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Volumn 7, Issue , 2013, Pages 243-265

Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections

Author keywords

Linezolid resistance; Oxazolidinone; Skin and soft tissue infections; Tedizolid; TR 700; TR 701 FA

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; AMPICILLIN; AZITHROMYCIN; CEFACLOR; CEFOTAXIME; CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COTRIMOXAZOLE; DA 7158; DALFOPRISTIN; DAPTOMYCIN; DOPAMINE RECEPTOR AFFECTING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; ERYTHROMYCIN; GENTAMICIN; LEVOFLOXACIN; LINEZOLID; OXACILLIN; QUINUPRISTIN; RIFAMPICIN; SEROTONIN AGONIST; TEDIZOLID; TEICOPLANIN; TETRACYCLINE; TIGECYCLINE; TOBRAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

EID: 84875996687     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S30728     Document Type: Review
Times cited : (26)

References (93)
  • 2
    • 0035907340 scopus 로고    scopus 로고
    • Soft tissue infections among injection drug users - San Francisco, California, 1996-2000
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC). Soft tissue infections among injection drug users - San Francisco, California, 1996-2000. MMWR Morb Mortal Wkly Rep. 2001;50(19):381-384.
    • (2001) MMWR Morb Mortal Wkly Rep , vol.50 , Issue.19 , pp. 381-384
  • 3
    • 70249139175 scopus 로고    scopus 로고
    • Trends in US hospital admissions for skin and soft tissue infections
    • Edelsberg J, Taneja C, Zervos M, et al. Trends in US hospital admissions for skin and soft tissue infections. Emerg Infect Dis. 2009;15(9): 1516-1518.
    • (2009) Emerg Infect Dis , vol.15 , Issue.9 , pp. 1516-1518
    • Edelsberg, J.1    Taneja, C.2    Zervos, M.3
  • 4
    • 77953013794 scopus 로고    scopus 로고
    • Skin and soft tissue infections in hospitalized and critically ill patients: A nationwide population-based study
    • Shen HN, Lu CL. Skin and soft tissue infections in hospitalized and critically ill patients: a nationwide population-based study. BMC Infect Dis. 2010;10:151.
    • (2010) BMC Infect Dis , vol.10 , pp. 151
    • Shen, H.N.1    Lu, C.L.2
  • 5
    • 33845422285 scopus 로고    scopus 로고
    • Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: Report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
    • Moet GJ, Jones RN, Biedenbach DJ, Stilwell MG, Fritsche TR. Contemporary causes of skin and soft tissue infections in North America, Latin America, and Europe: report from the SENTRY Antimicrobial Surveillance Program (1998-2004). Diagn Microbiol Infect Dis. 2007;57(1):7-13.
    • (2007) Diagn Microbiol Infect Dis , vol.57 , Issue.1 , pp. 7-13
    • Moet, G.J.1    Jones, R.N.2    Biedenbach, D.J.3    Stilwell, M.G.4    Fritsche, T.R.5
  • 6
    • 33747343208 scopus 로고    scopus 로고
    • Methicillin-resistant S. aureus infections among patients in the emergency department
    • Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med. 2006;355(7):666-674.
    • (2006) N Engl J Med , vol.355 , Issue.7 , pp. 666-674
    • Moran, G.J.1    Krishnadasan, A.2    Gorwitz, R.J.3
  • 7
    • 69049107589 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus strain USA300: Origin and epidemiology
    • Tenover FC, Goering RV. Methicillin-resistant Staphylococcus aureus strain USA300: origin and epidemiology. J Antimicrob Chemother. 2009;64(3):441-446.
    • (2009) J Antimicrob Chemother , vol.64 , Issue.3 , pp. 441-446
    • Tenover, F.C.1    Goering, R.V.2
  • 8
    • 69249106946 scopus 로고    scopus 로고
    • Comparative genomic analysis of European and Middle Eastern community-associated methicillin-resistant Staphylococcus aureus (CC80:ST80-IV) isolates by high-density microarray
    • Goering RV, Larsen AR, Skov R, Tenover FC, Anderson KL, Dunman PM. Comparative genomic analysis of European and Middle Eastern community-associated methicillin-resistant Staphylococcus aureus (CC80:ST80-IV) isolates by high-density microarray. Clin Microbiol Infect. 2009;15(8):748-755.
