genomics , vol.53 , pp. 369-376
    • Guipponi, M.1    Scott, H.S.2    Chen, H.3    Schebesta, A.4    Rossier, C.5    Antonarakis, S.E.6
  • 6
    • 0035980247 scopus 로고    scopus 로고
    • The human intersectin genes and their spliced variants are differentially expressed
    • Pucharcos, C.; Casas, C.; Nadal, M.; Estivill, X.; de la Luna, S. The human intersectin genes and their spliced variants are differentially expressed. Biochim. Biophys. Acta 2001, 1521, 1-11.
    • (2001) Biochim. Biophys. Acta , vol.1521 , pp. 1-11
    • Pucharcos, C.1    Casas, C.2    Nadal, M.3    Estivill, X.4    de la Luna, S.5
  • 7
    • 0033106167 scopus 로고    scopus 로고
    • The eh and sh3 domain ese proteins regulate endocytosis by linking to dynamin and eps15
    • Sengar, A.S.; Wang, W.; Bishay, J.; Cohen, S.; Egan, S.E. The eh and sh3 domain ese proteins regulate endocytosis by linking to dynamin and eps15. EMBO J. 1999, 18, 1159-1171.
    • (1999) EMBO J , vol.18 , pp. 1159-1171
    • Sengar, A.S.1    Wang, W.2    Bishay, J.3    Cohen, S.4    Egan, S.E.5
  • 8
    • 0034726027 scopus 로고    scopus 로고
    • Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis
    • Pucharcos, C.; Estivill, X.; de la Luna, S. Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett. 2000, 478, 43-51.
    • (2000) FEBS Lett , vol.478 , pp. 43-51
    • Pucharcos, C.1    Estivill, X.2    de la Luna, S.3
  • 11
    • 0035947775 scopus 로고    scopus 로고
    • Stonin 2: An adaptor-like protein that interacts with components of the endocytic machinery
    • Martina, J.A.; Bonangelino, C.J.; Aguilar, R.C.; Bonifacino, J.S. Stonin 2: An adaptor-like protein that interacts with components of the endocytic machinery. J. Cell Biol. 2001, 153, 1111-1120.
    • (2001) J. Cell Biol , vol.153 , pp. 1111-1120
    • Martina, J.A.1    Bonangelino, C.J.2    Aguilar, R.C.3    Bonifacino, J.S.4
  • 13
    • 78650435425 scopus 로고    scopus 로고
    • Intersecting pathways in cell biology
    • O'Bryan, J.P. Intersecting pathways in cell biology. Sci. Signal 2010, 3, re10.
    • (2010) Sci. Signal , vol.3
    • O'Bryan, J.P.1
  • 16
    • 0038032733 scopus 로고    scopus 로고
    • Intersectin 1l guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis
    • Zamanian, J.L.; Kelly, R.B. Intersectin 1l guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis. Mol. Biol. Cell 2003, 14, 1624-1637.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1624-1637
    • Zamanian, J.L.1    Kelly, R.B.2
  • 17
    • 0035905308 scopus 로고    scopus 로고
    • The intersectin 2 adaptor links wiskott aldrich syndrome protein (wasp)-mediated actin polymerization to t cell antigen receptor endocytosis
    • McGavin, M.K.; Badour, K.; Hardy, L.A.; Kubiseski, T.J.; Zhang, J.; Siminovitch, K.A. The intersectin 2 adaptor links wiskott aldrich syndrome protein (wasp)-mediated actin polymerization to t cell antigen receptor endocytosis. J. Exp. Med. 2001, 194, 1777-1787.
    • (2001) J. Exp. Med , vol.194 , pp. 1777-1787
    • McGavin, M.K.1    Badour, K.2    Hardy, L.A.3    Kubiseski, T.J.4    Zhang, J.5    Siminovitch, K.A.6
  • 18
    • 77951607840 scopus 로고    scopus 로고
    • Pleiotropic function of intersectin homologue cin1 in cryptococcus neoformans
    • Shen, G.; Whittington, A.; Song, K.; Wang, P. Pleiotropic function of intersectin homologue cin1 in cryptococcus neoformans. Mol. Microbiol. 2010, 76, 662-676.
    • (2010) Mol. Microbiol , vol.76 , pp. 662-676
    • Shen, G.1    Whittington, A.2    Song, K.3    Wang, P.4
  • 23
    • 33751188950 scopus 로고    scopus 로고
    • Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling
    • Martin, N.P.; Mohney, R.P.; Dunn, S.; Das, M.; Scappini, E.; O'Bryan, J.P. Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling. Mol. Pharmacol. 2006, 70, 1643-1653.
    • (2006) Mol. Pharmacol , vol.70 , pp. 1643-1653
    • Martin, N.P.1    Mohney, R.P.2    Dunn, S.3    Das, M.4    Scappini, E.5    O'Bryan, J.P.6
  • 25
    • 77955845001 scopus 로고    scopus 로고
    • Microexon-based regulation of itsn1 and src sh3 domains specificity relies on introduction of charged amino acids into the interaction interface
    • Dergai, M.; Tsyba, L.; Dergai, O.; Zlatskii, I.; Skrypkina, I.; Kovalenko, V.; Rynditch, A. Microexon-based regulation of itsn1 and src sh3 domains specificity relies on introduction of charged amino acids into the interaction interface. Biochem. Biophys. Res. Commun. 2010, 399, 307-312.
