-
1
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe, D. J. (2001) Alzheimer's disease: Genes, proteins, and therapy Physiol. Rev. 81, 741-766
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
2
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy, J. and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics Science 297, 353-356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
3
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome Proc. Natl. Acad. Sci. U.S.A. 82, 4245-4269
-
(1985)
Proc. Natl. Acad. Sci. U.S.A.
, vol.82
, pp. 4245-4269
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
4
-
-
4344688011
-
Targeting the neurotoxic species in Alzheimer's disease: Inhibitors of Aβ oligomerization
-
De Felice, F. G., Viera, M. N. N., Saraiva, L. M., Figueroa-Villar, J. D., Garci-Abreu, J., Liu, R., Chang, L., Klein, W. L., and Ferreira, S. T. (2004) Targeting the neurotoxic species in Alzheimer's disease: Inhibitors of Aβ oligomerization FASEB J. 18, 1366-1372
-
(2004)
FASEB J.
, vol.18
, pp. 1366-1372
-
-
De Felice, F.G.1
Viera, M.N.N.2
Saraiva, L.M.3
Figueroa-Villar, J.D.4
Garci-Abreu, J.5
Liu, R.6
Chang, L.7
Klein, W.L.8
Ferreira, S.T.9
-
5
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G., Beyreuther, K., and Muller-Hill, B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor Nature 325, 733-736
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
6
-
-
0023132387
-
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
-
Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., and Gajdusek, D. C. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease Science 235, 877-880
-
(1987)
Science
, vol.235
, pp. 877-880
-
-
Goldgaber, D.1
Lerman, M.I.2
McBride, O.W.3
Saffiotti, U.4
Gajdusek, D.C.5
-
7
-
-
0023109592
-
Amyloid β protein gene: CDNA, mRNA distribution, and genetic linkage near the Alzheimer locus
-
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., and Neve, R. L. (1987) Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus Science 235, 880-884
-
(1987)
Science
, vol.235
, pp. 880-884
-
-
Tanzi, R.E.1
Gusella, J.F.2
Watkins, P.C.3
Bruns, G.A.4
St George-Hyslop, P.5
Van Keuren, M.L.6
Patterson, D.7
Pagan, S.8
Kurnit, D.M.9
Neve, R.L.10
-
8
-
-
2142777413
-
Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides
-
Robakis, N. K., Ramakrishna, N., Wolfe, G., and Wisniewski, H. M. (1987) Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides Proc. Natl. Acad. Sci. U.S.A. 84, 4190-4194
-
(1987)
Proc. Natl. Acad. Sci. U.S.A.
, vol.84
, pp. 4190-4194
-
-
Robakis, N.K.1
Ramakrishna, N.2
Wolfe, G.3
Wisniewski, H.M.4
-
9
-
-
0033595706
-
β-Secretase cleavage of the Alzheimer's precursor protein by the transmembrane aspartic protease BACE
-
Vassar, R., Bennett, B. D., Babu-Khan, S., Khan, S., Mendiaz, E., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J.-C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) β-Secretase cleavage of the Alzheimer's precursor protein by the transmembrane aspartic protease BACE Science 286, 735-741
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Khan, S.4
Mendiaz, E.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.-C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
10
-
-
0033518251
-
Purification and cloning of amyloid precursor protein β-secretase from human brain
-
Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberberg, I., Power, M., Tanh, H., Tatsuno, G., Ting, J., Schenk, D., Suomensaari, S. M., Wang, S., Walker, D., and John, V. 1999, Purification and cloning of amyloid precursor protein β-secretase from human brain Nature 402, 537-540
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberberg, I.15
Power, M.16
Tanh, H.17
Tatsuno, G.18
Ting, J.19
Schenk, D.20
Suomensaari, S.M.21
Wang, S.22
Walker, D.23
John, V.24
more..