    • (2009) Clin Microbiol Infect , vol.15 , Issue.8 , pp. 748-755
    • Goering, R.V.1    Larsen, A.R.2    Skov, R.3    Tenover, F.C.4    Anderson, K.L.5    Dunman, P.M.6
  • 9
    • 84862665886 scopus 로고    scopus 로고
    • Nosocomial transmission of community-associated methicillin-resistant Staphylococcus aureus in Danish Hospitals
    • Hetem DJ, Westh H, Boye K, Jarløv JO, Bonten MJ, Bootsma MC. Nosocomial transmission of community-associated methicillin-resistant Staphylococcus aureus in Danish Hospitals. J Antimicrob Chemother. 2012;67(7):1775-1780.
    • (2012) J Antimicrob Chemother , vol.67 , Issue.7 , pp. 1775-1780
    • Hetem, D.J.1    Westh, H.2    Boye, K.3    Jarløv, J.O.4    Bonten, M.J.5    Bootsma, M.C.6
  • 10
    • 84863527369 scopus 로고    scopus 로고
    • Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010
    • Landrum ML, Neumann C, Cook C, et al. Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010. JAMA. 2012;308(1):50-59.
    • (2012) JAMA , vol.308 , Issue.1 , pp. 50-59
    • Landrum, M.L.1    Neumann, C.2    Cook, C.3
  • 11
    • 0030841073 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility
    • Hiramatsu K, Hanaki H, Ino T, Yabuta K, Oguri T, Tenover FC. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother. 1997;40(1): 135-136.
    • (1997) J Antimicrob Chemother , vol.40 , Issue.1 , pp. 135-136
    • Hiramatsu, K.1    Hanaki, H.2    Ino, T.3    Yabuta, K.4    Oguri, T.5    Tenover, F.C.6
  • 12
    • 0033580208 scopus 로고    scopus 로고
    • Emergence of vancomycin resistance in Staphylococcus aureus
    • Glycopeptide-Intermediate Staphylococcus aureus Working Group
    • Smith TL, Pearson ML, Wilcox KR, et al. Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. N Engl J Med. 1999;340(7): 493-501.
    • (1999) N Engl J Med , vol.340 , Issue.7 , pp. 493-501
    • Smith, T.L.1    Pearson, M.L.2    Wilcox, K.R.3
  • 13
    • 0037024849 scopus 로고    scopus 로고
    • Staphylococcus aureus resistant to vancomycin - United States, 2002
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC). Staphylococcus aureus resistant to vancomycin - United States, 2002. MMWR Morb Mortal Wkly Rep. 2002;51(26):565-567.
    • (2002) MMWR Morb Mortal Wkly Rep , vol.51 , Issue.26 , pp. 565-567
  • 15
    • 79960332126 scopus 로고    scopus 로고
    • LEADER Program results for 2009: An activity and spectrum analysis of linezolid using 6,414 clinical isolates from 56 medical centers in the United States
    • Farrell DJ, Mendes RE, Ross JE, Sader HS, Jones RN. LEADER Program results for 2009: an activity and spectrum analysis of linezolid using 6,414 clinical isolates from 56 medical centers in the United States. Antimicrob Agents Chemother. 2011;55(8):3684-3690.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.8 , pp. 3684-3690
    • Farrell, D.J.1    Mendes, R.E.2    Ross, J.E.3    Sader, H.S.4    Jones, R.N.5
  • 16
    • 84865300349 scopus 로고    scopus 로고
    • LEADER surveillance program results for 2010: An activity and spectrum analysis of linezolid using 6801 clinical isolates from the United States (61 medical centers)
    • Flamm RK, Farrell DJ, Mendes RE, Ross JE, Sader HS, Jones RN. LEADER surveillance program results for 2010: an activity and spectrum analysis of linezolid using 6801 clinical isolates from the United States (61 medical centers). Diagn Microbiol Infect Dis. 2012; 74(1):54-61.