    • (2010) Biochem. Biophys. Res. Commun , vol.399 , pp. 307-312
    • Dergai, M.1    Tsyba, L.2    Dergai, O.3    Zlatskii, I.4    Skrypkina, I.5    Kovalenko, V.6    Rynditch, A.7
  • 27
    • 84859119646 scopus 로고    scopus 로고
    • Wsp1 is downstream of cin1 and regulates vesicle transport and actin cytoskeleton as an effector of cdc42 and rac1 in cryptococcus neoformans
    • Shen, G.; Zhou, E.; Alspaugh, J.A.; Wang, P. Wsp1 is downstream of cin1 and regulates vesicle transport and actin cytoskeleton as an effector of cdc42 and rac1 in cryptococcus neoformans. Eukaryot. Cell 2012, 11, 471-481.
    • (2012) Eukaryot. Cell , vol.11 , pp. 471-481
    • Shen, G.1    Zhou, E.2    Alspaugh, J.A.3    Wang, P.4
  • 30
    • 0032563187 scopus 로고    scopus 로고
    • Dap160, a neural-specific eps15 homology and multiple sh3 domain-containing protein that interacts with drosophila dynamin
    • Roos, J.; Kelly, R.B. Dap160, a neural-specific eps15 homology and multiple sh3 domain-containing protein that interacts with drosophila dynamin. J. Biol. Chem. 1998, 273, 19108-19119.
    • (1998) J. Biol. Chem , vol.273 , pp. 19108-19119
    • Roos, J.1    Kelly, R.B.2
  • 31
    • 3242680909 scopus 로고    scopus 로고
    • Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis
    • Koh, T.W.; Verstreken, P.; Bellen, H.J. Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis. Neuron 2004, 43, 193-205.
    • (2004) Neuron , vol.43 , pp. 193-205
    • Koh, T.W.1    Verstreken, P.2    Bellen, H.J.3
  • 32
    • 3242693589 scopus 로고    scopus 로고
    • Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth
    • Marie, B.; Sweeney, S.T.; Poskanzer, K.E.; Roos, J.; Kelly, R.B.; Davis, G.W. Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth. Neuron 2004, 43, 207-219.
    • (2004) Neuron , vol.43 , pp. 207-219
    • Marie, B.1    Sweeney, S.T.2    Poskanzer, K.E.3    Roos, J.4    Kelly, R.B.5    Davis, G.W.6
  • 33
    • 66449095094 scopus 로고    scopus 로고
    • Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons
    • Thomas, S.; Ritter, B.; Verbich, D.; Sanson, C.; Bourbonniere, L.; McKinney, R.A.; McPherson, P.S. Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons. J. Biol. Chem. 2009, 284, 12410-12419.
    • (2009) J. Biol. Chem , vol.284 , pp. 12410-12419
    • Thomas, S.1    Ritter, B.2    Verbich, D.3    Sanson, C.4    Bourbonniere, L.5    McKinney, R.A.6    McPherson, P.S.7
  • 34
    • 34447115695 scopus 로고    scopus 로고
    • Intersectin-1s regulates the mitochondrial apoptotic pathway in endothelial cells
    • Predescu, S.A.; Predescu, D.N.; Knezevic, I.; Klein, I.K.; Malik, A.B. Intersectin-1s regulates the mitochondrial apoptotic pathway in endothelial cells. J. Biol. Chem. 2007, 282, 17166-17178.
    • (2007) J. Biol. Chem , vol.282 , pp. 17166-17178
    • Predescu, S.A.1    Predescu, D.N.2    Knezevic, I.3    Klein, I.K.4    Malik, A.B.5
  • 35
    • 0344443664 scopus 로고    scopus 로고
    • Intersectin regulates fission and internalization of caveolae in endothelial cells
    • Predescu, S.A.; Predescu, D.N.; Timblin, B.K.; Stan, R.V.; Malik, A.B. Intersectin regulates fission and internalization of caveolae in endothelial cells. Mol. Biol. Cell 2003, 14, 4997-5010.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 4997-5010
    • Predescu, S.A.1    Predescu, D.N.2    Timblin, B.K.3    Stan, R.V.4    Malik, A.B.5
  • 36
    • 0033603313 scopus 로고    scopus 로고
    • Ehsh1/intersectin, a protein that contains eh and sh3 domains and binds to dynamin and snap-25. A protein connection between exocytosis and endocytosis
    • Okamoto, M.; Schoch, S.; Sudhof, T.C. Ehsh1/intersectin, a protein that contains eh and sh3 domains and binds to dynamin and snap-25. A protein connection between exocytosis and endocytosis? J. Biol. Chem. 1999, 274, 18446-18454.
    • (1999) J. Biol. Chem , vol.274 , pp. 18446-18454
    • Okamoto, M.1    Schoch, S.2    Sudhof, T.C.3
  • 37
    • 20744437111 scopus 로고    scopus 로고
    • Kinetics of src homology 3 domain association with the proline-rich domain of dynamins: Specificity, occlusion, and the effects of phosphorylation
    • Solomaha, E.; Szeto, F.L.; Yousef, M.A.; Palfrey, H.C. Kinetics of src homology 3 domain association with the proline-rich domain of dynamins: Specificity, occlusion, and the effects of phosphorylation. J. Biol. Chem. 2005, 280, 23147-23156.
