-
2
-
-
0029921888
-
Cellular resistance to anthracyclines
-
Nielsen, D.; Maare, C.; Skovsgaard, T. Cellular resistance to anthracyclines. Gen. Pharmacol. 1996, 27, 251-255.
-
(1996)
Gen. Pharmacol.
, vol.27
, pp. 251-255
-
-
Nielsen, D.1
Maare, C.2
Skovsgaard, T.3
-
3
-
-
0033628853
-
Cellular mechanisms of multidrug resistance of tumor cells
-
Stavrovskaya, A.A. Cellular mechanisms of multidrug resistance of tumor cells. Biochem. Moscow 2000, 65, 95-106.
-
(2000)
Biochem. Moscow
, vol.65
, pp. 95-106
-
-
Stavrovskaya, A.A.1
-
4
-
-
80052253646
-
Anticancer prodrugs: An overview of major strategies and recent developments
-
Arpicco, S.; Dosio, F.; Stella, B.; Cattel, L. Anticancer prodrugs: An overview of major strategies and recent developments. Curr. Top. Med. Chem. 2011, 11, 2346-2381.
-
(2011)
Curr. Top. Med. Chem.
, vol.11
, pp. 2346-2381
-
-
Arpicco, S.1
Dosio, F.2
Stella, B.3
Cattel, L.4
-
5
-
-
12844268268
-
Glutathione transferases
-
Hayes, J.D.; Flanagan, J.U.; Jowsey, I.R. Glutathione transferases. Annu. Rev. Pharmacol. Toxicol. 2005, 45, 51-88.
-
(2005)
Annu. Rev. Pharmacol. Toxicol.
, vol.45
, pp. 51-88
-
-
Hayes, J.D.1
Flanagan, J.U.2
Jowsey, I.R.3
-
6
-
-
0029008428
-
Enzymes and transport-systems involved in the formation and disposition of glutathione S-conjugates-Role in bioactivation and detoxication mechanisms of xenobiotics
-
Commandeur, J.N.M.; Stijntjes, G.J.; Vermeulen, N.P.E. Enzymes and transport-systems involved in the formation and disposition of glutathione S-conjugates-Role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacol. Rev. 1995, 47, 271-330.
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 271-330
-
-
Commandeur, J.N.M.1
Stijntjes, G.J.2
Vermeulen, N.P.E.3
-
7
-
-
0034534421
-
Glutathione conjugation as a bioactivation reaction
-
Van Bladeren, P.J. Glutathione conjugation as a bioactivation reaction. Chem. Biol. Interact. 2000, 129, 61-76.
-
(2000)
Chem. Biol. Interact.
, vol.129
, pp. 61-76
-
-
van Bladeren, P.J.1
-
8
-
-
30144439026
-
Nomenclature for mammalian soluble glutathione transferases
-
Mannervik, B.; Board, P.G.; Hayes, J.D.; Listowsky, I.; Pearson, W.R. Nomenclature for mammalian soluble glutathione transferases. Methods Enzymol. 2005, 401, 1-8.
-
(2005)
Methods Enzymol.
, vol.401
, pp. 1-8
-
-
Mannervik, B.1
Board, P.G.2
Hayes, J.D.3
Listowsky, I.4
Pearson, W.R.5
-
9
-
-
0035887445
-
Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae
-
Ranson, H.; Rossiter, L.; Ortelli, F.; Jensen, B.; Wang, X.L.; Roth, C.W.; Collins, F.H.; Hemingway, J. Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Biochem. J. 2001, 359, 295-304.
-
(2001)
Biochem. J.
, vol.359
, pp. 295-304
-
-
Ranson, H.1
Rossiter, L.2
Ortelli, F.3
Jensen, B.4
Wang, X.L.5
Roth, C.W.6
Collins, F.H.7
Hemingway, J.8
-
10
-
-
0036202462
-
Plant glutathione transferases
-
Dixon, D.P.; Lapthorn, A.; Edwards, R. Plant glutathione transferases. Genome Biol. 2002, 3, 1-10.
-
(2002)
Genome Biol.
, vol.3
, pp. 1-10
-
-
Dixon, D.P.1
Lapthorn, A.2
Edwards, R.3
-
11
-
-
0032526942
-
A mixed disulfide bond in bacterial glutathione transferase: Functional and evolutionary implications
-
Rossjohn, J.; Polekhina, G.; Feil, S.C.; Allocati, N.; Masulli, M.; Di Ilio, C.; Parker, M.W. A mixed disulfide bond in bacterial glutathione transferase: Functional and evolutionary implications. Struct. Fold. Des. 1998, 6, 721-734.
