Simvastatin attenuates stroke-induced splenic atrophy and lung susceptibility to spontaneous bacterial infection in mice

Stroke

Volumn 44, Issue 4, 2013, Pages 1135-1143

  Jin, Rong ^a   Zhu, Xiaolei ^a   Liu, Lin ^a   Nanda, Anil ^a   Granger, D Neil ^b   Li, Guohong ^a,b  

^a Louisiana State University School of Medicine Shreveport   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Bacterial infection; Brain ischemia; Immune response; Spleen; Statin

Indexed keywords

GAMMA INTERFERON; PROTEIN BAX; PROTEIN BCL 2; SIMVASTATIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL INFECTION; BRAIN DAMAGE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN LEVEL; CONTROLLED STUDY; CYTOSOL; DISEASE ASSOCIATION; DRUG EFFECT; HISTOPATHOLOGY; INFECTION SENSITIVITY; LUNG INFECTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION; SPLEEN ATROPHY; SPLEEN CELL; SPLEEN DISEASE; SPLENECTOMY; WEIGHT REDUCTION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; APOPTOSIS; ATROPHY; BACTERIAL INFECTIONS; BCL-2-ASSOCIATED X PROTEIN; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; INFECTION; INTERFERON-GAMMA; LUNG; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-BCL-2; SIMVASTATIN; SPLEEN; SPLENECTOMY; STROKE;

EID: 84876205383     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.000633     Document Type: Article

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