An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration

EMBO Journal

Volumn 20, Issue 17, 2001, Pages 4973-4986

  Palacios, Felipe ^a   Price, Leo ^a,b   Schweitzer, Jill ^a   Collard, John G ^b   D'Souza Schorey, Crislyn ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Adherens junctions; ARF6; Cell cell adhesion; Epithelia; Membrane traffic

Indexed keywords

CADHERIN; GUANOSINE TRIPHOSPHATASE; SCATTER FACTOR;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL MIGRATION; CELL POLARITY; ENZYME ACTIVITY; EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; TIGHT JUNCTION;

ADHERENS JUNCTIONS; ADP-RIBOSYLATION FACTORS; AMINO ACID SUBSTITUTION; ANIMALS; CADHERINS; CELL LINE; CYTOPLASM; CYTOSKELETON; DOGS; EPITHELIAL CELLS; GTP PHOSPHOHYDROLASES; GUANOSINE TRIPHOSPHATE; MODELS, BIOLOGICAL; MOVEMENT; MUTAGENESIS, SITE-DIRECTED; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; TRANSFECTION; UROTHELIUM;

ANIMALIA;

EID: 0035801516     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.17.4973     Document Type: Article

References (41)

1. Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant
2. ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells
3. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
4. E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers
5. Molecular aspects of mesenchymal-epithelial interactions
6. Epithelial differentiation and the control of metastasis in carcinomas
7. ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA
8. Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
9. The role of ARF and Rab GTPases in membrane transport
10. Coupling assembly of the E-cadherin/β-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells
11. Phosphoinositides in membrane traffic at the synapse
12. Origins of cell polarity
13. A role for POR 1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements
14. ARF6 targets recycling vesicles to the plasma membrane: Insights from an ultrastructural investigation
15. 2+-dependent adhesion molecules
16. Regulation of cadherin adhesive activity
17. Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility
18. Phosphatidylinositol 4-phosphate 5-kinase α is a downstream effector of the small G protein ARF6 in membrane ruffle formation
19. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling
20. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery
21. Coendocytosis of cadherin and c-Met coupled to disruption of cell-cell adhesion in MDCK cells - Regulation by Rho, Rac and Rab small G proteins
22. Cell motility
23. Recycling of E-cadherin: A potential mechanism for regulating cadherin dynamics
24. Plasticity in epithelial cell phenotype: Modulation by expression of different cadherin cell adhesion molecules
25. Phosphoinositide lipids as signaling molecules: Common themes for signal transduction, cytoskeletal regulation and membrane trafficking
26. Expression of Rho GTPases using retroviral vectors
27. ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway
28. ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements
29. Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions
30. Rho-like GTPases: Their role in epithelial cell-cell adhesion and invasion
31. Modulation of epithelial morphogenesis and cell fate by cell-to-cell signals and regulated cell adhesion
32. HGF: A multifunctional growth factor controlling cell scattering
33. Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia
34. Effects of tyrosine phosphorylation on tight junctions in temperature-sensitive v-src-transfected MDCK cells
35. Pathways and mechanisms of avian trunk neural crest cell migration and localization
36. Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome
37. 3H]inositol-labeled phosphoinositide pools
38. Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells
39. Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin
40. Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells
41. Molecular and functional analysis of cadherin-based adherens junctions