    • (2005) J. Biol. Chem , vol.280 , pp. 23147-23156
    • Solomaha, E.1    Szeto, F.L.2    Yousef, M.A.3    Palfrey, H.C.4
  • 38
    • 0032489880 scopus 로고    scopus 로고
    • Dynamin at the neck of caveolae mediates their budding to form transport vesicles by gtp-driven fission from the plasma membrane of endothelium
    • Oh, P.; McIntosh, D.P.; Schnitzer, J.E. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by gtp-driven fission from the plasma membrane of endothelium. J. Cell Biol. 1998, 141, 101-114.
    • (1998) J. Cell Biol , vol.141 , pp. 101-114
    • Oh, P.1    McIntosh, D.P.2    Schnitzer, J.E.3
  • 40
    • 84863344871 scopus 로고    scopus 로고
    • Impaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium
    • Predescu, D.N.; Neamu, R.; Bardita, C.; Wang, M.; Predescu, S.A. Impaired caveolae function and upregulation of alternative endocytic pathways induced by experimental modulation of intersectin-1s expression in mouse lung endothelium. Biochem. Res. Int. 2012, 2012, 672705.
    • Biochem. Res. Int , vol.2012 , Issue.67 , pp. 2012
    • Predescu, D.N.1    Neamu, R.2    Bardita, C.3    Wang, M.4    Predescu, S.A.5
  • 41
    • 33846254873 scopus 로고    scopus 로고
    • Intersectin is a negative regulator of dynamin recruitment to the synaptic endocytic zone in the central synapse
    • Evergren, E.; Gad, H.; Walther, K.; Sundborger, A.; Tomilin, N.; Shupliakov, O. Intersectin is a negative regulator of dynamin recruitment to the synaptic endocytic zone in the central synapse. J. Neurosci. 2007, 27, 379-390.
    • (2007) J. Neurosci , vol.27 , pp. 379-390
    • Evergren, E.1    Gad, H.2    Walther, K.3    Sundborger, A.4    Tomilin, N.5    Shupliakov, O.6
  • 46
    • 84864143142 scopus 로고    scopus 로고
    • Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer stop in neurons
    • Morderer, D.; Nikolaienko, O.; Skrypkina, I.; Cherkas, V.; Tsyba, L.; Belan, P.; Rynditch, A. Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer stop in neurons. Gene 2012, 505, 360-364.
    • (2012) Gene , vol.505 , pp. 360-364
    • Morderer, D.1    Nikolaienko, O.2    Skrypkina, I.3    Cherkas, V.4    Tsyba, L.5    Belan, P.6    Rynditch, A.7
  • 47
    • 81455155113 scopus 로고    scopus 로고
    • Disc1: Structure, function, and therapeutic potential for major mental illness
    • Soares, D.C.; Carlyle, B.C.; Bradshaw, N.J.; Porteous, D.J. disc1: Structure, function, and therapeutic potential for major mental illness. ACS Chem. Neurosci. 2011, 2, 609-632.
    • (2011) ACS. Chem. Neurosci , vol.2 , pp. 609-632
    • Soares, D.C.1    Carlyle, B.C.2    Bradshaw, N.J.3    Porteous, D.J.4
  • 48
    • 0037155275 scopus 로고    scopus 로고
    • The activity of the gtpase-activating protein cdgap is regulated by the endocytic protein intersectin
    • Jenna, S.; Hussain, N.K.; Danek, E.I.; Triki, I.; Wasiak, S.; McPherson, P.S.; Lamarche-Vane, N. The activity of the gtpase-activating protein cdgap is regulated by the endocytic protein intersectin. J. Biol. Chem. 2002, 277, 6366-6373.
    • (2002) J. Biol. Chem , vol.277 , pp. 6366-6373
    • Jenna, S.1    Hussain, N.K.2    Danek, E.I.3    Triki, I.4    Wasiak, S.5    McPherson, P.S.6    Lamarche-Vane, N.7
  • 49
    • 77955291246 scopus 로고    scopus 로고
    • The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin
    • Ahmad, K.F.; Lim, W.A. The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin. PLoS One 2010, 5, e11291.
    • (2010) PLoS One , vol.5
    • Ahmad, K.F.1    Lim, W.A.2
  • 50
    • 78349289981 scopus 로고    scopus 로고
    • Autoinhibition of gef activity in intersectin 1 is mediated by the short sh3-dh domain linker
    • Kintscher, C.; Wuertenberger, S.; Eylenstein, R.; Uhlendorf, T.; Groemping, Y. Autoinhibition of gef activity in intersectin 1 is mediated by the short sh3-dh domain linker. Protein Sci. 2010, 19, 2164-2174.
    • (2010) Protein Sci , vol.19 , pp. 2164-2174
    • Kintscher, C.1    Wuertenberger, S.2    Eylenstein, R.3    Uhlendorf, T.4    Groemping, Y.5
  • 51
    • 58149191544 scopus 로고    scopus 로고
    • Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis
    • Jaffe, A.B.; Kaji, N.; Durgan, J.; Hall, A. Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis. J. Cell Biol. 2008, 183, 625-633.
