Computational models of tandem Src homology 2 domain interactions and application to phosphoinositide 3-kinase

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 7338-7345

  Barua, Dipak ^a   Faeder, James R ^b   Haugh, Jason M ^a,c  

^a North Carolina State University   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIOACTIVITY; COORDINATION REACTIONS; FLOW INTERACTIONS; GROWTH (MATERIALS); PLATELETS; POLYPEPTIDES; PROTEINS; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; VOLUMETRIC ANALYSIS;

ALTERNATIVE MECHANISMS; COMPUTATIONAL MODELS; COOPERATIVITY; DO-MAINS; EFFECTIVE VOLUMES; GROWTH FACTORS; HOMODIMERIZATION; IN VITRO; IN VITRO BINDINGS; INTRACELLULAR SIGNALS; ISOTHERMAL TITRATION CALORIMETRIES; KINETIC MODELS; KINETIC SCHEMES; MULTIPLE INTERACTIONS; ORDERS OF MAGNITUDES; PHOSPHOINOSITIDE; RECEPTOR BINDINGS; RECEPTOR SYSTEMS; SH2 DOMAINS; SIGNALING COMPLEXES; SIMPLE MODELS; SRC HOMOLOGY 2; STRUCTURAL CONSTRAINTS; SURFACE PLASMONS;

PEPTIDES;

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE P85; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN SH2; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; DIMERIZATION; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; KINETICS; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; HUMAN; METABOLISM; METHODOLOGY; PHYSIOLOGY; SRC HOMOLOGY DOMAIN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; HUMANS; KINETICS; MODELS, BIOLOGICAL; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SRC HOMOLOGY DOMAINS; SURFACE PLASMON RESONANCE;

EID: 43149099006     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708359200     Document Type: Article

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