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Volumn 288, Issue 15, 2013, Pages 10395-10405

The src family tyrosine kinase hck and the ets family transcription factors spib and ehf regulate transcytosis across a human follicle-associated epithelium model

Author keywords

[No Author keywords available]

Indexed keywords

ECTOPIC EXPRESSIONS; INTESTINAL EPITHELIAL CELLS; INTRACELLULAR REGULATION; INTRACELLULAR SIGNALING; MOLECULAR INSIGHTS; MUCOSAL IMMUNITY; MUCOSAL SECRETIONS; MUCOSAL SURFACE;

EID: 84876203961     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.437475     Document Type: Article
Times cited : (13)

References (57)
  • 1
    • 0034518344 scopus 로고    scopus 로고
    • Epithelial M cells.Differentiation and function
    • Kraehenbuhl, J.-P., and Neutra, M. R. (2000) Epithelial M cells. Differentiation and function. Annu. Rev. Cell Dev. Biol. 16, 301-332
    • (2000) Annu. Rev. Cell Dev. Biol , vol.16 , pp. 301-332
    • Kraehenbuhl, J.-P.1    Neutra, M.R.2
  • 2
    • 33644836224 scopus 로고    scopus 로고
    • Mucosal vaccines. The promise and the challenge
    • Neutra, M. R., and Kozlowski, P. A. (2006) Mucosal vaccines. The promise and the challenge. Nat. Rev. Immunol.6, 148-158
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 148-158
    • Neutra, M.R.1    Kozlowski, P.A.2
  • 3
    • 77952203545 scopus 로고    scopus 로고
    • Function of mucosa-associated lymphoid tissue in antibody formation
    • Brandtzaeg, P. (2010) Function of mucosa-associated lymphoid tissue in antibody formation. Immunol. Invest. 39, 303-355
    • (2010) Immunol. Invest , vol.39 , pp. 303-355
    • Brandtzaeg, P.1
  • 4
    • 84858271641 scopus 로고    scopus 로고
    • Gut-associated lymphoid tissues for the development of oral vaccines
    • Kunisawa, J., Kurashima, Y., and Kiyono, H. (2012) Gut-associated lymphoid tissues for the development of oral vaccines. Adv. Drug. Deliv. Rev. 64, 523-530
    • (2012) Adv. Drug. Deliv. Rev , vol.64 , pp. 523-530
    • Kunisawa, J.1    Kurashima, Y.2    Kiyono, H.3
  • 5
    • 84875829724 scopus 로고    scopus 로고
    • Antigen sampling in the small intestine
    • in press
    • Schulz, O., and Pabst, O. (2013) Antigen sampling in the small intestine. Trends Immunol., in press
    • (2013) Trends Immunol
    • Schulz, O.1    Pabst, O.2
  • 6
    • 29644443359 scopus 로고    scopus 로고
    • Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium
    • Tyrer, P., Foxwell, A. R., Cripps, A. W., Apicella, M. A., and Kyd, J. M. (2006) Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium. Infect. Immun. 74, 625-631
    • (2006) Infect. Immun , vol.74 , pp. 625-631
    • Tyrer, P.1    Foxwell, A.R.2    Cripps, A.W.3    Apicella, M.A.4    Kyd, J.M.5
  • 9
    • 70350370153 scopus 로고    scopus 로고
    • Secretory immunoglobulin A. Well beyond immune exclusion at mucosal surfaces
    • Corthe?sy, B. (2009) Secretory immunoglobulin A. Well beyond immune exclusion at mucosal surfaces. Immunopharmacol. Immunotoxicol. 31, 174-179
    • (2009) Immunopharmacol. Immunotoxicol , vol.31 , pp. 174-179
    • Corthesy, B.1
  • 10
    • 0026950068 scopus 로고
    • Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associatedMcells
