Chemokine fractalkine attenuates overactivation and apoptosis of BV-2 microglial cells induced by extracellular ATP

Neurochemical Research

Volumn 38, Issue 5, 2013, Pages 1002-1012

  Hao, Fei ^a   Zhang, Nan Nan ^a   Zhang, Dong Mei ^a   Bai, Hui Yu ^a   Piao, Hua ^a   Yuan, Bo ^a   Zhu, Hao Yue ^a   Yu, Huan ^a   Xiao, Cong Shu ^a   Li, Ai Ping ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

ATP; BV 2 microglial cell; Cytotoxicity; Fractalkine; PI3 K Akt pathway

Indexed keywords

ADENOSINE TRIPHOSPHATE; FRACTALKINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRAIN BV 2; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME PHOSPHORYLATION; EXPOSURE; FLOW CYTOMETRY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELL LINE; CHEMOKINE CX3CL1; MICE; MICROGLIA;

EID: 84876174009     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1010-7     Document Type: Article

References (42)

1. Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69 (Pubitemid 46011999)
2. Garden GA, Möller T (2006) Microglia biology in health and disease. J Neuroimmune Pharm 1:127-137 (Pubitemid 44257488)
3. Kim WK, Hwang SY, Oh ES, Piao HZ, Kim KW et al (2004) TGF-beta 1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity. J Immunol 172:7015-7023 (Pubitemid 38669143)
4. Saijo K, Glass CK (2011) Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11:775-787
5. Tambuyzer BR, Ponsaerts P, Nouwen EJ (2009) Microglia: gatekeepers of central nervous system immunology. J Leukocyte Biol 85:352-370
6. Monk PN, Shaw PJ (2006) ALS: life and death in a bad neighborhood. Nat Med 12:885-887 (Pubitemid 44175136)
7. Neumann H, Kotter MR, Franklin RJ (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132:288-295
8. Liu B, Wang K, Gao HM, Mandavilli B, Wang JY et al (2001) Molecular consequences of activated microglia in the brain: overactivation induces apoptosis. J Neurochem 77:182-189 (Pubitemid 32245092)
9. Polazzi E, Monti B (2010) Microglia and neuroprotection: from in vitro studies to therapeutic applications. Prog Neurobiol 92:293-315
10. Liang J, Takeuchi H, Jin S, Noda M, Li H et al (2010) Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway. Brain Res 1322:8-23
11. Nakamura Y (2002) Regulating factors for microglial activation. Biol Pharm Bull 25:945-953 (Pubitemid 39663211)
12. Matute C, Alberdi E, Domercq M, Sánchez-Gómez M-V, Pérez-Samartín A et al (2007) Excitotoxic damage to white matter. J Anat 210:693-702 (Pubitemid 46851004)
13. Fields RD, Burnstock G (2006) Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 7:423-436 (Pubitemid 44012283)
14. Delarasse C, Gonnord P, Galante M, Auger R, Daniel H et al (2009) Neural progenitor cell death is induced by extracellular ATP via ligation of P2X7 receptor. J Neurochem 109:846-857
15. Matute C (2011) Glutamate and ATP signalling in white matter pathology. J Anat 219:53-64
16. Farber K, Kettenmann H (2006) Purinergic signaling and microglia. Pflugers Arch 452:615-621 (Pubitemid 44015096)
17. Re DB, Przedborski S (2006) Fractalkine: moving from chemotaxis to neuroprotection. Nat Neurosci 9:859-861 (Pubitemid 43982534)
18. Cipriani R, Villa P, Chece G, Lauro C, Paladini A et al (2011) CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. J Neurosci 31:16327-16335
19. Pabon MM, Bachstetter AD, Hudson CE, Gemma C, Bickford PC (2011) CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. J Neuroinflamm 8:9
20. Rogers JT, Morganti JM, Bachstetter AD, Hudson CE, Peters MM et al (2011) CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. J Neurosci 31:16241-16250
21. Fuhrmann M, Bittner T, Jung CKE, Burgold S, Page RM et al (2010) Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci 13:411-413
22. Mizuno T, Kawanokuchi J, Numata K, Suzumura A (2003) Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res 979:65-70 (Pubitemid 36798062)
23. Lauro C, Di Angelantonio S, Cipriani R, Sobrero F, Antonilli L et al (2008) Activity of adenosine receptors type 1 is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons. J Immunol 180:7590-7596
24. Limatola C, Lauro C, Catalano M, Ciotti MT, Bertollini C et al (2005) Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. J Neuroimmunol 166:19-28 (Pubitemid 41074653)
25. Deiva K, Geeraerts T, Salim H, Leclerc P, Hery C et al (2004) Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci 20:3222-3232 (Pubitemid 40013533)
26. Boehme SA, Lio FM, Maciejewski-Lenoir D, Bacon KB, Conlon PJ (2000) The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia. J Immunol 165:397-403 (Pubitemid 30429532)
27. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27:229-237 (Pubitemid 20146292)
28. Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R et al (2012) Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Delta9-tetrahydrocannabinol in BV-2 microglial cells. Br J Pharmacol 165:2512-2528
29. Lee P, Hur J, Lee J, Kim J, Jeong J et al (2006) 15,16-dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide. Neurochem Int 48:60-66 (Pubitemid 41774280)
30. Lee JA, Song HY, Ju SM, Lee SJ, Seo WY et al (2010) Suppression of inducible nitric oxide synthase and cyclooxygenase-2 by cell-permeable superoxide dismutase in lipopolysaccharide- stimulated BV-2 microglial cells. Mol Cells 29:245-250
31. Shen S, Yu S, Binek J, Chalimoniuk M, Zhang X et al (2005) Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells. Neurochem Int 47:298-307 (Pubitemid 40943472)
32. Lee S, Lee J, Kim S, Park JY, Lee WH et al (2007) A dual role of lipocalin 2 in the apoptosis and deramification of activated microglia. J Immunol 179:3231-3241
33. Shigemoto-Mogami Y, Koizumi S, Tsuda M, Ohsawa K, Kohsaka S et al (2001) Mechanisms underlying extracellular ATP-evoked interleukin-6 release in mouse microglial cell line, MG-5. J Neurochem 78:1339-1349 (Pubitemid 32899765)
34. Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y et al (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8:752-758 (Pubitemid 43085841)
35. Xiang Z, Chen M, Ping J, Dunn P, Lv J et al (2006) Microglial morphology and its transformation after challenge by extracellular ATP in vitro. J Neurosci Res 83:91-101 (Pubitemid 43062013)
36. Choi DK, Koppula S, Suk K (2011) Inhibitors of microglial neurotoxicity: focus on natural products. Molecules 16:1021-1043
37. Hu X, Zhou H, Zhang D, Yang S, Qian L et al (2012) Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation. J Neuroimmune Pharm 7:187-201
38. Zujovic V, Benavides J, Vige X, Carter C, Taupin V (2000) Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 29:305-315 (Pubitemid 30121421)
39. Noda M, Doi Y, Liang J, Kawanokuchi J, Sonobe Y et al (2011) Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression. J Biol Chem 286:2308-2319
40. Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM et al (2006) Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 9:917-924 (Pubitemid 43980506)
41. Vinet J, van Weering HR, Heinrich A, Kalin RE, Wegner A et al (2012) Neuroprotective function for ramified microglia in hippocampal excitotoxicity. J Neuroinflamm 9:27
42. Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB et al (2009) Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro. J Neurochem 110:1547-1556