Novel glutathione-dependent thiopurine prodrugs: Evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 1, 2002, Pages 77-86

  Gunnarsdottir, Sjofn ^a,b   Rucki, Marian ^b   Elfarra, Adnan A ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2 ACETYLVINYLTHIO)GUANINE; 6 (2 ACETYLVINYLTHIO)PURINE; 6 MERCAPTOPURINE DERIVATIVE; ANTINEOPLASTIC AGENT; BUTANE; GLUTATHIONE; MALEIC ACID DIETHYL ESTER; MERCAPTOPURINE; PRODRUG; TIOGUANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW TOXICITY; CELL LEVEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG METABOLISM; DRUG STRUCTURE; DRUG UPTAKE; HUMAN; IC 50; LEUKOCYTE COUNT; LIVER TOXICITY; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; AREA UNDER CURVE; BONE MARROW DISEASES; CARCINOMA, RENAL CELL; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUTATHIONE; GUANINE; HEPATITIS, TOXIC; HUMANS; KIDNEY DISEASES; MICE; OXIDATION-REDUCTION; PRODRUGS; PURINES; SPECTROPHOTOMETRY, ULTRAVIOLET; TUMOR CELLS, CULTURED;

EID: 0036129205     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.1.77     Document Type: Article

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