The spectrum of systemic immune alterations after murine focal ischemia: Immunodepression versus immunomodulation

Stroke

Volumn 40, Issue 8, 2009, Pages 2849-2858

  Liesz, Arthur ^a   Hagmann, Sebastien ^a   Zschoche, Carolin ^a   Adamek, Johanna ^a   Zhou, Wei ^a   Sun, Li ^a   Hug, Andreas ^a   Zorn, Markus ^a   Dalpke, Alexander ^a   Nawroth, Peter ^a   Veltkamp, Roland ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Bacterial infection; Brain ischemia; Cytokines; Immune response; Leukocytes

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIUM CULTURE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HYPOTHERMIA; IMMUNE DEFICIENCY; IMMUNOMODULATION; LEUKOCYTE DIFFERENTIAL COUNT; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REGULATORY T LYMPHOCYTE; SEPSIS; SPLEEN LYMPHOCYTE; WEIGHT REDUCTION;

ANIMALS; BACTERIAL INFECTIONS; BRAIN ISCHEMIA; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; IMMUNE TOLERANCE; LYMPHOCYTE SUBSETS; MALE; MICE; MICE, INBRED C57BL; SEVERITY OF ILLNESS INDEX;

EID: 68749099666     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.109.549618     Document Type: Article

References (19)

1. Dirnagl U. Inflammation in stroke: the good, the bad, and the unknown. Ernst Schering Res Found Workshop. 2004;87-99.
2. Wang Q, Tang XN, Yenari MA. The inflammatory response in stroke. J Neuroimmunol. 2007;184:53-68.
3. Danton GH, Dietrich WD. Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol. 2003;62:127-136.
4. Nilupul Perera M, Ma HK, Arakawa S, Howells DW, Markus R, Rowe CC, Donnan GA. Inflammation following stroke. J Clin Neurosci. 2006;13:1-8.
5. Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, Ziemssen T, Prass K, Meisel A. Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke. 2007;38:770-773.
6. Offner H, Subramanian S, Parker SM, Afentoulis ME, Vandenbark AA, Hurn PD. Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab. 2006;26: 654-665.
7. Offner H, Subramanian S, Parker SM, Wang C, Afentoulis ME, Lewis A, Vandenbark AA, Hurn PD. Splenic atrophy in experimental stroke is accompanied by increased regulatory t cells and circulating macrophages. J Immunol. 2006;176:6523-6531.
8. Prass K, Meisel C, Hoflich C, Braun J, Halle E, Wolf T, Ruscher K, Victorov IV, Priller J, Dirnagl U, Volk HD, Meisel A. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke t helper cell type 1-like immunostimulation. J Exp Med. 2003;198:725-736.
9. Meisel C, Schwab JM, Prass K, Meisel A, Dirnagl U. Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci. 2005;6:775-786.
10. Schroeter M, Jander S. T-cell cytokines in injury-induced neural damage and repair. Neuromolecular Med. 2005;7:183-195.
11. del Zoppo G, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ. Inflammation and stroke: putative role for cytokines, adhesion molecules and inos in brain response to ischemia. Brain Pathol. 2000;10: 95-112.
12. Liesz A, Suri-Payer E, Veltkamp C, Dörr H, Sommer C, Rivest S, Giese T, Veltkamp R. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009;15:192-199.
13. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20: 84-91.
14. Hurn PD, Subramanian S, Parker SM, Afentoulis ME, Kaler LJ, Vandenbark AA, Offner H. T-and b-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J Cereb Blood Flow Metab. 2007;27:1798-1805.
15. Vogel J, Mobius C, Kuschinsky W. Early delineation of ischemic tissue in rat brain cryosections by high-contrast staining. Stroke. 1999;30: 1134-1141.
16. Li F, Omae T, Fisher M. Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats. Stroke. 1999;30:2464-2470; discussion 2470-2461.
17. Nemzek JA, Bolgos GL, Williams BA, Remick DG. Differences in normal values for murine white blood cell counts and other hematological parameters based on sampling site. Inflamm Res. 2001;50:523-527.
18. Ferrarese C, Mascarucci P, Zoia C, Cavarretta R, Frigo M, Begni B, Sarinella F, Frattola L, De Simoni MG. Increased cytokine release from peripheral blood cells after acute stroke. J Cereb Blood Flow Metab. 1999;19:1004-1009.
19. Koch HJ, Uyanik G, Bogdahn U, Ickenstein GW. Relation between laterality and immune response after acute cerebral ischemia. Neuroimmunomodulation. 2006;13:8-12.