    • Porta, C., James, P. S., Phillips, A. D., Savidge, T. C., Smith, M. W., and Cremaschi, D. (1992) Confocal analysis of fluorescent bead uptake by mouse Peyer's patch follicle-associatedMcells. Exp. Physiol. 77, 929-932
    • (1992) Exp. Physiol , vol.77 , pp. 929-932
    • Porta, C.1    James, P.S.2    Phillips, A.D.3    Savidge, T.C.4    Smith, M.W.5    Cremaschi, D.6
  • 11
    • 0029360440 scopus 로고
    • Selective transport of microparticles across Peyer's patch follicle-associated M cells from mice and rats
    • Smith, M. W., Thomas, N. W., Jenkins, P. G., Miller, N. G., Cremaschi, D., and Porta, C. (1995) Selective transport of microparticles across Peyer's patch follicle-associated M cells from mice and rats. Exp. Physiol. 80, 735-743
    • (1995) Exp. Physiol , vol.80 , pp. 735-743
    • Smith, M.W.1    Thomas, N.W.2    Jenkins, P.G.3    Miller, N.G.4    Cremaschi, D.5    Porta, C.6
  • 12
    • 80054919389 scopus 로고    scopus 로고
    • Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
    • Mantis, N. J., Rol, N., and Corthe'sy, B. (2011) Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 4, 603-611
    • (2011) Mucosal Immunol , vol.4 , pp. 603-611
    • Mantis, N.J.1    Rol, N.2    Corthe'Sy, B.3
  • 13
    • 0037103328 scopus 로고    scopus 로고
    • Selective adherence of IgA to murine Peyer's patch M cells. Evidence for a novel IgA receptor
    • Mantis, N. J., Cheung, M. C., Chintalacharuvu, K. R., Rey, J., Corthe'sy, B., and Neutra, M. R. (2002) Selective adherence of IgA to murine Peyer's patch M cells. Evidence for a novel IgA receptor. J. Immunol. 169, 1844-1851
    • (2002) J. Immunol , vol.169 , pp. 1844-1851
    • Mantis, N.J.1    Cheung, M.C.2    Chintalacharuvu, K.R.3    Rey, J.4    Corthe'Sy, B.5    Neutra, M.R.6
  • 14
    • 84856153560 scopus 로고    scopus 로고
    • Aprotocol for differentiation of human intestinal Caco-2 cells in asymmetric serumcontaining medium
    • Ferruzza, S., Rossi, C., Scarino, M. L., and Sambuy, Y. (2012)Aprotocol for differentiation of human intestinal Caco-2 cells in asymmetric serumcontaining medium. Toxicol. In Vitro 26, 1252-1255
    • (2012) Toxicol. in Vitro , vol.26 , pp. 1252-1255
    • Ferruzza, S.1    Rossi, C.2    Scarino, M.L.3    Sambuy, Y.4
  • 15
    • 0038946003 scopus 로고    scopus 로고
    • Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria
    • Kernéis, S., Bogdanova, A., Kraehenbuhl, J. P., and Pringault, E. (1997) Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277, 949-952
    • (1997) Science , vol.277 , pp. 949-952
    • Kernéis, S.1    Bogdanova, A.2    Kraehenbuhl, J.P.3    Pringault, E.4
  • 19
    • 0037817352 scopus 로고    scopus 로고
    • Transcytosis. Crossing cellular barriers
    • Tuma, P., and Hubbard, A. L. (2003) Transcytosis. Crossing cellular barriers. Physiol. Rev. 83, 871-932
    • (2003) Physiol. Rev , vol.83 , pp. 871-932
    • Tuma, P.1    Hubbard, A.L.2
  • 20
    • 0033213258 scopus 로고    scopus 로고
    • The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo
    • Luton, F., Verge's, M., Vaerman, J.-P., Sudol, M., and Mostov, K. E. (1999) The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo. Mol. Cell 4, 627-632
    • (1999) Mol. Cell , vol.4 , pp. 627-632
