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Volumn 64, Issue 6, 2012, Pages 523-530

Gut-associated lymphoid tissues for the development of oral vaccines

Author keywords

GALT; M cells; Mucosal vaccine; Peyer's patch

Indexed keywords

ANTIGEN DELIVERY SYSTEM; CLINICAL TRIAL; CURRENT STATUS; GALT; GASTROINTESTINAL TRACT; IMMUNE RESPONSE; KEY ELEMENTS; LYMPHOID TISSUE; MUCOSAL VACCINE; PEYER'S PATCHES;

EID: 84858271641     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2011.07.003     Document Type: Review
Times cited : (110)

References (74)
  • 1
    • 84882809886 scopus 로고    scopus 로고
    • Structure and function of intestinal mucosal epithelium
    • Academic Press, San Diego, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock, J.R. McGhee, L. Mayer (Eds.)
    • Kato T., Owen R.O. Structure and function of intestinal mucosal epithelium. Mucosal Immunology 2005, 131-152. Academic Press, San Diego. J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock, J.R. McGhee, L. Mayer (Eds.).
    • (2005) Mucosal Immunology , pp. 131-152
    • Kato, T.1    Owen, R.O.2
  • 2
    • 78449236736 scopus 로고    scopus 로고
    • Antimicrobial peptides: primeval molecules or future drugs?
    • Peters B.M., Shirtliff M.E., Jabra-Rizk M.A. Antimicrobial peptides: primeval molecules or future drugs?. PLoS Pathog. 2010, 6:e1001067.
    • (2010) PLoS Pathog. , vol.6
    • Peters, B.M.1    Shirtliff, M.E.2    Jabra-Rizk, M.A.3
  • 3
    • 84882832676 scopus 로고    scopus 로고
    • Mucosal immunoglobulins
    • Academic Press, San Diego, J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock, J.R. McGhee, L. Mayer (Eds.)
    • Mestecky J., Moro I., Kerr M.A., Woof J.M. Mucosal immunoglobulins. Mucosal Immunology 2005, 153-182. Academic Press, San Diego. J. Mestecky, M.E. Lamm, W. Strober, J. Bienenstock, J.R. McGhee, L. Mayer (Eds.).
    • (2005) Mucosal Immunology , pp. 153-182
    • Mestecky, J.1    Moro, I.2    Kerr, M.A.3    Woof, J.M.4
  • 4
    • 53849149024 scopus 로고    scopus 로고
    • Mucosal S-IgA enhancement: development of safe and effective mucosal adjuvants and mucosal antigen delivery vehicles
    • Kluwer Academic/Plenum Publishers, New York, C. Kaetzel (Ed.)
    • Kunisawa J., McGhee J., Kiyono H. Mucosal S-IgA enhancement: development of safe and effective mucosal adjuvants and mucosal antigen delivery vehicles. Mucosal Immune Defense: Immunoglobulin A 2007, 346-389. Kluwer Academic/Plenum Publishers, New York. C. Kaetzel (Ed.).
    • (2007) Mucosal Immune Defense: Immunoglobulin A , pp. 346-389
    • Kunisawa, J.1    McGhee, J.2    Kiyono, H.3
  • 5
    • 77952311371 scopus 로고    scopus 로고
    • Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis
    • Fagarasan S., Kawamoto S., Kanagawa O., Suzuki K. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu. Rev. Immunol. 2010, 28:243-273.
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 243-273
    • Fagarasan, S.1    Kawamoto, S.2    Kanagawa, O.3    Suzuki, K.4
  • 6
    • 53849114631 scopus 로고    scopus 로고
    • Immunological commonalities and distinctions between airway and digestive immunity
    • Kunisawa J., Nochi T., Kiyono H. Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol. 2008, 29:505-513.
    • (2008) Trends Immunol. , vol.29 , pp. 505-513
    • Kunisawa, J.1    Nochi, T.2    Kiyono, H.3
  • 11
    • 77957733251 scopus 로고    scopus 로고
    • Analysis of intestinal T cell populations and cytokine productions
    • Academic Press, Oxford, S. Kaufmann, D. Kabelitz (Eds.)
    • Kunisawa J., Kiyono H. Analysis of intestinal T cell populations and cytokine productions. Methods in Microbiology 2010, 183-193. Academic Press, Oxford. S. Kaufmann, D. Kabelitz (Eds.).