    • (2012) Diagn Microbiol Infect Dis , vol.74 , Issue.1 , pp. 54-61
    • Flamm, R.K.1    Farrell, D.J.2    Mendes, R.E.3    Ross, J.E.4    Sader, H.S.5    Jones, R.N.6
  • 17
    • 23744453392 scopus 로고    scopus 로고
    • A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: Methylation of 23S ribosomal RNA at A2503
    • Kehrenberg C, Schwarz S, Jacobsen L, Hansen LH, Vester B. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol. 2005; 57(4):1064-1073.
    • (2005) Mol Microbiol , vol.57 , Issue.4 , pp. 1064-1073
    • Kehrenberg, C.1    Schwarz, S.2    Jacobsen, L.3    Hansen, L.H.4    Vester, B.5
  • 18
    • 33745599646 scopus 로고    scopus 로고
    • The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics
    • Long KS, Poehlsgaard J, Kehrenberg C, Schwarz S, Vester B. The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics. Antimicrob Agents Chemother. 2006;50(7):2500-2505.
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.7 , pp. 2500-2505
    • Long, K.S.1    Poehlsgaard, J.2    Kehrenberg, C.3    Schwarz, S.4    Vester, B.5
  • 19
    • 42949115806 scopus 로고    scopus 로고
    • Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors
    • Smith LK, Mankin AS. Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. Antimicrob Agents Chemother. 2008;52(5): 1703-1712.
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.5 , pp. 1703-1712
    • Smith, L.K.1    Mankin, A.S.2
  • 20
    • 44449125584 scopus 로고    scopus 로고
    • First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States
    • Mendes RE, Deshpande LM, Castanheira M, DiPersio J, Saubolle MA, Jones RN. First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother. 2008;52(6):2244-2246.
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.6 , pp. 2244-2246
    • Mendes, R.E.1    Deshpande, L.M.2    Castanheira, M.3    Dipersio, J.4    Saubolle, M.A.5    Jones, R.N.6
  • 21
    • 34250028674 scopus 로고    scopus 로고
    • Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
    • Toh SM, Xiong L, Arias CA, et al. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol. 2007;64(6):1506-1514.
    • (2007) Mol Microbiol , vol.64 , Issue.6 , pp. 1506-1514
    • Toh, S.M.1    Xiong, L.2    Arias, C.A.3
  • 22
    • 33644655658 scopus 로고    scopus 로고
    • Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus
    • Cui L, Tominaga E, Neoh HM, Hiramatsu K. Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus. Antimicrob Agents Chemother. 2006;50(3):1079-1082.
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.3 , pp. 1079-1082
    • Cui, L.1    Tominaga, E.2    Neoh, H.M.3    Hiramatsu, K.4
  • 23
    • 79954583943 scopus 로고    scopus 로고
    • Daptomycin non-susceptibility in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous-VISA (hVISA): Implications for therapy after vancomycin treatment failure
    • Kelley PG, Gao W, Ward PB, Howden BP. Daptomycin non-susceptibility in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous-VISA (hVISA): implications for therapy after vancomycin treatment failure. J Antimicrob Chemother. 2011; 66(5):1057-1060.
    • (2011) J Antimicrob Chemother , vol.66 , Issue.5 , pp. 1057-1060
    • Kelley, P.G.1    Gao, W.2    Ward, P.B.3    Howden, B.P.4
  • 25
    • 84875991299 scopus 로고    scopus 로고
    • Silver Spring, MD: Food and Drug Administration (FDA); 2012. Available from, Accessed July 7, 2012
    • Cubicin® (daptomycin for injection) for intravenous use [prescribing information]. Silver Spring, MD: Food and Drug Administration (FDA); 2012. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021572s039lbl.pdf. Accessed July 7, 2012.
