Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke

Stroke

Volumn 42, Issue 7, 2011, Pages 2033-2044

  Jin, Rong ^a   Song, Zifang ^a   Yu, Shiyong ^a   Piazza, Abigail ^c   Nanda, Anil ^a   Penninger, Josef M ^d   Granger, D Neil ^b   Li, Guohong ^a,b  

^a Louisiana State University School of Medicine Shreveport   (United States)

^b Department of Molecular and Cellular Physiology ^*  (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

blood brain barrier; ischemic stroke; metallopeptidases; oxidative stress; PI3 kinase

Indexed keywords

CLAUDIN 5; COLLAGEN TYPE 4; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; MYOSIN LIGHT CHAIN; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN DAMAGE; BRAIN DYSFUNCTION; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; EMERGENCY TREATMENT; ENZYME ACTIVITY; GENE EXPRESSION; KNOCKOUT MOUSE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REPERFUSION; WILD TYPE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; NF-KAPPA B; OXIDATIVE STRESS; REPERFUSION INJURY; STROKE;

EID: 79960008346     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.601369     Document Type: Article

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