Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands

Journal of Biological Chemistry

Volumn 284, Issue 22, 2009, Pages 15289-15298

  Salomon, Dor ^a   Bonshtien, Arale ^a   Mayrose, Maya ^a,c   Zhang, Chao ^b   Shokat, Kevan M ^b   Sessa, Guido ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHOSPHORYLATION; BACTERIAL EFFECTOR; BIOLOGICAL FUNCTIONS; CONFORMATIONAL CHANGE; GENETIC APPROACH; HYPERSENSITIVE RESPONSE; IMMUNE RESPONSE; IN-VITRO; IN-VIVO; KINASE ACTIVITY; LIGAND BINDING; PHYSICAL INTERACTIONS; PLANT PROTEINS; PROTEIN KINASE; PSEUDOMONAS SYRINGAE; PTO SIGNALING; SMALL MOLECULE INHIBITOR; SMALL MOLECULES; SOLANUM LYCOPERSICUM; TRIGGERING ACTIVATION; YEAST TWO-HYBRID SYSTEM;

BACTERIOLOGY; LIGANDS; MOLECULES; PLANTS (BOTANY); PROTEINS; SIGNAL TRANSDUCTION;

FRUITS;

AVRPTO PROTEIN; AVRPTOB PROTEIN; BACTERIAL PROTEIN; PROTEIN KINASE; PTO PROTEIN; UNCLASSIFIED DRUG; 4 AMINO 5 (4 METHYLPHENYL) 7 (TERT BUTYL)PYRAZOLO(3,4 D)PYRIMIDINE; 4-AMINO-5-(4-METHYLPHENYL)-7-(TERT-BUTYL)PYRAZOLO(3,4-D)PYRIMIDINE; ADENOSINE TRIPHOSPHATE; AVRB PROTEIN, PSEUDOMONAS SYRINGAE; LIGAND; MUTANT PROTEIN; PHOSPHOTHREONINE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PTO PROTEIN, LYCOPERSICON; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; VEGETABLE PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME INHIBITION; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PLANT DEFENSE; PLANT PATHOGEN INTERACTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PSEUDOMONAS SYRINGAE; SIGNAL TRANSDUCTION; TOMATO; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IC 50; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MICROBIOLOGY; PHOSPHORYLATION; PLANT DISEASE; PLANT LEAF; PROTEIN BINDING; TOBACCO;

BACTERIA (MICROORGANISMS); LYCOPERSICON ESCULENTUM; PSEUDOMONAS SYRINGAE PV. TOMATO;

ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEINS; IMMUNITY, INNATE; INHIBITORY CONCENTRATION 50; LIGANDS; LYCOPERSICON ESCULENTUM; MUTANT PROTEINS; PHOSPHORYLATION; PHOSPHOTHREONINE; PLANT DISEASES; PLANT LEAVES; PLANT PROTEINS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PSEUDOMONAS SYRINGAE; PYRAZOLES; PYRIMIDINES; SIGNAL TRANSDUCTION; TOBACCO;

EID: 67649352691     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809724200     Document Type: Article

References (53)

