In vitro activity of tedizolid (TR-700) against linezolid-resistant staphylococci

Journal of Antimicrobial Chemotherapy

Volumn 67, Issue 1, 2012, Pages 167-169

  Rodríguez Avial, Iciar ^a   Culebras, Esther ^a   Betriu, Carmen ^a   Morales, Gracia ^b   Pena, Irene ^a   Picazo, Juan J ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b UNIVERSIDAD EUROPEA DE MADRID   (Spain)

Author keywords

Coagulase negative staphylococci; Oxazolidinones; Resistance; Staphylococcus aureus; Torezolid

Indexed keywords

CHLORAMPHENICOL; CLINDAMYCIN; COTRIMOXAZOLE; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; ERYTHROMYCIN; GENTAMICIN; LINEZOLID; RIFAMPICIN; TEDIZOLID; TEICOPLANIN; TETRACYCLINE; TIGECYCLINE; TOBRAMYCIN; VANCOMYCIN; 3 (3 FLUORO 4 (6 (2 METHYL 2H TETRAZOL 5 YL)PYRIDIN 3 YL)PHENYL) 5 HYDROXYMETHYLOXAZOLIDIN 2 ONE; 3-(3-FLUORO-4-(6-(2-METHYL-2H-TETRAZOL-5-YL)PYRIDIN-3-YL)PHENYL)-5-HYDROXYMETHYLOXAZOLIDIN-2-ONE; ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; OXAZOLIDINONE DERIVATIVE; TETRAZOLE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; BROTH DILUTION; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; DRUG EFFECT; HUMAN; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; STAPHYLOCOCCUS; STAPHYLOCOCCUS INFECTION;

ACETAMIDES; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; OXAZOLIDINONES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; TETRAZOLES;

EID: 84858244397     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkr403     Document Type: Article

References (11)

1. Tsiodras S, Gold HS, Sakoulas G et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 2001; 358: 207-8.
2. Morales G, Picazo JJ, Baos E et al. Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus. Clin Infect Dis 2010; 50: 821-5.
3. Biedenbach DJ, Farrell DJ, Mendes RE et al. Stability of linezolid activity in an era of mobile oxazolidinone resistance determinants: results from the 2009 Zyvoxw Annual Appraisal of Potency and Spectrum program. Diagn Microbiol Infect Dis 2010; 68: 459-67.
4. Picazo JJ, Betriu C, Rodríguez-Avial I et al. Comparative activities of daptomycin and several agents against staphylococcal blood isolates. Glycopeptide tolerance. Diagn Microbiol Infect Dis 2011; 70:373-9.
5. Potoski BA, Adams J, Clarke L et al. Epidemiological profile of linezolidresistant coagulase-negative staphylococci. Clin Infect Dis 2006; 43:165-71.
6. Picazo JJ, Betriu C, Culebras E et al. Activity of daptomycin against staphylococci collected from bloodstream infections in Spanish medical centers. Diagn Microbiol Infect Dis 2009; 64: 448-51.
7. Livermore DM, Mushtaq S, Warner M et al. Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococci. J Antimicrob Chemother 2009; 63: 713-5.
8. Shaw KJ, Poppe S, Schaadt R et al. In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. Antimicrob Agents Chemother 2008; 52: 4442-7.
9. Clinical and Laboratory Standards Institute. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically-Eighth Edition: Approved Standard M07-A8. CLSI, Wayne, PA, USA, 2009.
10. Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing: Twenty-first Informational Supplement M100-S21. CLSI, Wayne, PA, USA, 2011.
11. Prokocimer P, Bien P, Surber J et al. Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections. Antimicrob Agents Chemother 2011; 55: 583-92.