-
(1998)
Struct. Fold. Des.
, vol.6
, pp. 721-734
-
-
Rossjohn, J.1
Polekhina, G.2
Feil, S.C.3
Allocati, N.4
Masulli, M.5
Di Ilio, C.6
Parker, M.W.7
-
12
-
-
0020700627
-
Comparison of the distribution of microsomal and cytosolic glutathione S-transferase activities in different organs of the rat
-
DePierre, J.; Morgenstern, R. Comparison of the distribution of microsomal and cytosolic glutathione S-transferase activities in different organs of the rat. Biochem. Pharmacol. 1983, 32, 721-723.
-
(1983)
Biochem. Pharmacol.
, vol.32
, pp. 721-723
-
-
DePierre, J.1
Morgenstern, R.2
-
13
-
-
0023762542
-
Tissue distribution of drug-metabolizing enzymes in humans
-
Pacifici, G.; Franchi, M.; Bencini, C.; Repetti, F.; Di Lascio, N.; Muraro, G. Tissue distribution of drug-metabolizing enzymes in humans. Xenobiotica 1988, 18, 849-856.
-
(1988)
Xenobiotica
, vol.18
, pp. 849-856
-
-
Pacifici, G.1
Franchi, M.2
Bencini, C.3
Repetti, F.4
Di Lascio, N.5
Muraro, G.6
-
14
-
-
0031021397
-
Structure, catalytic mechanism, and evolution of the glutathione transferases
-
Armstrong, R.N. Structure, catalytic mechanism, and evolution of the glutathione transferases. Chem. Res. Toxicol. 1997, 10, 2-18.
-
(1997)
Chem. Res. Toxicol.
, vol.10
, pp. 2-18
-
-
Armstrong, R.N.1
-
15
-
-
33644852552
-
New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix
-
Grahn, E.; Novotny, M.; Jakobsson, E.; Gustafsson, A.; Grehn, L.; Olin, B.; Madsen, D.; Wahlberg, M.; Mannervik, B.; Kleywegt, G.J. New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix. Acta Crystallogr. Sect. D Biol. Crystallogr. 2006, 62, 197-207.
-
(2006)
Acta Crystallogr. Sect. D Biol. Crystallogr.
, vol.62
, pp. 197-207
-
-
Grahn, E.1
Novotny, M.2
Jakobsson, E.3
Gustafsson, A.4
Grehn, L.5
Olin, B.6
Madsen, D.7
Wahlberg, M.8
Mannervik, B.9
Kleywegt, G.J.10
-
16
-
-
0029853099
-
Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: Catalysis with different substrates involves different residues
-
Tan, K.L.; Chelvanayagam, G.; Parker, M.W.; Board, P.G. Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: Catalysis with different substrates involves different residues. Biochem. J. 1996, 319, 315-321.
-
(1996)
Biochem. J.
, vol.319
, pp. 315-321
-
-
Tan, K.L.1
Chelvanayagam, G.2
Parker, M.W.3
Board, P.G.4
-
17
-
-
0026051660
-
Mutation of an evolutionarily conserved tyrosine residue in the active-site of a human class alpha-glutathione transferase
-
Stenberg, G.; Board, P.G.; Mannervik, B. Mutation of an evolutionarily conserved tyrosine residue in the active-site of a human class alpha-glutathione transferase. FEBS Lett. 1991, 293, 153-155.
-
(1991)
FEBS Lett.
, vol.293
, pp. 153-155
-
-
Stenberg, G.1
Board, P.G.2
Mannervik, B.3
-
18
-
-
0026624869
-
Tyrosine-7 in human class-Pi glutathione-S-transferase is important for lowering the pka of the thiol-group of glutathione in the enzyme-glutathione complex
-
Kong, K.H.; Takasu, K.; Inoue, H.; Takahashi, K. Tyrosine-7 in human class-Pi glutathione-S-transferase is important for lowering the pka of the thiol-group of glutathione in the enzyme-glutathione complex. Biochem. Biophys. Res. Commun. 1992, 184, 194-197.
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.184
, pp. 194-197
-
-
Kong, K.H.1
Takasu, K.2
Inoue, H.3
Takahashi, K.4
-
19
-
-
0024588467
-
Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferase
-
Graminski, G.F.; Kubo, Y.; Armstrong, R.N. Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferase. Biochemistry 1989, 28, 3562-3568.