    • Cubicin® (daptomycin For Injection) For Intravenous Use [prescribing Information]
  • 26
    • 77749251875 scopus 로고    scopus 로고
    • Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus
    • Morales G, Picazo JJ, Baos E, et al. Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus. Clin Infect Dis. 2010;50(6):821-825.
    • (2010) Clin Infect Dis , vol.50 , Issue.6 , pp. 821-825
    • Morales, G.1    Picazo, J.J.2    Baos, E.3
  • 27
    • 84876001356 scopus 로고    scopus 로고
    • Trius Therapeutics, San Diego, CA: Trius Therapeutics; nd. Available from:, Accessed July 7, 2012
    • Trius Therapeutics. Tedizolid phosphate (TR-701) profile [web page on the Internet]. San Diego, CA: Trius Therapeutics; nd. Available from: http://www.triusrx.com/trius-therapeutics-tedizolid-profile.php. Accessed July 7, 2012.
    • Tedizolid Phosphate (TR-701) Profile [web Page On the Internet]
  • 28
    • 34447312842 scopus 로고    scopus 로고
    • Pharmacokinetics of DA-7218, a new oxazolidinone, and its active metabolite, DA-7157, after intravenous and oral administration of DA-7218 and DA-7157 to rats
    • Bae SK, Yang SH, Shin KN, Rhee JK, Yoo M, Lee MG. Pharmacokinetics of DA-7218, a new oxazolidinone, and its active metabolite, DA-7157, after intravenous and oral administration of DA-7218 and DA-7157 to rats. J Pharm Pharmacol. 2007;59(7):955-963.
    • (2007) J Pharm Pharmacol , vol.59 , Issue.7 , pp. 955-963
    • Bae, S.K.1    Yang, S.H.2    Shin, K.N.3    Rhee, J.K.4    Yoo, M.5    Lee, M.G.6
  • 29
    • 0037458217 scopus 로고    scopus 로고
    • Linezolid: The first oxazolidinone antimicrobial
    • Moellering RC. Linezolid: the first oxazolidinone antimicrobial. Ann Intern Med. 2003;138(2):135-142.
    • (2003) Ann Intern Med , vol.138 , Issue.2 , pp. 135-142
    • Moellering, R.C.1
  • 30
    • 0037821645 scopus 로고    scopus 로고
    • Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics
    • Colca JR, McDonald WG, Waldon DJ, et al. Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics. J Biol Chem. 2003;278(24):21972-21979.
    • (2003) J Biol Chem , vol.278 , Issue.24 , pp. 21972-21979
    • Colca, J.R.1    McDonald, W.G.2    Waldon, D.J.3
  • 31
    • 79952280648 scopus 로고    scopus 로고
    • Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent
    • Im WB, Choi SH, Park JY, Finn J, Yoon SH. Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. Eur J Med Chem. 2011;46(4):1027-1039.
    • (2011) Eur J Med Chem , vol.46 , Issue.4 , pp. 1027-1039
    • Im, W.B.1    Choi, S.H.2    Park, J.Y.3    Finn, J.4    Yoon, S.H.5
  • 34
    • 79959194196 scopus 로고    scopus 로고
    • In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model
    • Louie A, Liu W, Kulawy R, Drusano GL. In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model. Antimicrob Agents Chemother. 2011;55(7):3453-3460.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.7 , pp. 3453-3460
    • Louie, A.1    Liu, W.2    Kulawy, R.3    Drusano, G.L.4
  • 40
    • 78751689284 scopus 로고    scopus 로고
    • Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections
    • Prokocimer P, Bien P, Surber J, et al. Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections. Antimicrob Agents Chemother. 2011;55(2):583-592.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.2 , pp. 583-592
    • Prokocimer, P.1    Bien, P.2    Surber, J.3
  • 41
    • 84860148017 scopus 로고    scopus 로고
    • Pulmonary disposition of tedizolid following administration of once-daily oral 200-milligram tedizolid phosphate in healthy adult volunteers
    • Housman ST, Pope JS, Russomanno J, et al. Pulmonary disposition of tedizolid following administration of once-daily oral 200-milligram tedizolid phosphate in healthy adult volunteers. Antimicrob Agents Chemother. 2012;56(5):2627-2634.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.5 , pp. 2627-2634
    • Housman, S.T.1    Pope, J.S.2    Russomanno, J.3
  • 42
    • 84861889145 scopus 로고    scopus 로고
    • Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers
    • Sahre M, Sabarinath S, Grant M, et al. Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers. Int J Antimicrob Agents. 2012; 40(1):51-54.