    • (2010) Methods in Microbiology , pp. 183-193
    • Kunisawa, J.1    Kiyono, H.2
  • 12
    • 0024338548 scopus 로고
    • Regulation of IgA synthesis and immune response by T cells and interleukins
    • McGhee J.R., Mestecky J., Elson C.O., Kiyono H. Regulation of IgA synthesis and immune response by T cells and interleukins. J. Clin. Immunol. 1989, 9:175-199.
    • (1989) J. Clin. Immunol. , vol.9 , pp. 175-199
    • McGhee, J.R.1    Mestecky, J.2    Elson, C.O.3    Kiyono, H.4
  • 15
    • 0036686912 scopus 로고    scopus 로고
    • Lack of antigen-specific immune responses in anti-IL-7 receptor α chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen
    • Kunisawa J., Takahashi I., Okudaira A., Hiroi T., Katayama K., Ariyama T., Tsutsumi Y., Nakagawa S., Kiyono H., Mayumi T. Lack of antigen-specific immune responses in anti-IL-7 receptor α chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur. J. Immunol. 2002, 32:2347-2355.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2347-2355
    • Kunisawa, J.1    Takahashi, I.2    Okudaira, A.3    Hiroi, T.4    Katayama, K.5    Ariyama, T.6    Tsutsumi, Y.7    Nakagawa, S.8    Kiyono, H.9    Mayumi, T.10
  • 18
    • 48749091530 scopus 로고    scopus 로고
    • Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    • Tsuji M., Suzuki K., Kitamura H., Maruya M., Kinoshita K., Ivanov I.I., Itoh K., Littman D.R., Fagarasan S. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity 2008, 29:261-271.
    • (2008) Immunity , vol.29 , pp. 261-271
    • Tsuji, M.1    Suzuki, K.2    Kitamura, H.3    Maruya, M.4    Kinoshita, K.5    Ivanov, I.I.6    Itoh, K.7    Littman, D.R.8    Fagarasan, S.9
  • 20
    • 85047671391 scopus 로고
    • Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches
    • Clark M.A., Jepson M.A., Simmons N.L., Hirst B.H. Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches. Histochem. J. 1994, 26:271-280.
    • (1994) Histochem. J. , vol.26 , pp. 271-280
    • Clark, M.A.1    Jepson, M.A.2    Simmons, N.L.3    Hirst, B.H.4
  • 23
    • 0031913037 scopus 로고    scopus 로고
    • M-cell surface β1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer's patch M cells
    • Clark M.A., Hirst B.H., Jepson M.A. M-cell surface β1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer's patch M cells. Infect. Immun. 1998, 66:1237-1243.
    • (1998) Infect. Immun. , vol.66 , pp. 1237-1243
    • Clark, M.A.1    Hirst, B.H.2    Jepson, M.A.3
  • 24
    • 0030031402 scopus 로고    scopus 로고
    • The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches
    • Baumler A.J., Tsolis R.M., Heffron F. The lpf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:279-283.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 279-283
    • Baumler, A.J.1    Tsolis, R.M.2    Heffron, F.3
  • 25
    • 0020522187 scopus 로고
    • Determinants of reovirus interaction with the intestinal M cells and absorptive cells of murine intestine
    • Wolf J.L., Kauffman R.S., Finberg R., Dambrauskas R., Fields B.N., Trier J.S. Determinants of reovirus interaction with the intestinal M cells and absorptive cells of murine intestine. Gastroenterology 1983, 85:291-300.
    • (1983) Gastroenterology , vol.85 , pp. 291-300
    • Wolf, J.L.1    Kauffman, R.S.2    Finberg, R.3    Dambrauskas, R.4    Fields, B.N.5    Trier, J.S.6
  • 28
    • 77958157901 scopus 로고    scopus 로고
    • Sampling of the intestinal microbiota by epithelial M cells
    • Pickard J.M., Chervonsky A.V. Sampling of the intestinal microbiota by epithelial M cells. Curr. Gastroenterol. Rep. 2010, 12:331-339.
    • (2010) Curr. Gastroenterol. Rep. , vol.12 , pp. 331-339
    • Pickard, J.M.1    Chervonsky, A.V.2
  • 29
    • 0033521087 scopus 로고    scopus 로고
    • Organogenic role of B lymphocytes in mucosal immunity
    • Golovkina T.V., Shlomchik M., Hannum L., Chervonsky A. Organogenic role of B lymphocytes in mucosal immunity. Science 1999, 286:1965-1968.