1. Dardick, C., Chen, J., Richter, T., Ouyang, S., and Ronald, P. (2007) Plant Physiol. 143, 579-586
2. Arabidopsis Genome Initiative (2000) Nature 408, 796-815
3. Chisholm, S. T., Coaker, G., Day, B., and Staskawicz, B. J. (2006) Cell 124, 803-814
4. Jones, J. D. G., and Dangl, J. L. (2006) Nature 444, 323-329
5. Zipfel, C. (2008) Curr. Opin. Immunol. 20, 10-16
6. Chinchilla, D., Bauer, Z., Regenass, M., Boller, T., and Felix, G. (2006) Plant Cell 18, 465-476
7. Zipfel, C., Kunze, G., Chinchilla, D., Caniard, A., Jones, J. D. G., Boller, T., and Felix, G. (2006) Cell 125, 749-760
8. Caplan, J., Padmanabhan, M., and Dinesh-Kumar, S. P. (2008) Cell Host Microbe 3, 126-135
9. Martin, G. B., Bogdanove, A. J., and Sessa, G. (2003) Annu. Rev. Plant Biol. 54, 23-61
10. Brueggemana, R., Drukab, A., Nirmalaa, J., Cavileerc, T., Draderd, T., Rostokse, N., Mirlohif, A., Bennypaulg, H., Gilla, U., Kudrnah, D., Whitelawi, C., Kilianj, A., Hank, F., Sunl, Y., Gilla, K., Steffensonm, B., and Kleinhofs, A. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 14970-14975
11. Pedley, K. F., and Martin, G. B. (2003) Annu. Rev. Phytopathol. 41, 215-243
12. Abramovitch, R. B., Kim, Y. J., Chen, S., Dickman, M. B., and Martin, G. B. (2003) EMBO J. 22, 60-69
13. Cohn, J. R., and Martin, G. B. (2005) Plant J. 44, 139-154
14. Hauck, P., Thilmony, R., and He, S. Y. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 8577-8582
15. Navarro, L., Jay, F., Nomura, K., He, S. Y., and Voinnet, O. (2008) Science 321, 964-967
16. Shan, L. B., He, P., Li, J. M., Heese, A., Peck, S. C., Nurnberger, T., Martin, G. B., and Sheen, J. (2008) Cell Host Microbe 4, 17-27
17. Xiang, T. T., Zong, N., Zou, Y., Wu, Y., Zhang, J., Xing, W. M., Li, Y., Tang, X. Y., Zhu, L. H., Chai, J. J., and Zhou, J. M. (2008) Curr. Biol. 18, 74-80
18. Mur, L. A. J., Kenton, P., Lloyd, A. J., Ougham, H., and Prats, E. (2008) J. Exp. Bot. 59, 501-520
19. Mucyn, T. S., Clemente, A., Andriotis, V. M. E., Balmuth, A. L., Oldroyd, G. E. D., Staskawicz, B. J., and Rathjen, J. P. (2006) Plant Cell 18, 2792-2806
20. del Pozo, O., Pedley, K. F., and Martin, G. B. (2004) EMBO J. 23, 3072-3082
21. Ekengren, S. K., Liu, Y., Schiff, M., Dinesh-Kumar, S. P., and Martin, G. B. (2003) Plant J. 36, 905-917
22. Sessa, G., D'Ascenzo, M., Loh, Y. T., and Martin, G. B. (1998) J. Biol. Chem. 273, 15860-15865
23. Sessa, G., D'Ascenzo, M., and Martin, G. B. (2000) EMBO J. 19, 2257-2269
24. Kim, Y. J., Lin, N. C., and Martin, G. B. (2002) Cell 109, 589-598
25. Rathjen, J. P., Chang, J. H., Staskawicz, B. J., and Michelmore, R. W. (1999) EMBO J. 18, 3232-3240
26. Wu, A. J., Andriotis, V. M., Durrant, M. C., and Rathjen, J. P. (2004) Plant Cell 16, 2809-2821
27. Xing, W., Zou, Y., Liu, Q., Liu, J., Luo, X., Huang, Q., Chen, S., Zhu, L., Bi, R., Hao, Q., Wu, J. W., Zhou, J. M., and Chai, J. (2007) Nature 449, 243-247
28. Bishop, A. C., Buzko, O., and Shokat, K. M. (2001) Trends Cell Biol. 11, 167-172
