Activated sulfonamides are cleaved by glutathione-S-transferases

Drug Metabolism and Disposition

Volumn 27, Issue 9, 1999, Pages 986-991

  Koeplinger, Kenneth A ^a   Zhao, Zhiyang ^a   Peterson, Tillie ^a   Leone, Joseph W ^a   Schwende, Francis S ^a   Heinrikson, Robert L ^a   Tomasselli, Alfredo G ^a,b  

^a PFIZER INC   (United States)

^b Pfizer Inc ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; GLUTATHIONE TRANSFERASE; PNU 109112; PNU 143070; SULFONAMIDASE; SULFONAMIDE; TIPRANAVIR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL REACTION; CYTOSOL; DOG; DRUG POTENCY; DRUG STABILITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BIOTRANSFORMATION; CELL LINE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIURETICS; DOGS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE TRANSFERASE; HUMANS; HYDROLYSIS; ISOENZYMES; MALE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; SULFONAMIDES;

ANIMALIA; CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032868974     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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