    • (2008) J. Cell Biol , vol.183 , pp. 625-633
    • Jaffe, A.B.1    Kaji, N.2    Durgan, J.3    Hall, A.4
  • 52
    • 33846270032 scopus 로고    scopus 로고
    • Pten-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through cdc42
    • Martin-Belmonte, F.; Gassama, A.; Datta, A.; Yu, W.; Rescher, U.; Gerke, V.; Mostov, K. Pten-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through cdc42. Cell 2007, 128, 383-397.
    • (2007) Cell , vol.128 , pp. 383-397
    • Martin-Belmonte, F.1    Gassama, A.2    Datta, A.3    Yu, W.4    Rescher, U.5    Gerke, V.6    Mostov, K.7
  • 54
    • 0034703049 scopus 로고    scopus 로고
    • Intersectin can regulate the ras/map kinase pathway independent of its role in endocytosis
    • Tong, X.K.; Hussain, N.K.; Adams, A.G.; O'Bryan, J.P.; McPherson, P.S. Intersectin can regulate the ras/map kinase pathway independent of its role in endocytosis. J. Biol. Chem. 2000, 275, 29894-29899.
    • (2000) J. Biol. Chem , vol.275 , pp. 29894-29899
    • Tong, X.K.1    Hussain, N.K.2    Adams, A.G.3    O'Bryan, J.P.4    McPherson, P.S.5
  • 55
    • 0344875509 scopus 로고    scopus 로고
    • Intersectin activates ras but stimulates transcription through an independent pathway involving jnk
    • Mohney, R.P.; Das, M.; Bivona, T.G.; Hanes, R.; Adams, A.G.; Philips, M.R.; O'Bryan, J.P. Intersectin activates ras but stimulates transcription through an independent pathway involving jnk. J. Biol. Chem. 2003, 278, 47038-47045.
    • (2003) J. Biol. Chem , vol.278 , pp. 47038-47045
    • Mohney, R.P.1    Das, M.2    Bivona, T.G.3    Hanes, R.4    Adams, A.G.5    Philips, M.R.6    O'Bryan, J.P.7
  • 56
    • 0034282927 scopus 로고    scopus 로고
    • Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways
    • Adams, A.; Thorn, J.M.; Yamabhai, M.; Kay, B.K.; O'Bryan, J.P. Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways. J. Biol. Chem. 2000, 275, 27414-27420.
    • (2000) J. Biol. Chem , vol.275 , pp. 27414-27420
    • Adams, A.1    Thorn, J.M.2    Yamabhai, M.3    Kay, B.K.4    O'Bryan, J.P.5
  • 58
    • 84866375875 scopus 로고    scopus 로고
    • A new dimension to Ras function: A novel role for nucleotide-free Ras in class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation
    • Wong, K.A.; Russo, A.; Wang, X.; Chen, Y.-J.; Lavie, A.; O'Bryan, J.P. A new dimension to Ras function: A novel role for nucleotide-free Ras in class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation. PLoS One 2012, 7, e45360.
    • (2012) PLoS One , vol.7
    • Wong, K.A.1    Russo, A.2    Wang, X.3    Chen, Y.-J.4    Lavie, A.5    O'Bryan, J.P.6
  • 59
    • 84856779023 scopus 로고    scopus 로고
    • Intersectin 1 enhances cbl ubiquitylation of epidermal growth factor receptor through regulation of sprouty2-cbl interaction
    • Okur, M.N.; Zhu, J.O.; Fong, C.W.; Martinez, N.; Garcia-Dominguez, C.; Rojas, J.M.; Guy, G.; O'Bryan, J.P. Intersectin 1 enhances cbl ubiquitylation of epidermal growth factor receptor through regulation of sprouty2-cbl interaction. Mol. Cell Biol. 2012, 32, 817-825.
    • (2012) Mol. Cell Biol , vol.32 , pp. 817-825
    • Okur, M.N.1    Zhu, J.O.2    Fong, C.W.3    Martinez, N.4    Garcia-Dominguez, C.5    Rojas, J.M.6    Guy, G.7    O'Bryan, J.P.8
  • 62
    • 22744445536 scopus 로고    scopus 로고
    • Loss of ralt/mig-6 expression in erbb2-amplified breast carcinomas enhances erbb-2 oncogenic potency and favors resistance to herceptin
    • Anastasi, S.; Sala, G.; Huiping, C.; Caprini, E.; Russo, G.; Iacovelli, S.; Lucini, F.; Ingvarsson, S.; Segatto, O. Loss of ralt/mig-6 expression in erbb2-amplified breast carcinomas enhances erbb-2 oncogenic potency and favors resistance to herceptin. Oncogene 2005, 24, 4540-4548.