    • (2012) Int J Antimicrob Agents , vol.40 , Issue.1 , pp. 51-54
    • Sahre, M.1    Sabarinath, S.2    Grant, M.3
  • 46
    • 84925524148 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of single oral administration of tedizolid phosphate in healthy elderly subjects and adult control subjects
    • September 9-12, San Francisco, CA
    • Dreskin H, Muñoz KA, Fang E, et al. Safety and pharmacokinetics of single oral administration of tedizolid phosphate in healthy elderly subjects and adult control subjects. Poster presented at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy, September 9-12, 2012, San Francisco, CA.
    • (2012) Poster Presented At the 52nd Interscience Conference On Antimicrobial Agents and Chemotherapy
    • Dreskin, H.1    Muñoz, K.A.2    Fang, E.3
  • 48
    • 77951234516 scopus 로고    scopus 로고
    • Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges
    • Brown SD, Traczewski MM. Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. Antimicrob Agents Chemother. 2010;54(5):2063-2069.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.5 , pp. 2063-2069
    • Brown, S.D.1    Traczewski, M.M.2
  • 49
    • 77951217660 scopus 로고    scopus 로고
    • Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain
    • Betriu C, Morales G, Rodríguez-Avial I, et al. Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain. Antimicrob Agents Chemother. 2010;54(5):2212-2215.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.5 , pp. 2212-2215
    • Betriu, C.1    Morales, G.2    Rodríguez-Avial, I.3
  • 50
    • 67749127546 scopus 로고    scopus 로고
    • In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent
    • Schaadt R, Sweeney D, Shinabarger D, Zurenko G. In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. Antimicrob Agents Chemother. 2009;53(8):3236-3239.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.8 , pp. 3236-3239
    • Schaadt, R.1    Sweeney, D.2    Shinabarger, D.3    Zurenko, G.4
  • 51
    • 57049089598 scopus 로고    scopus 로고
    • In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains
    • Shaw KJ, Poppe S, Schaadt R, et al. In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. Antimicrob Agents Chemother. 2008;52(12):4442-4447.
    • (2008) Antimicrob Agents Chemother , vol.52 , Issue.12 , pp. 4442-4447
    • Shaw, K.J.1    Poppe, S.2    Schaadt, R.3
  • 53
    • 62549148632 scopus 로고    scopus 로고
    • TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogens
    • Jones RN, Moet GJ, Sader HS, Mendes RE, Castanheira M. TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogens. J Antimicrob Chemother. 2009;63(4):716-720.
    • (2009) J Antimicrob Chemother , vol.63 , Issue.4 , pp. 716-720
    • Jones, R.N.1    Moet, G.J.2    Sader, H.S.3    Mendes, R.E.4    Castanheira, M.5
  • 54
    • 78649681818 scopus 로고    scopus 로고
    • Comparative in vitro activities of torezolid (DA-7157) against clinical isolates of aerobic and anaerobic bacteria in South Korea
    • Yum JH, Choi SH, Yong D, et al. Comparative in vitro activities of torezolid (DA-7157) against clinical isolates of aerobic and anaerobic bacteria in South Korea. Antimicrob Agents Chemother. 2010;54(12):5381-5386.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.12 , pp. 5381-5386
    • Yum, J.H.1    Choi, S.H.2    Yong, D.3
  • 55
    • 84865432225 scopus 로고    scopus 로고
    • In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections
    • Prokocimer P, Bien P, Deanda C, Pillar CM, Bartizal K. In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections. Antimicrob Agents Chemother. 2012;56(9):4608-4613.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.9 , pp. 4608-4613
    • Prokocimer, P.1    Bien, P.2    Deanda, C.3    Pillar, C.M.4    Bartizal, K.5
  • 56
    • 84865436255 scopus 로고    scopus 로고
    • Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae
    • Choi S, Im W, Bartizal K. Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae. Antimicrob Agents Chemother. 2012;56(9):4713-4717.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.9 , pp. 4713-4717
    • Choi, S.1    Im, W.2    Bartizal, K.3
  • 57
    • 62549099077 scopus 로고    scopus 로고
    • Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci
    • Livermore DM, Mushtaq S, Warner M, Woodford N. Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci. J Antimicrob Chemother. 2009;63(4): 713-715.
