Antigen-specific cytolysis by neutrophils and NK cells expressing chimeric immune receptors bearing or signaling domains

Journal of Immunology

Volumn 161, Issue 1, 1998, Pages 375-384

  Roberts, Margo R ^a   Cooke, Keegan S ^b   Tran, Annie Chen ^a   Smith, Kent A ^c   Lin, Wei Yu ^a   Wang, Martin ^d   Dull, Thomas J ^a   Farson, Deborah ^a   Zsebo, Krisztina M ^e   Finer, Mitchell H ^a  

^a CELL GENESYS INC   (United States)

^b AMGEN INC   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

^e Biovest Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; FC RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CYTOLYSIS; EFFECTOR CELL; EXPRESSION VECTOR; FEMALE; LIGAND BINDING; MALE; MOUSE; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

ADULT; ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CYTOTOXICITY TESTS, IMMUNOLOGIC; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; FEMALE; GENETIC VECTORS; HUMANS; KILLER CELLS, NATURAL; MALE; MEMBRANE PROTEINS; MICE; MICE, SCID; MOLONEY MURINE LEUKEMIA VIRUS; NEUTROPHILS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSDUCTION, GENETIC;

EID: 7144261084     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Scholl, P. R., and R. S. Geha. 1993. Physical association between the high affinity IgG receptor (Fc gamma RI) and the gamma subunit of the high affinity IgE receptor (Fc epsilon RI gamma). Proc. Natl. Acad. Sci. USA 90:8847.
2. Ernst, L. K., A. M. Duchemin, and C. L. Anderson. 1993. Association of the high affinity receptor for IgG (Fc gamma RI) with the gamma subunit of the IgE receptor. Proc. Natl. Acad. Sci. USA 90:6023.
3. Masuda, M., and D. Roos. 1993. Association of all three types of Fc gamma R (CD64, CD32, and CD16) with a gamma-chain homodimer in cultured human monocytes. J. Immunol. 151:7188.
4. Qian, D., A. I. Sperling, D. W. Lancki, Y. Tatsumi, T. A. Barrett, J. A. Bluestone, and F. W. Fitch. 1993. The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes. Proc. Natl. Acad. Sci. USA 90:11875.
5. Letourneur, O., I. C. S. Kennedy, A. T. Brini, J. R. Ortaldo, J. J. O'Shea, and J.-P. Kinet. 1991. Characterization of the family of dinners associated with Fc receptors (Fc∈RI and FcγRIII). J. Immunol. 147:2652.
6. Wirthmueller, U., T. Kurosaki, M. S. Murakami, and J. V. Ravetch. 1992. Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain. J. Exp. Med. 175:1381.
7. Park, J.-G., and A. D. Schreiber. 1995. Determinants of the phagocytic signal mediated by the type IIIA Fcγ receptor, FcRIIIA: sequence requirements and interaction with protein kinases. Proc. Natl. Acad. Sci. USA 92:7381.
8. Cambier, J. C. 1995. Antigen and Fc receptor signaling: the awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J. Immunol. 155:3281.
9. Indik, Z. K., J. G. Park, S. Hunter, and A. D. Schreiber. 1995. The molecular dissection of Fc gamma receptor mediated phagocytosis. Blood 86:4389.
10. Pignata, C., K. V. S. Prasad, M. J. Robertson, H. Levine, C. E. Rudd, and J. Ritz. 1993. FcγRIIIA-mediated signaling involves src-family lck in human natural killer cells. J. Immunol. 151:6794.
11. Lck with FcγRIIIA (CD16) in natural killer cells. J. Exp. Med. 177:1475.
12. El-Hillal, O., T. Kurosaki, T. Yamamura, J.-P. Kinet, and A. M. Scharenberg. 1997. syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction. Proc. Natl. Acad. Sci. USA 94:1919.
13. Daeron, M. 1997. Fc receptor biology. Anna. Rev. Immunol. 15:203.
14. Qian, D., and A. Weiss. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205.
15. Romeo, C., and B. Seed. 1991. Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides. Cell 64:1037.
16. Irving, B. A., and A. Weiss. 1991. The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 64:891.
17. Hwu, P., G. E. Shafer, J. Treisman, D. G. Schindler, G. Gross, R. Cowher, S. A. Rosenberg, and Z. Eshhar. 1993. Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor γ chain. J. Exp. Med. 178:361.
18. + T lymphocytes armed with universal T-cell receptors. Blood 84:2878.
19. Tran, A.-C., D. Zhang, R. Byrn, and M. R. Roberts. 1994. Chimeric ζ-receptors direct human natural killer effector function to permit killing of NK-resistant tumor cells and HIV-infected T lymphocytes. J. Immunol. 155:1000.
20. Hege, K. M., K. S. Cooke, M. H. Finer, K. M. Zsebo, and M. R. Roberts. 1996. Systemic T cell-independent tumor immunity after transplantation of universal receptor-modified bone marrow into SCID mice. J. Exp. Med. 184:2261.
