Glutathione-dependent metabolism of cis-3-(9H-purin-6-ylthio)acrylic acid to yield the chemotherapeutic drug 6-mercaptopurine: Evidence for two distinct mechanisms in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 3, 1999, Pages 950-957

  Gunnarsdottir, Sjofn ^a   Elfarra, Adnan A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (9H PURIN 6 YLTHIO)ACRYLIC ACID; ACIVICIN; AMINOOXYACETIC ACID; AZATHIOPRINE DERIVATIVE; DIPEPTIDASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; MERCAPTOPURINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; DRUG MECHANISM; DRUG METABOLISM; ENZYME SUBUNIT; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LIVER HOMOGENATE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS;

6-MERCAPTOPURINE; ACRYLATES; AMINOOXYACETIC ACID; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CARBON-SULFUR LYASES; DIPEPTIDASES; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; ISOXAZOLES; KIDNEY; KINETICS; LIVER; MALE; PRODRUGS; PURINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032797568     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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