-
1
-
-
77952147465
-
Targeting the HGF/c-Met axis: State of play
-
Yap, T. A.; de Bono, J. S. Targeting the HGF/c-Met axis: State of play Mol. Cancer Ther. 2010, 9 (5) 1077-9
-
(2010)
Mol. Cancer Ther.
, vol.9
, Issue.5
, pp. 1077-1079
-
-
Yap, T.A.1
De Bono, J.S.2
-
2
-
-
73449111266
-
Developing c-MET pathway inhibitors for cancer therapy: Progress and challenges
-
Liu, X.; Newton, R. C.; Scherle, P. A. Developing c-MET pathway inhibitors for cancer therapy: Progress and challenges Trends Mol. Med. 2010, 16 (1) 37-45
-
(2010)
Trends Mol. Med.
, vol.16
, Issue.1
, pp. 37-45
-
-
Liu, X.1
Newton, R.C.2
Scherle, P.A.3
-
3
-
-
80051760389
-
Development of c-MET pathway inhibitors
-
Liu, X.; Newton, R. C.; Scherle, P. A. Development of c-MET pathway inhibitors Expert Opin. Invest. Drugs 2011, 20 (9) 1225-41
-
(2011)
Expert Opin. Invest. Drugs
, vol.20
, Issue.9
, pp. 1225-1241
-
-
Liu, X.1
Newton, R.C.2
Scherle, P.A.3
-
4
-
-
84856152266
-
Targeting MET in cancer: Rationale and progress
-
Gherardi, E.; Birchmeier, W.; Birchmeier, C.; Woude, G. V. Targeting MET in cancer: Rationale and progress Nat. Rev. Cancer 2012, 12 (2) 89-103
-
(2012)
Nat. Rev. Cancer
, vol.12
, Issue.2
, pp. 89-103
-
-
Gherardi, E.1
Birchmeier, W.2
Birchmeier, C.3
Woude, G.V.4
-
5
-
-
83455163518
-
Discovering potent inhibitors against c-Met kinase: Molecular design, organic synthesis and bioassay
-
Liang, Z.; Ding, X.; Ai, J.; Kong, X.; Chen, L.; Luo, C.; Geng, M.; Liu, H.; Chen, K.; Jiang, H. Discovering potent inhibitors against c-Met kinase: Molecular design, organic synthesis and bioassay Org. Biomol. Chem. 2012, 10, 421-30
-
(2012)
Org. Biomol. Chem.
, vol.10
, pp. 421-430
-
-
Liang, Z.1
Ding, X.2
Ai, J.3
Kong, X.4
Chen, L.5
Luo, C.6
Geng, M.7
Liu, H.8
Chen, K.9
Jiang, H.10
-
6
-
-
84865003342
-
Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors
-
Zhang, D.; Ai, J.; Liang, Z.; Li, C.; Peng, X.; Ji, Y.; Jiang, H.; Geng, M.; Luo, C.; Liu, H. Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors Bioorg. Med. Chem. 2012, 20 (17) 5169-80
-
(2012)
Bioorg. Med. Chem.
, vol.20
, Issue.17
, pp. 5169-5180
-
-
Zhang, D.1
Ai, J.2
Liang, Z.3
Li, C.4
Peng, X.5
Ji, Y.6
Jiang, H.7
Geng, M.8
Luo, C.9
Liu, H.10
-
7
-
-
80051760389
-
Development of c-MET pathway inhibitors
-
Liu, X.; Newton, R. C.; Scherle, P. A. Development of c-MET pathway inhibitors Expert Opin. Invest. Drugs 2011, 20 (9) 1225-41
-
(2011)
Expert Opin. Invest. Drugs
, vol.20
, Issue.9
, pp. 1225-1241
-
-
Liu, X.1
Newton, R.C.2
Scherle, P.A.3
-
8
-
-
77950797736
-
Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates
-
Underiner, T. L.; Herbertz, T.; Miknyoczki, S. J. Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates Anti-Cancer Agents Med. Chem. 2010, 10 (1) 7-27
-
(2010)
Anti-Cancer Agents Med. Chem.
, vol.10
, Issue.1
, pp. 7-27
-
-
Underiner, T.L.1
Herbertz, T.2
Miknyoczki, S.J.3
-
9
-
-
77958074157
-
TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation
-
Okamoto, W.; Okamoto, I.; Tanaka, K.; Hatashita, E.; Yamada, Y.; Kuwata, K.; Yamaguchi, H.; Arao, T.; Nishio, K.; Fukuoka, M.; Janne, P. A.; Nakagawa, K. TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation Mol. Cancer Ther. 2010, 9 (10) 2785-92
-
(2010)
Mol. Cancer Ther.