    • Luton, F.1    Verge'S, M.2    Vaerman, J.-P.3    Sudol, M.4    Mostov, K.E.5
  • 22
    • 49049119270 scopus 로고    scopus 로고
    • Hematopoietic cell kinase (Hck) isoforms and phagocyte duties from signaling and actin reorganization to migration and phagocytosis
    • Guiet, R., Poincloux, R., Castandet, J., Marois, L., Labrousse, A., Le Cabec, V., and Maridonneau-Parini, I. (2008) Hematopoietic cell kinase (Hck) isoforms and phagocyte duties. From signaling and actin reorganization to migration and phagocytosis. Eur. J. Cell Biol. 87, 527-542
    • (2008) Eur. J. Cell Biol , vol.87 , pp. 527-542
    • Guiet, R.1    Poincloux, R.2    Castandet, J.3    Marois, L.4    Labrousse, A.5    Le Cabec, V.6    Maridonneau-Parini, I.7
  • 23
    • 0028293147 scopus 로고
    • Functional overlap in the src gene family. Inactivation of hck and fgr impairs natural immunity
    • Lowell, C. A., Soriano, P., and Varmus, H. E. (1994) Functional overlap in the src gene family. Inactivation of hck and fgr impairs natural immunity. Genes Dev. 8, 387-398
    • (1994) Genes Dev , vol.8 , pp. 387-398
    • Lowell, C.A.1    Soriano, P.2    Varmus, H.E.3
  • 26
    • 0034748924 scopus 로고    scopus 로고
    • GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    • Shibata, Y., Berclaz, P. Y., Chroneos, Z. C., Yoshida, M., Whitsett, J. A., and Trapnell, B. C. (2001) GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity 15, 557-567
    • (2001) Immunity , vol.15 , pp. 557-567
    • Shibata, Y.1    Berclaz, P.Y.2    Chroneos, Z.C.3    Yoshida, M.4    Whitsett, J.A.5    Trapnell, B.C.6
  • 28
    • 0036893475 scopus 로고    scopus 로고
    • GMCSF, via PU.1, regulates alveolar macrophage FcγR-mediated phagocytosis and the IL-18/IFN-γ-mediated molecular connection between innate and adaptive immunity in the lung
    • Berclaz, P. Y., Shibata, Y., Whitsett, J. A., and Trapnell, B. C. (2002) GMCSF, via PU.1, regulates alveolar macrophage FcγR-mediated phagocytosis and the IL-18/IFN-γ-mediated molecular connection between innate and adaptive immunity in the lung. Blood 100, 4193-4200
    • (2002) Blood , vol.100 , pp. 4193-4200
    • Berclaz, P.Y.1    Shibata, Y.2    Whitsett, J.A.3    Trapnell, B.C.4
  • 29
    • 0036884161 scopus 로고    scopus 로고
    • Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1
    • Berclaz, P. Y., Zsengelle'r, Z., Shibata, Y., Otake, K., Strasbaugh, S., Whitsett, J. A., and Trapnell, B. C. (2002) Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1. J. Immunol. 169, 6332-6342
    • (2002) J. Immunol , vol.169 , pp. 6332-6342
    • Berclaz, P.Y.1    Zsengelle'R, Z.2    Shibata, Y.3    Otake, K.4    Strasbaugh, S.5    Whitsett, J.A.6    Trapnell, B.C.7
  • 30
    • 0027979552 scopus 로고
    • Differential expression of sucraseisomaltase in clones isolated from early and late passages of the cell line Caco-2. Evidence for glucose-dependent negative regulation
    • Chantret, I., Rodolosse, A., Barbat, A., Dussaulx, E., Brot-Laroche, E., Zweibaum, A., and Rousset, M. (1994) Differential expression of sucraseisomaltase in clones isolated from early and late passages of the cell line Caco-2. Evidence for glucose-dependent negative regulation. J. Cell Sci. 107, 213-225