-
11
-
-
0142092495
-
Human β-secretase (BACE) and BACE inhibitors
-
Beck, J. P., Bienkowski, M. J., Sinha, S., and Heinrikson, R. L. (2003) Human β-secretase (BACE) and BACE inhibitors J. Med. Chem. 46, 4625-4630
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4625-4630
-
-
Beck, J.P.1
Bienkowski, M.J.2
Sinha, S.3
Heinrikson, R.L.4
-
12
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein Nature 391, 387-390
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
Saftig, P.2
Craessaerts, K.3
Vanderstichele, H.4
Guhde, G.5
Annaert, W.6
Von Figura, K.7
Van Leuven, F.8
-
13
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
-
Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity Nature 398, 513-517
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
14
-
-
0038664363
-
Reconstitution of γ-secretase activity
-
Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Reconstitution of γ-secretase activity Nat. Cell Biol. 5, 486-488
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 486-488
-
-
Edbauer, D.1
Winkler, E.2
Regula, J.T.3
Pesold, B.4
Steiner, H.5
Haass, C.6
-
15
-
-
0036323445
-
Alzheimer's disease and cerebrovascular pathology: An update
-
Jellinger, K. A. (2002) Alzheimer's disease and cerebrovascular pathology: An update J. Neural Transm. 109, 813-836
-
(2002)
J. Neural Transm.
, vol.109
, pp. 813-836
-
-
Jellinger, K.A.1
-
16
-
-
0142138664
-
Pathogenesis of cerebral amyloid angiopathy
-
Rensink, A. A., de Waal, R. M., Kremer, B., and Verbeek, M. M. (2003) Pathogenesis of cerebral amyloid angiopathy Brain Res. Brain Res. Rev. 43, 207-223
-
(2003)
Brain Res. Brain Res. Rev.
, vol.43
, pp. 207-223
-
-
Rensink, A.A.1
De Waal, R.M.2
Kremer, B.3
Verbeek, M.M.4
-
17
-
-
78651087735
-
Sporadic cerebral amyloid angiopathy
-
Attems, J., Jellinger, K., Thal, D. R., and Van Nostrand, W. (2011) Sporadic cerebral amyloid angiopathy Neuropathol. Appl. Neurobiol. 37, 75-93
-
(2011)
Neuropathol. Appl. Neurobiol.
, vol.37
, pp. 75-93
-
-
Attems, J.1
Jellinger, K.2
Thal, D.R.3
Van Nostrand, W.4
-
18
-
-
34548812551
-
The role of amyloid β peptide 42 in Alzheimer's disease
-
Findeis, M. A. (2007) The role of amyloid β peptide 42 in Alzheimer's disease Pharmacol. Ther. 116, 266-286
-
(2007)
Pharmacol. Ther.
, vol.116
, pp. 266-286
-
-
Findeis, M.A.1
-
19
-
-
0025296269
-
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
-
Levy, E., Carman, M. D., Fernandez-Madrid, I. J., Power, M. D., Lieberburg, I., van Duinen, S. G., Bots, G. T., Luyendijk, W., and Frangione, B. (1990) Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type Science 248, 1124-1126
-
(1990)
Science
, vol.248
, pp. 1124-1126
-
-
Levy, E.1
Carman, M.D.2
Fernandez-Madrid, I.J.3
Power, M.D.4
Lieberburg, I.5
Van Duinen, S.G.6
Bots, G.T.7
Luyendijk, W.8
Frangione, B.9
-
20
-
-
0025369198
-
Amyloid β protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)
-
Van Broeckhoven, C., Haan, J., Bakker, E., Hardy, J. A., Van Hul, W., Wehnert, A., Vegter-Van der Vlis, M., and Roos, R. A. (1990) Amyloid β protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch) Science 248, 1120-1122
-
(1990)
Science
, vol.248
, pp. 1120-1122
-
-
Van Broeckhoven, C.1
Haan, J.2
Bakker, E.3
Hardy, J.A.4
Van Hul, W.5
Wehnert, A.6
Vegter-Van Der Vlis, M.7
Roos, R.A.8
-
21
-
-
0034982951
-
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
-
Grabowski, T. J., Cho, H. S., Vonsattel, J. P., Rebeck, G. W., and Greenberg, S. M. (2001) Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy Ann. Neurol. 49, 697-705
-
(2001)
Ann. Neurol.