    • (2005) Oncogene , vol.24 , pp. 4540-4548
    • Anastasi, S.1    Sala, G.2    Huiping, C.3    Caprini, E.4    Russo, G.5    Iacovelli, S.6    Lucini, F.7    Ingvarsson, S.8    Segatto, O.9
  • 63
    • 13244283225 scopus 로고    scopus 로고
    • Gene 33 is an endogenous inhibitor of epidermal growth factor (egf) receptor signaling and mediates dexamethasone-induced suppression of egf function
    • Xu, D.; Makkinje, A.; Kyriakis, J.M. Gene 33 is an endogenous inhibitor of epidermal growth factor (egf) receptor signaling and mediates dexamethasone-induced suppression of egf function. J. Biol. Chem. 2005, 280, 2924-2933.
    • (2005) J. Biol. Chem , vol.280 , pp. 2924-2933
    • Xu, D.1    Makkinje, A.2    Kyriakis, J.M.3
  • 64
    • 37149025094 scopus 로고    scopus 로고
    • The evolutionarily conserved ebr module of ralt/mig6 mediates suppression of the egfr catalytic activity
    • Anastasi, S.; Baietti, M.F.; Frosi, Y.; Alema, S.; Segatto, O. The evolutionarily conserved ebr module of ralt/mig6 mediates suppression of the egfr catalytic activity. Oncogene 2007, 26, 7833-7846.
    • (2007) Oncogene , vol.26 , pp. 7833-7846
    • Anastasi, S.1    Baietti, M.F.2    Frosi, Y.3    Alema, S.4    Segatto, O.5
  • 65
    • 34548494357 scopus 로고    scopus 로고
    • The k15 protein of kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective sh3 domain interaction
    • Lim, C.S.; Seet, B.T.; Ingham, R.J.; Gish, G.; Matskova, L.; Winberg, G.; Ernberg, I.; Pawson, T. The k15 protein of kaposi's sarcoma-associated herpesvirus recruits the endocytic regulator intersectin 2 through a selective sh3 domain interaction. Biochemistry 2007, 46, 9874-9885.
    • (2007) Biochemistry , vol.46 , pp. 9874-9885
    • Lim, C.S.1    Seet, B.T.2    Ingham, R.J.3    Gish, G.4    Matskova, L.5    Winberg, G.6    Ernberg, I.7    Pawson, T.8
  • 66
    • 84867590782 scopus 로고    scopus 로고
    • The lmp2a protein of epstein-barr virus regulates phosphorylation of itsn1 and shb adaptors by tyrosine kinases
    • Dergai, O.; Dergai, M.; Skrypkina, I.; Matskova, L.; Tsyba, L.; Gudkova, D.; Rynditch, A. The lmp2a protein of epstein-barr virus regulates phosphorylation of itsn1 and shb adaptors by tyrosine kinases. Cell. Signal 2013, 25, 33-40.
    • (2013) Cell. Signal , vol.25 , pp. 33-40
    • Dergai, O.1    Dergai, M.2    Skrypkina, I.3    Matskova, L.4    Tsyba, L.5    Gudkova, D.6    Rynditch, A.7
  • 68
    • 0036828940 scopus 로고    scopus 로고
    • Ephb receptors regulate dendritic spine development via intersectin, cdc42 and n-wasp
    • Irie, F.; Yamaguchi, Y. Ephb receptors regulate dendritic spine development via intersectin, cdc42 and n-wasp. Nat. Neurosci. 2002, 5, 1117-1118.
    • (2002) Nat. Neurosci , vol.5 , pp. 1117-1118
    • Irie, F.1    Yamaguchi, Y.2
  • 69
    • 52449109668 scopus 로고    scopus 로고
    • Dap160/intersectin binds and activates apkc to regulate cell polarity and cell cycle progression
    • Chabu, C.; Doe, C.Q. Dap160/intersectin binds and activates apkc to regulate cell polarity and cell cycle progression. Development 2008, 135, 2739-2746.
    • (2008) Development , vol.135 , pp. 2739-2746
    • Chabu, C.1    Doe, C.Q.2
  • 71
    • 73249129521 scopus 로고    scopus 로고
    • Constitutional runx1 deletion presenting as non-syndromic thrombocytopenia with myelodysplasia: 21q22 itsn1 as a candidate gene in mental retardation
    • Van der Crabben, S.; van Binsbergen, E.; Ausems, M.; Poot, M.; Bierings, M.; Buijs, A. Constitutional runx1 deletion presenting as non-syndromic thrombocytopenia with myelodysplasia: 21q22 itsn1 as a candidate gene in mental retardation. Leuk. Res. 2010, 34, e8-e12.
    • (2010) Leuk. Res , vol.34
    • Van der Crabben, S.1    van Binsbergen, E.2    Ausems, M.3    Poot, M.4    Bierings, M.5    Buijs, A.6
  • 76
    • 0032878103 scopus 로고    scopus 로고
    • Alu-splice cloning of human intersectin (itsn), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in down syndrome
    • Pucharcos, C.; Fuentes, J.J.; Casas, C.; de la Luna, S.; Alcantara, S.; Arbones, M.L.; Soriano, E.; Estivill, X.; Pritchard, M. Alu-splice cloning of human intersectin (itsn), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in down syndrome. Eur. J. Hum. Genet. 1999, 7, 704-712.