    • (1994) J. Cell Sci , vol.107 , pp. 213-225
    • Chantret, I.1    Rodolosse, A.2    Barbat, A.3    Dussaulx, E.4    Brot-Laroche, E.5    Zweibaum, A.6    Rousset, M.7
  • 34
    • 0033838876 scopus 로고    scopus 로고
    • Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells. A technical update
    • Kernéis, S., Caliot, E., Stubbe, H., Bogdanova, A., Kraehenbuhl, J., and Pringault, E. (2000) Molecular studies of the intestinal mucosal barrier physiopathology using cocultures of epithelial and immune cells. A technical update. Microbes Infect. 2, 1119-1124
    • (2000) Microbes Infect , vol.2 , pp. 1119-1124
    • Kernéis, S.1    Caliot, E.2    Stubbe, H.3    Bogdanova, A.4    Kraehenbuhl, J.5    Pringault, E.6
  • 35
    • 84863205849 scopus 로고    scopus 로고
    • NIH Image to ImageJ. 25 years of image analysis
    • Schneider, C. A., Rasband, W. S., and Eliceiri, K. W. (2012) NIH Image to ImageJ. 25 years of image analysis. Nat. Methods 9, 671-675
    • (2012) Nat. Methods , vol.9 , pp. 671-675
    • Schneider, C.A.1    Rasband, W.S.2    Eliceiri, K.W.3
  • 36
    • 0242289603 scopus 로고    scopus 로고
    • RT-PCR for the pseudogene- free amplification of the glyceraldehyde-3- phosphate dehydrogenase gene (gapd)
    • Harper, L. V., Hilton, A. C., and Jones, A. F. (2003) RT-PCR for the pseudogene- free amplification of the glyceraldehyde-3-phosphate dehydrogenase gene (gapd). Mol. Cell Probes 17, 261-265
    • (2003) Mol. Cell Probes , vol.17 , pp. 261-265
    • Harper, L.V.1    Hilton, A.C.2    Jones, A.F.3
  • 37
    • 1642575957 scopus 로고    scopus 로고
    • Size-dependent internalization of particles via the pathways of clathrin- and caveolae- mediated endocytosis
    • Rejman, J., Oberle, V., Zuhorn, I. S., and Hoekstra, D. (2004) Size-dependent internalization of particles via the pathways of clathrin- and caveolae- mediated endocytosis. Biochem. J. 377, 159-169
    • (2004) Biochem. J , vol.377 , pp. 159-169
    • Rejman, J.1    Oberle, V.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 38
    • 0033151933 scopus 로고    scopus 로고
    • A technique for the study of endocytosis in human oral epithelial cells
    • Innes, N.P., and Ogden, G. R. (1999) A technique for the study of endocytosis in human oral epithelial cells. Arch. Oral Biol. 44, 519-523
    • (1999) Arch. Oral Biol , vol.44 , pp. 519-523
    • Innes, N.P.1    Ogden, G.R.2
  • 39
    • 33947265152 scopus 로고    scopus 로고
    • An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells
    • des Rieux, A., Fievez, V., Théate, I., Mast, J., Préat, V., and Schneider, Y.-J. (2007) An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells. Eur. J. Pharm. Sci. 30, 380-391
    • (2007) Eur. J. Pharm. Sci , vol.30 , pp. 380-391
    • Des Rieux, A.1    Fievez, V.2    Théate, I.3    Mast, J.4    Préat, V.5    Schneider, Y.-J.6
  • 40
    • 0037036415 scopus 로고    scopus 로고
    • P59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner
    • Carréno, S., Caron, E., Cougoule, C., Emorine, L. J., and Maridonneau- Parini, I. (2002) p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner. J. Biol. Chem. 277, 21007-21016
    • (2002) J. Biol. Chem , vol.277 , pp. 21007-21016