, vol.49
, pp. 697-705
-
-
Grabowski, T.J.1
Cho, H.S.2
Vonsattel, J.P.3
Rebeck, G.W.4
Greenberg, S.M.5
-
22
-
-
0029920991
-
Enhanced pathologic properties of Dutch-type mutant amyloid β-protein
-
Davis, J. and Van Nostrand, W. E. (1996) Enhanced pathologic properties of Dutch-type mutant amyloid β-protein Proc. Natl. Acad. Sci. U.S.A. 93, 2996-3000
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 2996-3000
-
-
Davis, J.1
Van Nostrand, W.E.2
-
23
-
-
0031017399
-
Rapid degeneration of cultured human brain pericytes by amyloid β protein
-
Verbeek, M. M., de Waal, R. M., Schipper, J. J., and Van Nostrand, W. E. (1997) Rapid degeneration of cultured human brain pericytes by amyloid β protein J. Neurochem. 68, 1135-1141
-
(1997)
J. Neurochem.
, vol.68
, pp. 1135-1141
-
-
Verbeek, M.M.1
De Waal, R.M.2
Schipper, J.J.3
Van Nostrand, W.E.4
-
24
-
-
0034282630
-
Substitutions at codon 22 of Alzheimer's Aβ peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells
-
Miravalle, L., Tokuda, T., Chiarle, R., Giaccone, G., Bugiani, O., Tagliavini, F., Frangione, B., and Ghiso, J. (2000) Substitutions at codon 22 of Alzheimer's Aβ peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells J. Biol. Chem. 275, 27110-27116
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27110-27116
-
-
Miravalle, L.1
Tokuda, T.2
Chiarle, R.3
Giaccone, G.4
Bugiani, O.5
Tagliavini, F.6
Frangione, B.7
Ghiso, J.8
-
25
-
-
0034049538
-
Charge alterations of E22 enhance the pathogenic properties of the amyloid β-protein
-
Melchor, J. P., McVoy, L., and Van Nostrand, W. E. (2000) Charge alterations of E22 enhance the pathogenic properties of the amyloid β-protein J. Neurochem. 74, 2209-2212
-
(2000)
J. Neurochem.
, vol.74
, pp. 2209-2212
-
-
Melchor, J.P.1
McVoy, L.2
Van Nostrand, W.E.3
-
26
-
-
0035980088
-
Pathogenic effects of D23N Iowa mutant amyloid β-protein
-
Van Nostrand, W. E., Melchor, J. P., Cho, H. S., Greenberg, S. M., and Rebeck, G. W. (2001) Pathogenic effects of D23N Iowa mutant amyloid β-protein J. Biol. Chem. 276, 32860-32866
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32860-32866
-
-
Van Nostrand, W.E.1
Melchor, J.P.2
Cho, H.S.3
Greenberg, S.M.4
Rebeck, G.W.5
-
27
-
-
0038176528
-
In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis
-
Stine, W. B., Jr., Dahlgren, K. N., Krafft, G. A., and LaDu, M. J. (2003) In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis J. Biol. Chem. 278, 11612-11622
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11612-11622
-
-
Stine Jr., W.B.1
Dahlgren, K.N.2
Krafft, G.A.3
Ladu, M.J.4
-
28
-
-
57449091884
-
Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils
-
Paravastua, A. K., Leapman, R. D., Yau, W. M., and Tycko, R. (2008) Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils Proc. Natl. Acad. Sci. U.S.A. 105, 18349-18354
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 18349-18354
-
-
Paravastua, A.K.1
Leapman, R.D.2
Yau, W.M.3
Tycko, R.4
-
29
-
-
77951975748
-
Structural conversion of neurotoxic amyloid-β(1-42) oligomers to fibrils
-
Ahmed, M., Davis, J., Aucoin, D., Sato, T., Ahuja, S., Aimoto, S., Elliott, J. I., Van Nostrand, W. E., and Smith, S. O. (2010) Structural conversion of neurotoxic amyloid-β(1-42) oligomers to fibrils Nat. Struct. Mol. Biol. 17, 561-567
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 561-567
-
-
Ahmed, M.1
Davis, J.2
Aucoin, D.3
Sato, T.4
Ahuja, S.5
Aimoto, S.6
Elliott, J.I.7
Van Nostrand, W.E.8
Smith, S.O.9
-
30
-
-
70349295278
-
Structure-neurotoxicity relationships of amyloid β-protein oligomers
-
