Virtual screening for Raf-1 kinase inhibitors based on pharmacophore model of substituted ureas

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1240-1249

  Li, Hui Fang ^a   Lu, Tao ^a   Zhu, Tian ^a   Jiang, Yong Jun ^b   Rao, Sha Sha ^c   Hu, Li Ye ^a   Xin, Bo Tao ^a   Chen, Ya Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Molecular docking; Pharmacophore; Raf 1 kinase inhibitors; Virtual screening

Indexed keywords

NCI 0062052; NCI 0120649; NCI 0149855; NCI 0212040; NCI 0341662; NCI 0342021; NCI 0647884; NCI 0648594; NCI 0672592; NCI 0681620; NCI 0687769; NCI 0687770; NCI 0687776; NCI 0697654; PHOSPHOTRANSFERASE INHIBITOR; RAF PROTEIN INHIBITOR; SORAFENIB; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; PHARMACOPHORE; PREDICTION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; VIRTUAL REALITY;

EID: 60549090412     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.016     Document Type: Article

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