-
(1989)
Biochemistry
, vol.28
, pp. 3562-3568
-
-
Graminski, G.F.1
Kubo, Y.2
Armstrong, R.N.3
-
20
-
-
0030010768
-
Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1
-
Widersten, M.; Bjornestedt, R.; Mannervik, B. Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1. Biochemistry 1996, 35, 7731-7742.
-
(1996)
Biochemistry
, vol.35
, pp. 7731-7742
-
-
Widersten, M.1
Bjornestedt, R.2
Mannervik, B.3
-
21
-
-
0032143366
-
The three-dimensional structure of a class-Pi glutathione S-transferase complexed with glutathione: The active-site hydration provides insights into the reaction mechanism
-
Parraga, A.; Garcia-Saez, I.; Walsh, S.B.; Mantle, T.J.; Coll, M. The three-dimensional structure of a class-Pi glutathione S-transferase complexed with glutathione: The active-site hydration provides insights into the reaction mechanism. Biochem. J. 1998, 333, 811-816.
-
(1998)
Biochem. J.
, vol.333
, pp. 811-816
-
-
Parraga, A.1
Garcia-Saez, I.2
Walsh, S.B.3
Mantle, T.J.4
Coll, M.5
-
22
-
-
55049084123
-
Glutathione transferase: New model for glutathione activation
-
Dourado, D.; Fernandes, P.A.; Mannervik, B.; Ramos, M.J. Glutathione transferase: New model for glutathione activation. Chem. Eur. J. 2008, 14, 9591-9598.
-
(2008)
Chem. Eur. J.
, vol.14
, pp. 9591-9598
-
-
Dourado, D.1
Fernandes, P.A.2
Mannervik, B.3
Ramos, M.J.4
-
23
-
-
0034637481
-
Identification, characterization, and crystal structure of the omega class glutathione transferases
-
Board, P.G.; Coggan, M.; Chelvanayagam, G.; Easteal, S.; Jermiin, L.S.; Schulte, G.K.; Danley, D.E.; Hoth, L.R.; Griffor, M.C.; Kamath, A.V.; et al. Identification, characterization, and crystal structure of the omega class glutathione transferases. J. Biol. Chem. 2000, 275, 24798-24806.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 24798-24806
-
-
Board, P.G.1
Coggan, M.2
Chelvanayagam, G.3
Easteal, S.4
Jermiin, L.S.5
Schulte, G.K.6
Danley, D.E.7
Hoth, L.R.8
Griffor, M.C.9
Kamath, A.V.10
-
24
-
-
0037163126
-
Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana
-
Dixon, D.P.; Davis, B.G.; Edwards, R. Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana. J. Biol. Chem. 2002, 277, 30859-30869.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30859-30869
-
-
Dixon, D.P.1
Davis, B.G.2
Edwards, R.3
-
25
-
-
0023637816
-
Expression of class Pi-glutathione transferase in human-malignant melanoma-cells
-
Mannervik, B.; Castro, V.M.; Danielson, U.H.; Tahir, M.K.; Hansson, J.; Ringborg, U. Expression of class Pi-glutathione transferase in human-malignant melanoma-cells. Carcinogenesis 1987, 8, 1929-1932.
-
(1987)
Carcinogenesis
, vol.8
, pp. 1929-1932
-
-
Mannervik, B.1
Castro, V.M.2
Danielson, U.H.3
Tahir, M.K.4
Hansson, J.5
Ringborg, U.6
-
26
-
-
0029561598
-
The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
-
Hayes, J.D.; Pulford, D.J. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit. Rev. Biochem. Mol. Biol. 1995, 30, 445-600.
-
(1995)
Crit. Rev. Biochem. Mol. Biol.
, vol.30
, pp. 445-600
-
-
Hayes, J.D.1
Pulford, D.J.2
-
27
-
-
0029954846
-
Glutathione and related enzymes in multidrug resistance
-
O'Brien, M.L.; Tew, K.D. Glutathione and related enzymes in multidrug resistance. Eur. J. Cancer 1996, 32A, 967-978.