Ono, K., Condron, M. M., and Teplow, D. B. (2009) Structure-neurotoxicity relationships of amyloid β-protein oligomers Proc. Natl. Acad. Sci. U.S.A. 106, 14745-14750
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 14745-14750
-
-
Ono, K.1
Condron, M.M.2
Teplow, D.B.3
-
31
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002) Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo Nature 416, 535-539
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
32
-
-
49149124343
-
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., and Selkoe, D. J. (2008) Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory Nat. Med. 14, 837-842
-
(2008)
Nat. Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
33
-
-
33344463679
-
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
-
Glabe, C. G. (2006) Common mechanisms of amyloid oligomer pathogenesis in degenerative disease Neurobiol. Aging 27, 570-575
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 570-575
-
-
Glabe, C.G.1
-
34
-
-
0037195163
-
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease
-
Urbanc, B., Cruz, J., Le, R., Sanders, J., Hsiao Ashe, K., Duff, K., Stanley, H. E., Irizarry, M. C., and Hyman, B. T. (2002) Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease Proc. Natl. Acad. Sci. U.S.A. 99, 13990-13995
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 13990-13995
-
-
Urbanc, B.1
Cruz, J.2
Le, R.3
Sanders, J.4
Hsiao Ashe, K.5
Duff, K.6
Stanley, H.E.7
Irizarry, M.C.8
Hyman, B.T.9
-
35
-
-
0031983456
-
Pathogenic cell surface amyloid β-protein fibril assembly in cultured human cerebrovascular smooth muscle cells
-
Van Nostrand, W. E., Melchor, J., and Ruffini, L. (1998) Pathogenic cell surface amyloid β-protein fibril assembly in cultured human cerebrovascular smooth muscle cells J. Neurochem. 70, 216-223
-
(1998)
J. Neurochem.
, vol.70
, pp. 216-223
-
-
Van Nostrand, W.E.1
Melchor, J.2
Ruffini, L.3
-
36
-
-
0026447529
-
Complement activation by β-amyloid in Alzheimer's disease
-
Rogers, J., Cooper, N. R., Webster, S., Schulz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., and Lieberburg, I. (1992) Complement activation by β-amyloid in Alzheimer's disease Proc. Natl. Acad. Sci. U.S.A. 89, 10016-10020
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 10016-10020
-
-
Rogers, J.1
Cooper, N.R.2
Webster, S.3
Schulz, J.4
McGeer, P.L.5
Styren, S.D.6
Civin, W.H.7
Brachova, L.8
Bradt, B.9
Lieberburg, I.10
-
37
-
-
0035575742
-
β-Amyloid fibrils activate the C1 complex of complement under physiological conditions: Evidence for a binding site for Aβ on the C1q globular regions
-
Tacnet-Delorme, P., Chevallier, S., and Arlaud, G. J. (2001) β-Amyloid fibrils activate the C1 complex of complement under physiological conditions: Evidence for a binding site for Aβ on the C1q globular regions J. Immunol. 167, 6374-6381
-
(2001)
J. Immunol.
, vol.167
, pp. 6374-6381
-
-
Tacnet-Delorme, P.1
Chevallier, S.2
Arlaud, G.J.3
-
38
-
-
19944421400
-
The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: Therapeutic implications
-
Rozemuller, A. J., van Gool, W. A., and Eikelenboom, P. (2005) The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: Therapeutic implications Curr. Drug Targets: CNS Neurol. Disord. 4, 223-233
-
(2005)
Curr. Drug Targets: CNS Neurol. Disord.
, vol.4
, pp. 223-233
-
-
Rozemuller, A.J.1
Van Gool, W.A.2
Eikelenboom, P.3
-
39
-
-
70349323417
-
CD14 and toll-like receptors 2 and are required for fibrillar Aβ-stimulated microglial activation
-
Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., and Landreth, G. E. (2009) CD14 and toll-like receptors 2 and are required for fibrillar Aβ-stimulated microglial activation J. Neurosci. 29, 11982-11992
-
(2009)