29. Bishop, A. C., Ubersax, J. A., Petsch, D. T., Matheos, D. P., Gray, N. S., Blethrow, J., Shimizu, E., Tsien, J. Z., Schultz, P. G., Rose, M. D., Wood, J. L., Morgan, D. O., and Shokat, K. M. (2000) Nature 407, 395-401
30. Bohmer, M., and Romeis, T. (2007) Plant Mol. Biol. 65, 817-827
31. Brodersen, P., Petersen, M., Nielsen, H. B., Zhu, S. J., Newman, M. A., Shokat, K. M., Rietz, S., Parker, J., and Mundy, J. (2006) Plant J. 47, 532-546
32. Levin, S. E., Zhang, C., Kadlecek, T. A., Shokat, K. M., and Weiss, A. (2008) J. Biol. Chem. 30, 15419-15430
33. Papa, F. R., Zhang, C., Shokat, K., and Walter, P. (2003) Science 302, 1533-1537
34. Zhang, C., Kenski, D. M., Paulson, J. L., Bonshtien, A., Sessa, G., Cross, J. V., Templeton, D. J., and Shokat, K. M. (2005) Nat. Methods 2, 435-441
35. Frederick, R. D., Thilmony, R. L., Sessa, G., and Martin, G. B. (1998) Mol. Cell 2, 241-245
36. Pedley, K. F., and Martin, G. B. (2004) J. Biol. Chem. 279, 49229-49235
37. Zhou, J., Loh, Y. T., Bressan, R. A., and Martin, G. B. (1995) Cell 83, 925-935
38. Benjamin, K. R., Zhang, C., Shokat, K. M., and Herskowitz, I. (2003) Genes Dev. 17, 1524-1539
39. Bishop, C. B., Kung, C., Shah, K., Witucki, L., Shokat, K. M., and Liu, Y. (1999) J. Am. Chem. Soc. 121, 627-631
40. Golemis, E. A., Gyuris, J., and Brent, R. (1995) in Current Protocols in Molecular Biology (Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K., eds) Vol. 3, pp. 20.1.1-20.1.28, John Wiley and Sons, New York
41. Tang, X., Frederick, R. D., Zhou, J., Halterman, D. A., Jia, Y., and Martin, G. B. (1996) Science 274, 2060-2063
42. Xiao, F., He, P., Abramovitch, R. B., Dawson, J. E., Nicholson, L. K., Sheen, J., and Martin, G. B. (2007) Plant J. 52, 595-614
43. Reynolds, A., and Lundblad, V. (1989) in Current Protocols in Molecular Biology (Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K., eds) Vol. 2, pp. 13.6.1-13.6.4, John Wiley and Sons Inc., New York
44. Zhou, J., Tang, X., and Martin, G. B. (1997) EMBO J. 16, 3207-3218
45. Salmeron, J. M., Oldroyd, G. E., Rommens, C. M., Scofield, S. R., Kim, H. S., Lavelle, D. T., Dahlbeck, D., and Staskawicz, B. J. (1996) Cell 86, 123-133
46. Bishop, A. C., Shah, K., Liu, Y., Witucki, L., Kung, C., and Shokat, K. M. (1998) Curr. Biol. 8, 257-266
47. Scofield, S. R., Tobias, C. M., Rathjen, J. P., Chang, J. H., Lavelle, D. T., Michelmore, R. W., and Staskawicz, B. J. (1996) Science 274, 2063-2065
48. Jones, M. H., Huneycutt, B. J., Pearson, C. G., Zhang, C., Morgan, G., Shokat, K., Bloom, K., and Winey, M. (2005) Curr. Biol. 15, 160-165
49. Scheeff, E. D., and Bourne, P. E. (2005) PLoS Comput. Biol. 1, e49
50. Shan, L., Thara, V. K., Martin, G. B., Zhou, J. M., and Tang, X. (2000) Plant Cell 12, 2323-2338
51. Quintaje, S. B., and Orchard, S. (2008) Mol. Cell Proteomics 7, 1409-1419
52. Weiss, E. L., Bishop, A., Shokat, K., and Drubin, D. G. (2000) Nat. Cell Biol. 2, 677-685
53. Gu, Y. Q., Yang, C., Thara, V. K., Zhou, J., and Martin, G. B. (2000) Plant Cell 12, 771-786