-
(1996)
Eur. J. Cancer
, vol.32 A
, pp. 967-978
-
-
O'Brien, M.L.1
Tew, K.D.2
-
28
-
-
0023037085
-
Overexpression of a novel anionic glutathione transferase in multidrug-resistant human-breast cancer-cells
-
Batist, G.; Tulpule, A.; Sinha, B.K.; Katki, A.G.; Myers, C.E.; Cowan, K.H. Overexpression of a novel anionic glutathione transferase in multidrug-resistant human-breast cancer-cells. J. Biol. Chem. 1986, 261, 5544-5549.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 5544-5549
-
-
Batist, G.1
Tulpule, A.2
Sinha, B.K.3
Katki, A.G.4
Myers, C.E.5
Cowan, K.H.6
-
29
-
-
0032612963
-
Evidence for the Involvement of the Glutathione Pathway in Drug Resistance in AML
-
In Kaspers, G.J.L., Pieters, R., Veerman, A.J.P., Eds.; Kluwer Academic/Plenum Publishers: New York, NY, USA
-
Sargent, J.M.; Williamson, C.; Hall, A.G.; Elgie, A.W.; Taylor, C.G. Evidence for the Involvement of the Glutathione Pathway in Drug Resistance in AML. In Drug Resistance in Leukemia and Lymphoma III; Kaspers, G.J.L., Pieters, R., Veerman, A.J.P., Eds.; Kluwer Academic/Plenum Publishers: New York, NY, USA, 1999; pp. 205-209.
-
(1999)
Drug Resistance in Leukemia and Lymphoma III
, pp. 205-209
-
-
Sargent, J.M.1
Williamson, C.2
Hall, A.G.3
Elgie, A.W.4
Taylor, C.G.5
-
30
-
-
0028283529
-
Expression of glutathione-S-transferase-Alpha and glutathione-S-transferase-Pi in gastric-cancer-A correlation with cisplatin resistance
-
Kodera, Y.; Isobe, K.; Yamauchi, M.; Kondo, K.; Akiyama, S.; Ito, K.; Nakashima, I.; Takagi, H. Expression of glutathione-S-transferase-Alpha and glutathione-S-transferase-Pi in gastric-cancer-A correlation with cisplatin resistance. Cancer Chemother. Pharmacol. 1994, 34, 203-208.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.34
, pp. 203-208
-
-
Kodera, Y.1
Isobe, K.2
Yamauchi, M.3
Kondo, K.4
Akiyama, S.5
Ito, K.6
Nakashima, I.7
Takagi, H.8
-
31
-
-
0033105414
-
Regulation of JNK signaling by GSTp
-
Adler, V.; Yin, Z.M.; Fuchs, S.Y.; Benezra, M.; Rosario, L.; Tew, K.D.; Pincus, M.R.; Sardana, M.; Henderson, C.J.; Wolf, C.R.; et al. Regulation of JNK signaling by GSTp. EMBO J. 1999, 18, 1321-1334.
-
(1999)
EMBO J.
, vol.18
, pp. 1321-1334
-
-
Adler, V.1
Yin, Z.M.2
Fuchs, S.Y.3
Benezra, M.4
Rosario, L.5
Tew, K.D.6
Pincus, M.R.7
Sardana, M.8
Henderson, C.J.9
Wolf, C.R.10
-
32
-
-
17944399129
-
Novel markers of susceptibility to carcinogens in diet: Associations with colorectal cancer
-
Sweeney, C.; Coles, B.F.; Nowell, S.; Lang, N.P.; Kadlubar, F.F. Novel markers of susceptibility to carcinogens in diet: Associations with colorectal cancer. Toxicology 2002, 181, 83-87.
-
(2002)
Toxicology
, vol.181
, pp. 83-87
-
-
Sweeney, C.1
Coles, B.F.2
Nowell, S.3
Lang, N.P.4
Kadlubar, F.F.5
-
33
-
-
73449121064
-
Glutathione transferases as targets for cancer therapy
-
Ruzza, P.; Rosato, A.; Rossi, C.R.; Floreani, M.; Quintieri, L. Glutathione transferases as targets for cancer therapy. Anti-Cancer Agents Med. Chem. 2009, 9, 763-777.
-
(2009)
Anti-Cancer Agents Med. Chem.