J. Neurosci.
, vol.29
, pp. 11982-11992
-
-
Reed-Geaghan, E.G.1
Savage, J.C.2
Hise, A.G.3
Landreth, G.E.4
-
40
-
-
12044254746
-
Binding of human apolipoprotein e to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease
-
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schemchel, D., Saunders, A. M., Goldgaber, D., and Roses, A. D. (1993) Binding of human apolipoprotein E to synthetic amyloid β peptide: Isoform-specific effects and implications for late-onset Alzheimer disease Proc. Natl. Acad. Sci. U.S.A. 90, 8098-8102
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 8098-8102
-
-
Strittmatter, W.J.1
Weisgraber, K.H.2
Huang, D.Y.3
Dong, L.M.4
Salvesen, G.S.5
Pericak-Vance, M.6
Schemchel, D.7
Saunders, A.M.8
Goldgaber, D.9
Roses, A.D.10
-
41
-
-
0027931854
-
Isoform-specific binding of apolipoprotein e to β-amyloid
-
LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., and Frail, D. E. (1994) Isoform-specific binding of apolipoprotein E to β-amyloid J. Biol. Chem. 269, 23403-23406
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 23403-23406
-
-
Ladu, M.J.1
Falduto, M.T.2
Manelli, A.M.3
Reardon, C.A.4
Getz, G.S.5
Frail, D.E.6
-
42
-
-
0027970307
-
Acceleration of Alzheimer's fibril formation by apolipoprotein-E in vitro
-
Wisniewski, T., Castano, E. M., Golabek, A., Vogel, T., and Frangione, B. (1994) Acceleration of Alzheimer's fibril formation by apolipoprotein-E in vitro Am. J. Pathol. 145, 1030-1035
-
(1994)
Am. J. Pathol.
, vol.145
, pp. 1030-1035
-
-
Wisniewski, T.1
Castano, E.M.2
Golabek, A.3
Vogel, T.4
Frangione, B.5
-
43
-
-
2542430828
-
ApoE and Aβ42 interactions: Effects of isoform and conformation on structure and function
-
Manelli, A. M., Stine, W. B., van Eldik, L. J., and LaDu, M. J. (2004) ApoE and Aβ42 interactions: Effects of isoform and conformation on structure and function J. Mol. Neurosci. 23, 235-246
-
(2004)
J. Mol. Neurosci.
, vol.23
, pp. 235-246
-
-
Manelli, A.M.1
Stine, W.B.2
Van Eldik, L.J.3
Ladu, M.J.4
-
44
-
-
0033593027
-
Apolipoprotein e is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease
-
Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., Ghetti, B., and Paul, S. M. (1999) Apolipoprotein E is essential for amyloid deposition in the APPV717F transgenic mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. U.S.A. 96, 15233-15238
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 15233-15238
-
-
Bales, K.R.1
Verina, T.2
Cummins, D.J.3
Du, Y.4
Dodel, R.C.5
Saura, J.6
Fishman, C.E.7
Delong, C.A.8
Piccardo, P.9
Petegnief, V.10
Ghetti, B.11
Paul, S.M.12
-
45
-
-
16644395500
-
Apolipoprotein e is required for the formation of filamentous amyloid, but not for amorphous Aβ deposition, in an AβPP/PS double transgenic mouse model of Alzheimer's disease
-
Costa, D. A., Nilsson, L. N., Bales, K. R., Paul, S. M., and Potter, H. (2004) Apolipoprotein E is required for the formation of filamentous amyloid, but not for amorphous Aβ deposition, in an AβPP/PS double transgenic mouse model of Alzheimer's disease J. Alzheimer's Dis. 6, 509-514
-
(2004)