    • (1999) Eur. J. Hum. Genet , vol.7 , pp. 704-712
    • Pucharcos, C.1    Fuentes, J.J.2    Casas, C.3    de la Luna, S.4    Alcantara, S.5    Arbones, M.L.6    Soriano, E.7    Estivill, X.8    Pritchard, M.9
  • 80
    • 1242341923 scopus 로고    scopus 로고
    • Incipient alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    • Blalock, E.M.; Geddes, J.W.; Chen, K.C.; Porter, N.M.; Markesbery, W.R.; Landfield, P.W. Incipient alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc. Natl. Acad. Sci. USA 2004, 101, 2173-2178.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2173-2178
    • Blalock, E.M.1    Geddes, J.W.2    Chen, K.C.3    Porter, N.M.4    Markesbery, W.R.5    Landfield, P.W.6
  • 81
    • 0033869715 scopus 로고    scopus 로고
    • Endocytic Pathway Abnormalities Precede Amyloid Beta Deposition In Sporadic Alzheimer's disease and Down Syndrome: Differential Effects of Apoe Genotype and Presenilin Mutations
    • Cataldo, A.M.; Peterhoff, C.M.; Troncoso, J.C.; Gomez-Isla, T.; Hyman, B.T.; Nixon, R.A. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic alzheimer's disease and down syndrome: differential effects of apoe genotype and presenilin mutations. Am. J. Pathol. 2000, 157, 277-286.
    • (2000) Am. J. Pathol , vol.157 , pp. 277-286
    • Cataldo, A.M.1    Peterhoff, C.M.2    Troncoso, J.C.3    Gomez-Isla, T.4    Hyman, B.T.5    Nixon, R.A.6
  • 82
    • 41149154002 scopus 로고    scopus 로고
    • Dscr1/rcan1 Regulates Vesicle Exocytosis and Fusion Pore Kinetics: Implications For Down Syndrome and Alzheimer's disease
    • Keating, D.J.; Dubach, D.; Zanin, M.P.; Yu, Y.; Martin, K.; Zhao, Y.F.; Chen, C.; Porta, S.; Arbones, M.L.; Mittaz, L.; et al. Dscr1/rcan1 regulates vesicle exocytosis and fusion pore kinetics: Implications for down syndrome and alzheimer's disease. Hum. Mol. Genet. 2008, 17, 1020-1030.
    • (2008) Hum. Mol. Genet , vol.17 , pp. 1020-1030
    • Keating, D.J.1    Dubach, D.2    Zanin, M.P.3    Yu, Y.4    Martin, K.5    Zhao, Y.F.6    Chen, C.7    Porta, S.8    Arbones, M.L.9    Mittaz, L.10
  • 83
    • 0032453895 scopus 로고    scopus 로고
    • Genomic structure, sequence, and refined mapping of the human intersectin gene (itsn), which encompasses 250 kb on chromosome 21q22.1→q22.2
    • Guipponi, M.; Scott, H.S.; Hattori, M.; Ishii, K.; Sakaki, Y.; Antonarakis, S.E. Genomic structure, sequence, and refined mapping of the human intersectin gene (itsn), which encompasses 250 kb on chromosome 21q22.1→q22.2. Cytogenet. Cell Genet. 1998, 83, 218-220.
    • (1998) Cytogenet. Cell Genet , vol.83 , pp. 218-220
    • Guipponi, M.1    Scott, H.S.2    Hattori, M.3    Ishii, K.4    Sakaki, Y.5    Antonarakis, S.E.6
  • 84
    • 34547843693 scopus 로고    scopus 로고
    • Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-jun-nh2-terminal kinase
    • Scappini, E.; Koh, T.W.; Martin, N.P.; O'Bryan, J.P. Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-jun-nh2-terminal kinase. Hum. Mol. Genet. 2007, 16, 1862-1871.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 1862-1871
    • Scappini, E.1    Koh, T.W.2    Martin, N.P.3    O'Bryan, J.P.4
  • 85
    • 20744453511 scopus 로고    scopus 로고
    • Cdc42 and ras cooperate to mediate cellular transformation by intersectin-l
    • Wang, J.B.; Wu, W.J.; Cerione, R.A. Cdc42 and ras cooperate to mediate cellular transformation by intersectin-l. J. Biol. Chem. 2005, 280, 22883-22891.
    • (2005) J. Biol. Chem , vol.280 , pp. 22883-22891
    • Wang, J.B.1    Wu, W.J.2    Cerione, R.A.3
  • 86
    • 84869503510 scopus 로고    scopus 로고
    • Intersectin 1 is required for neuroblastoma tumorigenesis
    • Russo, A.; O'Bryan, J.P. Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene 2012, 31, 4828-4834.
    • (2012) Oncogene , vol.31 , pp. 4828-4834
    • Russo, A.1    O'Bryan, J.P.2
  • 88
    • 77956169567 scopus 로고    scopus 로고
    • Reduction of intersectin1-s induced apoptosis of human glioblastoma cells
    • Ma, Y.; Wang, B.; Li, W.; Ying, G.; Fu, L.; Niu, R.; Gu, F. Reduction of intersectin1-s induced apoptosis of human glioblastoma cells. Brain Res. 2010, 1351, 222-228.