    • (2009) J Antimicrob Chemother , vol.63 , Issue.4 , pp. 713-715
    • Livermore, D.M.1    Mushtaq, S.2    Warner, M.3    Woodford, N.4
  • 58
    • 33748680963 scopus 로고    scopus 로고
    • In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis
    • Vera-Cabrera L, Gonzalez E, Rendon A, et al. In vitro activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis. Antimicrob Agents Chemother. Sep 2006;50(9): 3170-3172.
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.9 , pp. 3170-3172
    • Vera-Cabrera, L.1    Gonzalez, E.2    Rendon, A.3
  • 60
    • 0035928419 scopus 로고    scopus 로고
    • Linezolid resistance in a clinical isolate of Staphylococcus aureus
    • Tsiodras S, Gold HS, Sakoulas G, et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet. 2001;358(9277):207-208.
    • (2001) Lancet , vol.358 , Issue.9277 , pp. 207-208
    • Tsiodras, S.1    Gold, H.S.2    Sakoulas, G.3
  • 61
    • 71249101537 scopus 로고    scopus 로고
    • Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin
    • Locke JB, Hilgers M, Shaw KJ. Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob Agents Chemother. 2009;53(12):5275-5278.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.12 , pp. 5275-5278
    • Locke, J.B.1    Hilgers, M.2    Shaw, K.J.3
  • 62
    • 78649660049 scopus 로고    scopus 로고
    • Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3
    • Locke JB, Morales G, Hilgers M, et al. Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3. Antimicrob Agents Chemother. 2010;54(12):5352-5355.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.12 , pp. 5352-5355
    • Locke, J.B.1    Morales, G.2    Hilgers, M.3
  • 63
    • 78649668302 scopus 로고    scopus 로고
    • Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations
    • Locke JB, Finn J, Hilgers M, et al. Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. Antimicrob Agents Chemother. 2010;54(12):5337-5343.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.12 , pp. 5337-5343
    • Locke, J.B.1    Finn, J.2    Hilgers, M.3
  • 64
    • 71249138911 scopus 로고    scopus 로고
    • Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700)
    • Locke JB, Hilgers M, Shaw KJ. Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother. 2009;53(12):5265-5274.
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.12 , pp. 5265-5274
    • Locke, J.B.1    Hilgers, M.2    Shaw, K.J.3
  • 65
    • 73949088615 scopus 로고    scopus 로고
    • Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): Studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines
    • Lemaire S, Van Bambeke F, Appelbaum PC, Tulkens PM. Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines. J Antimicrob Chemother. 2009;64(5):1035-1043.