J. Alzheimer's Dis.
, vol.6
, pp. 509-514
-
-
Costa, D.A.1
Nilsson, L.N.2
Bales, K.R.3
Paul, S.M.4
Potter, H.5
-
46
-
-
0028921915
-
Characterization of Apolipoprotein J-Alzheimers Aβ interaction
-
Matsubara, E., Fragnione, B., and Ghiso, J. (1995) Characterization of Apolipoprotein J-Alzheimers Aβ interaction J. Biol. Chem. 270, 7563-7567
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7563-7567
-
-
Matsubara, E.1
Fragnione, B.2
Ghiso, J.3
-
47
-
-
0036678856
-
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease
-
DeMattos, R. B., O'dell, M. A., Parsadanian, M., Taylor, J. W., Harmony, J. A., Bales, K. R., Paul, S. M., Aronow, B. J., and Holtzman, D. M. (2002) Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. U.S.A. 99, 10843-10848
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 10843-10848
-
-
Demattos, R.B.1
O'Dell, M.A.2
Parsadanian, M.3
Taylor, J.W.4
Harmony, J.A.5
Bales, K.R.6
Paul, S.M.7
Aronow, B.J.8
Holtzman, D.M.9
-
48
-
-
78449232720
-
Apolipoprotein A-1 deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1dE9 mice
-
Lefterov, I., Fitz, N. F., Cronican, A. A., Fogg, A., Lefterov, P., Kodali, R., Wetzel, R., and Koldamova, R. (2010) Apolipoprotein A-1 deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1dE9 mice J. Biol. Chem. 285, 36945-36957
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 36945-36957
-
-
Lefterov, I.1
Fitz, N.F.2
Cronican, A.A.3
Fogg, A.4
Lefterov, P.5
Kodali, R.6
Wetzel, R.7
Koldamova, R.8
-
49
-
-
78449255602
-
Overexpression of human apolipoprotein A-I preserves cognition and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer's disease
-
Lewis, T. L., Cao, D., Lu, H., Mans, R. A., Su, Y. R., Jungbauer, L., Linton, M. F., Fazio, S., LaDu, M. J., and Li, L. (2010) Overexpression of human apolipoprotein A-I preserves cognition and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer's disease J. Biol. Chem. 285, 36958-36968
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 36958-36968
-
-
Lewis, T.L.1
Cao, D.2
Lu, H.3
Mans, R.A.4
Su, Y.R.5
Jungbauer, L.6
Linton, M.F.7
Fazio, S.8
Ladu, M.J.9
Li, L.10
-
50
-
-
0029661902
-
α-1-Antichymotrypsin interaction with Aβ(1-40) inhibits fibril formation but does not affect the peptide toxicity
-
Aksenova, M. V., Aksenova, M. Y., Butterfield, D. A., and Carney, J. M. (1996) α-1-Antichymotrypsin interaction with Aβ(1-40) inhibits fibril formation but does not affect the peptide toxicity Neurosci. Lett. 211, 45-48
-
(1996)
Neurosci. Lett.
, vol.211
, pp. 45-48
-
-
Aksenova, M.V.1
Aksenova, M.Y.2
Butterfield, D.A.3
Carney, J.M.4
-
51
-
-
0035696320
-
The inflammation-induced pathological chaperones ACT and apoE are necessary catalysts of Alzheimer amyloid formation
-
Potter, H., Wefes, I. M., and Nilsson, L. N. (2001) The inflammation-induced pathological chaperones ACT and apoE are necessary catalysts of Alzheimer amyloid formation Neurobiol. Aging 22, 923-930
-
(2001)
Neurobiol. Aging
, vol.22
, pp. 923-930
-
-
Potter, H.1
Wefes, I.M.2
Nilsson, L.N.3
-
52
-
-
2542450276
-
Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants
-
Schwarzman, A. L., Tsiper, M., Wente, H., Wang, A., Vitek, M. P., Vasiliev, V., and Goldgaber, D. (2004) Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants Amyloid 11, 1-9
-
(2004)
Amyloid
, vol.11
, pp. 1-9
-
-
Schwarzman, A.L.1
Tsiper, M.2
Wente, H.3
Wang, A.4
Vitek, M.P.5
Vasiliev, V.6
Goldgaber, D.7
-
53
-
-
40649096849
-
Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity
-
Buxbaum, J. N., Ye, Z., Reixach, N., Friske, L., Levy, C., Das, P., Golde, T., Masliah, E., Roberts, A. R., and Bartfai, T. (2008) Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity Proc. Natl. Acad. Sci. U.S.A. 105, 2681-2686
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 2681-2686
-
-
Buxbaum, J.N.1
Ye, Z.2
Reixach, N.3
Friske, L.4
Levy, C.5
Das, P.6
Golde, T.7
Masliah, E.8
Roberts, A.R.9
Bartfai, T.10
-
54
-
-
0035816709
-
Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid
-
Kakio, A., Nishimoto, S. I., Yanagisawa, K., Kozutsumi, Y., and Matsuzaki, K. (2001) Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid J. Biol. Chem. 276, 24985-24990
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24985-24990
-
-
Kakio, A.1
Nishimoto, S.I.2
Yanagisawa, K.3
Kozutsumi, Y.4
Matsuzaki, K.5
-
55
-
-
16344382167
-
Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides
-
Yamamoto, N., Hirabayashi, Y., Amari, M., Yamaguchi, H., Romanov, G., Van Nostrand, W. E., and Yanagisawa, K. (2005) Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides FEBS Lett. 579, 2185-2190
-
(2005)
FEBS Lett.