    • Carréno, S.1    Caron, E.2    Cougoule, C.3    Emorine, L.J.4    Maridonneau- Parini, I.5
  • 41
    • 0025071307 scopus 로고
    • Brush-border membrane alkaline phosphatase activity in mouse Peyer's patch follicle-associated enterocytes
    • Brown, D., Cremaschi, D., James, P. S., Rossetti, C., and Smith, M. W. (1990) Brush-border membrane alkaline phosphatase activity in mouse Peyer's patch follicle-associated enterocytes. J. Physiol. 427, 81-88
    • (1990) J. Physiol , vol.427 , pp. 81-88
    • Brown, D.1    Cremaschi, D.2    James, P.S.3    Rossetti, C.4    Smith, M.W.5
  • 42
    • 77953252401 scopus 로고    scopus 로고
    • Adenoviral transduction of enterocytes and M-cells using in vitro models based on Caco-2 cells. The coxsackievirus and adenovirus receptor (CAR) mediates both apical and basolateral transduction
    • Kesisoglou, F., Schmiedlin-Ren, P., Fleisher, D., and Zimmermann, E. M. (2010) Adenoviral transduction of enterocytes and M-cells using in vitro models based on Caco-2 cells. The coxsackievirus and adenovirus receptor (CAR) mediates both apical and basolateral transduction. Mol. Pharm. 7, 619-629
    • (2010) Mol. Pharm , vol.7 , pp. 619-629
    • Kesisoglou, F.1    Schmiedlin-Ren, P.2    Fleisher, D.3    Zimmermann, E.M.4
  • 44
    • 79953005486 scopus 로고    scopus 로고
    • Ets2 regulates colonic stem cells and sensitivity to tumorigenesis
    • Mu'nera, J., Cecen?a, G., Jedlicka, P., Wankell, M., and Oshima, R. G. (2011) Ets2 regulates colonic stem cells and sensitivity to tumorigenesis. Stem Cells 29, 430-439
    • (2011) Stem Cells , vol.29 , pp. 430-439
    • Mu'Nera, J.1    Cecena, G.2    Jedlicka, P.3    Wankell, M.4    Oshima, R.G.5
  • 45
    • 70349435300 scopus 로고    scopus 로고
    • The Ets-domain transcription factor Spdef promotes maturation of goblet and Paneth cells in the intestinal epithelium
    • Gregorieff, A., Stange, D. E., Kujala, P., Begthel, H., van den Born, M., Korving, J., Peters, P. J., and Clevers, H. (2009) The Ets-domain transcription factor Spdef promotes maturation of goblet and Paneth cells in the intestinal epithelium. Gastroenterology 137, 1333-1345.e1-e3
    • (2009) Gastroenterology , vol.137 , Issue.1333-1345
    • Gregorieff, A.1    Stange, D.E.2    Kujala, P.3    Begthel, H.4    Van Den Born, M.5    Korving, J.6    Peters, P.J.7    Clevers, H.8
  • 47
    • 2942560606 scopus 로고    scopus 로고
    • IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes
    • Sui, L., Li, N., Liu, Q., Zhang, W., Wan, T., Wang, B., Luo, K., Sun, H., and Cao, X. (2004) IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. Biochem. Biophys. Res. Commun. 319, 920-928
    • (2004) Biochem. Biophys. Res. Commun , vol.319 , pp. 920-928
    • Sui, L.1    Li, N.2    Liu, Q.3    Zhang, W.4    Wan, T.5    Wang, B.6    Luo, K.7    Sun, H.8    Cao, X.9
  • 48
    • 0036786472 scopus 로고    scopus 로고
    • Mac-1 (CD11b/CD18) as accessory molecule for FcγR (CD89) binding of IgA
    • Van Spriel, A. B., Leusen, J. H., Vilé, H., and Van De Winkel, J. G. (2002) Mac-1 (CD11b/CD18) as accessory molecule for FcγR (CD89) binding of IgA. J. Immunol. 169, 3831-3836
    • (2002) J. Immunol , vol.169 , pp. 3831-3836
    • Van Spriel, A.B.1    Leusen, J.H.2    Vilé, H.3    Van De Winkel, J.G.4