    • (1999) Science , vol.286 , pp. 1965-1968
    • Golovkina, T.V.1    Shlomchik, M.2    Hannum, L.3    Chervonsky, A.4
  • 33
    • 24644466385 scopus 로고    scopus 로고
    • Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes
    • Lin X.P., Almqvist N., Telemo E. Human small intestinal epithelial cells constitutively express the key elements for antigen processing and the production of exosomes. Blood Cells Mol. Dis. 2005, 35:122-128.
    • (2005) Blood Cells Mol. Dis. , vol.35 , pp. 122-128
    • Lin, X.P.1    Almqvist, N.2    Telemo, E.3
  • 39
    • 20744431722 scopus 로고    scopus 로고
    • Peyer's patch dendritic cells as regulators of mucosal adaptive immunity
    • Sato A., Iwasaki A. Peyer's patch dendritic cells as regulators of mucosal adaptive immunity. Cell. Mol. Life Sci. 2005, 62:1333-1338.
    • (2005) Cell. Mol. Life Sci. , vol.62 , pp. 1333-1338
    • Sato, A.1    Iwasaki, A.2
  • 40
    • 58149242530 scopus 로고    scopus 로고
    • A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts
    • Dullaers M., Li D., Xue Y., Ni L., Gayet I., Morita R., Ueno H., Palucka K.A., Banchereau J., Oh S. A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts. Immunity 2009, 30:120-129.
    • (2009) Immunity , vol.30 , pp. 120-129
    • Dullaers, M.1    Li, D.2    Xue, Y.3    Ni, L.4    Gayet, I.5    Morita, R.6    Ueno, H.7    Palucka, K.A.8    Banchereau, J.9    Oh, S.10
  • 42
    • 77954898661 scopus 로고    scopus 로고
    • The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut
    • Suzuki K., Maruya M., Kawamoto S., Sitnik K., Kitamura H., Agace W.W., Fagarasan S. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity 2010, 33:71-83.
    • (2010) Immunity , vol.33 , pp. 71-83
    • Suzuki, K.1    Maruya, M.2    Kawamoto, S.3    Sitnik, K.4    Kitamura, H.5    Agace, W.W.6    Fagarasan, S.7
  • 43
    • 38449094767 scopus 로고    scopus 로고
    • The multifunctional role of antibodies in the protective response to bacterial T cell-independent antigens
    • Mond J.J., Kokai-Kun J.F. The multifunctional role of antibodies in the protective response to bacterial T cell-independent antigens. Curr. Top. Microbiol. Immunol. 2008, 319:17-40.
    • (2008) Curr. Top. Microbiol. Immunol. , vol.319 , pp. 17-40
    • Mond, J.J.1    Kokai-Kun, J.F.2
  • 44
    • 20744453946 scopus 로고    scopus 로고
    • A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense
    • Kunisawa J., Kiyono H. A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense. Cell. Mol. Life Sci. 2005, 62:1308-1321.
    • (2005) Cell. Mol. Life Sci. , vol.62 , pp. 1308-1321
    • Kunisawa, J.1    Kiyono, H.2
  • 47
    • 37049033289 scopus 로고    scopus 로고
    • Entry route of Salmonella typhimurium directs the type of induced immune response
    • Martinoli C., Chiavelli A., Rescigno M. Entry route of Salmonella typhimurium directs the type of induced immune response. Immunity 2007, 27:975-984.
    • (2007) Immunity , vol.27 , pp. 975-984
    • Martinoli, C.1    Chiavelli, A.2    Rescigno, M.3
  • 48
    • 3242794249 scopus 로고    scopus 로고
    • Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice
    • Fleeton M.N., Contractor N., Leon F., Wetzel J.D., Dermody T.S., Kelsall B.L. Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J. Exp. Med. 2004, 200:235-245.
    • (2004) J. Exp. Med. , vol.200 , pp. 235-245
    • Fleeton, M.N.1    Contractor, N.2    Leon, F.3    Wetzel, J.D.4    Dermody, T.S.5    Kelsall, B.L.6
  • 49
    • 34247354537 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production
    • Kunisawa J., Kurashima Y., Gohda M., Higuchi M., Ishikawa I., Miura F., Ogahara I., Kiyono H. Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. Blood 2007, 109:3749-3756.