, vol.579
, pp. 2185-2190
-
-
Yamamoto, N.1
Hirabayashi, Y.2
Amari, M.3
Yamaguchi, H.4
Romanov, G.5
Van Nostrand, W.E.6
Yanagisawa, K.7
-
56
-
-
34248151111
-
Inhibition of familial cerebral amyloid angiopathy mutant amyloid β-protein fibril assembly by myelin basic protein
-
Hoos, M. D., Ahmed, M., Smith, S. O., and Van Nostrand, W. E. (2007) Inhibition of familial cerebral amyloid angiopathy mutant amyloid β-protein fibril assembly by myelin basic protein J. Biol. Chem. 282, 9952-9961
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9952-9961
-
-
Hoos, M.D.1
Ahmed, M.2
Smith, S.O.3
Van Nostrand, W.E.4
-
57
-
-
66649118037
-
Myelin basic protein binds to and inhibits the fibrillar assembly of Aβ42 in vitro
-
Hoos, M. D., Ahmed, M., Smith, S. O., and Van Nostrand, W. E. (2009) Myelin basic protein binds to and inhibits the fibrillar assembly of Aβ42 in vitro Biochemistry 48, 4720-4727
-
(2009)
Biochemistry
, vol.48
, pp. 4720-4727
-
-
Hoos, M.D.1
Ahmed, M.2
Smith, S.O.3
Van Nostrand, W.E.4
-
58
-
-
78149255950
-
Amino terminal domain of myelin basic protein inhibits amyloid β-protein fibril assembly
-
Liao, M. C., Hoos, M. D., Aucoin, D., Ahmed, M., Davis, J., Smith, S. O., and Van Nostrand, W. E. (2010) Amino terminal domain of myelin basic protein inhibits amyloid β-protein fibril assembly J. Biol. Chem. 285, 35590-35598
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35590-35598
-
-
Liao, M.C.1
Hoos, M.D.2
Aucoin, D.3
Ahmed, M.4
Davis, J.5
Smith, S.O.6
Van Nostrand, W.E.7
-
59
-
-
0026595567
-
Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs
-
Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C., and Glabe, C. (1992) Assembly and aggregation properties of synthetic Alzheimer's A4/β amyloid peptide analogs J. Biol. Chem. 267, 546-554
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 546-554
-
-
Burdick, D.1
Soreghan, B.2
Kwon, M.3
Kosmoski, J.4
Knauer, M.5
Henschen, A.6
Yates, J.7
Cotman, C.8
Glabe, C.9
-
60
-
-
10744219665
-
Solution NMR studies of the Aβ(1-40) and Aβ(1-42) peptides establish that the met35 oxidation state affects the mechanism of amyloid formation
-
Hou, L. M., Shao, H., Zhang, Y., Li, H., Menon, N. K., Neuhaus, E. B., Brewer, J. M., Byeon, I. J. L., Ray, D. G., Vitek, M. P., Iwashita, T., Makula, R. A., Przybyla, A. B., and Zagorski, M. G. (2004) Solution NMR studies of the Aβ(1-40) and Aβ(1-42) peptides establish that the met35 oxidation state affects the mechanism of amyloid formation J. Am. Chem. Soc. 126, 1992-2005
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 1992-2005
-
-
Hou, L.M.1
Shao, H.2
Zhang, Y.3
Li, H.4
Menon, N.K.5
Neuhaus, E.B.6
Brewer, J.M.7
Byeon, I.J.L.8
Ray, D.G.9
Vitek, M.P.10
Iwashita, T.11
Makula, R.A.12
Przybyla, A.B.13
Zagorski, M.G.14
-
61
-
-
83055176454
-
Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR
-
Fawzi, N. L., Ying, J., Ghirlando, R., Torchia, D. A., and Clore, G. M. (2011) Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR Nature 480, 268-272
-
(2011)
Nature
, vol.480
, pp. 268-272
-
-
Fawzi, N.L.1
Ying, J.2
Ghirlando, R.3
Torchia, D.A.4
Clore, G.M.5
-