    • (2009) J Antimicrob Chemother , vol.64 , Issue.5 , pp. 1035-1043
    • Lemaire, S.1    van Bambeke, F.2    Appelbaum, P.C.3    Tulkens, P.M.4
  • 66
    • 80054700069 scopus 로고    scopus 로고
    • Impact of granulocytes on the antimicrobial effect of tedizolid in a mouse thigh infection model
    • Drusano GL, Liu W, Kulawy R, Louie A. Impact of granulocytes on the antimicrobial effect of tedizolid in a mouse thigh infection model. Antimicrob Agents Chemother. 2011;55(11):5300-5305.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.11 , pp. 5300-5305
    • Drusano, G.L.1    Liu, W.2    Kulawy, R.3    Louie, A.4
  • 67
    • 84864390984 scopus 로고    scopus 로고
    • Comparative efficacies of human simulated exposures of tedizolid and linezolid against Staphylococcus aureus in the murine thigh infection model
    • Keel RA, Tessier PR, Crandon JL, Nicolau DP. Comparative efficacies of human simulated exposures of tedizolid and linezolid against Staphylococcus aureus in the murine thigh infection model. Antimicrob Agents Chemother. 2012;56(8):4403-4407.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.8 , pp. 4403-4407
    • Keel, R.A.1    Tessier, P.R.2    Crandon, J.L.3    Nicolau, D.P.4
  • 69
    • 77954665038 scopus 로고    scopus 로고
    • Evaluation of the Combined Therapy of DA-7218, a New Oxazolidinone, and Trimethoprim/Sulfamethoxazole in the Treatment of Experimental Actinomycetoma by Nocardia brasiliensis
    • May 24
    • Espinoza-González NA, Welsh O, Ocampo-Candiani J, et al. Evaluation of the Combined Therapy of DA-7218, a New Oxazolidinone, and Trimethoprim/Sulfamethoxazole in the Treatment of Experimental Actinomycetoma by Nocardia brasiliensis. Curr Drug Deliv. May 24, 2010.
    • (2010) Curr Drug Deliv
    • Espinoza-González, N.A.1    Welsh, O.2    Ocampo-Candiani, J.3
  • 70
    • 38949197227 scopus 로고    scopus 로고
    • Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis
    • Espinoza-González NA, Welsh O, de Torres NW, et al. Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis. Molecules. 2008;13(1):31-40.
    • (2008) Molecules , vol.13 , Issue.1 , pp. 31-40
    • Espinoza-González, N.A.1    Welsh, O.2    de Torres, N.W.3
  • 71
    • 80051825841 scopus 로고    scopus 로고
    • Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins
    • Yamaki J, Synold T, Wong-Beringer A. Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins. Antimicrob Agents Chemother. 2011;55(9):4432-4435.
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.9 , pp. 4432-4435
    • Yamaki, J.1    Synold, T.2    Wong-Beringer, A.3
  • 72
    • 84875986258 scopus 로고    scopus 로고
    • Trius Therapeutics, In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2010 [updated November 9, 2011]. Available from, Accessed July 7, 2012
    • Trius Therapeutics. TR-701 FA vs Linezolid for the treatment of acute bacterial skin and skin structure infections (ABSSSI). In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2010 [updated November 9, 2011]. Available from: http://clinicaltrials.gov/ct2/show/NCT01170221?term=tedizolid&rank=4.NLMidentifier:NCT01170221. Accessed July 7, 2012.
    • TR-701 FA Vs Linezolid For the Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)
  • 73
    • 84875978494 scopus 로고    scopus 로고
    • Trius Therapeutics, San Diego, CA: Trius Therapeutics; nd. Available from, Accessed July 7, 2012
    • Trius Therapeutics. Phase 3 clinical results: TR-701 posters and publications [web page on the Internet]. San Diego, CA: Trius Therapeutics; nd. Available from: http://www.triusrx.com/trius-therapeutics-tedizolid-results.php. Accessed July 7, 2012.
    • Phase 3 Clinical Results: TR-701 Posters and Publications [web Page On the Internet]
  • 75
    • 84876005159 scopus 로고    scopus 로고
    • Trius Therapeutics, In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine, updated August 1, 2012]. Available from:, Accessed January 10, 2013
    • Trius Therapeutics. TR-701 FA vs linezolid for the treatment of acute bacterial skin and skin structure infections. In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2011 [updated August 1, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT01421511?term=tedizolid&rank=14.NLMidentifier:NCT01421511. Accessed January 10, 2013.
    • (2011) TR-701 FA Vs Linezolid For the Treatment of Acute Bacterial Skin and Skin Structure Infections
  • 79
    • 84875989211 scopus 로고    scopus 로고
    • Trius Therapeutics, In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine, updated September 5, 2012]. Available from:, Accessed July 7, 2012
    • Trius Therapeutics. A phase 2 safety and exploratory skin lesion measurement of TR-701 FA study. In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2012 [updated September 5, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT01519778?term=tedizolid&rank=10.NLMidentifier:NCT01519778. Accessed July 7, 2012.