, vol.9
, Issue.10
, pp. 2785-2792
-
-
Okamoto, W.1
Okamoto, I.2
Tanaka, K.3
Hatashita, E.4
Yamada, Y.5
Kuwata, K.6
Yamaguchi, H.7
Arao, T.8
Nishio, K.9
Fukuoka, M.10
Janne, P.A.11
Nakagawa, K.12
-
10
-
-
77950797736
-
Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates
-
Underiner, T. L.; Herbertz, T.; Miknyoczki, S. J. Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates Anti-Cancer Agents Med. Chem. 2010, 10 (1) 7-27
-
(2010)
Anti-Cancer Agents Med. Chem.
, vol.10
, Issue.1
, pp. 7-27
-
-
Underiner, T.L.1
Herbertz, T.2
Miknyoczki, S.J.3
-
11
-
-
80052806086
-
Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)
-
Cui, J. J.; Tran-Dube, M.; Shen, H.; Nambu, M.; Kung, P. P.; Pairish, M.; Jia, L.; Meng, J.; Funk, L.; Botrous, I.; McTigue, M.; Grodsky, N.; Ryan, K.; Padrique, E.; Alton, G.; Timofeevski, S.; Yamazaki, S.; Li, Q.; Zou, H.; Christensen, J.; Mroczkowski, B.; Bender, S.; Kania, R. S.; Edwards, M. P. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK) J. Med. Chem. 2011, 54 (18) 6342-63
-
(2011)
J. Med. Chem.
, vol.54
, Issue.18
, pp. 6342-6363
-
-
Cui, J.J.1
Tran-Dube, M.2
Shen, H.3
Nambu, M.4
Kung, P.P.5
Pairish, M.6
Jia, L.7
Meng, J.8
Funk, L.9
Botrous, I.10
McTigue, M.11
Grodsky, N.12
Ryan, K.13
Padrique, E.14
Alton, G.15
Timofeevski, S.16
Yamazaki, S.17
Li, Q.18
Zou, H.19
Christensen, J.20
Mroczkowski, B.21
Bender, S.22
Kania, R.S.23
Edwards, M.P.24
more..
-
12
-
-
59149084702
-
Pharmacophore modeling studies of type i and type II kinase inhibitors of Tie2
-
Xie, Q. Q.; Xie, H. Z.; Ren, J. X.; Li, L. L.; Yang, S. Y. Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2 J. Mol. Graphics Modell. 2009, 27 (6) 751-8
-
(2009)
J. Mol. Graphics Modell.
, vol.27
, Issue.6
, pp. 751-758
-
-
Xie, Q.Q.1
Xie, H.Z.2
Ren, J.X.3
Li, L.L.4
Yang, S.Y.5
-
13
-
-
60549090412
-
Virtual screening for Raf-1 kinase inhibitors based on pharmacophore model of substituted ureas
-
Li, H. F.; Lu, T.; Zhu, T.; Jiang, Y. J.; Rao, S. S.; Hu, L. Y.; Xin, B. T.; Chen, Y. D. Virtual screening for Raf-1 kinase inhibitors based on pharmacophore model of substituted ureas Eur. J. Med. Chem. 2009, 44 (3) 1240-9
-
(2009)
Eur. J. Med. Chem.
, vol.44
, Issue.3
, pp. 1240-1249
-
-
Li, H.F.1
Lu, T.2
Zhu, T.3
Jiang, Y.J.4
Rao, S.S.5
Hu, L.Y.6
Xin, B.T.7
Chen, Y.D.8
-
14
-
-
56149110450
-
Towards more accurate pharmacophore modeling: Multicomplex-based comprehensive pharmacophore map and most-frequent-feature pharmacophore model of CDK2
-
Zou, J.; Xie, H. Z.; Yang, S. Y.; Chen, J. J.; Ren, J. X.; Wei, Y. Q. Towards more accurate pharmacophore modeling: Multicomplex-based comprehensive pharmacophore map and most-frequent-feature pharmacophore model of CDK2 J. Mol. Graphics Modell. 2008, 27 (4) 430-8
-
(2008)