, vol.9
, pp. 763-777
-
-
Ruzza, P.1
Rosato, A.2
Rossi, C.R.3
Floreani, M.4
Quintieri, L.5
-
34
-
-
0032797568
-
Glutathione-Dependent metabolism of cis-3-(9H-purin-6-ylthio) acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: Evidence for two distinct mechanisms in rats
-
Gunnarsdottir, S.; Elfarra, A.A. Glutathione-Dependent metabolism of cis-3-(9H-purin-6-ylthio) acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: Evidence for two distinct mechanisms in rats. J. Pharmacol. Exp. Ther. 1999, 290, 950-957.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.290
, pp. 950-957
-
-
Gunnarsdottir, S.1
Elfarra, A.A.2
-
35
-
-
0027507524
-
Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats
-
Elfarra, A.; Hwang, I. Targeting of 6-mercaptopurine to the kidneys. Metabolism and kidney-selectivity of S-(6-purinyl)-L-cysteine analogs in rats. Drug Metab. Dispos. 1993, 21, 841-845.
-
(1993)
Drug Metab. Dispos.
, vol.21
, pp. 841-845
-
-
Elfarra, A.1
Hwang, I.2
-
36
-
-
0033845660
-
2 production, cell surface protein thiol oxidation and NF-kappa B activation status
-
2 production, cell surface protein thiol oxidation and NF-kappa B activation status. J. Cell Sci. 2000, 113, 2671-2678.
-
(2000)
J. Cell Sci.
, vol.113
, pp. 2671-2678
-
-
Maellaro, E.1
Dominaci, S.2
del Bello, B.3
Valentini, M.A.4
Pieri, L.5
Perego, P.6
Supino, R.7
Zumino, F.8
Lorenzini, E.9
Paolicchi, A.10
-
37
-
-
0036129205
-
Novel glutathione-dependent thiopurine prodrugs: Evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice
-
Gunnarsdottir, S.; Rucki, M.; Elfarra, A.A. Novel glutathione-dependent thiopurine prodrugs: Evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice. J. Pharmacol. Exp. Ther. 2002, 301, 77-86.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, pp. 77-86
-
-
Gunnarsdottir, S.1
Rucki, M.2
Elfarra, A.A.3
-
38
-
-
1342281164
-
Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen
-
Gunnarsdottir, S.; Elfarra, A.A. Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen. Drug Metab. Dispos. 2004, 32, 321-327.
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 321-327
-
-
Gunnarsdottir, S.1
Elfarra, A.A.2
-
39
-
-
34247130587
-
Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs
-
Eklund, B.I.; Gunnarsdottir, S.; Elfarra, A.A.; Mannervik, B. Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs. Biochem. Pharmacol. 2007, 73, 1829-1841.
-
(2007)
Biochem. Pharmacol
, vol.73
, pp. 1829-1841
-
-
Eklund, B.I.1
Gunnarsdottir, S.2
Elfarra, A.A.3
Mannervik, B.4
-
40
-
-
0028106016
-
Glutathione-associated enzymes in anticancer drug-resistance
-
Tew, K.D. Glutathione-associated enzymes in anticancer drug-resistance. Cancer Res. 1994, 54, 4313-4320.
-
(1994)
Cancer Res.
, vol.54
, pp. 4313-4320
-
-
Tew, K.D.1
-
41
-
-
33746265794
-
Divergent activities of human glutathione transferases in the bioactivation of azathioprine
-
Eklund, B.I.; Moberg, M.; Bergquist, J.; Mannervik, B. Divergent activities of human glutathione transferases in the bioactivation of azathioprine. Mol. Pharmacol. 2006, 70, 747-754.
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 747-754
-
-
Eklund, B.I.1
Moberg, M.2
Bergquist, J.3
Mannervik, B.4
-
42
-
-
9144252139
-
Reviewing the mechanism of action of thiopurine drugs: Towards a new paradigm in clinical practice
-
Cara, C.J.; Pena, A.S.; Sans, M.; Rodrigo, L.; Guerrero-Esteo, M.; Hinojosa, J.; Garcia-Paredes, J.; Guijarro, L.G. Reviewing the mechanism of action of thiopurine drugs: Towards a new paradigm in clinical practice. Med. Sci. Monit. 2004, 10, 247-254.
-
(2004)
Med. Sci. Monit.
, vol.10
, pp. 247-254
-
-
Cara, C.J.1
Pena, A.S.2
Sans, M.3
Rodrigo, L.4
Guerrero-Esteo, M.5
Hinojosa, J.6
Garcia-Paredes, J.7
Guijarro, L.G.8
-
43
-
-
0037545338
-
JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity
-
Shami, P.J.; Saavedra, J.E.; Wang, L.Y.; Bonifant, C.L.; Diwan, B.A.; Singh, S.V.; Gu, Y.J.; Fox, S.D.; Buzard, G.S.; Citro, M.L.; et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol. Cancer Ther. 2003, 2, 409-417.
