Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs

Biochemical Pharmacology

Volumn 73, Issue 11, 2007, Pages 1829-1841

  Eklund, Birgitta I ^a   Gunnarsdottir, Sjofn ^b   Elfarra, Adnan A ^b   Mannervik, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Bioactivation; Chemotherapy; cis 6 (2 Acetylvinylthio)purine; Glutathione transferase; Thiopurine prodrugs; trans 6 (2 Acetylvinylthio)guanine

Indexed keywords

4 GLUTATHIONYLBUTAN 2 ONE; 4 GLUTATHIONYLBUTEN 2 ONE; 6 MERCAPTOPURINE DERIVATIVE; 6,2 ACETYLVINYLTHIOGUANINE; 6,2 ACETYLVINYLTHIOPURINE; ANTINEOPLASTIC AGENT; GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A4; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE M2; GLUTATHIONE TRANSFERASE P1; PRODRUG; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CATALYSIS; CHEMICAL BOND; DRUG TARGETING; ELIMINATION REACTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PREDICTION; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

6-MERCAPTOPURINE; ANTINEOPLASTIC AGENTS; AZATHIOPRINE; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS; MASS SPECTROMETRY; PRODRUGS; SPECTROPHOTOMETRY, ULTRAVIOLET; THIOGUANINE;

EID: 34247130587     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.02.002     Document Type: Article

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