    • (2007) Blood , vol.109 , pp. 3749-3756
    • Kunisawa, J.1    Kurashima, Y.2    Gohda, M.3    Higuchi, M.4    Ishikawa, I.5    Miura, F.6    Ogahara, I.7    Kiyono, H.8
  • 50
    • 35349027729 scopus 로고    scopus 로고
    • Nanoparticles and microparticles as vaccine-delivery systems
    • Singh M., Chakrapani A., O'Hagan D. Nanoparticles and microparticles as vaccine-delivery systems. Expert Rev. Vaccines 2007, 6:797-808.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 797-808
    • Singh, M.1    Chakrapani, A.2    O'Hagan, D.3
  • 52
    • 0025998909 scopus 로고
    • ISCOMS-a novel strategy for mucosal immunization?
    • Mowat A.M., Donachie A.M. ISCOMS-a novel strategy for mucosal immunization?. Immunol. Today 1991, 12:383-385.
    • (1991) Immunol. Today , vol.12 , pp. 383-385
    • Mowat, A.M.1    Donachie, A.M.2
  • 54
    • 0034806367 scopus 로고    scopus 로고
    • Microparticle vaccine approaches to stimulate mucosal immunisation
    • Brayden D.J., Baird A.W. Microparticle vaccine approaches to stimulate mucosal immunisation. Microbes Infect. 2001, 3:867-876.
    • (2001) Microbes Infect. , vol.3 , pp. 867-876
    • Brayden, D.J.1    Baird, A.W.2
  • 55
    • 0030470545 scopus 로고    scopus 로고
    • Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres
    • Tabata Y., Inoue Y., Ikada Y. Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres. Vaccine 1996, 14:1677-1685.
    • (1996) Vaccine , vol.14 , pp. 1677-1685
    • Tabata, Y.1    Inoue, Y.2    Ikada, Y.3
  • 56
    • 0032567133 scopus 로고    scopus 로고
    • Oral immunization with enterocoated microbeads induces antigen-specific cytolytic T-cell responses
    • Vogel K., Kantor J., Wood L., Rivera R., Schlom J. Oral immunization with enterocoated microbeads induces antigen-specific cytolytic T-cell responses. Cell. Immunol. 1998, 190:61-67.
    • (1998) Cell. Immunol. , vol.190 , pp. 61-67
    • Vogel, K.1    Kantor, J.2    Wood, L.3    Rivera, R.4    Schlom, J.5
  • 57
    • 0034668160 scopus 로고    scopus 로고
    • Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses
    • Kunisawa J., Okudaira A., Tsutsumi Y., Takahashi I., Nakanishi T., Kiyono H., Mayumi T. Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses. Vaccine 2000, 19:589-594.
    • (2000) Vaccine , vol.19 , pp. 589-594
    • Kunisawa, J.1    Okudaira, A.2    Tsutsumi, Y.3    Takahashi, I.4    Nakanishi, T.5    Kiyono, H.6    Mayumi, T.7
  • 58
    • 0027259027 scopus 로고
    • Stability of liposomes in vitro and their uptake by rat Peyer's patches following oral administration
    • Aramaki Y., Tomizawa H., Hara T., Yachi K., Kikuchi H., Tsuchiya S. Stability of liposomes in vitro and their uptake by rat Peyer's patches following oral administration. Pharm. Res. 1993, 10:1228-1231.
    • (1993) Pharm. Res. , vol.10 , pp. 1228-1231
    • Aramaki, Y.1    Tomizawa, H.2    Hara, T.3    Yachi, K.4    Kikuchi, H.5    Tsuchiya, S.6
  • 59
    • 0031307162 scopus 로고    scopus 로고
    • Application of liposomes for development of oral vaccines: study of in vitro stability of liposomes and antibody response to antigen associated with liposomes after oral immunization
    • Han M., Watarai S., Kobayashi K., Yasuda T. Application of liposomes for development of oral vaccines: study of in vitro stability of liposomes and antibody response to antigen associated with liposomes after oral immunization. J. Vet. Med. Sci. 1997, 59:1109-1114.