62
-
-
77954907699
-
Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aβ into off-pathway conformers
-
Ladiwala, A. R. A., Lin, J. C., Bale, S. S., Marcelino-Cruz, A. M., Bhattacharya, M., Dordick, J. S., and Tessier, P. M. (2010) Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aβ into off-pathway conformers J. Biol. Chem. 285, 24228-24237
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 24228-24237
-
-
Ladiwala, A.R.A.1
Lin, J.C.2
Bale, S.S.3
Marcelino-Cruz, A.M.4
Bhattacharya, M.5
Dordick, J.S.6
Tessier, P.M.7
-
63
-
-
84860386735
-
Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site specific binding
-
Ono, K., Li, L., Takamura, Y., Yoshiike, Y., Zhu, L., Han, F., Mao, X., Ikeda, T., Takasaki, J., Nishijo, H., Takashima, A., Teplow, D., Zagorski, M., and Yamada, M. (2012) Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site specific binding J. Biol. Chem. 287, 14631-14643
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 14631-14643
-
-
Ono, K.1
Li, L.2
Takamura, Y.3
Yoshiike, Y.4
Zhu, L.5
Han, F.6
Mao, X.7
Ikeda, T.8
Takasaki, J.9
Nishijo, H.10
Takashima, A.11
Teplow, D.12
Zagorski, M.13
Yamada, M.14
-
64
-
-
84873722367
-
Apolipoprotein e and Alzheimer's disease: Risk, mechanisms and therapy
-
Liu, C. C., Kanekiyo, T., Xu, H., and Bu, G. (2013) Apolipoprotein E and Alzheimer's disease: Risk, mechanisms and therapy Nat. Rev. Neurol. 9, 106-118
-
(2013)
Nat. Rev. Neurol.
, vol.9
, pp. 106-118
-
-
Liu, C.C.1
Kanekiyo, T.2
Xu, H.3
Bu, G.4
-
65
-
-
0025746681
-
The immunohistochemical evidence of amyloid diffuse deposits as a pathological hallmark in Alzheimer's disease
-
Behrouz, N., Defossez, A., Delacourte, A., and Mazzuca, M. (1991) The immunohistochemical evidence of amyloid diffuse deposits as a pathological hallmark in Alzheimer's disease J. Gerontol. 46, B209-B212
-
(1991)
J. Gerontol.
, vol.46
-
-
Behrouz, N.1
Defossez, A.2
Delacourte, A.3
Mazzuca, M.4
-
66
-
-
0024413224
-
Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease
-
Wisniewski, H. M., Bancher, C., Barcikowska, M., Wen, G. Y., and Currie, J. (1989) Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease Acta Neuropathol. 78, 337-347
-
(1989)
Acta Neuropathol.
, vol.78
, pp. 337-347
-
-
Wisniewski, H.M.1
Bancher, C.2
Barcikowska, M.3
Wen, G.Y.4
Currie, J.5
-
67
-
-
0024365717
-
Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases
-
Barker, R. L., Loegering, D. A., Ten, R. M., Hamann, K. J., Pease, L. R., and Gleich, G. J. (1989) Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases J. Immunol. 143, 952-959
-
(1989)
J. Immunol.
, vol.143
, pp. 952-959
-
-
Barker, R.L.1
Loegering, D.A.2
Ten, R.M.3
Hamann, K.J.4
Pease, L.R.5
Gleich, G.J.6
-
68
-
-
33645108790
-
High-resolution atomic force microscopy of soluble Aβ42 oligomers
-
Mastrangelo, I. A., Ahmed, M., Sato, T., Liu, W., Wang, C., Hough, P., and Smith, S. O. (2006) High-resolution atomic force microscopy of soluble Aβ42 oligomers J. Mol. Biol. 358, 106-119
-
(2006)
J. Mol. Biol.
, vol.358
, pp. 106-119
-
-
Mastrangelo, I.A.1
Ahmed, M.2
Sato, T.3
Liu, W.4
Wang, C.5
Hough, P.6
Smith, S.O.7
|