21. Finer, M. H., T. J. Dull, L. Qin, D. Parson, and M. R. Roberts. 1994. kat: a high efficiency retroviral transduction system for primary human T lymphocytes. Blood 83:43.
22. Kornbluth, J., N. Flomenberg, and B. Dupont. 1982. Cell surface phenotype of a cloned line of human NK cells. J. Immunol. 129:2831.
23. Athens, J. W., O. P. Haab, S. O. Raab, A. M. Mauer, H. Ashenbrucker, G. E. Cartwright, and M. M. Wintrobe. 1961. Leukokinetic studies. IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J. Clin. Invest. 40:989.
24. Van Bekkum, D. W., L. J. Dooren, J. M. Vossen, and P. T. A. Schellekens. 1985. Immune reconstitution of radiation chimeras. Bone Marrow Transplantation: Biological Mechanisms and Clinical Practice. Marcel Dekker, New York, p. 311.
25. Weissman, A. M., D. Hou, D. G. Orloff, W. S. Modi, H. Seuanez, S. J. O'Brien, and R. D. Klausner. 1988. Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex. Proc. Natl. Acad. Sci. USA 85:9709.
26. Hazenbos, W. L., J. E. Gessner, F. M. Hofhuis, H. Kuipers, D. Meyer, I. A. Heijnen, R. E. Schmidt, M. Sandor, P. J. Capel, M. Daeron, J. G. an de Winkel, and J. S. Verbeek. 1996. Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity 5:181.
27. Blank, U., C. Ra, L. Miller, K. White, H. Metzger, and J.-P. Kinet. 1989. Complete structure and expression in transfected cells of high affinity IgE receptor. Nature 337:187.
28. Indik, Z. K., S., Hunter, M. M. Huang, X. Q. Pan, P. Chien, C., Kelly, A. I. Levinson, R. P. Kimberly, and A. D. Schreiber. 1994. The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI. Exp. Hematol. 22:599.
29. Kolanus, W., C. Romeo, and B. Seed. 1992. Lineage-independent activation of immune system effector function by myeloid Fc receptors. EMBO J. 11:4861.
30. Kushner, B. H., and N. K. Cheung. 1992. Absolute requirement of CD11/CD18 adhesion molecules, FcRII and the phosphatidylinositol-linked FcRIII for monoclonal antibody-mediated neutrophil antihuman tumor cytotoxicity. Blood 79:1484.
31. 2+ response in human neutrophils. J. Biol. Chem. 270:10671.
32. Elsasser, D., T. Valerius, R. Repp, G. J. Weiner, Y. Deo, J. R. Kalden, J. G. van de Winkel, G. T. Stevenson, M. J. Glennie, and M. Gramatzki. 1996. HLA class II as potential target antigen on malignant B cells for therapy with bispecific antibodies in combination with granulocyte colony-stimulating factor. Blood 87:3803.
33. Irving, B. A., A. C. Chan, and A. Weiss. 1993. Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J. Exp. Med. 177:1093.
34. Combadiere, B., M. Freedman, L. Chen, E. W. Shores, P. Love, and M. J. Lenardo. 1996. Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis. J. Exp. Med. 183:2109.
35. Shores, E. W., T. Tran, A. Grinberg, C. L. Sommers, H. Shen, and P. E. Love. 1997. Role of the multiple T cell receptor (TCR)-ζ chain signaling motifs in the selection of the T cell repertoire. J. Exp. Med. 185:893.
36. Johnson, S. A., C. M. Pleiman, L. Pao, J. Schneringer, K. Hippen, and J. C. Cambier. 1995. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J. Immunol. 155:4596.
37. Osman, N., H. Turner, S. Lucas, K. Reif, and D. A. Cantrell. 1996. The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains. Eur. J. Immunol. 26:1063.
38. Zenner, G., T. Vorherr, T. Mustelin, and P. Burn. 1996. Differential and multiple binding of signal transducing molecules to the ITAMs of the TCR-zeta chain. J. Cell Biochem. 63:94.
39. Zoller, K. E., I. A. MacNeil, and J. S. Brugge. 1997. Protein tyrosine kinases Syk and ZAP-70 disply distinct requirements for Src family kinases in immune response receptor signal transduction. J. Immunol. 158:1650.
40. Liu, C. P., W. Y. Lin, M. Huang, J. W. Kappler, and P. Marrack. 1997. Development and function of T cells in T cell antigen receptor/CD3 ζ knockout mice reconstituted with Fc∈RI γ. Proc. Natl. Acad. Sci. USA 94:616.
41. Lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. J. Exp. Med. 178:1701.
42. Stockmeyer, B., T. Valerius, R. Repp, I. A. Heijnen, H. J. Buhring, Y. M. Deo, J. R. Kalden, M. Gramatzki, and J. G. van de Winkel. 1997. Preclinical studies with Fc(gamma)R bispecific antibodies and granulocyte colony-stimulating factor-primed neutrophils as effector cells against HER-2/neu overexpressing breast cancer. Cancer Res. 57:696.
43. Yashwant, M. D., R. F. Graziano, R. Repp, and J. G. J. van de Winkel. 1997. Clinical significance of IgG Fc receptors and FcγR-directed immunotherapies. Immunol. Today 18:127.