Cellular response to a glutathione S-transferase P1-1 activated prodrug

Molecular Pharmacology

Volumn 58, Issue 1, 2000, Pages 167-174

  Rosario, Lilliam A ^a   O'Brien, Miechelle L ^a   Henderson, Colin J ^b   Wolf, C Roland ^b   Tew, Kenneth D ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANFOSFAMIDE; CHLORMETHINE DERIVATIVE; CISPLATIN; DOXORUBICIN; GAMMA GLUTAMYL ALPHA AMINO BETA(2 ETHYL N,N,N'N' TETRAKIS (2 CHLOROETHYL)PHOSPHORAMIDATE) SULFONYL PROPIONYL PHENYLGLYCINE; GLUTATHIONE TRANSFERASE; MELPHALAN; MITOXANTRONE; PACLITAXEL; PRODRUG; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; CROSS RESISTANCE; CYTOTOXICITY; DNA STRAND BREAKAGE; DRUG SYNTHESIS; GENE EXPRESSION REGULATION; LONG TERM EXPOSURE; MOLECULAR CLONING; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0033917834     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.1.167     Document Type: Article

References (28)

1. Adler V, Yin Z, Fuchs SY, Benezra M, Rosario L, Tew KD, Pincus MR, Sardana M, Henderson CJ, Wolf CR, Davis R and Ronai Z (1999) Regulation of JNK signaling by GSTp. EMBO J. 18:1321-1334.
2. Ausbel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA and Struhl K (1994) Current Protocols in Molecular Biology (Chanda VB ed), John Wiley & Sons, New York.
3. Bolton MG, Colvin OM and Hilton J (1991) Specificity of isozymes of murine hepatic glutathione S-transferase for the conjugation of glutathione with L-phenylalanine mustard. Cancer Res. 51:2410-2415.
4. Breuninger LM, Paul S, Gaughan K, Miki T, Chan A, Aaronson SA and Kruh GD (1995) Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution. Cancer Res. 55:5342-5347.
5. Chang TK, Weber GF, Crespi CL and Waxman DJ (1993) Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res. 53:5629-5637.
6. Ciaccio PJ, Shen H, Kruh GD and Tew KD (1996) Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells. Biochem Biophys Res Commun 222:111-116.
7. Ciaccio PJ, Tew KD and LaCreta FP (1990) The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione. Cancer Commun 2:279-286.
8. Ciaccio PJ, Tew KD and LaCreta FP (1991) Enzymatic conjugation of chlorambucil with glutathione is catalyzed by human glutathione S-transferases and inhibited by ethacrynic acid. Biochem Pharmacol 42:1504-1507.
9. Comporti M (1989) Three models of free radical-induced cell injury. Chem Biol Interact 72:1-56.
10. Habig WH, Pabst MJ and Jakoby WB (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139.
11. Hayes JD and Pulford DJ (1995) The glutathione S-tranaferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30:445-600.
12. Henderson CJ, Smith AG, Ure J, Brown K, Bacon EJ and Wolf CR (1998) Increased skin tumor genesis in mice lacking pi class glutathione S-transferases. Proc Natl Acad Sci USA 95:5275-5280.
13. Kauvar LM (1996) Peptidomimetic drugs: A comment on progress and prospects. Nat Biotechnol 14:709.
14. Keppler D, Leier I and Jedlitschky G (1997) Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol Chem 378:787-791.
15. Kozak M (1978) How do eukaryotic ribosomes select initiation regions in messenger RNA? Cell 15:1109-1123.
16. Lyttle MH, Satyam A, Hocker MD, Bauer KE, Caldwell CG, Hui HC, Morgan AS, Mergia A and Kauvar LM (1994) Glutathione-S-transferase activates novel alkylating agents. Med Chem 37:1501-1507.
17. Morgan AS, Sanderson PE, Borch RF, Tew KD, Niitsu Y, Takayama T, VonHoff DD, Izbicka E, Mangold G, Paul C, Broberg U, Mannervik B, Henner WD and Kauvar LM (1998) Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione-S-transferase. Cancer Res 58:2568-2575.
18. Mulcahy TT, Wartman MA, Bailey HH and Gipp JJ (1997) Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J Biol Chem 272:7445-7454.
19. O'Brien M, Kruh GD and Tew KD (2000) The influence of co-ordinate overexpression of glutathione phase II detoxification gene products in drug resistance. J Pharmacol Exp Ther, in press.
20. O'Brien ML and Tew KD (1996) Glutathione and related enzymes in multidrug resistance. Eur J Cancer 32:967-978.
21. O'Brien ML, Vulevic B, Freer S, Boyd J, Shen H and Tew KD (1999) A glutathione peptidomimetic drug modulator of the multidrug resistance associated protein. J Pharmacol Exp Ther 291:1348-1355.
22. Olive PL, Frazer G and Banath JP (1993) Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay. Radiat Res 136:130-136.
23. Satyam A, Hocker MD, Kane-Maguire KA, Morgan AS, Villar HO and Lyttle MH (1996) Design, synthesis and evaluation of latent alkylating agents activated by glutathione S-transferase. Med Chem 39:1736-1747.
24. Schisselbauer JC, Hogan WM, Buetow KH and Tew KD (1992) Heterogeneity of glutathione S-transferase enzyme and gene expression in ovarian carcinoma. Pharmacogenetics 2:63-72.
25. Shen H, Schultz MP and Tew KD (1999) Glutathione conjugate interactions with DNA-dependent protein kinase. J Pharmacol Exp Ther 290:1101-1106.
26. Tew KD (1994) Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 54:4313-4320.
27. Tew KD, O'Brien M, Laing NM and Shen H (1998) Coordinate changes in expression of protective genes in drug-resistant cells. Chem Biol Interact 111: 199-211.
28. Wild AC, Gipp JJ and Mulcahy T (1998) Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene. Biochem J 332:373-381.