    • (2010) Brain Res , vol.1351 , pp. 222-228
    • Ma, Y.1    Wang, B.2    Li, W.3    Ying, G.4    Fu, L.5    Niu, R.6    Gu, F.7
  • 89
    • 0035433907 scopus 로고    scopus 로고
    • Involvement of pi3k in pkcepsilon-mediated oncogenic signal in rat colonic epithelial cells
    • Marras, E.; Concari, P.; Cortellezzi, L.; Dondi, D.; de Eguileor, M.; Perletti, G. Involvement of pi3k in pkcepsilon-mediated oncogenic signal in rat colonic epithelial cells. Int. J. Oncol. 2001, 19, 395-399.
    • (2001) Int. J. Oncol , vol.19 , pp. 395-399
    • Marras, E.1    Concari, P.2    Cortellezzi, L.3    Dondi, D.4    de Eguileor, M.5    Perletti, G.6
  • 93
    • 0037069425 scopus 로고    scopus 로고
    • Expression profiling of cd34+ hematopoietic stem/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia
    • Qian, Z.; Fernald, A.A.; Godley, L.A.; Larson, R.A.; Le Beau, M.M. Expression profiling of cd34+ hematopoietic stem/progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc. Natl. Acad. Sci. USA 2002, 99, 14925-14930.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14925-14930
    • Qian, Z.1    Fernald, A.A.2    Godley, L.A.3    Larson, R.A.4    Le Beau, M.M.5
  • 98
    • 0025365140 scopus 로고
    • Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7
    • Bremner, R.; Balmain, A. Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 1990, 61, 407-417.
    • (1990) Cell , vol.61 , pp. 407-417
    • Bremner, R.1    Balmain, A.2
  • 100
    • 0025520003 scopus 로고
    • Expression of the normal h-ras1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes
    • Spandidos, D.A.; Frame, M.; Wilkie, N.M. Expression of the normal h-ras1 gene can suppress the transformed and tumorigenic phenotypes induced by mutant ras genes. Anticancer Res. 1990, 10, 1543-1554.
    • (1990) Anticancer Res , vol.10 , pp. 1543-1554
    • Spandidos, D.A.1    Frame, M.2    Wilkie, N.M.3
  • 101
    • 0024154082 scopus 로고
    • The normal human h-ras1 gene can act as an onco-suppressor
    • Spandidos, A.; Wilkie, N.M. The normal human h-ras1 gene can act as an onco-suppressor. Br. J. Cancer Suppl. 1988, 9, 67-71.
    • (1988) Br. J. Cancer Suppl , vol.9 , pp. 67-71
    • Spandidos, A.1    Wilkie, N.M.2
  • 102
    • 0023715225 scopus 로고
    • Inhibition of nih 3t3 cell proliferation by a mutant ras protein with preferential affinity for gdp
    • Feig, L.A.; Cooper, G.M. Inhibition of nih 3t3 cell proliferation by a mutant ras protein with preferential affinity for gdp. Mol. Cell Biol. 1988, 8, 3235-3243.
    • (1988) Mol. Cell Biol , vol.8 , pp. 3235-3243
    • Feig, L.A.1    Cooper, G.M.2
  • 106
    • 33746555367 scopus 로고    scopus 로고
    • A functional switch from lung cancer resistance to susceptibility at the pas1 locus in kras2la2 mice
    • To, M.D.; Perez-Losada, J.; Mao, J.H.; Hsu, J.; Jacks, T.; Balmain, A. A functional switch from lung cancer resistance to susceptibility at the pas1 locus in kras2la2 mice. Nat. Genet. 2006, 38, 926-930.
    • (2006) Nat. Genet , vol.38 , pp. 926-930
    • To, M.D.1    Perez-Losada, J.2    Mao, J.H.3    Hsu, J.4    Jacks, T.5    Balmain, A.6
  • 107
    • 52949118488 scopus 로고    scopus 로고
    • Kras regulatory elements and exon 4a determine mutation specificity in lung cancer
    • To, M.D.; Wong, C.E.; Karnezis, A.N.; del Rosario, R.; di Lauro, R.; Balmain, A. Kras regulatory elements and exon 4a determine mutation specificity in lung cancer. Nat. Genet. 2008, 40, 1240-1244.
    • (2008) Nat. Genet , vol.40 , pp. 1240-1244
    • To, M.D.1    Wong, C.E.2    Karnezis, A.N.3    del Rosario, R.4    di Lauro, R.5    Balmain, A.6
  • 108
    • 84883186892 scopus 로고    scopus 로고
    • Interactions between wild-type and mutant ras genes in lung and skin carcinogenesis
    • To, M.D.; Rosario, R.D.; Westcott, P.M.; Banta, K.L.; Balmain, A. Interactions between wild-type and mutant ras genes in lung and skin carcinogenesis. Oncogene 2012, doi:10.1038/onc.2012.404
    • (2012) Oncogene
    • To, M.D.1    Rosario, R.D.2    Westcott, P.M.3    Banta, K.L.4    Balmain, A.5
  • 109
    • 42449118549 scopus 로고    scopus 로고
    • Mechanisms of asymmetric cell division: Flies and worms pave the way
    • Gonczy, P. Mechanisms of asymmetric cell division: Flies and worms pave the way. Nat. Rev. Mol. Cell Biol. 2008, 9, 355-366.