    • (1997) J. Vet. Med. Sci. , vol.59 , pp. 1109-1114
    • Han, M.1    Watarai, S.2    Kobayashi, K.3    Yasuda, T.4
  • 60
    • 0029905843 scopus 로고    scopus 로고
    • Lectin-bearing polymerized liposomes as potential oral vaccine carriers
    • Chen H., Torchilin V., Langer R. Lectin-bearing polymerized liposomes as potential oral vaccine carriers. Pharm. Res. 1996, 13:1378-1383.
    • (1996) Pharm. Res. , vol.13 , pp. 1378-1383
    • Chen, H.1    Torchilin, V.2    Langer, R.3
  • 61
    • 0032033578 scopus 로고    scopus 로고
    • Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo
    • Foster N., Clark M.A., Jepson M.A., Hirst B.H. Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo. Vaccine 1998, 16:536-541.
    • (1998) Vaccine , vol.16 , pp. 536-541
    • Foster, N.1    Clark, M.A.2    Jepson, M.A.3    Hirst, B.H.4
  • 64
    • 0031939292 scopus 로고    scopus 로고
    • Utilizing bacterial mechanisms of epithelial cell entry: invasin-induced oral uptake of latex nanoparticles
    • Hussain N., Florence A.T. Utilizing bacterial mechanisms of epithelial cell entry: invasin-induced oral uptake of latex nanoparticles. Pharm. Res. 1998, 15:153-156.
    • (1998) Pharm. Res. , vol.15 , pp. 153-156
    • Hussain, N.1    Florence, A.T.2
  • 67
    • 0032167625 scopus 로고    scopus 로고
    • Studying M cells and their role in infection
    • Jepson M.A., Clark M.A. Studying M cells and their role in infection. Trends Microbiol. 1998, 6:359-365.
    • (1998) Trends Microbiol. , vol.6 , pp. 359-365
    • Jepson, M.A.1    Clark, M.A.2
  • 68
    • 32944462721 scopus 로고    scopus 로고
    • Bacterial adhesion and entry into host cells
    • Pizarro-Cerda J., Cossart P. Bacterial adhesion and entry into host cells. Cell 2006, 124:715-727.
    • (2006) Cell , vol.124 , pp. 715-727
    • Pizarro-Cerda, J.1    Cossart, P.2
  • 70
    • 0037103328 scopus 로고    scopus 로고
    • Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor
    • Mantis N.J., Cheung M.C., Chintalacharuvu K.R., Rey J., Corthesy B., Neutra M.R. Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. J. Immunol. 2002, 169:1844-1851.
    • (2002) J. Immunol. , vol.169 , pp. 1844-1851
    • Mantis, N.J.1    Cheung, M.C.2    Chintalacharuvu, K.R.3    Rey, J.4    Corthesy, B.5    Neutra, M.R.6
  • 71
    • 0024597894 scopus 로고
    • Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins
    • Weltzin R., Lucia-Jandris P., Michetti P., Fields B.N., Kraehenbuhl J.P., Neutra M.R. Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins. J. Cell Biol. 1989, 108:1673-1685.
    • (1989) J. Cell Biol. , vol.108 , pp. 1673-1685
    • Weltzin, R.1    Lucia-Jandris, P.2    Michetti, P.3    Fields, B.N.4    Kraehenbuhl, J.P.5    Neutra, M.R.6
  • 72
    • 77954759581 scopus 로고    scopus 로고
    • Recognition of secretory IgA by DC-SIGN: implications for immune surveillance in the intestine
    • Baumann J., Park C.G., Mantis N.J. Recognition of secretory IgA by DC-SIGN: implications for immune surveillance in the intestine. Immunol. Lett. 2010, 131:59-66.
    • (2010) Immunol. Lett. , vol.131 , pp. 59-66
    • Baumann, J.1    Park, C.G.2    Mantis, N.J.3
  • 73
    • 0029063450 scopus 로고
    • Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes
    • Zhou F., Kraehenbuhl J.P., Neutra M.R. Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes. Vaccine 1995, 13:637-644.
    • (1995) Vaccine , vol.13 , pp. 637-644
    • Zhou, F.1    Kraehenbuhl, J.P.2    Neutra, M.R.3
  • 74
    • 0025908008 scopus 로고
    • Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells
    • Pappo J., Ermak T.H., Steger H.J. Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells. Immunology 1991, 73:277-280.
    • (1991) Immunology , vol.73 , pp. 277-280
    • Pappo, J.1    Ermak, T.H.2    Steger, H.J.3


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