GM-CSF, via PU.1, regulates alveolar macrophage FcγR-mediated phagocytosis and the IL-18/IFN-γ-mediated molecular connection between innate and adaptive immunity in the lung

Blood

Volumn 100, Issue 12, 2002, Pages 4193-4200

  Berclaz, Pierre Yves ^a   Shibata, Yoko ^a   Whitsett, Jeffrey A ^a   Trapnell, Bruce C ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 8; MESSENGER RNA; OPSONIN; SURFACTANT PROTEIN C; TRANSCRIPTION FACTOR PU 1;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HOST RESISTANCE; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; LUNG INFECTION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS INFECTION;

EID: 0036893475     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-04-1102     Document Type: Article

References (55)

1. Fels AO, Cohn ZA. The alveolar macrophage. J Appl Physiol. 1986;60:353-369.
2. Medzhitov R, Janeway CA Jr. Innate immunity: Impact on the adaptive immune response. Curr Opin Immunol. 1997;9:4-9.
3. Rhodes J. Macrophage heterogeneity in receptor activity: the activation of macrophage Fc receptor function in vivo and in vitro. J Immunol. 1975;114:976-981.
4. Ravetch JV, BoJJand S. JgG Fc receptors. Annu Rev Immunol. 2001;19:275-290.
5. Indik ZK, Park JG, Hunter S, Schreiber AD. The molecular dissection of Fcγ receptor mediated phagocytosis. Blood. 1995;86:4389-4399.
6. Greenberg S, Chang P, Silverstein SC. Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages. J Exp Med. 1993;177:529-534.
7. Darby C, Geahlen RL, Schreiber AD. Stimulation of macrophage Fcγ RIIIA activates the receptorassociated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and P62/GAP-associated protein. J Immunol. 1994;152:5429-5437.
8. Greenberg S. Modular components of phagocytosis. J Leukoc Biol. 1999;66:712-717.
9. Hunter S, Indik ZK, Kim MK, Cauley MD, Park JG, Schreiber AD. Inhibition of Fcγ receptor-mediated phagocytosis by a nonphagocytic Fcγ receptor. Blood. 1998;91:1762-1768.
10. Aderem A, Underhill DM. Mechanisms of phagocytosis in macrophages. Annu Rev Immunol. 1999;17:593-623.
11. Majeed M,Caveggion E, Lowell CA, Berton G. Role of Src kinases and Syk in Fcγ receptor-mediated phagocytosis and phagosome-lysosome fusion. J Leukoc Biol. 2001;70:801-811.
12. Akagawa KS, Kamoshita K, Tokunaga T. Effects of granulocyte-macrophage colony-stimulating factor and colony-stimulating factor-1 on the proliferation and differentiation of murine alveolar macrophages. J Immunol. 1988;141:3383-3390.
13. Chen BD, Mueller M, Chou TH. Role of granulocyte/macrophage colony-stimulating factor in the regulation of murine alveolar macrophage proliferation and differentiation. J Immunol. 1988;141:139-144.
14. Lemaire I, Yang H, Lauzon W, Gendron N. M-CSF and GM-CSF promote alveolar macrophage differentiation into multinucleated giant cells with distinct phenotypes. J Leukoc Biol. 1996;60:509-518.
15. Trapnell BC, Whitsett JA. Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annu Rev Physiol. 2002;64:775-802.
16. Dranoff G, Crawford AD, Sadelain M, et al. Involvement of granulocyte-macrophage colonystimulating factor in pulmonary homeostasis. Science. 1994;264:713-716.
17. Stanley E, Lieschke GJ, Grail D, et al. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994;91:5592-5596.
18. Paine R III, Preston AM, Wilcoxen S, et al. Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice. J Immunol. 2000;164:2602-2609.
19. LeVine AM, Reed JA, Kurak KE, Cianciolo E, Whitsett JA. GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection. J Clin Invest. 1999;103:563-569.
20. Shibata Y, Berclaz P-Y, Chroneos Z, Yoshida H, Whitsett JA, Trapnell BC. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity. 2001;15:557-567.
21. Coleman DL, Chodakewitz JA, Bartiss AH, Mellors JW. Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages. Blood. 1988;72:573-578.
22. Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science, 1994;265:1573-1577.
23. McKercher SR, Torbett BE, Anderson KL, et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities, EMBO J. 1996;15:5647-5658.
24. DeKoter RP, Walsh JC, Singh H. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 1998;17:4456-4468.
25. Nathan CF, Prendergast TJ, Wiebe ME, et al. Activation of human macrophages: Comparison of other cytokines with interferon γ. J Exp Med. 1984;160:600-605.
26. Erbe DV, Collins JE, Shen L, Graziano RF, Fanger MW. The effect of cytokines on the expression and function of Fc receptors for IgG on human myeloid cells. Mol Immunol. 1990;27:5767.
27. Schijns VE, Haagmans BL, Rijke EO, Huang S, Aguet M, Horzinek MC. IFN-γ receptor-deficient mice generate antiviral Th1-characteristic cytokine profiles but altered antibody responses. J Immunol. 1994;153:2029-2037.