    • (2008) Nat. Rev. Mol. Cell Biol , vol.9 , pp. 355-366
    • Gonczy, P.1
  • 110
    • 72549092813 scopus 로고    scopus 로고
    • Dividing cellular asymmetry: Asymmetric cell division and its implications for stem cells and cancer
    • Neumuller, R.A.; Knoblich, J.A. dividing cellular asymmetry: Asymmetric cell division and its implications for stem cells and cancer. Genes. Dev. 2009, 23, 2675-2699.
    • (2009) Genes. Dev , vol.23 , pp. 2675-2699
    • Neumuller, R.A.1    Knoblich, J.A.2
  • 111
    • 84864759128 scopus 로고    scopus 로고
    • The clathrin adaptor dab2 recruits eh domain scaffold proteins to regulate integrin beta1 endocytosis
    • Teckchandani, A.; Mulkearns, E.E.; Randolph, T.W.; Toida, N.; Cooper, J.A. The clathrin adaptor dab2 recruits eh domain scaffold proteins to regulate integrin beta1 endocytosis. Mol. Biol. Cell. 2012, 23, 2905-2916.
    • (2012) Mol. Biol. Cell , vol.23 , pp. 2905-2916
    • Teckchandani, A.1    Mulkearns, E.E.2    Randolph, T.W.3    Toida, N.4    Cooper, J.A.5
  • 112
    • 0742306892 scopus 로고    scopus 로고
    • Stimulation-dependent recycling of integrin beta1 regulated by arf6 and rab11
    • Powelka, A.M.; Sun, J.; Li, J.; Gao, M.; Shaw, L.M.; Sonnenberg, A.; Hsu, V.W. Stimulation-dependent recycling of integrin beta1 regulated by arf6 and rab11. Traffic 2004, 5, 20-36.
    • (2004) Traffic , vol.5 , pp. 20-36
    • Powelka, A.M.1    Sun, J.2    Li, J.3    Gao, M.4    Shaw, L.M.5    Sonnenberg, A.6    Hsu, V.W.7
  • 113
    • 30044449424 scopus 로고    scopus 로고
    • Interactions between ehd proteins and rab11-fip2: A role for ehd3 in early endosomal transport
    • Naslavsky, N.; Rahajeng, J.; Sharma, M.; Jovic, M.; Caplan, S. Interactions between ehd proteins and rab11-fip2: A role for ehd3 in early endosomal transport. Mol. Biol. Cell 2006, 17, 163-177.
    • (2006) Mol. Biol. Cell , vol.17 , pp. 163-177
    • Naslavsky, N.1    Rahajeng, J.2    Sharma, M.3    Jovic, M.4    Caplan, S.5
  • 114
    • 16344363943 scopus 로고    scopus 로고
    • Rab11 in recycling endosomes regulates the sorting and basolateral transport of e-cadherin
    • Lock, J.G.; Stow, J.L. Rab11 in recycling endosomes regulates the sorting and basolateral transport of e-cadherin. Mol. Biol. Cell 2005, 16, 1744-1755.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1744-1755
    • Lock, J.G.1    Stow, J.L.2
  • 115
    • 0035801516 scopus 로고    scopus 로고
    • An essential role for arf6-regulated membrane traffic in adherens junction turnover and epithelial cell migration
    • Palacios, F.; Price, L.; Schweitzer, J.; Collard, J.G.; D'Souza-Schorey, C. An essential role for arf6-regulated membrane traffic in adherens junction turnover and epithelial cell migration. EMBO J. 2001, 20, 4973-4986.
    • (2001) EMBO J , vol.20 , pp. 4973-4986
    • Palacios, F.1    Price, L.2    Schweitzer, J.3    Collard, J.G.4    D'Souza-Schorey, C.5
  • 117
    • 33747612463 scopus 로고    scopus 로고
    • Intersectin-1l nucleotide exchange factor regulates secretory granule exocytosis by activating cdc42
    • Malacombe, M.; Ceridono, M.; Calco, V.; Chasserot-Golaz, S.; McPherson, P.S.; Bader, M.F.; Gasman, S. Intersectin-1l nucleotide exchange factor regulates secretory granule exocytosis by activating cdc42. EMBO J. 2006, 25, 3494-3503.
    • (2006) EMBO J , vol.25 , pp. 3494-3503
    • Malacombe, M.1    Ceridono, M.2    Calco, V.3    Chasserot-Golaz, S.4    McPherson, P.S.5    Bader, M.F.6    Gasman, S.7
  • 118
    • 84861870842 scopus 로고    scopus 로고
    • Human intersectin 2 (itsn2) binds to eps8 protein and enhances its degradation
    • Ding, X.; Yang, Z.; Zhou, F.; Hu, X.; Zhou, C.; Luo, C.; He, Z.; Liu, Q.; Li, H.; Yan, F.; et al. Human intersectin 2 (itsn2) binds to eps8 protein and enhances its degradation. BMB Rep. 2012, 45, 183-188.
    • (2012) BMB Rep , vol.45 , pp. 183-188
    • Ding, X.1    Yang, Z.2    Zhou, F.3    Hu, X.4    Zhou, C.5    Luo, C.6    He, Z.7    Liu, Q.8    Li, H.9    Yen, F.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.