J. Mol. Graphics Modell.
, vol.27
, Issue.4
, pp. 430-438
-
-
Zou, J.1
Xie, H.Z.2
Yang, S.Y.3
Chen, J.J.4
Ren, J.X.5
Wei, Y.Q.6
-
15
-
-
84863266769
-
Computer-aided drug design: Lead discovery and optimization
-
Xiang, M.; Cao, Y.; Fan, W.; Chen, L.; Mo, Y. Computer-aided drug design: Lead discovery and optimization Comb. Chem. High Throughput Screening 2012, 15 (4) 328-37
-
(2012)
Comb. Chem. High Throughput Screening
, vol.15
, Issue.4
, pp. 328-337
-
-
Xiang, M.1
Cao, Y.2
Fan, W.3
Chen, L.4
Mo, Y.5
-
16
-
-
79957815715
-
Identification and synthesis of N′-(2-oxoindolin-3-ylidene) hydrazide derivatives against c-Met kinase
-
Liang, Z.; Zhang, D.; Ai, J.; Chen, L.; Wang, H.; Kong, X.; Zheng, M.; Liu, H.; Luo, C.; Geng, M.; Jiang, H.; Chen, K. Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase Bioorg. Med. Chem. Lett. 2011, 21 (12) 3749-54
-
(2011)
Bioorg. Med. Chem. Lett.
, vol.21
, Issue.12
, pp. 3749-3754
-
-
Liang, Z.1
Zhang, D.2
Ai, J.3
Chen, L.4
Wang, H.5
Kong, X.6
Zheng, M.7
Liu, H.8
Luo, C.9
Geng, M.10
Jiang, H.11
Chen, K.12
-
17
-
-
79953213695
-
Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met
-
Rickert, K. W.; Patel, S. B.; Allison, T. J.; Byrne, N. J.; Darke, P. L.; Ford, R. E.; Guerin, D. J.; Hall, D. L.; Kornienko, M.; Lu, J.; Munshi, S. K.; Reid, J. C.; Shipman, J. M.; Stanton, E. F.; Wilson, K. J.; Young, J. R.; Soisson, S. M.; Lumb, K. J. Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met J. Biol. Chem. 2011, 286 (13) 11218-25
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.13
, pp. 11218-11225
-
-
Rickert, K.W.1
Patel, S.B.2
Allison, T.J.3
Byrne, N.J.4
Darke, P.L.5
Ford, R.E.6
Guerin, D.J.7
Hall, D.L.8
Kornienko, M.9
Lu, J.10
Munshi, S.K.11
Reid, J.C.12
Shipman, J.M.13
Stanton, E.F.14
Wilson, K.J.15
Young, J.R.16
Soisson, S.M.17
Lumb, K.J.18
-
18
-
-
52449117457
-
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: Synthesis, biophysical and biological evaluation
-
Zagotto, G.; Sissi, C.; Lucatello, L.; Pivetta, C.; Cadamuro, S. A.; Fox, K. R.; Neidle, S.; Palumbo, M. Aminoacyl-anthraquinone conjugates as telomerase inhibitors: Synthesis, biophysical and biological evaluation J. Med. Chem. 2008, 51 (18) 5566-74
-
(2008)
J. Med. Chem.
, vol.51
, Issue.18
, pp. 5566-5574
-
-
Zagotto, G.1
Sissi, C.2
Lucatello, L.3
Pivetta, C.4
Cadamuro, S.A.5
Fox, K.R.6
Neidle, S.7
Palumbo, M.8
-
19
-
-
0027204125
-
Synthesis and antitumor properties of an anthraquinone bisubstituted by the copper chelating peptide Gly-Gly-L-His
-
Morier-Teissier, E.; Boitte, N.; Helbecque, N.; Bernier, J. L.; Pommery, N.; Duvalet, J. L.; Fournier, C.; Hecquet, B.; Catteau, J. P.; Henichart, J. P. Synthesis and antitumor properties of an anthraquinone bisubstituted by the copper chelating peptide Gly-Gly-L-His J. Med. Chem. 1993, 36 (15) 2084-90
-
(1993)
J. Med. Chem.
, vol.36
, Issue.15
, pp. 2084-2090
-
-
Morier-Teissier, E.1
Boitte, N.2
Helbecque, N.3
Bernier, J.L.4
Pommery, N.5
Duvalet, J.L.6
Fournier, C.7
Hecquet, B.8
Catteau, J.P.9
Henichart, J.P.10
-
20
-
-
0026655215
-
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G
-
Zembower, D. E.; Kam, C. M.; Powers, J. C.; Zalkow, L. H. Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G J. Med. Chem. 1992, 35 (9) 1597-605
-
(1992)
J. Med. Chem.
, vol.35
, Issue.9
, pp. 1597-1605
-
-
Zembower, D.E.1
Kam, C.M.2
Powers, J.C.3
Zalkow, L.H.4
|