28. Gajewski TF, Joyce J, Fitch FW. Antiproliferative effect of IFN-γ. in immune regulation, III: differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-γ. J Immunol. 1989;143:15-22.
29. Otake K, Ennist DL, Harrod K, Trapnell BC. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses. Hum Gene Ther. 1998;9:2207-2222.
30. Xing Z, Zganiacz A, Wang J, Divangahi M, Nawaz F. IL-12-independent Th1-type immune responses to respiratory viral infection: Requirement of IL-18 for IFN-γ release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes. J Immunol. 2000;164:2575-2584.
31. Basu S, Dunn AR, Marino MW, et al. Increased tolerance to endotoxin by granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol. 1997;159:1412-1417.
32. Noguchi Y, Wada H, Marino MW, Old LJ. Regulation of IFN-γ production in granulocyte-macrophage colony-stimulating factor-deficient mice. Eur J Immunol. 1998;28:3980-3988.
33. Reed JA, Ikegami M, Cianciolo ER, et al. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am J Physiol. 1999;276:L556-L563.
34. Huffman JA, Hull WM, Dranoff G, Mulligan RC, Whitsett JA. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice [see comments]. J Clin Invest. 1996;97:649-655.
35. Shibata Y, Otake K, Zsengeller Z, Plalaniyar N, Trapnell BC. Alveolar macrophage deficiency in M-CSF-deficient, osteopetrotic mice spontaneously corrects with age and is associated with matrix metalloproteinase expression and emphysema. Blood. 2001;98:2845-2852.
36. Mbawuike IN, Herscowitz HB. MH-S, a murine alveolar macrophage cell line: Morphological, cytochemical, and functional characteristics. J Leukoc Biol. 1989;46:119-127.
37. DeKoter RP, Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science. 2000;288:1439-1441.
38. Trapnell BC. Adenoviral vectors for gene transfer. Adv Drug Deliv Rev. 1993;12:185-199.
39. Rosenfeld MA, Yoshimura K, Trapnell BC, et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell. 1992;68:143-155.
40. Zsengeller ZK, Otake K, Hossain S-A,Berclaz P-Y, Trapnell BC. Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection. J Virol. 2000;74:9655-9667.
41. Mittereder N, March KL, Trapnell BC. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J Virol. 1996;70:7498-7509.
42. Nagaoka I, Trapnell BC, Crystal RG. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. J Clin Invest. 1990;85:2023-2027.
43. Eichbaum QG, lyer R, Raveh DP, Mathieu C, Ezekowitz RA. Restriction of interferon γ responsiveness and basal expression of the myeloid human FcγR1b gene is mediated by a functional PU.1 site and a transcription initiator consensus. J Exp Med. 1994;179:1985-1996.
44. Feinman R, Qiu WQ, Pearse RN, et al. PU.1 and an HLH family member contribute to the myeloidspecific transcription of the FcγRIIIA promoter. EMBO J. 1994;13:3852-3860.
45. Unkeless JC. Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med. 1979;150:580-596.
46. Ravetch JV, Luster AD, Weinshank R, et al. Structural heterogeneity and functional domains of murine immunoglobulin G Fc receptors. Science. 1986;234:718-725.
47. Hashimoto S, Suzuki T, Dong HY, Yamazaki N, Matsushima K. Serial analysis of gene expression in human monocytes and macrophages. Blood. 1999;94:837-844.
48. Crowley MT, Costello PS, Fitzer-Attas CJ, et al. A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages. J Exp Med. 1997;186:1027-1039.
49. Suzuki T, Kono H, Hirose N, et al. Differential involvement of Src family kinases in Fcγ receptor-mediated phagocytosis. J Immunol. 2000;165:473-482.
50. Cox D, Tseng CC, Bjekic G, Greenberg S. A requirement for phosphatidylinositol 3-kinase in pseudopod extension. J Biol Chem. 1999;274:1240-1247.
51. Cooney DS, Phee H, Jacob A, Coggeshall KM. Signal transduction by human-restricted Fcγ RIIa involves three distinct cytoplasmic kinase families leading to phagocytosis. J Immunol. 2001;167:844-854.
52. Trapnell BC, Otake K. Implications of the innate immune system for adenovirus-mediated gene transfer. In: Seth PA, ed. Human Adenoviruses: Basic Science to Clinical Applications. Austin, TX: R. G. Landes; 1998:253-262.
53. Rabinovitch M, Hamburg SI, Fleit HB. Interferon-induced enhancement of Fc receptor-mediated macrophage phagocytosis. J Reticuloendothel Soc. 1980;28(suppl):27s-28s.
54. Zhang T, Kawakami K, Qureshi MH, Okamura H, Kurimoto M, Saito A. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of interferon γ by natural killer cells. Infect Immun. 1997;65:3594-3599.
55. Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T, Nakanishi K. Regulation of interferon γ production by IL-12 and IL-18. Curr Opin Immunol. 1998;10:259-264.