    • (2012) A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study
  • 80
    • 0035992065 scopus 로고    scopus 로고
    • Hematologic effects of linezolid: Summary of clinical experience
    • Gerson SL, Kaplan SL, Bruss JB, et al. Hematologic effects of linezolid: summary of clinical experience. Antimicrob Agents Chemother. 2002;46(8):2723-2726.
    • (2002) Antimicrob Agents Chemother , vol.46 , Issue.8 , pp. 2723-2726
    • Gerson, S.L.1    Kaplan, S.L.2    Bruss, J.B.3
  • 81
    • 0037439508 scopus 로고    scopus 로고
    • Linezolid for the treatment of multidrug-resistant, gram-positive infections: Experience from a compassionate-use program
    • Birmingham MC, Rayner CR, Meagher AK, Flavin SM, Batts DH, Schentag JJ. Linezolid for the treatment of multidrug-resistant, gram-positive infections: experience from a compassionate-use program. Clin Infect Dis. 2003;36(2):159-168.
    • (2003) Clin Infect Dis , vol.36 , Issue.2 , pp. 159-168
    • Birmingham, M.C.1    Rayner, C.R.2    Meagher, A.K.3    Flavin, S.M.4    Batts, D.H.5    Schentag, J.J.6
  • 87
    • 3943102110 scopus 로고    scopus 로고
    • Causal relationship between neuropathy and prolonged linezolid use
    • Frippiat F, Derue G. Causal relationship between neuropathy and prolonged linezolid use. Clin Infect Dis. 2004;39(3):439.
    • (2004) Clin Infect Dis , vol.39 , Issue.3 , pp. 439
    • Frippiat, F.1    Derue, G.2
  • 88
    • 0242721139 scopus 로고    scopus 로고
    • Linezolid-associated toxic optic neuropathy: A report of 2 cases
    • Lee E, Burger S, Shah J, et al. Linezolid-associated toxic optic neuropathy: a report of 2 cases. Clin Infect Dis. 2003;37(10):1389-1391.
    • (2003) Clin Infect Dis , vol.37 , Issue.10 , pp. 1389-1391
    • Lee, E.1    Burger, S.2    Shah, J.3
  • 89
    • 84875998443 scopus 로고    scopus 로고
    • Trius Therapeutics, In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine, [updated December 5, 2012]. Available from: Accessed July 7, 2012
    • Trius Therapeutics. A phase 1, open-label, 10 day safety study. In: ClinicalTrials.gov [website on the Internet]. Bethseda, MD: US National Library of Medicine; 2012 [updated December 5, 2012]. Available from: http://clinicaltrials.gov/ct2/show?term=tedizolid&rank=11.NLMidentifier:NCT01623401. Accessed July 7, 2012.
    • (2012) A Phase 1, Open-label, 10 Day Safety Study
  • 91
    • 84255201091 scopus 로고    scopus 로고
    • The oxazolidinones: Past, present, and future
    • Shaw KJ, Barbachyn MR. The oxazolidinones: past, present, and future. Ann N Y Acad Sci. 2011;1241:48-70.
    • (2011) Ann N Y Acad Sci , vol.1241 , pp. 48-70
    • Shaw, K.J.1    Barbachyn, M.R.2
  • 93
    • 0942268839 scopus 로고    scopus 로고
    • Pharmacokinetics of DA-7867, a new oxazolidinone, after intravenous or oral administration to rats: Intestinal first-pass effect
    • Bae SK, Chung WS, Kim EJ, et al. Pharmacokinetics of DA-7867, a new oxazolidinone, after intravenous or oral administration to rats: intestinal first-pass effect. Antimicrob Agents Chemother. 2004;48(2):659-662
    • (2004) Antimicrob Agents Chemother , vol.48 , Issue.2 , pp. 659-662
    • Bae, S.K.1    Chung, W.S.2    Kim, E.J.3


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