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 409-417
-
-
Shami, P.J.1
Saavedra, J.E.2
Wang, L.Y.3
Bonifant, C.L.4
Diwan, B.A.5
Singh, S.V.6
Gu, Y.J.7
Fox, S.D.8
Buzard, G.S.9
Citro, M.L.10
-
44
-
-
34547138439
-
JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
-
Kiziltepe, T.; Hideshima, T.; Ishitsuka, K.; Ocio, E.M.; Raje, N.; Catley, L.; Li, C.Q.; Trudel, L.J.; Yasui, H.; Vallet, S.; et al. JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells. Blood 2007, 110, 709-718.
-
(2007)
Blood
, vol.110
, pp. 709-718
-
-
Kiziltepe, T.1
Hideshima, T.2
Ishitsuka, K.3
Ocio, E.M.4
Raje, N.5
Catley, L.6
Li, C.Q.7
Trudel, L.J.8
Yasui, H.9
Vallet, S.10
-
45
-
-
84859054218
-
JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells
-
Laschak, M.; Spindler, K.D.; Schrader, A.J.; Hessenauer, A.; Streicher, W.; Schrader, M.; Cronauer, M.V. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells. BMC Cancer 2012, 12, 130:1-130:10.
-
(2012)
BMC Cancer
, vol.12
-
-
Laschak, M.1
Spindler, K.D.2
Schrader, A.J.3
Hessenauer, A.4
Streicher, W.5
Schrader, M.6
Cronauer, M.V.7
-
46
-
-
84954358567
-
Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs
-
Chakrapani, H.; Kalathur, R.C.; Maciag, A.E.; Citro, M.L.; Ji, X.H.; Keefer, L.K.; Saavedra, J.E. Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs. Bioorg. Med. Chem. 2008, 16, 9764-9771.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 9764-9771
-
-
Chakrapani, H.1
Kalathur, R.C.2
McIag, A.E.3
Citro, M.L.4
Ji, X.H.5
Keefer, L.K.6
Saavedra, J.E.7
-
47
-
-
2142753987
-
Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug
-
Findlay, V.J.; Townsend, D.M.; Saavedra, J.E.; Buzard, G.S.; Citro, M.L.; Keefer, L.K.; Ji, X.H.; Tew, K.D. Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug. Mol. Pharmacol. 2004, 65, 1070-1079.
-
(2004)
Mol. Pharmacol.
, vol.65
, pp. 1070-1079
-
-
Findlay, V.J.1
Townsend, D.M.2
Saavedra, J.E.3
Buzard, G.S.4
Citro, M.L.5
Keefer, L.K.6
Ji, X.H.7
Tew, K.D.8
-
48
-
-
0032843826
-
Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides
-
Zhao, Z.; Koeplinger, K.A.; Peterson, T.; Conradi, R.A.; Burton, P.S.; Suarato, A.; Heinrikson, R.L.; Tomasselli, A.G. Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides. Drug Metab. Dispos. 1999, 27, 992-998.
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 992-998
-
-
Zhao, Z.1
Koeplinger, K.A.2
Peterson, T.3
Conradi, R.A.4
Burton, P.S.5
Suarato, A.6
Heinrikson, R.L.7
Tomasselli, A.G.8
-
49
-
-
0032868974
-
Activated sulfonamides are cleaved by glutathione-S-transferases
-
Koeplinger, K.A.; Zhao, Z.Y.; Peterson, T.; Leone, J.W.; Schwende, F.S.; Heinrikson, R.L.; Tomasselli, A.G. Activated sulfonamides are cleaved by glutathione-S-transferases. Drug Metab. Dispos. 1999, 27, 986-991.
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 986-991
-
-
Koeplinger, K.A.1
Zhao, Z.Y.2
Peterson, T.3
Leone, J.W.4
Schwende, F.S.5
Heinrikson, R.L.6
Tomasselli, A.G.7
-
50
-
-
62749159756
-
Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy
-
Axarli, I.; Labrou, N.E.; Petrou, C.; Rassias, N.; Cordopatis, P.; Clonis, Y.D. Sulphonamide-based bombesin prodrug analogues for glutathione transferase, useful in targeted cancer chemotherapy. Eur. J. Med. Chem. 2009, 44, 2009-2016.