  • 49
    • 0037448612 scopus 로고    scopus 로고
    • Molecular biology of the Ets family of transcription factors
    • Oikawa, T., and Yamada, T. (2003) Molecular biology of the Ets family of transcription factors. Gene 303, 11-34
    • (2003) Gene , vol.303 , pp. 11-34
    • Oikawa, T.1    Yamada, T.2
  • 50
    • 2442649014 scopus 로고    scopus 로고
    • Oligosaccharide side chains on human secretory IgA serve as receptors for ricin
    • Mantis, N. J., Farrant, S. A., and Mehta, S. (2004) Oligosaccharide side chains on human secretory IgA serve as receptors for ricin. J. Immunol. 172, 6838-6845
    • (2004) J. Immunol , vol.172 , pp. 6838-6845
    • Mantis, N.J.1    Farrant, S.A.2    Mehta, S.3
  • 52
    • 0032533818 scopus 로고    scopus 로고
    • Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab)2. A possible implication for mucosal defense
    • Crottet, P., and Corthe'sy, B. (1998) Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab)2. A possible implication for mucosal defense. J. Immunol. 161, 5445-5453
    • (1998) J. Immunol , vol.161 , pp. 5445-5453
    • Crottet, P.1    Corthe'Sy, B.2
  • 53
    • 77954759581 scopus 로고    scopus 로고
    • Recognition of secretory IgA by DC-SIGN. Implications for immune surveillance in the intestine
    • Baumann, J., Park, C. G., and Mantis, N. J. (2010) Recognition of secretory IgA by DC-SIGN. Implications for immune surveillance in the intestine. Immunol. Lett. 131, 59-66
    • (2010) Immunol. Lett , vol.131 , pp. 59-66
    • Baumann, J.1    Park, C.G.2    Mantis, N.J.3
  • 54
    • 33845473482 scopus 로고    scopus 로고
    • Antibodies enhance interaction of Vibrio cholerae with intestinal M-like cells
    • Blanco, L. P., and Dirita, V. J. (2006) Antibodies enhance interaction of Vibrio cholerae with intestinal M-like cells. Infect. Immun. 74, 6957-6964
    • (2006) Infect. Immun , vol.74 , pp. 6957-6964
    • Blanco, L.P.1    Dirita, V.J.2
  • 55
    • 0028337425 scopus 로고
    • Hck expression correlates with granulocyte-macrophage colony- stimulating factor-induced proliferation in HL-60 cells
    • Linnekin, D., Howard, O. M., Park, L., Farrar, W., Ferris, D., and Longo, D. L. (1994) Hck expression correlates with granulocyte-macrophage colony- stimulating factor-induced proliferation in HL-60 cells. Blood 84, 94-103
    • (1994) Blood , vol.84 , pp. 94-103
    • Linnekin, D.1    Howard, O.M.2    Park, L.3    Farrar, W.4    Ferris, D.5    Longo, D.L.6
  • 57
    • 25444494965 scopus 로고    scopus 로고
    • Activation and mitogen-activated protein kinase regulation of transcription factors Ets and NF-γB in Mycobacterium- infected macrophages and role of these factors in tumor necrosis factor γ and nitric oxide synthase 2 promoter function
    • Lee, S.-B., and Schorey, J. S. (2005) Activation and mitogen-activated protein kinase regulation of transcription factors Ets and NF-γB in Mycobacterium- infected macrophages and role of these factors in tumor necrosis factor γ and nitric oxide synthase 2 promoter function. Infect. Immun. 73, 6499-6507
    • (2005) Infect. Immun , vol.73 , pp. 6499-6507
    • Lee, S.-B.1    Schorey, J.S.2


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