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 2009-2016
-
-
Axarli, I.1
Labrou, N.E.2
Petrou, C.3
Rassias, N.4
Cordopatis, P.5
Clonis, Y.D.6
-
51
-
-
0028356487
-
Glutathione-S-Transferase activates novel alkylating agents
-
Lyttle, M.H.; Satyam, A.; Hocker, M.D.; Bauer, K.E.; Caldwell, C.G.; Hui, H.C.; Morgan, A.S.; Mergia, A.; Kauvar, L.M. Glutathione-S-Transferase activates novel alkylating agents. J. Med. Chem. 1994, 37, 1501-1507.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1501-1507
-
-
Lyttle, M.H.1
Satyam, A.2
Hocker, M.D.3
Bauer, K.E.4
Caldwell, C.G.5
Hui, H.C.6
Morgan, A.S.7
Mergia, A.8
Kauvar, L.M.9
-
52
-
-
0029863194
-
Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase
-
Satyam, A.; Hocker, M.D.; Kane-Maguire, K.A.; Morgan, A.S.; Villar, H.O.; Lyttle, M.H. Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase. J. Med. Chem. 1996, 39, 1736-1747.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1736-1747
-
-
Satyam, A.1
Hocker, M.D.2
Kane-Maguire, K.A.3
Morgan, A.S.4
Villar, H.O.5
Lyttle, M.H.6
-
53
-
-
0142258488
-
Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer
-
Townsend, D.M.; Shen, H.X.; Staros, A.L.; Gate, L.; Tew, K.D. Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer. Mol. Cancer Ther. 2002, 1, 1089-1095.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 1089-1095
-
-
Townsend, D.M.1
Shen, H.X.2
Staros, A.L.3
Gate, L.4
Tew, K.D.5
-
54
-
-
17544385571
-
Tumor efficacy and bone marrow-sparing properties of ter286, a cytotoxin activated by glutathione S-transferase
-
Morgan, A.S.; Sanderson, P.E.; Borch, R.F.; Tew, K.D.; Niitsu, Y.; Takayama, T.; von Hoff, D.D.; Izbicka, E.; Mangold, G.; Paul, C.; et al. Tumor efficacy and bone marrow-sparing properties of ter286, a cytotoxin activated by glutathione S-transferase. Cancer Res. 1998, 58, 2568-2575.
-
(1998)
Cancer Res.
, vol.58
, pp. 2568-2575
-
-
Morgan, A.S.1
Sanderson, P.E.2
Borch, R.F.3
Tew, K.D.4
Niitsu, Y.5
Takayama, T.6
von Hoff, D.D.7
Izbicka, E.8
Mangold, G.9
Paul, C.10
-
55
-
-
0033917834
-
Cellular response to a glutathione S-transferase P1-1 Activated Prodrug
-
Rosario, L.A.; O'Brien, M.L.; Henderson, C.J.; Wolf, C.R.; Tew, K.D. Cellular response to a glutathione S-transferase P1-1 Activated Prodrug. Mol. Pharmacol. 2000, 58, 167-174.
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 167-174
-
-
Rosario, L.A.1
O'Brien, M.L.2
Henderson, C.J.3
Wolf, C.R.4
Tew, K.D.5
-
56
-
-
22544443334
-
Multi-Institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer
-
Kavanagh, J.J.; Gershenson, D.M.; Choi, H.; Lewis, L.; Patel, K.; Brown, G.L.; Garcia, A.; Spriggs, D.R. Multi-Institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer. Int. J. Gynecol. Cancer 2005, 15, 593-600.
-
(2005)
Int. J. Gynecol. Cancer
, vol.15
, pp. 593-600
-
-
Kavanagh, J.J.1
Gershenson, D.M.2
Choi, H.3
Lewis, L.4
Patel, K.5
Brown, G.L.6
Garcia, A.7
Spriggs, D.R.8
-
57
-
-
84875982795
-
Synthesis of GSH-linked tyrosinase-activated melanoma prodrugs
-
Ruzza, P.; Calderan, A.; Nassi, A.; Quintieri, L. Synthesis of GSH-linked tyrosinase-activated melanoma prodrugs. J. Pept. Sci. 2012, 18, S157.
-
(2012)
J. Pept. Sci.
, vol.18
-
-
Ruzza, P.1
Calderan, A.2
Nassi, A.3
Quintieri, L.4
|